Clinical Trials on Toxic Optic Neuropathy in United Kingdom

Total 1431 results

Rigshospitalet, Denmark
University of Colorado, Denver; King's College Hospital NHS Trust; Odense University... and other collaborators

Recruiting

NA-AION Risk Factors: New Perspectives (NARROW)

Non-arteritic Ischemic Optic Neuropathy | Optic Disk Drusen

Denmark, United Kingdom, United States, Australia, Canada, France, Iran, Islamic Republic of, Israel, New Zealand
Santhera Pharmaceuticals

Completed

Study to Assess Efficacy,Safety and Tolerability of Idebenone in the Treatment of Leber's Hereditary Optic Neuropathy (RHODOS)

Leber's Hereditary Optic Neuropathy

Canada, Germany, United Kingdom
Emory University

Completed

Vision Restoration Therapy (VRT) to Treat Non-Arteritic Anterior Ischemic Optic Neuropathy

Non-Arteritic Anterior Ischemic Optic Neuropathy

United States
GenSight Biologics

Completed

RESCUE and REVERSE Long-term Follow-up (RESTORE)

Leber Hereditary Optic Neuropathy

United States, France, Italy, United Kingdom, Germany
Jeffrey L Goldberg

Completed

NT-501 CNTF Implant for Ischemic Optic Neuropathy: Safety, Neuroprotection and Neuroenhancement

Ischemic Optic Neuropathy/Optic Nerve Stroke

United States
Neuro-Ophthalmologic Associates, PC
Acorda Therapeutics

Completed

A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) (Ampyra)

Non Arteritic Ischemic Optic Neuropathy

United States
University of Colorado, Denver
Genentech, Inc.

Completed

Ranibizumab Therapy for Non-arteritic Ischemic Optic Neuropathy (NAION)

Nonarteritic Anterior Ischemic Optic Neuropathy

United States
Santhera Pharmaceuticals

Completed

RHODOS Follow-up Single-visit Study (RHODOS-OFU)

Leber's Hereditary Optic Neuropathy

Canada, Germany, United Kingdom
GenSight Biologics

Completed

REALITY LHON Registry (REALITY)

Leber Hereditary Optic Neuropathy

United States, France, Italy, Spain, United Kingdom
Santhera Pharmaceuticals

Completed

Historical Case Record Survey of Visual Acuity Data From Patients With Leber's Hereditary Optic Neuropathy (LHON)

Leber's Hereditary Optic Neuropathy (LHON)

Belgium, Netherlands, France, Germany, Norway, United Kingdom, Italy
GenSight Biologics

Active, not recruiting

Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year (REFLECT)

Leber Hereditary Optic Neuropathy

Belgium, Spain, United States, France, United Kingdom, Taiwan, Italy
Eli Lilly and Company

Completed

A Study to Determine if There is a Possible Association Between NAION and Phosphodiesterase Type 5 (PDE5) Inhibitors

Nonarteritic Anterior Ischemic Optic Neuropathy

United States
Ohio State University

Completed

Safety and Efficacy of Using SightSaver Visual Evoked Potential (VEP) for VEP Monitoring in Prone Spine Surgery (SightSaver)

Ischemic Optic Neuropathy

United States
Santhera Pharmaceuticals

Completed

Study to Assess the Efficacy and Safety of Raxone in LHON Patients (LEROS)

Leber's Hereditary Optic Neuropathy (LHON)

United States, United Kingdom, Spain, Poland, Austria, Belgium, Bulgaria, Germany, Italy, Portugal
Regenera Pharma Ltd

Terminated

Efficacy & Safety of RPh201 Treatment in Patients With Previous Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)

Nonarteritic Anterior Ischemic Optic Neuropathy

United States
Quark Pharmaceuticals

Terminated

Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)

Non Arteritic Anterior Ischemic Optic Neuropathy

United States, Australia, Germany, China, India, Italy, Singapore, Israel
Wills Eye
United States Department of Defense

Completed

Electric Stimulation of the Eye to Improve Vision After Trauma (TES)

Trauma | Multiple Sclerosis (MS) | Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)

United States
Medical College of Wisconsin

Terminated

Near-infrared Light-emitting Diode (NIR-LED) Therapy for Leber's Hereditary Optic Neuropathy (LHON) (LHON)

Leber's Hereditary Optic Neuropathy (LHON)

United States
National Eye Institute (NEI)

Unknown

Ischemic Optic Neuropathy Decompression Trial Followup (IONDT Followup)

Ischemic Optic Neuropathy

United States
University of Colorado, Denver

Terminated

Choroidal Thickness in Optic Neuropathy

Optic Nerve Disorders

United States
Neurophth Therapeutics Inc

Active, not recruiting

Gene Therapy Clinical Trial for the Treatment of Leber's Hereditary Optic Neuropathy Associated With ND4 Mutations

Leber Hereditary Optic Neuropathy (LHON)

United States
Neurophth Therapeutics Inc

Recruiting

Gene Therapy Clinical Trial for the Treatment of Leber's Hereditary Optic Neuropathy Associated With ND1 Mutations

Leber Hereditary Optic Neuropathy (LHON)

China, United States
Quark Pharmaceuticals

Completed

Safety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION Patients

Optic Atrophy | Non-arteritic Anterior Ischemic Optic Neuropathy

United States, Israel
Randy Kardon

Recruiting

New Non-invasive Modalities for Assessing Retinal Structure and Function

Leber Hereditary Optic Neuropathy | Ischemic Optic Neuropathy | Hemianopia | Branch Retinal Artery Occlusion | Acute Zonal Occult Outer Retinopathy

United States
MD Stem Cells

Recruiting

Stem Cell Ophthalmology Treatment Study II (SCOTS2)

Glaucoma | Age-Related Macular Degeneration | Macular Degeneration | Retinitis Pigmentosa | Leber Hereditary Optic Neuropathy | Optic Atrophy | Blindness | Optic Neuropathy | Vision, Low | Retinal Disease | Stargardt Disease | Maculopathy | Retinopathy | Optic Nerve Disease | Nonarteritic Ischemic Optic Neuropathy | Vision... and other conditions

United States, United Arab Emirates
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

A Study to Assess Whether PDE5 Inhibitors Increase the Chance of Triggering the Onset of Acute NAION

Optic Neuropathy, Ischemic

United States, Spain, Germany, Italy, France, United Kingdom
Stanford University

Recruiting

Hyperbaric Oxygen Therapy for Optic Neuropathies (HBOT)

Glaucoma | Optic Neuropathy

United States
Bayer

Terminated

PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)

Anterior Ischemic Optic Neuropathy

United States, Australia, Canada
University College London Hospitals

Completed

Muscle Structure, Function and Gait in dHMN (GAIT-dHMN)

Distal Hereditary Motor Neuropathy, Type II | Distal Hereditary Motor Neuropathy, Type V | Distal Hereditary Motor Neuronopathy Type I | Distal Hereditary Motor Neuronopathy Type VI

United Kingdom
Amgen

Recruiting

Study of Inebilizumab in Pediatric Subjects With Neuromyelitis Optica Spectrum Disorder

Neuromyelitis Optica Spectrum Disorder

United Kingdom, United States, Sweden, Netherlands
Byron Lam
National Eye Institute (NEI)

Active, not recruiting

Safety Study of an Adeno-associated Virus Vector for Gene Therapy of Leber's Hereditary Optic Neuropathy (LHON)

Leber's Hereditary Optic Neuropathy

United States
Hoffmann-La Roche

Recruiting

A Study To Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, And Pharmacodynamics Of Satralizumab In Pediatric Patients With Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorder (NMOSD) (SAkuraSun)

Neuromyelitis Optica Spectrum Disorder | NMOSD

Poland, United Kingdom, Argentina, Italy, France, United States
Stealth BioTherapeutics Inc.

Completed

A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for Treatment of Leber's Hereditary Optic Neuropathy

Leber's Hereditary Optic Neuropathy

United States
Edison Pharmaceuticals Inc

No longer available

Emergency Administration of EPI-743 to a Single Patient With Leber's Hereditary Optic Neuropathy [LHON]

Leber's Hereditary Optic Neuropathy

United States
Oxford Brookes University
Guy's and St Thomas' NHS Foundation Trust; Oxford University Hospitals NHS... and other collaborators

Recruiting

Lifestyle Weight Management Program: Interviews and Stakeholder Meetings.

Multiple Sclerosis | Neuromyelitis Optica

United Kingdom
University of Minnesota

Completed

Photobiomodulation Therapy and Nerve Density for Patients With Diabetic or Chemotherapy-associated Neuropathy

Neuropathy | Neuropathy, Diabetic | Neuropathy Toxic

United States
AbbVie (prior sponsor, Abbott)

Completed

A Randomized, Double-blind, Placebo- and Active-controlled Study of the Electric Current Effects of ABT-639 on the Spontaneous Activity of Pain Sensory Receptors in Patients With Diabetic Peripheral Neuropathy

Diabetic Neuropathic Pain

United Kingdom
Imperial College London

Completed

Clinical Phenotyping and Genotyping of HIV-Associated Sensory Neuropathy: The HIV-POGO Study (HIV-POGO)

HIV | Neuropathic Pain | Sensory Neuropathy

United Kingdom
Hoffmann-La Roche
Chugai Pharmaceutical

Completed

Efficacy and Safety Study of Satralizumab (SA237) as Add-on Therapy to Treat Participants With Neuromyelitis Optica (NMO) and NMO Spectrum Disorder (NMOSD)

Neuromyelitis Optica (NMO) | NMO Spectrum Disorder (NMOSD)

Spain, Italy, United States, Japan, Poland, Taiwan, Germany, United Kingdom, Hungary, France, Ukraine
Abide Therapeutics

Completed

Central Pain Study for ABX-1431

Multiple Sclerosis | Neuromyelitis Optica Spectrum Disorder | Transverse Myelitis | Longitudinally Extensive Transverse Myelitis

United Kingdom
Wills Eye

Completed

Comparing Rates of Glaucoma in Professional Wind Versus Non-Wind Instrument Players

Glaucoma | Intraocular Pressure | Optic Neuropathy

United States
University of Miami

Terminated

Biomechanics of Optic Neuropathy

Optic Neuropathy

United States
MedRhythms, Inc.
Alexion Pharmaceuticals, Inc.

Not yet recruiting

Acceptability and Safety of MR-C-014 in Persons With Neuromyelitis Optica Spectrum Disorder (aNiMatO)

Neuromyelitis Optica Spectrum Disorder

United States
Johns Hopkins University
Genentech, Inc.; Guthy Jackson Charitable Foundation

Completed

Efficacy of Bevacizumab (Avastin) in Treatment of Acute NMO Exacerbations

Neuromyelitis Optica | Neuromyelitis Optica Spectrum Disorder

United States
Alexion Pharmaceuticals, Inc.

Recruiting

Registry of Patients With AQP4+ NMOSD Treated With Alexion C5 Inhibitor Therapies

Neuromyelitis Optica Spectrum Disorder | NMOSD | AQP4+ NMOSD

United States
Massachusetts General Hospital

Active, not recruiting

High Frequency Impulse Therapy for Neuropathic Pain in NMOSD

Neuromyelitis Optica

United States
CorEvitas

Enrolling by invitation

CorEvitas SPHERES (Synergy of Prospective Health & Experimental Research for Emerging Solutions) Registry for Neuromyelitis Optica Spectrum Disorder (NMOSD)

Neuromyelitis Optica Spectrum Disorder

United States
Accure Therapeutics
Simbec Research

Completed

BN201 SAD MAD Study in Healthy Subjects

Optic Neuritis | Optic; Neuritis, With Demyelination

United Kingdom
Amgen

Recruiting

Observational Safety Study in Women With Neuromyelitis Optica Spectrum Disorder (NMOSD) Exposed to UPLIZNA® During Pregnancy

Pregnancy Related | Neuromyelitis Optica Spectrum Disorder

United States
Hoffmann-La Roche

Active, not recruiting

A Study to Evaluate the Safety and Efficacy of Satralizumab in Participants With Neuromyelitis Optica Spectrum Disorder (NMOSD)

Neuromyelitis Optica Spectrum Disorder

United States, Spain, United Kingdom, Taiwan, Hungary, Korea, Republic of, Japan, Croatia, Bulgaria, Canada, Germany, Italy, Poland, Puerto Rico, Romania, Turkey, Ukraine, Malaysia

Clinical Trials on Toxic Optic Neuropathy in United Kingdom

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