Clinical Trials on Young Healthy Adults (no Medical Condition/Disease) in South Africa

Total 291 results

North-West University, South Africa
GlaxoSmithKline; Novartis; Pfizer; Boehringer Ingelheim; Medical Research Council; Medical... and other collaborators

Active, not recruiting

The African-PREDICT Study (PREDICT)

Cardiovascular Diseases | Hypertension | Health Risk Behaviors | Arterial Stiffness | Young | Renin Hypertension

South Africa
University of Cape Town
Karolinska Institutet

Completed

Use of Low Sensitivity Pregnancy Test for Self-assessment of Medical Abortion (m-Assist+)

Completion of Medical Abortion

South Africa
St George Hospital, Australia
National Health and Medical Research Council, Australia; The University of... and other collaborators

Unknown

Portable Health Files Improve Quality of Care and Health Outcomes: a Randomized Controlled Trial (PHF-RCT)

Personal Health Records | Chronic Medical Conditions | Electronic Medical Record

Australia
Immtech Pharmaceuticals, Inc

Terminated

Randomized, Double-Blind Phase 1 Safety and Tolerability Study of Pafuramidine Maleate (DB289) in Healthy Subjects

Healthy

South Africa
GlaxoSmithKline

Completed

Study to Identify and Characterize Bacteria Causing Acute Otitis Media in South African Children

Acute Otitis Media

South Africa
Boehringer Ingelheim

Completed

To Determine Blood Concentrations of Ibuprofen and Caffeine in a Tablet Against Ibuprofen Alone From Another Tablet

Healthy

South Africa
Novo Nordisk A/S

Completed

Comparison of Two Insulin Aspart Formulations in Healthy Volunteers

Healthy | Diabetes

South Africa
Novo Nordisk A/S

Completed

Bioequivalence of Two Formulations of Biphasic Insulin Aspart 50 in Healthy Male Subjects

Healthy | Diabetes

South Africa
Novo Nordisk A/S

Completed

Bioequivalence of Two Formulations of Biphasic Insulin Aspart 70 in Healthy Male Subjects

Healthy | Diabetes

South Africa
Medical University of South Carolina

Completed

Low Intensity Focused Ultrasound Pulses (LIFUP) to Modulate Pain

Healthy Adults

United States
University of Witwatersrand, South Africa
University of Stellenbosch; University of Cape Town; University of KwaZulu; University...

Completed

Group B Strep Correlates of Protection Study (GBSCoP)

Maternal Health, Child Health, Infectious Diseases

South Africa
MedImmune LLC

Completed

A Study to Evaluate the Immunogenicity of Quadrivalent LAIV (MEDI8662) in Adults 18 to 49 Years of Age (MI-CP206)

Healthy or Stable Underlying Chronic Medical Condition

United States
Sanofi

Completed

A Clinical Trial of Patients With Solid Tumours Receiving Granulocyte Colony Stimulating Factor as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Docetaxel Based Regimen (Grano-Tax)

Neoplasms (no Otherwise Specified)

South Africa
University of Maryland, College Park
National Institute on Drug Abuse (NIDA); Medical Research Council, South Africa

Active, not recruiting

Siyakhana Peer: Evaluating a Peer Recovery Coach Model to Reduce Substance Use Stigma in South African HIV Care

Substance-Related Disorders | HIV | Substance Use | Substance Use Disorders | Treatment Adherence | Treatment Adherence and Compliance | Stigmatization | Delivery of Health Care | Stigma, Social | Attitude of Health Personnel | Community Health Workers | Health Personnel | Health Personnel Attitude | Health Care Seeking... and other conditions

South Africa
University of KwaZulu
University of California, San Francisco; Centers for Disease Control and Prevention and other collaborators

Completed

Effectiveness of an HIV-adapted IMCI Training and Supervision Programme for Community Health Workers

Infant Feeding Practices | Prevention of Mother-to-child Transmission of HIV | Antenatal Health Care Utilization | Postnatal Health Care Utilization

South Africa
MedImmune LLC

Completed

A Study to Evaluate the Immunogenicity of Quadrivalent LAIV in Adults 18 to 49 Years of Age (MI-CP185)

Healthy or Stable Underlying Chronic Medical Condition

United States
University of Cape Town

Completed

Health System Dynamic & Resource Requirement in a South African COVID-19 Field Hospital

COVID-19 Pandemic | Low-Income Population | Global Health | Health Resources | Field Hospitals | Health Systems

South Africa
University of Maryland, College Park
National Institute of Mental Health (NIMH); Medical Research Council, South...

Completed

Community Health Worker Training to Reduce Depression and Substance Use Stigma in TB/HIV Care in South Africa (Siyakhana)

Substance-Related Disorders | Depression | Tuberculosis | Hiv | Mental Health Disorder | Mental Disorder | Health Care Utilization | Treatment Adherence and Compliance | Social Stigma | Attitude of Health Personnel | Community Health Workers | Health Care Delivery

South Africa
IGM Biosciences, Inc.

Terminated

Evaluation of IGM-6268 in Healthy Adults and Patients With Mild to Moderate COVID-19

COVID-19 | Healthy Volunteers

South Africa
Alvotech Swiss AG

Completed

AVT03 With Prolia in Healthy Male Subjects

Healthy Male Subjects

South Africa, Australia, New Zealand
Eastern Virginia Medical School
Gilead Sciences; United States Agency for International Development (USAID); FHI... and other collaborators

Active, not recruiting

Project Engage: Oral PrEP Acceptability

Adherence, Medication | Acceptability of Health Care

South Africa, Zimbabwe
Boston University
National Institute of Mental Health (NIMH); Africa Health Research Institute

Completed

Life Plans Intervention Study

HIV/AIDS | Health Knowledge, Attitudes, Practice | Chronic HIV Infection

South Africa
Alvotech Swiss AG

Completed

AVT03 With Xgeva in Healthy Male Subjects

This is a Phase I Study Conducted in Healthy Volunteers

United Kingdom, South Africa, Poland
Desmond Tutu HIV Foundation
Karolinska Institutet; University of North Carolina, Chapel Hill; ViiV Healthcare and other collaborators

Completed

Bidirectional, Upbeat Communication and Differentiated, Distanced Care for Young People (BUDDY)

HIV Infections | Covid19 | Health Care Utilization | Gender-based Violence

South Africa
University of Western Sydney

Active, not recruiting

Computer-based Cognitive Rehabilitation Program for Healthy Older Adults, Older People With Mild Cognitive Impairment and Mild Dementia

Mild Cognitive Impairment | Mild Dementia | Healthy Older Adults

Australia
Acclarent

Completed

Anesthetic Effect of Lidocaine/Epinephrine Solution Delivered Via Iontophoresis to External Auditory Apparatus (IONTO)

Recurrent Acute Otitis Media | Acute Otitis Media | Chronic Otitis Media

United States
Sanofi Pasteur, a Sanofi Company

Recruiting

Study of a Quadrivalent Meningococcal Conjugate Vaccine (MenACYW Conjugate Vaccine) Given With Routine Pediatric Vaccines in Healthy Infants and Toddlers in India and the Republic of South Africa (MEQ00064)

Healthy Volunteers | Meningococcal Immunisation

South Africa, India
International Partnership for Microbicides, Inc.

Completed

An Expanded Safety Study of Dapivirine Gel 4789 in Africa

HIV Infections | Acquired Immunodeficiency Syndrome | Healthy

South Africa
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Bafetinib in Treating Patients With Recurrent High-Grade Glioma or Brain Metastases

Adult Anaplastic Astrocytoma | Adult Anaplastic Ependymoma | Adult Anaplastic Oligodendroglioma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Recurrent Adult Brain Tumor | Tumors Metastatic to Brain | Adult Anaplastic Oligoastrocytoma

United States
Bayer

Completed

Phase Ib Study of Anetumab Ravtansine in Combination With Pemetrexed and Cisplatin in Mesothelin-expressing Solid Tumors

Medical Oncology

United States, Italy
Sanofi Pasteur, a Sanofi Company

Completed

Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Healthy Adults, Adolescents, Children, and Toddlers in India and Healthy Adolescents and Children in the Republic of South Africa (MET55)

Healthy Volunteers (Meningococcal Infection)

India, South Africa
Instituto de Atención Pediátrica

Completed

Microbiology of Otitis Media in Costarrican Children After PCV13 Introduction (Microbiology)

Otitis Media in Children

Costa Rica
Pfizer

Completed

Pharmacokinetics Of Azithromycin Immediate Release And Extended Release Formulation In Kids With Acute Otitis Media

Acute Otitis Media

Costa Rica
Janssen Vaccines & Prevention B.V.
National Institute of Allergy and Infectious Diseases (NIAID); Beth Israel... and other collaborators

Completed

Safety, Tolerability, and Immunogenicity Study of Homologous Ad26 Mosaic Vector Vaccine Regimens or Heterologous Ad26 Mosaic and MVA Mosaic Vector Vaccine Regimens With Glycoprotein 140 (gp140) for Human Immunodeficiency Virus (HIV) Prevention

Healthy

United States, South Africa, Thailand, Uganda, Rwanda
Currax Pharmaceuticals

Completed

Four Arm Safety & Efficacy With Antipyrine and Benzocaine Otic Solution in Children With Acute Otitis Media

Acute Otitis Media

United States
University of Athens

Unknown

Central Blood Pressure in Adolescents and Young Adults

Hypertension | Healthy

Greece
Medical University of South Carolina

Recruiting

Spectral Characteristics of Memory Transformation (MEM_MOD)

Healthy

United States
Pfizer

Completed

Estimation Of Effect Of Ketoconazole On Pharmacokinetics Of Crizotinib In Healthy Volunteers

Healthy

United States
Pfizer

Completed

Estimation Of Effect Of Rifampin On Pharmacokinetics Of Crizotinib In Healthy Volunteers

Healthy

United States
Otonomy, Inc.

Completed

Open-Label Study of OTO-201 for Treatment of AOMT

Acute Otitis Media | AOMT

United States
Tusker Medical

Completed

Adult Study to Evaluate Placement of Tympanostomy Tubes In-office (ADEPT) (ADEPT)

AOM - Acute Otitis Media | Eustachian Tube Dysfunction | Barotrauma;Ear | OME - Otitis Media With Effusion

United States
OncoTherapy Science, Inc.

Completed

Study to Evaluate Systemic Bioavailability of Oral OTS167 in Healthy Adult Subjects

Healthy

Australia
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Next-Day Residual Effects of Gabapentin, Diphenhydramine and Triazolam on Simulated Driving Performance in Normal Volunteers

Healthy

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

Comparing the Reliability of Expressed Prostatic Secretion (EPS) and Post Massage Urine (PMU) for the Prediction of Prostate Cancer Biopsy Outcome

Healthy | Prostate Cancer | Conditions Influencing Health Status

United States
PhotoniCare, Inc.
TTi Health Research & Economics

Recruiting

Otitis Treatment With OtoSight™ - Modification of Antibiotic Treatment Intervention in Children (OTO-MATIC)

Otitis Media Acute

United States
Otonomy, Inc.

Completed

Open-Label Study of OTO-201 for Middle Ear Effusion Evaluating Trans-Tympanostomy Tube Administration

Bilateral Middle Ear Effusion

United States
Fox Chase Cancer Center
National Cancer Institute (NCI)

Completed

Pazopanib Hydrochloride in Treating Patients With Advanced Angiosarcoma

Recurrent Adult Soft Tissue Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage IV Adult Soft Tissue Sarcoma | Adult Angiosarcoma

United States
Tusker Medical

Completed

In-Office Tympanostomy Tube Placement in Children (OTTER) (OTTER)

AOM - Acute Otitis Media | OME - Otitis Media With Effusion

United States, Canada
Janssen Vaccines & Prevention B.V.

Completed

A Study to Evaluate the Safety and Immunogenicity of Seasonal Influenza Vaccine and an Adenovirus Serotype 26- Based Vaccine Encoding for the Respiratory Syncytial Virus Pre-fusion F Protein (Ad26.RSV.preF), With and Without Co-administration, in Adults Aged 60 Years and Older in Stable Health

Healthy

United States
RedHill Biopharma Limited
Medical University of South Carolina; National Cancer Institute (NCI); FDA Office... and other collaborators

Completed

ABC294640 in Treating Patients With Advanced Solid Tumors (ABC-101)

Pancreatic Cancer | Unspecified Adult Solid Tumor, Protocol Specific

United States

Clinical Trials on Young Healthy Adults (no Medical Condition/Disease) in South Africa

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