Clinical Trials on Systemic Treatment in South Africa

Total 9509 results

Columbia University
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Treatment Options for Protease Inhibitor-exposed Children (NEVEREST-III)

HIV Infections | HIV/AIDS

South Africa
University of Oxford
University of Cape Town

Completed

A Study of MVA85A, in Asymptomatic Volunteers Infected With TB, HIV or Both

HIV Infections | TB

South Africa
University of California, Los Angeles

Active, not recruiting

Neighborhood Alcohol & HIV Prevention in South African Townships (Philani)

Nutrition Disorders | HIV | Fetal Alcohol Syndrome

South Africa
Basilea Pharmaceutica

Completed

An Open-label Study of APX001 for Treatment of Patients With Candidemia/Invasive Candidiasis Caused by Candida Auris (APEX)

Candidemia | Candida Infection | Invasive Candidiases

South Africa
Centre for the AIDS Programme of Research in South...
Columbia University

Completed

Promoting Engagement in the Drug Resistant TB-HIV Care Continuum in South Africa PRAXIS Study (PRAXIS)

Adherence, Patient

South Africa
CONRAD
RTI International; Match Research; UZ-UCSF Collaborative Research Programme

Completed

The Quatro Study: Acceptability Study of (Placebo) Vaginal Delivery Forms for Preventing HIV and Unintended Pregnancy

HIV | Contraception

South Africa, Zimbabwe
University of California, San Francisco

Unknown

Couples in Context: An RCT of a Couples-based HIV Prevention Intervention

HIV Prevention

South Africa
Population Council

Active, not recruiting

A Crossover Adherence and Acceptability Study Assessing a DPP Capsule for HIV and Pregnancy Prevention

HIV Infections

South Africa
HIV Vaccine Trials Network
National Institute of Allergy and Infectious Diseases (NIAID)

Active, not recruiting

Evaluating Safety and Immune Response to the HIV-1 CH505 Transmitted/Founder gp120 Adjuvanted With GLA-SE in Healthy, HIV-exposed Uninfected Infants (HVTN 135)

HIV Infections

South Africa
University of Virginia
University of Venda

Active, not recruiting

Effectiveness of Point-of-use Water Treatment Technologies to Prevent Stunting Among Children in South Africa

Environmental Exposure | Diarrhoea;Infectious;Presumed | Diarrhea, Infantile | Diarrhea Tropical | Enteropathy | Malnutrition, Child

South Africa
University of California, San Francisco
University of Washington

Completed

Engagement to Care South Africa (ICARE)

HIV

South Africa
Johns Hopkins University
National Institute on Drug Abuse (NIDA); University of Witwatersrand, South... and other collaborators

Completed

A Smoking Cessation Trial in HIV-infected Patients in South Africa (JHU)

Smoking Cessation | HIV

South Africa
UNC Lineberger Comprehensive Cancer Center
Fogarty International Center of the National Institute of Health

Completed

Finding Barriers and Designing Solutions to Promote Women s Cancer Screening in South Africa (FIND)

Cervical Cancer

South Africa
University of California, Los Angeles
Emory University; BroadReach Healthcare; USAID, South Africa; South African Department...

Completed

Evaluation of Secondary Distribution of HIV Self-screening Tests by Women With HIV (HIVSSSA)

HIV Infections | HIV Seropositivity | ART

South Africa
Wits Health Consortium (Pty) Ltd
London School of Hygiene and Tropical Medicine; King's College London; Karolinska... and other collaborators

Completed

The CHAPS Trial: Combined HIV Adolescent PrEP and Prevention (CHAPS)

HIV/AIDS

South Africa
UMC Utrecht
ZonMw: The Netherlands Organisation for Health Research and Development; Wits... and other collaborators

Completed

The Intensified Treatment Monitoring Strategy to Prevent Accumulation of Drug Resistance (ITREMA) Trial (ITREMA)

HIV/AIDS

South Africa
World Bank
Department for International Development, United Kingdom; Wits Reproductive... and other collaborators

Completed

Smart Linkage-to-HIV Care Via a Smartphone App (SmartLtC)

HIV Infections | Antiretroviral Therapy | Patient Compliance | Viral Load | Cell Phone

South Africa
Boston University
Bill and Melinda Gates Foundation; University of Witwatersrand, South Africa

Completed

Revised Simplified Algorithm for Treatment Eligibility for HIV (SLATEII) (SLATEII)

HIV/AIDS | Antiretroviral Therapy

South Africa
Boston University
National Institute of Allergy and Infectious Diseases (NIAID); University of...

Completed

Rapid Initiation of Antiretroviral Therapy to Promote Early HIV/AIDS Treatment in South Africa (RapIT Study) (RapIT)

HIV

South Africa
University of KwaZulu

Completed

Management and Optimization of Nutrition, Antenatal, Reproductive, Child Health & HIV Care (MONARCH)

Pregnancy | HIV

South Africa
PATH
University of KwaZulu

Completed

Study to Determine Impact of Feeding Buddies on Adherence to WHO PMTCT Guidelines in South Africa

HIV | PMTCT

South Africa
CONRAD

Withdrawn

Paper Applicator Acceptability Study

HIV Prevention

South Africa
University of KwaZulu

Completed

Isolated Vascularized Gastric Tube Biliary Enteric Drainage: A Paediatric Case Series Experience.

Biliary Obstruction | Choledochal Cyst

South Africa
University of Pretoria
University of Stellenbosch

Recruiting

Screening Study for Cervical Pre-cancer and Cancer Prevention in South African Women. (DiaVACCS)

Cervical Cancer | CIN2 | High Grade Sil

South Africa
National Institute of Allergy and Infectious Diseases...
United States Agency for International Development (USAID)

Completed

Social and Economic Outcomes of HIV/AIDS Care and Treatment in HIV Infected South African Adults

HIV Infections

South Africa
Johns Hopkins University
National Institute of Mental Health (NIMH); Aurum Institute

Completed

Post-release Retention in HIV Care for Ex-inmates in South Africa

Hiv | Adherence, Patient

South Africa
Boston University
National Institute of Mental Health (NIMH)

Active, not recruiting

Effectiveness of Transdiagnostic Cognitive Behavioral Therapy for Improving HIV Treatment Outcomes in South Africa (CETA)

HIV/AIDS | Violence

South Africa
Desmond Tutu HIV Centre
Merck Sharp & Dohme LLC; European and Developing Countries Clinical Trials...

Unknown

Preparing for Adolescent HIV Vaccine Trials in South Africa: (CATSA)

HIV Infections | HIV Infection

South Africa
Africa Health Research Institute
London School of Hygiene and Tropical Medicine; University College, London; University... and other collaborators

Recruiting

Home-based Intervention to Test and Start (HITS)

HIV | HIV Testing | Linkage to Care

South Africa
Duke University
The Emmes Company, LLC

Recruiting

Pharmacokinetics of Antiretroviral Drugs in Lactating Women and Breastmilk Fed Infants Under 6 Months of Age in Botswana (BMS02)

HIV Infections | Lactating Women on Select DOI | Breastmilk Fed Infants of Mothers on Select DOI

South Africa
International AIDS Vaccine Initiative
ModernaTX, Inc.; AURUM Tembisa Clinical Research; Center for Family Health Research

Active, not recruiting

A Study to Evaluate the Safety and Immunogenicity of eOD-GT8 60mer mRNA Vaccine (mRNA-1644)

HIV-1-infection

Rwanda, South Africa
University of KwaZulu
Medical Research Council, South Africa; Centre for the AIDS Programme of Research...

Completed

Immediate or Deferred Pre-exposure Prophylaxis for HIV Prevention: Safe Options for Pregnant and Lactating Women (PrEP)

HIV-1-infection

South Africa
International Partnership for Microbicides, Inc.
Gilead Sciences

Withdrawn

Reversing the Epidemic in Africa With Choices in HIV Prevention (REACH)

HIV-1-infection

South Africa
University of Pretoria

Completed

Efficacy of Using a Closing Pack to Reduce Postpartum Sepsis

Prevention of Postpartum Sepsis

South Africa
Gritstone bio, Inc.

Completed

Study of Self-Amplifying Messenger Ribonucleic Acid (samRNA) Vaccines Against COVID-19 in Healthy Adults and People Living With Human Immunodeficiency Virus (HIV)

COVID-19 | SARS-CoV-2

South Africa
RTI International
Medical Research Council, South Africa

Completed

Cape Town Young Women's Health CoOp

Human Immunodeficiency Virus (HIV) | Condomless Sex | Alcohol and Drug Use | Sexually Transmitted Infections (STIs) | Violence and Victimization | Access and Linkage to Healthcare | Education Advancement

South Africa
UNC Lineberger Comprehensive Cancer Center
National Cancer Institute (NCI)

Recruiting

Acceptability and Feasibility of Combination Treatment for Cervical Precancer Among South African Women Living With HIV (ACT2)

Cervical Cancer | Human Immunodeficiency Virus | Human Papillomavirus | CIN2 | CIN3

South Africa
University of Witwatersrand, South Africa
Bill and Melinda Gates Foundation

Completed

Immunogenicity and Safety of Trivalent Influenza Vaccine in Non-pregnant HIV-infected Women

Influenza | Human Immunodeficiency Virus

South Africa
University of California, San Francisco
National Institute of Allergy and Infectious Diseases (NIAID); University Hospital... and other collaborators

Not yet recruiting

Pragmatic Use of Next-generation Sequencing for Management of Drug-resistant Tuberculosis (TSELiOT)

Drug-resistant Tuberculosis | Cost-Benefit Analysis | HIV Coinfection

South Africa
University of Witwatersrand, South Africa

Completed

Validation of Implementation of Cervical Dysplasia Treatment Modalities in HIV-Seropositive Women (VICAR2)

Cervical Intraepithelial Neoplasia

South Africa
Lannett Company, Inc.
Parexel; FARMOVS (Pty) Ltd

Completed

A Study to Demonstrate Pharmacokinetic and Pharmacodynamic Biosimilarity Between HEC-Glargine and US-Lantus® in Healthy Male Volunteers

Type 2 Diabetes Mellitus | Type 1 Diabetes Mellitus

South Africa
Cycle Pharmaceuticals Ltd.
Parexel

Completed

Bioavailability Food-Effect Study of an Oral Nitisinone Formulation to Treat Hereditary Tyrosinemia (HT-1)

Hereditary Tyrosinemia, Type I

South Africa
Massachusetts General Hospital
National Institute of Mental Health (NIMH); National Institutes of Health (NIH) and other collaborators

Completed

Safer Conception for Women - Understanding Use of Periconception PrEP

HIV Prevention | Conception

South Africa
Cycle Pharmaceuticals Ltd.
Parexel

Completed

Bioequivalence Study of Two Oral Nitisinone Formulations to Treat Hereditary Tyrosinemia (HT-1)

Hereditary Tyrosinemia, Type I

South Africa
Laboratorios Leti, S.L.

Completed

Efficacy-safety Study of Sublingual Immunotherapy With Depigmented-polymerized Pollen Extracts to Treat Rhinoconjunctivitis (GPIT)

Allergic Rhinoconjunctivitis

South Africa
bioLytical Laboratories

Recruiting

Diagnostic Sensitivity and Specificity of iStatis HBsAg Test at the Point-Of-Care Site Settings

Hepatitis B | Hepatitis B Infection

South Africa
University of KwaZulu
University of California, San Francisco; Centers for Disease Control and Prevention and other collaborators

Completed

Effectiveness of an HIV-adapted IMCI Training and Supervision Programme for Community Health Workers

Infant Feeding Practices | Prevention of Mother-to-child Transmission of HIV | Antenatal Health Care Utilization | Postnatal Health Care Utilization

South Africa
Serum Institute of India Pvt. Ltd.
University of Stellenbosch; South African Tuberculosis Vaccine Initiative; Vakzine... and other collaborators

Completed

Study to Evaluate the Safety and Immunogenicity of VPM1002 in Comparison With BCG in HIV-exposed/-Unexposed Newborn Infants in South Africa

Tuberculosis

South Africa
Aeras
University of Oxford; University of Cape Town

Completed

A Study of MVA85A in Healthy Infants

Tuberculosis

South Africa
Hoffmann-La Roche

Completed

A Study of RoActemra/Actemra (Tocilizumab) Plus DMARDs in Patients With Rheumatoid Arthritis

Rheumatoid Arthritis

South Africa

Clinical Trials on Systemic Treatment in South Africa

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