Clinical Trials on Urinary Tract Infection Empiric Antibiotic in South Africa

Total 4180 results

Bill & Melinda Gates Medical Research Institute

Completed

Early Bactericidal Activity of TBA-7371 in Pulmonary Tuberculosis

Pulmonary Tuberculosis

South Africa
PENTA Foundation
Baylor College of Medicine; University Hospital Birmingham NHS Foundation Trust and other collaborators

Recruiting

DTG/3TC Fixed Dose Formulations for the Maintenance of Virological Suppression in Children With HIV Infection Aged 2 to <15 Years Old (D3 (Penta21))

HIV Infections

Spain, United Kingdom, Thailand, South Africa, Uganda
International Partnership for Microbicides, Inc.

Completed

Safety and Efficacy Trial of a Dapivirine Vaginal Matrix Ring in Healthy HIV-Negative Women

HIV Infections

South Africa, Uganda
National Institute of Allergy and Infectious Diseases...
Novartis Vaccines; HIV Vaccine Trials Network; IPPOX Foundation

Completed

Safety and Immune Response to a Clade C DNA HIV Vaccine (HVTN111)

HIV Infections

South Africa, Zambia, Tanzania
International Maternal Pediatric Adolescent AIDS...
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Not yet recruiting

Safety and Immunogenicity of VPM1002 Vaccination or BCG Revaccination Against TB in Pre-Adolescents Living With and Without HIV in South Africa

HIV Infections | Tuberculosis

South Africa
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety, Pharmacokinetics, and Anti-Viral Activity of VRC01 and VRC01LS in the Serum and Mucosa of Healthy, HIV-Uninfected Adults

HIV Infections

United States, South Africa
Merck Sharp & Dohme LLC

Completed

Doravirine/Islatravir (DOR/ISL) in Pediatric Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Who Are <18 Years of Age and Weigh ≥35 kg (MK-8591A-028)

HIV-1 Infection

United States, Italy, Russian Federation, South Africa, Thailand
ViiV Healthcare

Active, not recruiting

Safety and Efficacy of Dolutegravir/Lamivudine (DTG/3TC) in Therapy-naive Human Immunodeficiency Virus-1 (HIV-1) Infected Adolescents

HIV Infections

Thailand, Kenya, South Africa
National Institute of Allergy and Infectious Diseases...
Duke University; National Institutes of Health (NIH); Department of Health and... and other collaborators

Not yet recruiting

A Clinical Trial in Adult Participants Without HIV and in Overall Good Health to Evaluate the Safety and Immunogenicity of CD4BS CH505M5 Pr-NP1 Followed by CH505 TF chTrimer Boost Both Adjuvanted With Either Lipid Nanoparticles (LNPs) or 3M-052-AF + Alum

HIV

United States, South Africa
Kirby Institute
ViiV Healthcare; University of Witwatersrand, South Africa; University of Liverpool and other collaborators

Completed

COHIVE: Coronavirus (COVID-19) Outcomes in HIV Evaluation in Resource Limited Settings

Coronavirus Infection | HIV-infection/Aids

Uganda, Cameroon, Argentina, Brazil, India, Malaysia, Nigeria, South Africa, Thailand, Zimbabwe
University of Cape Town
Medical University of Vienna; University of Washington

Completed

Acid-Base and Point of Care Ultrasound in Severe Preeclampsia

Pre-Eclampsia

South Africa
University of North Carolina, Chapel Hill
National Institute on Alcohol Abuse and Alcoholism (NIAAA); University of Stellenbosch and other collaborators

Completed

The Trajectory of Fetal Alcohol Spectrum Disorders (FASD) Across the Life Span: Continuing Prevention and Longitudinal Epidemiology

Fetal Alcohol Spectrum Disorders

South Africa
National Institute of Allergy and Infectious Diseases...

Completed

Acute HIV Infection Observational Study

HIV Infections

United States, Malawi, South Africa, Tanzania, Uganda
University of Oxford
Bill and Melinda Gates Foundation; Medical Research Council, South Africa; University... and other collaborators

Unknown

COVID-19 Vaccine (ChAdOx1 nCoV-19) Trial in South African Adults With and Without HIV-infection

Coronavirus

South Africa
RTI International
Kheth'Impilo

Completed

Implementation Research for Vulnerable Women in South Africa

HIV | Substance Abuse

United States, South Africa
Columbia University
Bill and Melinda Gates Foundation; University of Cape Town; EngenderHealth

Terminated

Screen and Treat for Cervical Cancer Prevention (SAT)

Cervical Cancer

South Africa
University of Cape Town
Stanford University

Recruiting

Point-of-care Ultrasound Abnormalities in Eclampsia

Eclampsia

South Africa
Gilead Sciences

Active, not recruiting

Study To Evaluate Emtricitabine/Tenofovir Alafenamide (F/TAF) in Human Immunodeficiency Virus 1 (HIV-1) Infected Children and Adolescents Virologically Suppressed on a 2- Nucleoside/Nucleotide Reverse Transcriptase Inhibitor (2-NRTI)-Containing Regimen

HIV-1

United States, Panama, South Africa
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Active, not recruiting

Evaluating the Pharmacokinetics, Safety, and Tolerability of Bedaquiline in Infants, Children, and Adolescents With Multidrug-Resistant Tuberculosis, Living With or Without HIV

HIV | Tuberculosis

Haiti, India, South Africa
Allecra
Medpace, Inc.

Completed

Safety and Efficacy Study of Cefepime-AAI101 in the Treatment of Complicated Urinary Tract Infections

Urinary Tract Infections

United States, Serbia, Hungary, Estonia, South Africa, Belarus, Poland, Ukraine, Argentina, Bulgaria, Croatia, Georgia, Latvia, Lithuania, Mexico, Peru, Russian Federation, Slovakia, Spain
University of California, Los Angeles
National Institute of Mental Health (NIMH); HIV Prevention Trials Network

Completed

Community Mobilization, Mobile Testing, Same-Day Results, and Post-Test Support for HIV in Sub-Saharan Africa and Thailand

HIV Infections

South Africa, Tanzania, Thailand, Zimbabwe
Kirby Institute

Active, not recruiting

Body Composition Sub-study of the D2EFT Trial

HIV Infections

Malaysia, Zimbabwe, India, South Africa, Thailand
University of Maryland, College Park
National Institute on Drug Abuse (NIDA); Medical Research Council, South Africa

Active, not recruiting

Siyakhana Peer: Evaluating a Peer Recovery Coach Model to Reduce Substance Use Stigma in South African HIV Care

Substance-Related Disorders | HIV | Substance Use | Substance Use Disorders | Treatment Adherence | Treatment Adherence and Compliance | Stigmatization | Delivery of Health Care | Stigma, Social | Attitude of Health Personnel | Community Health Workers | Health Personnel | Health Personnel Attitude | Health Care Seeking... and other conditions

South Africa
Merck Sharp & Dohme LLC

Completed

MK-8527 Single-Dose Trial in HIV-1 Infected Participants (MK-8527-004)

Human Immunodeficiency Virus

Romania, South Africa
University of Cape Town
National Institute of Mental Health (NIMH)

Completed

Task Sharing Counseling Intervention by Community Health Workers for Prenatal Depression in South Africa (AFFIRM-SA)

Postpartum Depression | Clinical Depression | Moderate Depression

South Africa
Boston University Charles River Campus
National Institute of Mental Health (NIMH); University of Cape Town

Recruiting

Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa

Depression | Pregnancy Related | Medication Adherence | Posttraumatic Stress Disorder

United States, South Africa
The Aurum Institute NPC
Coalition for Epidemic Preparedness Innovations

Recruiting

Phase 2a Trial to Evaluate Safety and Immunogenicity of COVID-19 Vaccine Strategies in HIV-infected/Uninfected Adults. (AUR1-8-341)

COVID-19

South Africa
The Aurum Institute NPC
Johns Hopkins University

Recruiting

Comparing Treatment Completion Of Daily Rifapentine & Isoniazid For One Month (1HP) To Weekly High Dose Rifapentine & Isoniazid For 3 Months (3HP) In Persons Living With HIV and in Household Contacts of Recently Diagnosed Tuberculosis Patients (1 to 3)

Tuberculosis | HIV Seropositivity | Household Contact

South Africa, India, Indonesia, Mozambique
PATH
National Institute of Allergy and Infectious Diseases (NIAID); National Institutes... and other collaborators

Completed

Phase II Safety and Acceptability of an Investigational Injectable Product, TMC278LA, for Pre-Exposure Prophylaxis (TMC278LA)

Human Immunodeficiency Virus (HIV)

United States, South Africa, Zimbabwe
Medecins Sans Frontieres, Netherlands
London School of Hygiene and Tropical Medicine; University College, London; University... and other collaborators

Active, not recruiting

PRACTECAL-PKPD Sub Study (PRACTECAL-PKPD)

Multi-drug Resistant Tuberculosis | Pulmonary Tuberculosis | Extensively Drug-Resistant Tuberculosis

Belarus, South Africa
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating Strategies to Reduce Mother-to-Child Transmission of HIV Infection in Resource-Limited Countries (PROMISE)

HIV Infections

Malawi, South Africa, Tanzania, Zimbabwe, India, Uganda, Zambia
University of Cape Town
University of Michigan; Brigham and Women's Hospital; Fogarty International Center... and other collaborators

Completed

An Observational Study of Distress, Immune Function, and Pain in HIV.

Chronic Pain | HIV | Distress, Emotional | Central Sensitisation | Immune System and Related Disorders

South Africa
University of Witwatersrand, South Africa
Bill and Melinda Gates Foundation

Recruiting

A Randomised, Multi-centre, Double-blind, Phase 3 Study to Observe the Effectiveness, Safety and Tolerability of Molnupiravir Compared to Placebo Administered Orally to High-risk Adult Outpatients With Mild COVID-19 Receiving Local Standard of Care in South Africa (CoTeT)

COVID-19

South Africa
Maastricht University Medical Center

Completed

Incubation Time and Test of Cure of Chlamydia Trachomatis (Incure)

Chlamydia Trachomatis Infection

Netherlands
Maastricht Radiation Oncology

Completed

Predicting Outcome in Cervix Carcinoma: a Prospective Study (POCER)

Cervical Cancer

Netherlands, South Africa
Vaccine Company, Inc.

Active, not recruiting

Study of VXCO-100, a SARS-CoV Candidate Vaccine, in Adults in the Republic of South Africa

SARS-CoV-2 | SARS-CoV

South Africa
National Institute of Allergy and Infectious Diseases...
Microbicide Trials Network

Completed

Adherence and Acceptability to and Blood Levels of Tenofovir Gel and Tablets in HIV Uninfected Women

HIV Infections

United States, Uganda, South Africa
Gilead Sciences

Recruiting

Study of Bictegravir/Emtricitabine/Tenofovir Alafenamide Fixed Dose Combination in Adolescents and Children With Human Immunodeficiency Virus-1

HIV-1 Infection

United States, Thailand, Uganda, South Africa
Boston University Charles River Campus
Massachusetts General Hospital; University of Witwatersrand, South Africa

Not yet recruiting

Identifying and Addressing Barriers to Retention in the Cervical Cancer Treatment Cascade Among Women With HIV in South Africa: Part 2

Cervical Cancer | Hiv

United States, South Africa
Bill & Melinda Gates Medical Research Institute
Global Alliance for TB Drug Development; Janssen Pharmaceutica; Otsuka Pharmaceutical...

Recruiting

Efficacy and Safety Evaluation of Two to Four Months of Treatment With the Combination Regimens of DBOS and PBOS in Adults With Pulmonary Tuberculosis

Pulmonary Tuberculosis

South Africa, Philippines
Eli Lilly and Company

Completed

A Study of LY2623091 in Male and Females With Chronic Kidney Disease

Chronic Kidney Disease

Bulgaria, South Africa
Wits Health Consortium (Pty) Ltd
Fred Hutchinson Cancer Center; Janssen Vaccines & Prevention B.V.; Right to Care and other collaborators

Recruiting

Sisonke 2 - A COVID-19 Vaccine Boost Open Label Study. (Sisonke Boost)

SARS CoV 2 Infection

South Africa
Janssen Research & Development, LLC

Completed

A Study of Switching to RPV Plus Other ARVs in HIV-1-infected Children (Aged 2 to <12 Years) Who Are Virologically Suppressed

HIV

Italy, Thailand, Spain, Uganda, Portugal, South Africa
University of Cape Town
National Institutes of Health (NIH); Texas Tech University Health Sciences... and other collaborators

Terminated

Catalysing the Containment of COVID-19 (C3-RCT)

COVID-19

South Africa
Genzyme, a Sanofi Company

Completed

A Study of GT160-246 Versus Vancomycin in Patients With Clostridium Difficile-Associated Diarrhea

Clostridium Difficile-Associated Diarrhea | Antibiotic-associated Diarrhea | Clostridium Enterocolitis | Clostridium Difficile Diarrhea | Antibiotic-associated Colitis

United States, Canada, United Kingdom, Puerto Rico
ANRS, Emerging Infectious Diseases
European and Developing Countries Clinical Trials Partnership (EDCTP); European...

Recruiting

Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis (INTENSE-TBM)

Tuberculous Meningitis

Côte D'Ivoire, Madagascar, South Africa, Uganda
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Pharmacokinetics, Safety, and Tolerability of Doravirine (MK-1439) and Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate (MK-1439A) in HIV-1-Infected Children and Adolescents

HIV Infections

United States, South Africa, Thailand
National Institute of Allergy and Infectious Diseases...
GlaxoSmithKline; Sanofi Pasteur, a Sanofi Company; HIV Vaccine Trials Network

Completed

Safety and Immunogenicity of Clade C ALVAC and gp120 HIV Vaccine (HVTN107)

HIV Infections

South Africa, Mozambique, Zimbabwe
Immune Biosolutions Inc

Completed

Phase 1&2 Study to Evaluate the Safety & Efficacy of Inhaled IBIO123 in Severe COVID-19 Illness

COVID-19

Ukraine, South Africa
Centers for Disease Control and Prevention

Completed

High Dose Rifapentine Pharmacokinetics, Tolerability and Safety Dosage Rifapentine for Treatment of Tuberculosis (TBTC-29PK)

Smear Positive, Pan-sensitive, Pulmonary Tuberculosis

United States, South Africa, Uganda

Clinical Trials on Urinary Tract Infection Empiric Antibiotic in South Africa

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