Search clinical trials for: ACT-541478 100 mg

Total 1652 results

GlaxoSmithKline

Completed

A Type 2 Diabetes Study of the Longer-Term Glycemic Effect of AVANDAMET vs. Metformin

Diabetes Mellitus, Type 2

United States, Taiwan, Argentina, Canada, Philippines, Korea, Republic of, Mexico, Brazil, Pakistan
Novo Nordisk A/S

Completed

Research Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or Obesity (STEP 2)

Obesity | Overweight

United States, India, Japan, Russian Federation, United Kingdom, Canada, Spain, South Africa, Germany, Greece, United Arab Emirates, Argentina, Puerto Rico
Seoul Medical Center

Completed

ED50 and ED95 of Intrathecal Bupivacaine With or Without Epinephrine for Total Knee Replacement Arthroplasty

Spinal Anesthesia | Total Knee Replacement Arthroplasty

Korea, Republic of
Otsuka Pharmaceutical Development & Commercialization...

Completed

Pharmacokinetic and Safety Trial to Determine the Appropriate Dose for Pediatric Patients With Multidrug Resistant Tuberculosis

Pediatric | Multidrug Resistant Tuberculosis

Philippines, South Africa
Boehringer Ingelheim

Completed

Bioequivalence Trial of 2 Dose Strengths of BI 201335 NA Soft Gelatine Capsules

Hepatitis C

Japan
JMackem Co., Ltd
Seoul National University Hospital

Recruiting

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Oral Administration of AJH-2947 in Healthy Korean and/or Caucasian Adult Male Subjects

Diabetic Neuropathies | Neuropathic Pain | Post Herpetic Neuralgia

Korea, Republic of
Bayer
Amgen

Completed

Study to Determine the Safety, Maximum Tolerated Dose, Pharmacokinetics of Sorafenib (BAY43-9006)

Carcinoma

United States
MedImmune LLC

Completed

Multiple Ascending Doses of MEDI6012 in Subjects With Stable Atherosclerotic Cardiovascular Disease

Cardiovascular Disease | Atherosclerosis

United States
Shanghai Henlius Biotech

Active, not recruiting

A Clinical Study to Compare the Efficacy, Safety and Immunogenicity of HLX04 and Bevacizumab Combined XELOX or mFOLFOX6 in the First-line Treatment of mCRC

Metastatic Colorectal Cancer (mCRC)

China
Abbott
PPD

Completed

Study to Investigate the Effects of Different Doses of S-adenosyl-L-methionine (SAMe) in Subjects With Nonalcoholic Fatty Liver Disease and Non-treated Matched Healthy Volunteers as Control Group (EXPO)

Non Alcoholic Fatty Liver Disease

France, Germany, Poland, Russian Federation
MedImmune LLC
MedImmune Ltd

Completed

Study to Evaluate the Efficacy and Safety of MEDI-563 in Adults With Uncontrolled Asthma

Asthma

United States, Brazil, Bulgaria, Mexico, Peru, Poland, Russian Federation, Argentina, Canada, Colombia
Janssen Research & Development, LLC

Completed

A Study to Examine the Pharmacokinetics, Safety and Tolerability of Multiple Oral Doses of TMC435 in Healthy Chinese Participants

Healthy

China
MiMedx Group, Inc.

Terminated

Dehydrated Human Amnion/Chorion Membrane Micrografts(dHACM) Injectable in the Treatment of Recalcitrant Plantar Fasciitis (dHACM)

Plantar Fasciitis

United States
KGL, Inc.
NYU Langone Health; Milton S. Hershey Medical Center; Allergan; State University... and other collaborators

Completed

Comparison of Tazarotene and Minocycline Therapies for Maintenance of Facial Acne Vulgaris

Acne Vulgaris

United States
Pfizer

Active, not recruiting

Study to Evaluate Efficacy and Safety of PF-04965842 With or Without Topical Medications in Subjects Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis (JADE EXTEND)

Dermatitis, Atopic

China, United States, Spain, Taiwan, Germany, Australia, Canada, Hungary, Korea, Republic of, Poland, Serbia, Bulgaria, Czechia, Japan, Latvia, United Kingdom, Belgium, Israel, Italy, Finland, Mexico, Romania, Slovakia, Argentina, Brazil, Chil... and more
Dr. Reddy's Laboratories Limited

Completed

Bioequivalence Study of Alendronate Sodium Tablets 70 mg of Dr. Reddy's Under Fasting Conditions

Healthy

India
Merck Sharp & Dohme LLC

Completed

An Efficacy and Safety Study of Grazoprevir (MK-5172) + Elbasvir (MK-8742) in the Treatment of Chronic Hepatitis C Virus in Participants Who Are Co-Infected With Human Immunodeficiency Virus:C-EDGE CO-INFXN (MK-5172-061)

Chronic Hepatitis C
Morten Lindbaek
Norwegian Institute of Public Health; Sorlandet Hospital HF; Norwegian University...

Completed

Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice (NorTick_EM)

Lyme Disease | Erythema Migrans | Erythema Chronicum Migrans | Borreliosis | Early Lyme Disease

Norway
Pharmacosmos A/S

Completed

Open-label Pharmacokinetic Study of Iron Isomaltoside 1000 (Monofer®) Administered by 500 mg IV Bolus Injection or 1000 mg Intravenous Infusion to Patients With Non-hematological Malignancies Associated With Chemotherapy Induced Anaemia (CIA) (PK-CIA-04)

Non-hematological Malignancies
Novo Nordisk A/S

Completed

Research Study Investigating Study Medicine (NNC9204-1177) for Weight Management in People With Overweight or Obesity

Obesity | Metabolism and Nutrition Disorder

United States
Jazz Pharmaceuticals
Evidilya S.r.l.

Not yet recruiting

Epidyolex® in Lennox Gastaut and Dravet Syndrome: an Observational Study in ITALY (EpiTALY)

Dravet Syndrome | Lennox Gastaut Syndrome

Italy
University of North Carolina, Chapel Hill
Allergan

Withdrawn

Effects of Eluxadoline (Viberzi®) 100 mg Twice Daily on Diarrhea-Associated Fecal Incontinence (ELXDFI)

Diarrhea | Fecal Incontinence | Urge Incontinence | Anal Incontinence | Accidental Bowel Leakage
dr. P. Noordzij
Pharmacosmos A/S

Recruiting

Intravenous Iron to Treat Postoperative Anemia in Older Cardiac Surgery Patients (AGE-ANEMIA)

Iron Deficiency Anemia

Netherlands
Ardea Biosciences, Inc.

Completed

Naïve HIV POC Monotherapy Trial

HIV Infections

Germany, United Kingdom
Idorsia Pharmaceuticals Ltd.

Completed

Pharmacokinetic Interaction Between Diltiazem and ACT-541468 in Healthy Subjects

Healthy Subjects

Germany
Sandoz

Completed

A Relative Bioavailability Study of Metformin HCL Tablets, 1000 mg Under Fasting Conditions

Type 2 Diabetes
MedImmune LLC

Completed

Safety and Tolerability Study of MEDI-551, a B-cell Depleting Agent, to Treat Relapsing Forms of Multiple Sclerosis

Multiple Sclerosis, Relapsing Forms

United States, Spain, Poland, Ukraine
Pfizer

Completed

First Safety Study in Humans of a Single Dose of CPG 52364

Healthy Volunteers

United States
Mylan Pharmaceuticals Inc

Completed

Fasting Study of Sumatriptan Succinate Tablets 100 mg to Imitrex® Tablets 100 mg

Healthy

United States
Mylan Pharmaceuticals Inc

Completed

Food Study of Sumatriptan Succinate Tablets 100 mg to Imitrex® Tablets 100 mg

Healthy

United States
SFJ Pharmaceuticals, Inc.
SFJ Pharmaceuticals, Inc.

Terminated

Study to Evaluate the Safety, Tolerability, PK, and PD of PB2452 With and Without Ticagrelor Pretreatment in Chinese Healthy Volunteers

Healthy

China
Ionis Pharmaceuticals, Inc.

Completed

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ISIS 443139 in Participants With Early Manifest Huntington's Disease

Huntington's Disease

Canada, United Kingdom, Germany
Jiangsu HengRui Medicine Co., Ltd.

Completed

Efficacy and Safety Study of SP2086 in Combination With Metformin in Patients With Type 2 Diabetes

Type 2 Diabetes

China
Actelion

Completed

Study of the Electrocardiographic Effects of Ponesimod in Healthy Male and Female Subjects

Healthy

United States
The Netherlands Cancer Institute

Recruiting

Body Surface Area-based vs Concentration-based Dosing of Cisplatin for Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Women With Advanced Ovarian Cancer (CisCon)

Fallopian Tube Carcinoma | Peritoneal Cancer | FIGO Stage III Ovarian Cancer

Netherlands
Debiopharm International SA

Completed

A Study to Evaluate the Absorption, Metabolism, and Excretion and Absolute Bioavailability of Xevinapant in Healthy Male Participants

Healthy Volunteers

United Kingdom
UCB Pharma SA

Completed

Comparison of Brivaracetam Oral Tablet (10 mg, 50 mg, 75 mg and 100 mg) and Brivaracetam Injection (100 mg) in Healthy Volunteers

Healthy Volunteers

Netherlands
Sandoz

Completed

Study to Test the Hypothesis of Non-inferior Efficacy and Safety of Ferrum Lek® (Iron (III) Hydroxide Polymaltosate), 100 mg Chewable Tablets (Lek d.d., Slovenia), as Compared With MALTOFER® (Vifor S.A., Switzerland), in Subjects With Mild and Moderate Iron Deficiency Anemia.

Mild and Moderate Iron-deficiency Anaemia

Russian Federation
University Medical Centre Ljubljana
University of Ljubljana School of Medicine, Slovenia

Completed

Duration of Doxycycline Treatment in EM Patients

Erythema Chronicum Migrans

Slovenia
Janssen Research & Development, LLC

Withdrawn

A Dose Range Finding Study of JNJ-39758979 in Patients With Active Rheumatoid Arthritis Currently Treated With Methotrexate

Active Rheumatoid Arthritis; Rheumatoid Arthritis
Merck Sharp & Dohme LLC

Completed

A Study to Investigate the Safety and Tolerability of MK-0517 in Healthy Subjects (MK-0517-012)

Postoperative Nausea and Vomiting | Chemotherapy-Induced Nausea and Vomiting
Centre Hospitalier Universitaire, Amiens
Merck Serono International SA

Completed

May Metformin be Used in Renal Failure?

Renal Disorder Associated With Type II Diabetes Mellitus

France
U.S. Army Medical Research and Development Command

Completed

Safety and Tolerability of Antiplaque Chewing Gum in a Gingivitis Population (APCG)

Gingivitis | Plaque

United States
Merck Sharp & Dohme LLC

Completed

30-Week Extension to an Initial Combination Study (24 Weeks in Duration) of Sitagliptin With Pioglitazone (0431-064)

Type 2 Diabetes Mellitus
VA Office of Research and Development

Completed

Pharmacological Treatment of Generalized Anxiety Disorder in the Elderly (Sert-GAD)

Generalized Anxiety Disorder

United States
Merck Sharp & Dohme LLC

Completed

Initial Combination With Pioglitazone Study (0431-064)

Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC

Completed

MK0431 (Sitagliptin) and Metformin Co-Administration Factorial Study in Patients With Type 2 Diabetes Mellitus (0431-036)

Type 2 Diabetes Mellitus
aTyr Pharma, Inc.
Foundation for Sarcoidosis Research

Completed

Study of Intravenous ATYR1923 (Efzofitimod) for Pulmonary Sarcoidosis

Pulmonary Sarcoidosis

United States
Virginia Commonwealth University

Terminated

Pilot Study of the Safety and Efficacy of Anakinra (Recombinant Human Interleukin-1 Receptor Antagonist) in Pulmonary Hypertension

Pulmonary Hypertension

United States
Nektar Therapeutics

Completed

A Study in Cancer Patients With Hepatic Impairment to Evaluate the Pharmacokinetics and Safety of NKTR-102 (Etirinotecan Pegol)

Advanced or Metastatic Solid Tumors in Patients With Hepatic Impairment

United States

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