Clinical Trials on Therapy, Gene

Total 3247 results

Ultragenyx Pharmaceutical Inc

Completed

Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Sialic Acid in Patients With Glucosamine (UDP-N-acetyl)-2-epimerase Myopathy (GNEM) or Hereditary Inclusion Body Myopathy (HIBM) (GNEM)

Hereditary Inclusion Body Myopathy | GNE Myopathy | Distal Myopathy With Rimmed Vacuoles | Distal Myopathy, Nonaka Type

United States, Canada, United Kingdom, Israel, Italy, Bulgaria, France
Cairo University

Recruiting

Ultrasound Guided Versus Non-Guided Prolotherapy for Internal Derangement of Temporomandibular Joint.

Pain, Chronic | Myofascial Pain Syndrome | Ultrasound Therapy; Complications | TMJ Disc Disorder | Injection Site | TMJ | Prolotherapy | Internal Derangement | Clicking Tinnitus | Anterior Disc Displacement | Masticatory Muscle

Egypt
Roswell Park Cancer Institute
Jazz Pharmaceuticals

Recruiting

CPX-351 for the Treatment of Secondary Acute Myeloid Leukemia in Patients Younger Than 60 Years Old

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Secondary Acute Myeloid Leukemia | Therapy-Related Acute Myeloid Leukemia | Acute Myeloid Leukemia With Myelodysplasia-Related Changes

United States
Hebei Medical University Fourth Hospital

Not yet recruiting

Clinical Research on the Effect of Aspirin on the Disease Free Survival Rate of Esophageal Carcinoma

Aspirin as an Adjuvant Therapy, to Observe Its Effect on the Disease Free Survival Rate of Patients With Esophageal Squamous Cell Carcinoma

China
Sun Yat-sen University

Active, not recruiting

Apatinib and Camrelizumab in Recurrent or Metastatic Nasopharyngeal Carcinoma With First-line Treatment Failure

Nasopharyngeal Carcinoma | Chemotherapy Effect | Immunotherapy | Recurrent Nasopharyngeal Carcinoma | Metastatic Nasopharyngeal Carcinoma | Molecular Targeted Therapy

China
Autolus Limited

Enrolling by invitation

Long-term Follow-up of Patients Treated With Autologous T Cells Genetically Modified

Multiple Myeloma | DLBCL | T Cell Lymphoma | Patients Followed for up to 15 Years Following Their First Dose of AUTO CAR T Cell Therapy | ALL, Adult and Pediatric

United Kingdom
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Culturally Adapted Parenting Intervention for Spanish-Speaking Parents in Improving Outcomes of Younger Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia Survivors at Risk for Late Neurocognitive Effects

Childhood Acute Myeloid Leukemia in Remission | Cancer Survivor | Childhood Acute Lymphoblastic Leukemia in Remission | Cognitive Side Effects of Cancer Therapy

United States
National Cancer Institute (NCI)

Completed

Decitabine, Vorinostat, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

Previously Treated Myelodysplastic Syndrome | Recurrent Adult Acute Myeloid Leukemia | Secondary Acute Myeloid Leukemia | Untreated Adult Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | Therapy-Related Acute Myeloid Leukemia

United States
University College, London

Not yet recruiting

Trial of Lu-177 DOTATATE (Lutathera®) in Unlicensed Indications

Medullary Thyroid Carcinoma | Bronchial and Thymic Neuroendocrine Tumour | Paraganglioma/ Phaeochromocytoma | Those Requiring Repeat Peptide Receptor Radionuclide Therapy
Lei Li

Recruiting

Niraparib Plus Anlotinib for Recurrent Ovarian Cancer

Chemotherapy | Ovarian Carcinoma | Survival Outcomes | Adverse Events | Niraparib | Anlotinib | CA125 | Targeted Therapy | Recurrent Ovarian Cancer

China
Roswell Park Cancer Institute
National Cancer Institute (NCI)

Terminated

Photoacoustic Imaging for Measuring Tumors and Normal Tissue in Patients With Head and Neck Cancer

Head and Neck Squamous Cell Carcinoma | Head and Neck Carcinoma | Radiation Therapy Recipient | Head and Neck Lymph Node | Laryngeal Neoplasm

United States
Northwestern University
National Institutes of Health (NIH); Alzheimer's Association; Illinois Department... and other collaborators

Completed

Communication Bridge Speech Therapy Research Study

Frontotemporal Dementia | Primary Progressive Aphasia

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Neurobehavioral Complications in Children Who Were Previously Treated With Steroids and Intrathecal Therapy for Acute Lymphoblastic Leukemia

Leukemia | Neurotoxicity | Long-term Effects Secondary to Cancer Therapy in Children | Psychosocial Effects of Cancer and Its Treatment

United States
AGO Study Group
Essex Pharma GmbH; MedServ. GmbH, Wiesbaden

Completed

Combination Chemotherapy Consisting of Pegylated Liposomal Doxorubicin and Carboplatin in Malignant Gynecologic Tumours

Cervical Cancers | Cancer of the Ovary Treated as 2nd Line Therapy | Muellerian Mixed Tumours | Tumours of the Uterus | Non-Epithelial Ovarian Tumours

Germany
Pôle Saint Hélier
University Hospital, Angers; Rennes University Hospital; Université Européenne...

Completed

Evaluation and Neural Basis of Communication in Patients With Multiple Sclerosis (COGNISEP)

Multiple Sclerosis | Social Cognition | Theory of Mind | Neuropsychology | Psychological Therory

France
Ultragenyx Pharmaceutical Inc

Terminated

Study to Evaluate the Safety and Efficacy of Aceneuramic Acid Extended-Release (Ace-ER) Tablets in Patients With Glucosamine (UDP-N-acetyl)-2-epimerase Myopathy (GNEM) or Hereditary Inclusion Body Myopathy (HIBM)

Hereditary Inclusion Body Myopathy | GNE Myopathy | Distal Myopathy With Rimmed Vacuoles | Distal Myopathy, Nonaka Type | Quadriceps Sparing Myopathy

United States, Canada, United Kingdom, Israel, Italy, Bulgaria, France
Ultragenyx Pharmaceutical Inc
Newcastle University

Completed

GNE-Myopathy Disease Monitoring Program (GNEM-DMP): A Registry and Prospective Observational Natural History Study to Assess GNE Myopathy or Hereditary Inclusion Body Myopathy (HIBM)

Hereditary Inclusion Body Myopathy | GNE Myopathy | Nonaka Disease | Quadriceps Sparing Myopathy (QSM) | Distal Myopathy With Rimmed Vacuoles (DMRV)

United States, Bulgaria, Canada, France, United Kingdom
University Hospital, Bonn

Recruiting

Multiparametric Cardiac MRI in Patients Under CAR T-cell Therapy

Follicular Lymphoma | Multiple Myeloma | Myocarditis | Cytokine Release Syndrome | DLBCL | MCL | ALL | CAR T-cell Therapy | PCBCL

Germany
M.D. Anderson Cancer Center

Recruiting

Venetoclax and Azacitidine for the Treatment of Acute Myeloid Leukemia in the Post-Transplant Setting

Acute Myeloid Leukemia | Therapy-Related Acute Myeloid Leukemia | Acute Bilineal Leukemia | Acute Biphenotypic Leukemia | T Acute Lymphoblastic Leukemia | Mixed Phenotype Acute Leukemia

United States
University Medical Centre Ljubljana

Active, not recruiting

Conduction System Pacing Versus Biventricular Pacing for Cardiac resYNChronization (CSP-SYNC)

Heart Failure | Left Bundle-Branch Block | Cardiac Remodeling, Ventricular | Dilated Cardiomyopathy With Conduction Defect | Resynchronization Therapy

Slovenia
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Unknown

Treatment of Bevacizumab Followed by Steroid in RN

Brain Injuries | Nasopharyngeal Carcinoma | Adverse Effect of Radiation Therapy

China
Guangxi Medical University
Guilin Medical College; Second Affiliated Hospital of Guangzhou Medical University and other collaborators

Unknown

Comparative Study of Human Immunodeficiency Virus Negative Host Talaromyces Between Voriconazole and Amphotericin Sequential Itraconazole Therapy (CSHHTVASIT)

Talaromyces in Human Immunodeficiency Virus Negative | To Compare Voriconazole and Amphotericin Sequential Itraconazole Therapy | To Dynamically Monitor the Anti-Interferon-γ Autoantibodies

China
Pontificia Universidad Catolica de Chile

Completed

Topical 10 % Nifedipine Versus 5% Sildenafil in Secondary Raynaud

Lupus Erythematosus, Systemic | Dermatomyositis | Ultrasound Therapy; Complications | Raynaud Disease | Raynaud Phenomenon Due to Trauma | System; Sclerosis

Chile
Massachusetts General Hospital

Recruiting

Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)

Lynch Syndrome | Genetic Predisposition to Disease | Prostate Cancer | BRCA1 Mutation | BRCA2 Mutation | Prostatic Neoplasm | ATM Gene Mutation | MMR Mutation

United States
Blueprint Medicines Corporation

Terminated

(HARMONY) Study of BLU-701 in EGFR-mutant NSCLC

Neoplasms | Respiratory Tract Diseases | Neoplasms by Histologic Type | Lung Diseases | Neoplasms by Site | Adenocarcinoma | Carcinoma | Carcinoma, Non-Small-Cell Lung | Respiratory Tract Neoplasms | Thoracic Neoplasms | Carcinoma, Bronchogenic | Bronchial Neoplasms | Neoplasms, Nerve Tissue | Non Small Cell Lung... and other conditions

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

Remote Telemonitoring of Patient-Generated Physiologic Health Data and Patient-Reported Outcomes

Stage IV Prostate Cancer AJCC v8 | Hepatobiliary Neoplasm | Stage III Renal Cell Cancer AJCC v8 | Stage IV Renal Cell Cancer AJCC v8 | Stage III Uterine Corpus Cancer AJCC v8 | Stage IV Uterine Corpus Cancer AJCC v8 | Stage IVA Uterine Corpus Cancer AJCC v8 | Stage IVB Uterine Corpus Cancer AJCC v8 | Malignant Neoplasm and other conditions

United States
Shen Lin

Unknown

Anti-HER2 Therapy in Patients of HER2 Positive Metastatic Carcinoma of Digestive System

Colorectal Cancer | Esophageal Squamous Cell Carcinoma | Biliary Tract Cancer | Targeted Therapy | HER2

China
Amsterdam UMC, location VUmc
GGZ inGeest; Parnassia Bavo Groep

Terminated

Online Cognitive Training in PD, MS and Depressed Patients Treated With Electroconvulsive Therapy

Multiple Sclerosis | Idiopathic Parkinson's Disease | Elderly Post Electric Convulsive Therapy

Netherlands
Lei Li

Completed

A Study on Association Between HR Genes and the HRD Status in Chinese Epithelial Ovarian Cancer

Epithelial Ovarian Cancer | BRCA1 Mutation | BRCA2 Mutation | Homologous Recombination Deficiency | Prognosis | Chinese | Homologous Recombination Genes

China
Nobelpharma

Completed

Efficacy Confirmation Study of NPC-09

GNE Myopathy | Nonaka Disease | Distal Myopathy With Rimmed Vacuoles (DMRV) | Hereditary Inclusion Body Myopathy (hIBM)

Japan
The Cleveland Clinic

Recruiting

Efficacy of Low-intensity Shockwave vs Radial Wave for Treatment of Erectile Dysfunction and Pelvic Pain

Erectile Dysfunction | Chronic Prostatitis | Chronic Pelvic Pain Syndrome | Erectile Dysfunction Following Radical Prostatectomy | Erectile Dysfunction Following Radiation Therapy | Erectile Dysfunction Due to Arterial Insufficiency | Erectile Dysfunction Due to Arterial Disease

United States
Affiliated Hospital of Qinghai University

Not yet recruiting

Cardiotoxicity of Targeted Therapy for HER-2 Positive Breast Cancer Patients at High Altitude

HER2-positive Breast Cancer | Targeted Therapy | Cardiac Toxicity | High Altitude

China
National Cancer Institute (NCI)

Recruiting

Comparing the Addition of an Anti-Cancer Drug, Pomalidomide, to the Usual Chemotherapy Treatment (Daunorubicin and Cytarabine Liposome) in Newly Diagnosed Acute Myeloid Leukemia With Myelodysplastic Syndrome-Related Changes

Acute Myeloid Leukemia | Chronic Myelomonocytic Leukemia | Myelodysplastic Syndrome | Myeloproliferative Neoplasm | Acute Myeloid Leukemia With Multilineage Dysplasia | Acute Myeloid Leukemia Post Cytotoxic Therapy

United States
Massachusetts General Hospital

Active, not recruiting

The Transitions Project: Supporting Adults During the Shift From Cancer Treatment to Surveillance

Non Small Cell Lung Cancer | Mesothelioma | Small-cell Lung Cancer | Cognitive Behavioral Therapy

United States
RWTH Aachen University
Bayer

Completed

Rivaroxaban Compared to Vitamin K Antagonist Upon Development of Cardiovascular Calcification

Atrial Fibrillation or Pulmonary Embolism | Need of Long Term Oral Anticoagulation Therapy (OAT) | Existent Coronary or Valvular Calcification, or Both and Agatston Score > 50 in at Least One Location

Germany
Northwestern University
National Cancer Institute (NCI)

Terminated

Cryotherapy in Preventing Peripheral Neuropathy and Nail Toxicity in Patients With Breast Cancer Who Are Receiving Paclitaxel

Pain | Peripheral Neuropathy | Stage IV Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIIC Breast Cancer | Recurrent Breast Cancer | Chemotherapeutic Agent Toxicity | Therapy-related Toxicity

United States
NYU Langone Health
Washington University School of Medicine

Terminated

A Pilot Study of Metabolic Effects of Omentectomy (OMT)

Patients Who Consented to Undergo Laparoscopic Gastric Banding Surgery for Weight Loss and Consent to Participate in This studyBMI ≥35 kg/m2 | Confirmed Type 2 Diabetes Treated With Oral Agents and/or Only Diet Therapy | Age 18-64 Years

United States
Ultragenyx Pharmaceutical Inc

Terminated

A Study to Evaluate the Safety of Aceneuramic Acid Extended Release (Ace-ER; UX001) Tablets in Glucosamine (UDP-N-acetyl)-2-Epimerase (GNE) Myopathy (GNEM) (Also Known as Hereditary Inclusion Body Myopathy [HIBM]) Patients With Severe Ambulatory Impairment

Hereditary Inclusion Body Myopathy | GNE Myopathy | Inclusion Body Myopathy 2 | Distal Myopathy With Rimmed Vacuoles | Distal Myopathy, Nonaka Type | Quadriceps Sparing Myopathy

Canada, United States, Bulgaria
M.D. Anderson Cancer Center
National Cancer Institute (NCI); Genentech, Inc.

Recruiting

Venetoclax and Azacitidine for the Treatment of Relapsed or Refractory High-Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia

Recurrent Chronic Myelomonocytic Leukemia | Recurrent Myelodysplastic Syndrome | Refractory Chronic Myelomonocytic Leukemia | Refractory Myelodysplastic Syndrome | Therapy-Related Myelodysplastic Syndrome

United States
University Hospital, Clermont-Ferrand
Laboratoire HEMOTECH

Withdrawn

Catheter Dysfunction Rate in Patients Undergoing Kidney Replacement Therapy. Evaluation of the Safety and Efficacy of Anti-reflux Valves Without Heparin Lock Solution (DUKE)

Chronic Renal Failure | Haemodialysis, Haemodiafiltration, Haemofiltration | Kidney Replacement Therapy | Catheter Infection, Catheter Dysfunction, Catheter Related Bloodstream Infections

France
Kutahya Health Sciences University

Completed

The Effect of Music Therapy in COVID-19 Patients Given Prone Position

Anxiety | Respiratory Distress Syndrome | Music Therapy | Intensive Care Units | Nursing

Turkey
Massachusetts General Hospital
National Cancer Institute (NCI)

Completed

Proton Beam Radiation Therapy in Treating Young Patients Who Have Undergone Biopsy or Surgery for Medulloblastoma or Pineoblastoma

Brain and Central Nervous System Tumors | Long-term Effects Secondary to Cancer Therapy in Children

United States
National Cancer Institute (NCI)

Active, not recruiting

Using the Anticancer Drug Olaparib to Treat Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome With an Isocitrate Dehydrogenase (IDH) Mutation

Acute Myeloid Leukemia | Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Recurrent Acute Myeloid Leukemia | Recurrent Myelodysplastic Syndrome | Refractory Acute Myeloid Leukemia | Refractory Myelodysplastic Syndrome | Acute Myeloid Leukemia Post Cytotoxic Therapy

United States
Haukeland University Hospital
University of Bergen; Helse Stavanger HF; Helse Vest; Forskningsrådet; Folkehelse... and other collaborators

Active, not recruiting

Integrated Treatment of Hepatitis C Virus Infection (INTRO-HCV)

Hepatitis C, Chronic | Opioid Dependence, on Agonist Therapy

Norway
Centre Hospitalier Régional d'Orléans

Completed

Impact of Prone Position in Patients Under Spontaneous Breathing on Intubation or Non-invasive Ventilation or Death Incidence During COVID-19 Acute Respiratory Distress (PROVID-19)

Respiratory Distress Syndrome | COVID19 | Prone Position | Oxygen Therapy | Spontaneous Ventilation

France, Monaco
Tanta University

Not yet recruiting

Fexofenadine Versus Gabapentin for Uremic Pruritus in Patients on Regular Hemodialysis

Hemodialysis | ESRD | Renal Replacement Therapy | End-stage Renal Disease | Uremic Pruritus | Chronic Kidney Disease-associated Pruritus

Egypt
University Ghent
Research Foundation Flanders

Not yet recruiting

Effect and Cost-utility of of High Intensity vs. Low Intensity Speech Intervention in Children With Cleft Palate

Cleft Lip and Palate | Cleft Palate Children | Speech Therapy | Speech Disorders in Children
University Ghent
Research Foundation Flanders

Recruiting

Effect of Performance-specific Cleft Speech Intervention and Long-term Learning in Children With a Cleft Palate

Cleft Lip and Palate | Cleft Palate Children | Speech Therapy | Speech Disorders in Children

Belgium
National Taiwan University Hospital

Completed

Generic VEL/SOF With or Without RBV for HIV/HCV Coinfected Patients

Human Immunodeficiency Virus | Hepatitis C Virus Infection, Response to Therapy of

Taiwan
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Donor Natural Killer Cells and Donor Stem Cell Transplant in Treating Patients With High Risk Myeloid Malignancies

Acute Myeloid Leukemia | Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Chronic Myelomonocytic Leukemia | Acute Erythroid Leukemia | Acute Megakaryoblastic Leukemia | Myelodysplastic Syndrome | High Risk Myelodysplastic Syndrome | Blast Phase Chronic Myelogenous Leukemia,... and other conditions

United States

Clinical Trials on Therapy, Gene

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CROs in Bulgaria

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