Clinical Trials on Thoracic Empyema in United Kingdom

Total 4929 results

Institute of Child Health

Completed

Urokinase Versus Primary Video-Assisted Thorascopic Surgery for Empyema

Empyema

United Kingdom
University of Milano Bicocca
Azienda Ospedaliera San Gerardo di Monza

Completed

The Role of Surgery in Patients With Coronavirus Disease - 19 (COVID-19) Related Thoracic Complications (SThor-CoV-2)

COVID-19 | Pneumothorax | Hemothorax | Abscess | Surgical Complication | Empyema, Pleural | Thoracic

Italy, United States, Brazil, India, United Kingdom
Royal Brompton & Harefield NHS Foundation Trust

Completed

Use of Endobronchial Valves in Non-Upper Lobe Heterogeneous Emphysema

Heterogeneous Emphysema

United Kingdom
Chelsea and Westminster NHS Foundation Trust

Unknown

Bronchoscopic Intrabullous Autologous Blood Instillation (BIABI) for Emphysema (BIABI)

Bullous Emphysema

United Kingdom
Heart of England NHS Trust
University of Warwick; University of Birmingham

Completed

Chest Wall Motion Analysis in Disease (CWM)

Lung Neoplasms | Pulmonary Disease, Chronic Obstructive | Surgery | Cystic Fibrosis | Mesothelioma | Empyema, Pleural | Pectus Excavatum | Pectus Carinatum

United Kingdom
Heart of England NHS Trust
British Lung Foundation

Completed

Computed Tomography Assessment of Regional Ventilation (CURVE) (CURVE)

Lung Neoplasms | Pulmonary Disease, Chronic Obstructive | Emphysema | Lung Diseases, Interstitial

United Kingdom
Chelsea and Westminster NHS Foundation Trust

Completed

Bronchoscopic Lung Volume Reduction Using Blood

Emphysema

United Kingdom
Royal Marsden NHS Foundation Trust
Merck Sharp & Dohme LLC; Institute of Cancer Research, United Kingdom; National...

Unknown

Pembrolizumab and Palliative Radiotherapy in Lung (PEAR)

Thoracic Tumours

United Kingdom
Royal Brompton & Harefield NHS Foundation Trust

Unknown

LVR in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial Valves (BLOOD-VALVES)

Chronic Obstructive Pulmonary Disease | Emphysema

United Kingdom
Boston Scientific Corporation
PneumRx, Inc.

Completed

Randomized Comparison of the RePneu Lung Volume Reduction Coil (LVRC) to Standard of Care for the Treatment of Emphysema (RESET Study)

Emphysema

United Kingdom
Apreo Health, Inc.

Recruiting

Study to Assess Safety, Feasibility, and Preliminary Efficacy of the Apreo Implant for Severe Emphysema (BREATHE-2)

Emphysema or COPD

United Kingdom, Austria, Netherlands
University of Southampton
Solent NHS Trust

Completed

Implementing and Evaluating the Genie Tool in COPD (GeCop)

Emphysema | COPD

United Kingdom
University of East Anglia

Unknown

Simvastatin in Chronic Obstructive Pulmonary Disease (COPD)

Emphysema | COPD

United Kingdom
Royal Brompton & Harefield NHS Foundation Trust
Imperial College London

Unknown

Lung Volume Reduction Coil Microbiome Study (LVRC-Micro)

Chronic Obstructive Pulmonary Disease | Emphysema

United Kingdom
Royal Brompton & Harefield NHS Foundation Trust
Medical Research Council; The Hillingdon Hospitals NHS Foundation Trust

Terminated

Post-hospitalisation Nutritional Support and Gait Speed in COPD

Respiratory Tract Diseases | Lung Diseases, Obstructive | Pulmonary Disease, Chronic Obstructive | Pulmonary Emphysema | Bronchitis, Chronic

United Kingdom
Beam Therapeutics Inc.

Not yet recruiting

A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)

Alpha 1-Antitrypsin Deficiency

United Kingdom
Royal Brompton & Harefield NHS Foundation Trust
Medical Research Council

Completed

Is the Short Physical Performance Battery a Useful Outcome Measure in Chronic Obstructive Pulmonary Disease

Lung Diseases | Disease Progression | Lung Diseases, Obstructive | Pulmonary Disease, Chronic Obstructive | Pulmonary Emphysema | Bronchitis, Chronic

United Kingdom
Royal Brompton & Harefield NHS Foundation Trust

Completed

BioGlue or Vivostat in the Control of Air Leak in Thoracic Surgery

Thoracic Surgery | Air Leak

United Kingdom
Royal Brompton & Harefield NHS Foundation Trust
Medical Research Council; The Hillingdon Hospitals NHS Foundation Trust; West...

Completed

Do the SPPB and 4-metre Gait Speed Predict Hospital Readmission in Patients Hospitalised for Acute Exacerbation if COPD?

Respiratory Tract Diseases | Lung Diseases | Disease Progression | Lung Diseases, Obstructive | Pulmonary Disease, Chronic Obstructive | Pulmonary Emphysema | Bronchitis, Chronic

United Kingdom
Pulmonx Corporation

Completed

Post-Market Clinical Evaluation of the Zephyr Valve 5.5-LP EBV

Pulmonary Emphysema

United Kingdom, Switzerland, Germany
Alnylam Pharmaceuticals

Terminated

A Study of an Investigational Drug, ALN-AAT, in Healthy Adult Subjects and Patients With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

Antitrypsin Deficiency Liver Disease

United Kingdom
Grifols Therapeutics LLC

Completed

Alpha-1-Antitrypsin (AAT) To Treat Emphysema In AAT-Deficient Patients (EXACTLE)

Alpha 1-Antitrypsin Deficiency

Denmark, Sweden, United Kingdom
University Hospital Southampton NHS Foundation...

Recruiting

Transthoracic Ultrasound Evaluation of Thoracic Aortic Aneurysms

Thoracic Aortic Aneurysm

United Kingdom
Medtronic - MITG

Completed

A Post-market Study of the Endo GIA™ Reinforced Reload With Tri-Staple™ Technology

Non-emergent, Abdominal or Thoracic Procedures

United Kingdom
Alnylam Pharmaceuticals

Terminated

A Study of ALN-AAT02 in Healthy Participants and Participants With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

United Kingdom
Wave Life Sciences Ltd.

Recruiting

A Phase 1 Research Study to Evaluate Safety, Tolerability, and Pharmacokinetics of WVE-006 in Healthy Participants With Wild-type AAT Expression (RestorAATion-1) (RestorAATion-1)

Alpha-1 Antitrypsin Deficiency

United Kingdom
Swedish Medical Center

Completed

Management of Pleural Space Infections

Empyema, Pleural | Parapneumonic Effusion

United States
Papworth Hospital NHS Foundation Trust

Unknown

Effective Treatments for Thoracic Aortic Aneurysms (ETTAA Study): A Prospective Cohort Study (ETTAA)

Thoracic Aortic Aneurysm

United Kingdom
Liverpool Heart and Chest Hospital NHS Foundation...

Unknown

Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery (AZATAAR)

Thoracic Aneurysm

United Kingdom
Children's Mercy Hospital Kansas City

Withdrawn

Empyema Treated With tPA & DNAse

Empyema

United States
Children's Mercy Hospital Kansas City

Completed

Thoracoscopy Versus Fibrinolysis in Children With Empyema

Empyema

United States
Medtronic Cardiovascular

Completed

Safety and Efficacy of Valiant Mona LSA Stent Graft System

Thoracic Aortic Aneurysms

United States, United Kingdom
University of Nottingham
Nottingham University Hospitals NHS Trust

Recruiting

Functional and Structural Lung Imaging in Chronic Obstructive Pulmonary Disease (FASTCOPD)

Chronic Obstructive Pulmonary Disease | Alpha 1-Antitrypsin Deficiency

United Kingdom
Ethicon Endo-Surgery

Completed

A Prospective, Multi-Center Evaluation of the ENSEAL X1 Large Jaw Tissue Sealer

Colectomy; Gynecological; Thoracic

United States, United Kingdom
Guy's and St Thomas' NHS Foundation Trust

Recruiting

Preoperative Paravertebral Block in Cancer Surgery of the Lung (ParaSOL)

Anesthesia, Local | Thoracic Neoplasm | Acute Post-thoracotomy Pain | Chronic Pain Post-Procedural

United Kingdom
Arrowhead Pharmaceuticals

Active, not recruiting

Study of Fazirsiran (TAK-999, ARO-AAT) in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATD)

Alpha 1-Antitrypsin Deficiency

Austria, Germany, United Kingdom
Pulmonx Corporation

Active, not recruiting

Fissure Closure With the AeriSeal System for CONVERTing Collateral Ventilation Status (CONVERT) (CONVERT)

Emphysema | COPD | Severe Emphysema

United Kingdom, France, Netherlands, Germany, Australia, Italy, Switzerland
Pulmonx Corporation

Completed

To Improve Lung Function and Symptoms for Emphysema Patients Using Zephyr Valves (TRANSFORM)

COPD | Heterogeneous Emphysema

Netherlands, Sweden, United Kingdom, Germany, France, Belgium
Teesside University
Barts & The London NHS Trust; South Tees Hospitals NHS Foundation Trust

Completed

Exploring Robotic-assisted Thoracic Surgery for Lung Cancer (ROSE)

Lung Cancer | Surgery | Thoracic Cancer

United Kingdom
Denver Health and Hospital Authority

Completed

Treatment of Complicated Parapneumonic Effusion With Fibrinolytic Therapy Versus VATs Decortication

Coagulopathy | Empyema, Pleural | Parapneumonic Effusion

United States
Arrowhead Pharmaceuticals

Terminated

A Study of ARC-AAT in Healthy Volunteer Subjects and Patients With Alpha-1 Antitrypsin Deficiency (AATD)

Alpha-1 Antitrypsin Deficiency

Australia, Netherlands, Germany, United Kingdom
Imperial College London
Gene Logic

Completed

Regulation of Inflammatory Mediators in Chronic Obstructive Pulmonary Disease

Emphysema | COPD

United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust
University of Sheffield

Completed

Sheffield Multiple Rib Fractures Study: (SMuRFS)

Rib Fractures

United Kingdom
Imperial College London
Novartis; Boehringer Ingelheim; Royal Brompton & Harefield NHS Foundation Trust

Completed

Regulation of the Release of Inflammatory Mediators From Lung Macrophages.

Emphysema | COPD | Chronic Bronchitis

United Kingdom
Imperial College London

Completed

Leukocyte Function in Chronic Obstructive Pulmonary Disease (COPD)

Emphysema | COPD | Chronic Bronchitis

United Kingdom
Kamada, Ltd.

Completed

International Study Evaluating the Safety and Efficacy of Inhaled, Human, Alpha-1 Antitrypsin (AAT) in Alpha-1 Antitrypsin Deficient Patients With Emphysema

Emphysema

United Kingdom, Canada, Denmark, Germany, Ireland, Netherlands, Sweden
Z Factor Limited
Hammersmith Medicines Research; Centessa Pharmaceuticals plc

Terminated

A Single Ascending and Repeated Dose Study of Oral ZF874 in Healthy Volunteers and PiXZ Subjects

Alpha1 Anti-Trypsin Deficiency

United Kingdom
Imperial College London

Suspended

Serratus Anterior Block and Catheter Use in Rib Fractures in the Emergency Department (SABRE)

Anesthesia | Rib Fractures

United Kingdom
University Medical Center Groningen

Completed

Identifying REsponders and Exploring Mechanisms of ACTION of the Endobronchial Coil Treatment for Emphysema (REACTION)

Chronic Obstructive Pulmonary Disease (COPD)

Netherlands, United Kingdom
Kamada, Ltd.
Syneos Health

Recruiting

Evaluate Efficacy and Safety of "Kamada-AAT for Inhalation" in Patients With AATD (InnovAATe)

Alpha 1-Antitrypsin Deficiency

United Kingdom, Sweden, Ireland, Netherlands, Belgium, Finland

Clinical Trials on Thoracic Empyema in United Kingdom

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