Clinical Trials on Subjects With Severe, Refractory Sclerotic Skin Changes

Total 163 results

Abramson Cancer Center of the University of Pennsylvania

Terminated

Ablative Fractional Laser for Sclerotic GVHD-Associated Joint Contractures

Subjects With Severe, Refractory Sclerotic Skin Changes

United States
Mundipharma Research GmbH & Co KG

Completed

A Randomised, Double Blind, Placebo and Active Controlled, Double Dummy,Parallel Group Study to Determine the Safety and Efficacy of Oxycodone/Naloxone Prolonged Release Tablets in Subjects With Moderate to Severe, Chronic Nonmalignant Pain

Subjects With Moderate to Severe, Chronic Nonmalignant Pain
Tongji Hospital

Recruiting

A 6-month Follow-up Study of Patients With Severe Fever With Thrombocytopenia Syndrome

Severe Fever With Thrombocytopenia Syndrome

China
Qin Ning

Recruiting

Evaluate the Efficacy and Safety of Various Treatment Schemes for Severe Fever With Thrombocytopenia Syndrome(SFTS)

Severe Fever With Thrombocytopenia Syndrome

China
University of South Carolina
U.S. Army Medical Research and Development Command

Completed

Dietary Seaweed and Early Breast Cancer: A Randomized Trial

Seaweed Associated Changes in Healthy Subjects

United States
Tongji Hospital

Recruiting

Efficacy of Intravenous Immunoglobulin in Patients With Hemorrhagic Fever With Renal Syndrome: a Prospective Study

HFRS (Hemorrhagic Fever With Renal Syndrome)

China
U.S. Army Medical Research and Development Command
Walter Reed Army Institute of Research (WRAIR); US Army Medical Research Institute... and other collaborators

Completed

Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever

Hemorrhagic Fever With Renal Syndrome

United States
U.S. Army Medical Research and Development Command

Enrolling by invitation

Ribavirin for Hemorrhagic Fever With Renal Syndrome

Hemorrhagic Fever With Renal Syndrome

Korea, Republic of
U.S. Army Medical Research and Development Command
Walter Reed Army Institute of Research (WRAIR); US Army Medical Research Institute... and other collaborators

Completed

Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines (HTNV/PUUV)

Hemorrhagic Fever With Renal Syndrome

United States
U.S. Army Medical Research and Development Command

Withdrawn

Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany (HFRS)

Hemorrhagic Fever With Renal Syndrome

Germany
Ilocos Training and Regional Medical Center

Not yet recruiting

Effectiveness Of High Dose Melatonin As Adjunctive Therapy For Dengue Fever With Warning Signs

Dengue Fever With Warning Signs
Wolfson Medical Center

Unknown

Intrapartum Fever and Histopathological Placental Findings

Histological Placental Inflamation With or Without Fever
Assaf-Harofeh Medical Center

Unknown

Accuracy of Measurement of Surface Body Temperature Using the Health e Pod Device (Card Guard) Compared to Gold Standard Equipment

All Children Admitted to the ED | Children With Fever

Israel
Assistance Publique - Hôpitaux de Paris

Unknown

Neurofeedback Rehabilitation Based on Motor Imaging in Patients in the Immobilization Phase (REMINARY)

Healthy Subjects, Patients With Amyotrophic Lateral Sclerosis, Patients With Shoulder Surgery

France
Nestlé

Completed

Effect of Starter Formula on Infection Prevention

Gastro-intestinal Infections | Infections With Fever

France, Germany, Netherlands
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Stem Cell Transplant Using Peripheral and Cord Blood Stem Cells to Treat Severe Aplastic Anemia and Myelodysplastic Syndrome

Severe Aplastic Anemia (SAA) | Myelodysplastic Syndrome (MDS) With Refractory Anemia (RA)

United States
Fred Hutchinson Cancer Center
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Allogeneic Hematopoietic Cell Transplantation for Severe Systemic Sclerosis

Systemic Scleroderma | Severe Systemic Sclerosis

United States
Kyowa Kirin Co., Ltd.

Active, not recruiting

A Phase 3 Study of KHK4827 in Patients With Systemic Sclerosis

Moderate to Severe Systemic Sclerosis

Japan
University Hospital, Ghent

Completed

A Protocol Based Treatment for Early and Severe Systemic Sclerosis With (Anti-CD20), Rituximab

Early and Severe Systemic Sclerosis

Belgium
Connecticut Children's Medical Center

Completed

Video Discharge Instructions for Fever and ED Recidivism

Children Who Present to the ED With Minor Febrile Illnesses

United States
Novartis Pharmaceuticals

Completed

Study of Efficacy and Safety of Canakinumab in Patients With Hereditary Periodic Fevers

Hereditary Periodic Fevers

Belgium, Italy, Japan, Russian Federation, Turkey, Spain, Germany, United Kingdom, France, United States, Ireland, Israel, Canada, Hungary, Netherlands, Switzerland
University of California, San Francisco

Completed

Adding Malabsorption for Failed Gastric Bypass

Clinically Severe Obesity | Obesity Recidivism | Inadequate Initial Weight Loss | Poor Weight Loss | Persistent Obesity | Refractory Obesity | Intractable Obesity

United States
Clexio Biosciences Ltd.

Recruiting

A Study of CLE-400 (Topical Gel) for the Treatment of Chronic Pruritus in Adult Subjects With Notalgia Paresthetica

Chronic Pruritus in Adult Subjects With Notalgia Paresthetica (NP)

United States
Galderma R&D

Completed

Performance of Different Application Regimens of ACTINICA® on Protection From UVR-induced Erythema After One Day of Sun Exposure in Fair-skinned Healthy Subjects.

Healthy Subjects, Male or Female, of 18-60 Years Old, With Phototype I, II or III, Not Pre-treated/Pre-protected Skin

France
Amgen

Completed

Study of AMG 162 in Subjects With Advanced Cancer Currently Being Treated With Intravenous (IV) Bisphosphonates

Bone Metastases in Men With Hormone-Refractory Prostate Cancer | Bone Metastases in Subjects With Advanced Breast Cancer | Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma
Gunma University

Completed

Effect and Safety of Local Injection of Botulinum Toxin Type B Against Digital Ulcer in Systemic Sclerosis

Systemic Sclerosis Patients With Digital Ulcers

Japan
Insel Gruppe AG, University Hospital Bern
ETH Zurich

Not yet recruiting

Swiss 2024 Continous Fever Monitoring in Pediatric Oncology Patients

Pediatric Oncology Patients With Risk for Infections

Switzerland
Jiangsu HengRui Medicine Co., Ltd.

Recruiting

A Trial of SHR-A1811versus Pyrotinib in Combination With Capecitabine in HER2-Positive, Unresectable and/or Metastatic Breast Cancer Subjects Previously Treated With Trastuzumab and Taxane

HER2-Positive, Unresectable and/or Metastatic Breast Cancer Subjects Previously Treated With Trastuzumab and Taxane

China
Amgen

Completed

Open-Label Access Protocol of Denosumab for Subjects With Advanced Cancer

Bone Metastases in Men With Hormone-Refractory Prostate Cancer | Bone Metastases in Subjects With Advanced Breast Cancer

Spain, Czechia, Peru, Russian Federation, Austria, Lithuania, Poland, South Africa, Italy, Ukraine, Israel, Argentina, Belgium, Brazil, France, Hungary, Japan, Latvia, Panama
Gangnam Severance Hospital

Unknown

Inflammatory Markers for Postoperative Complications in Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy

Korea, Republic of
Michael M. Pham

Terminated

A Study to Evaluate the Safety and Tolerability of Oral Ixazomib in Scleroderma-related Lung Disease Patients

Systemic Sclerosis | Scleroderma, Systemic | Scleroderma, Diffuse | Diffuse Cutaneous Systemic Sclerosis | Interstitial Lung Disease | Scleroderma | Systemic Sclerosis, Diffuse | Diffuse Systemic Sclerosis | Pulmonary Fibrosis Interstitial | Diffuse Scleroderma | Diffuse Cutaneous Scleroderma | Progressive Systemic... and other conditions

United States
Amgen

Completed

Denosumab (AMG 162) in Bisphosphonate Naive Metastatic Breast Cancer

Breast Cancer | Metastases | Bone Metastases in Subjects With Advanced Breast Cancer
Amgen

Completed

Safety and Efficacy Study of Romiplostim to Treat Immune Thrombocytopenia (ITP) in Pediatric Patients

Thrombocytopenia | Immune Thrombocytopenia | Idiopathic Thrombocytopenic Purpura | Thrombocytopenia in Pediatric Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP) | Thrombocytopenia in Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP) | Thrombocytopenic Purpura

United States, Canada, Australia
Amgen

Completed

Safety and Efficacy Study of Romiplostim (AMG 531) to Treat ITP in Pediatric Subjects

Idiopathic Thrombocytopenic Purpura | Thrombocytopenia in Pediatric Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP) | Thrombocytopenia in Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP)
Yale University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Naltrexone for Antipsychotic-Induced Weight Gain (NTX)

Schizophrenia | Schizoaffective Disorder | Schizophreniform Disorder | Bipolar Disorder | Severe Major Depression With Psychotic Features

United States
Amgen

Completed

Open Label Extension to SRE Studies in United Kingdom and Czech Republic Only

Bone Metastases in Men With Hormone-Refractory Prostate Cancer | Bone Metastases in Subjects With Advanced Breast Cancer | Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma

United Kingdom, Czech Republic
Institute of Tropical Medicine, Belgium

Completed

Filter Paper Blood Spots Collected During Fever as a Source for Post-travel Diagnosis in Travelers (JOKA-II)

Fever

Belgium
University of Erlangen-Nürnberg Medical School

Unknown

Abatacept Bone Effects in Psoriatic Arthritis With Bone Biomarker

Evaluate Bone Changes in Patients With PsA

Germany
Eli Lilly and Company

Active, not recruiting

A Study of Baricitinib (LY3009104) in Adult and Pediatric Japanese Participants With NNS/CANDLE, SAVI, and AGS

Aicardi Goutieres Syndrome | Nakajo-Nishimura Syndrome | Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy and Elevated Temperature Syndrome | STING-Associated Vasculopathy With Onset in Infancy

Japan
Rambam Health Care Campus

Withdrawn

The Effect of Probiotics on Response to Therapy and on Adverse Effect in Patients Treated With Colchicine for Familial Mediterranean Fever.

Familial Mediterranean Fever (FMF )
Hospices Civils de Lyon

Unknown

Non-interventional Study Describing Epidemiology, Prognosis and Patient Healthcare Costs in France, 2010-2017 (PROGRESS)

Lung Diseases, Interstitial | Lung Disease With Systemic Sclerosis

France
Sheba Medical Center

Completed

Kineret (Anakinra), in Adult Patients With Colchicine-Resistant Familial Mediterranean Fever (FMF)

Familial Mediterranean Fever

Israel
Véronique Hentgen

Active, not recruiting

Physical Abilities of Teenagers With Familial Mediterranean Fever (Sport & FMF)

Familial Mediterranean Fever

France
Medipol University
Istanbul University - Cerrahpasa (IUC)

Completed

The Movement Imagery Ability in Patients With Familial Mediterranean Fever

Familial Mediterranean Fever

Turkey
Hospices Civils de Lyon

Completed

A Diagnostic Test for Familial Mediterranean Fever (DEPIST-FMF)

Familial Mediterranean Fever

France
Novartis Pharmaceuticals

Completed

Evaluate the Safety and Efficacy of Canakinumab in Pediatric Patients With Colchicine Intolerant or Colchicine Resistant Familial Mediterranean Fever (FMF) (CONTROL FMF)

Colchicine Resistant/Intolerant Familial Mediterranean Fever

Israel
Centre hospitalier de l'Université de Montréal...
St. Joseph's Healthcare Hamilton; McGill University; Canadian Institutes of Health... and other collaborators

Not yet recruiting

Mycophenolate Mofetil in Systemic Sclerosis With Subclinical Interstitial Lung Disease (SSc-mILD)

Systemic Sclerosis | Interstitial Lung Disease | Systemic Sclerosis With Lung Involvement

Canada
University Hospital, Caen

Completed

PortoSinusoidal Vascular Diseases and Systemic Sclerosis

PSVD With or Without SSc

France
University Hospital, Montpellier

Not yet recruiting

Assessment of microRNAs Role in Familial Mediterranean Fever FMF Pathophysiology (miRinFMF)

Familial Mediterranean Fever

France
Sohag University

Not yet recruiting

Clinical and Molecular Evaluation of Childern With Familial Meditterranean Fever and Their Siblings

Familial Mediterranean Fever

Egypt

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