Clinical Trials on Symptomatic Severe Aortic Stenosis

Total 1196 results

NYU Langone Health

Completed

Aortic Valve and Root Measurements Under Real-Time 3-Dimensional Visualization During Angiography

Coronary Artery Disease | Aortic Stenosis

United States
REDNVIA Co., Ltd.

Recruiting

A Study to Evaluate the Efficacy and Safety of DA-1229 (Evogliptin) in Patient's Calcific Aortic Valve Disease With Mild to Moderate Aortic Stenosis (EVOID-AS)

Calcific Aortic Valve Disease

United States
David C. Rotzinger

Recruiting

Impact of Fast-rotation Coronary CT in Patients Undergoing Aortic Stenosis Workup (FAST-CCT)

Cardiovascular Diseases | Aortic Valve Stenosis | Coronary Stenosis

Switzerland
Amsterdam UMC, location VUmc

Recruiting

Assessment of Cardiac Function, Microvascular Function and Cardiac Perfusion in Different Disease Stages of Hypertrophic Cardiomyopathy (FUSION-HCM)

Hypertrophic Cardiomyopathy | Hypertrophic Cardiomyopathy, Obstructive

Netherlands
Oslo University Hospital
Oslo Metropolitan University

Not yet recruiting

10-year Follow-up After Aortic Valve Replacement Surgery (AVR-10year)

Quality of Life | Aortic Stenosis | Anxiety | Depressive Symptoms
Guangdong Provincial People's Hospital

Recruiting

Observational Study for Patients With Hypertrophic Cardiomyopathy

HCM - Hypertrophic Cardiomyopathy

China
Imbria Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Safety, Tolerability, and Efficacy of IMB-1018972 in Patients With Non-obstructive Hypertrophic Cardiomyopathy Trial (IMPROVE-HCM)

Non-obstructive Hypertrophic Cardiomyopathy

United States, United Kingdom
LianBio LLC

Active, not recruiting

A Study to Evaluate the Efficacy and Safety of Mavacamten in Chinese Adults With Symptomatic Obstructive HCM

Obstructive Hypertrophic Cardiomyopathy

China
Hangzhou Valgen Medtech Co., Ltd

Active, not recruiting

Feasibility Study of the DragonFire for Hypertrophic Obstructive Cardiomyopathy

Obstructive Hypertrophic Cardiomyopathy

China
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Patients' Long-Term Survival of Obstructive Hypertrophic Cardiomyopathy (HCM)

Cardiomyopathy | Obstructive Hypertrophic Cardiomyopathy

United States
Steen Hvitfeldt Poulsen

Completed

The Effect of Metoprolol in Patients With Hypertrophic Obstructive Cardiomyopathy. (TEMPO)

Hypertrophic Cardiomyopathy

Denmark
Abbott Medical Devices

Completed

Triple Chamber Pacing in Hypertrophic Obstructive Cardiomyopathy (HOCM) Patients - TRICHAMPION STUDY (TRICHAMPION)

Hypertrophic Cardiomyopathy With Obstruction

Spain
University of Catania

Completed

Reobtain Coronary Ostia Cannulation Beyond Transcatheter Aortic Valve Stent (RE-ACCESS) (RE-ACCESS)

Coronary Artery Disease | Aortic Stenosis

Italy
Far Eastern Memorial Hospital

Unknown

Presentations of Hypertrophic Cardiomyopathy on Myocardial Perfusion Imaging

Hypertrophic Cardiomyopathy | Myocardial Perfusion Imaging

Taiwan
RWTH Aachen University

Completed

Examination of Valve Insufficiency Before and After MitraClip or TAVI Procedure by 3D Echocardiography Compared to MRI (3D_TTE_TAVI)

Aortic Stenosis | Mitral Valve Insufficiency | Development of Standardized Assessment TAVI and MitraClip Procedures by Echocardiography

Germany
Swan Medical S. L.

Terminated

Dokimos Plus Aortic Valve Implant in 80 Patients Diagnosed With a Heart Valve Disease and Requiring Valve Replacement

Stenosis | Regurgitation, Aortic

Spain
National Taiwan University Hospital

Not yet recruiting

EEG/MECG/EMG Evaluating the Severity of Aortic Stenosis, Heart Failure and Ischemic Stroke Through an Artificial Intelligenceassisted System.

CVD

Taiwan
Mayo Clinic

Recruiting

Prevalence of Transthyretin Cardiac Amyloidosis in Clinically Significant Aortic Stenosis

Aortic Stenosis | Transthyretin Amyloidosis | Transthyretin Cardiac Amyloidosis | Transthyretin Amyloid Cardiomyopathy

United States
Baystate Medical Center
Springfield College

Completed

Physical and Functional Recovery From Cardiac Surgery in Hospitalized Patients: A Feasibility Pilot Study

Coronary Artery Disease | Aortic Valve Stenosis | Mitral Valve Insufficiency | Mitral Valve Stenosis | Aortic Valve Regurgitation | Coronary Artery Bypass Graft Triple Vessel

United States
China National Center for Cardiovascular Diseases

Recruiting

Efficacy and Safety of Thoracoscopic Morrow Surgery in the Treatment of Hypertrophic Obstructive Cardiomyopathy

Minimally Invasive Surgery | Cardiomyopathy, Hypertrophic Obstructive

China
Shandong Suncadia Medicine Co., Ltd.

Recruiting

A Trial of HRS-1893 in Healthy Volunteers and Patients With Obstructive Hypertrophic Cardiomyopathy

Obstructive Hypertrophic Cardiomyopathy

China
Morten Steen Kvistholm Jensen
Odense University Hospital; Zealand University Hospital; Viborg Regional Hospital

Recruiting

Treatment Effects of Bisoprolol and Verapamil in Symptomatic Patients With Non-obstructive Hypertrophic Cardiomyopathy (TEMPO II)

Non-obstructive Hypertrophic Cardiomyopathy

Denmark
Imperial College London
British Heart Foundation

Recruiting

Electromechanically Optimised Right Ventricular Pacing In Hypertrophic Cardiomyopathy (EMORI-HCM) (EMORI-HCM)

Hypertrophic Cardiomyopathy | Hypertrophic Obstructive Cardiomyopathy

United Kingdom
St. Antonius Hospital
Erasmus Medical Center

Recruiting

Surgical Septal Myectomy vs Percutaneous Transluminal Alcohol Septal Ablation in Patients With Hypertrophic Obstructive Cardiomyopathy (AMARONE)

Hypertrophic Cardiomyopathy

Netherlands
Cytokinetics

Completed

Dose-finding Study to Evaluate the Safety, Tolerability, PK, and PD of CK-3773274 in Adults With HCM (REDWOOD-HCM)

Hypertrophic Cardiomyopathy (HCM)

United States, Spain, Italy, Netherlands
University Hospital, Motol

Completed

Effect of Metoprolol in Post Alcohol Septal Ablation Patients With Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy

Czechia
MyoKardia, Inc.

Completed

Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy (EXPLORER-HCM)

Obstructive Hypertrophic Cardiomyopathy

United States, France, Germany, Czechia, Spain, Belgium, Denmark, Portugal, Netherlands, Israel, Poland, United Kingdom, Italy
The Cleveland Clinic

Completed

Conduction Abnormalities With Severe Aortic Stenosis Before and After Transcatheter Aortic Valve Replacement

Bradycardia

United States
Assiut University
Manchester University NHS Foundation Trust

Unknown

Early Outcomes of Concomitant Transcatheter Aortic Valve Implantation and Off-pump Coronary Artery Bypass Grafting in Management of Severe Symptomatic Aortic Stenosis and Coronary Artery Disease

Coronary Artery Disease | Aortic Valve Disease

Egypt
Tomsk National Research Medical Center of the Russian...

Completed

Mitral Valve in Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Russian Federation
TriFlo Cardiovascular, Inc.

Not yet recruiting

Transcatheter Treatment of Tricuspid Valve Regurgitation

Symptomatic Severe Tricuspid Regurgitation

Italy
University Hospital, Strasbourg, France

Not yet recruiting

Expression of Sodium-glucose Co-transporter 2 in Human Heart (SGLT2-MICRA)

Aortic Valve Stenosis

France
University of Virginia

Recruiting

Platelet Adhesion in the Pathobiology of Aortic Stenosis

Aortic Valve Stenosis

United States
University Hospital, Lille
Ministry of Health, France

Recruiting

Balloon-Expandable Versus Self-expanding Transcatheter Heart Valve for Treatment of Symptomatic Native Aortic Valve Stenosis (BEST) (BEST)

Aortic Valve Stenosis

France
Radboud University Medical Center

Recruiting

Myeloid Cells in Aortic Valve Stenosis (MIRACLE)

Aortic Valve Stenosis | Aortic Valve Disease

Netherlands
Meril Life Sciences Pvt. Ltd.

Recruiting

Myval Global Study of Myval™ THV Series Implanted in Patients With Native Severe Aortic Valve Stenosis.

Aortic Valve Stenosis

Slovenia, Spain, Turkey, Italy, Netherlands, Estonia, Poland
University Hospital, Rouen
University Hospital, Caen

Recruiting

Measurement of Myocardial Stiffness Using Elastometry in Patients With Aortic Stenosis (ELASTOP-AS)

Aortic Valve Stenosis

France
Biotronik AG
Medstar Health Research Institute

Completed

BIOVALVE - I / II Clincial Investigation (BIOVALVE)

Aortic Valve Stenosis | Heart Valve Diseases

Belgium, Germany, Switzerland, Netherlands
Catharina Ziekenhuis Eindhoven

Active, not recruiting

Stress Aortic Valve Index for Assessing Risk in Aortic Valve Stenosis Patients (SAVI-AoS)

Aortic Valve Stenosis

Denmark, Netherlands, United States
Cardiawave SA

Completed

Valvosoft First-In-Man Study in Severe Symptomatic Aortic Stenosis

Aortic Valve Stenosis

France, Netherlands
Cardiawave SA

Active, not recruiting

Valvosoft First-In-Human Study in Severe Symptomatic Aortic Stenosis

Aortic Valve Stenosis

Serbia
Aarhus University Hospital Skejby

Completed

Pressure Gradient vs. Flow Relationships in Patients With Symptomatic Valvular Aortic Stenosis (PREFLOW)

Aortic Valve Stenosis

Denmark
Edwards Lifesciences

Active, not recruiting

ExCEED: CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic, Severe, Calcific, Aortic Stenosis

Aortic Valve Stenosis

United States
University Hospital Inselspital, Berne

Completed

Morbidity and Mortality Due to Deferral of Aortic Valve Replacement in Patients With Severe Aortic Stenosis (AS DEFER)

Aortic Valve Stenosis

Switzerland
Heinrich-Heine University, Duesseldorf

Completed

Evaluation of BAV in Different Hemodynamic Entities of Severe AS (BAV)

Aortic Valve Stenosis

Germany
Henry Ford Health System

Withdrawn

CPX in Paradoxical Low Flow Aortic Stenosis

Aortic Valve Stenosis

United States
University Hospital Inselspital, Berne

Completed

Volume Challenge Added to DSE in the Diagnosis of Severe LFLGAS (FLOW-AS)

Aortic Valve Stenosis

Switzerland
German Heart Institute
Charite University, Berlin, Germany

Unknown

Validation of a Novel, Non-Dimensional Approach for Estimation of Pressure Gradients in Aortic Stenosis (AVD-PowerLaw)

Aortic Valve Stenosis

Germany
Institut für Pharmakologie und Präventive Medizin
Edwards Lifesciences

Completed

Quality of Care in AS IMPULSE Study (IMPULSE)

Aortic Valve Stenosis

United Kingdom, Germany, Switzerland, Austria, France, Italy, Netherlands, Czechia, Spain
Rennes University Hospital

Completed

Low Flow Low Gradient Aortic Stenosis Relevance of the (re)Search for a Contractile Reserve (LOWAS)

Aortic Valve Stenosis

France

Clinical Trials on Symptomatic Severe Aortic Stenosis

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