Search clinical trials for: Acid Sensing Ion Channel Blockers

Total 10188 results

Augusta University

Unknown

Study of Amiloride on Vascular Phenotypes in Young Adults With Prehypertension (SAPHA)

Prehypertension

United States
Centre Hospitalier Universitaire de Nice

Unknown

Acid-Sensing Ion Channel and Migraine Disease Proof of Concept Study on the Efficacy of Amiloride in the Prophylaxis of Migraine Aura (APAM)

Migraine With Aura

France
Ospedale San Raffaele

Completed

Natriuretic Effect of Amiloride in Relation to the Alpha Adducin Gene (ADD-AMI) RS4961 Variant (ADD-AMI)

Genetic Hypertension | Hypertension Essential | Salt Excess

Italy
FDA Office of Orphan Products Development
University of North Carolina

Completed

Study of Uridine Triphosphate (UTP) as an Aerosol Spray for Cystic Fibrosis

Cystic Fibrosis
University of North Carolina, Chapel Hill

Completed

Do Acid Sensing Ion Channels Contribute to Heartburn?

Gastroesophageal Reflux Disease | Heartburn

United States
University of Utah
Center for Addiction and Mental Health

Active, not recruiting

Pharmacokinetics of Amiloride Nasal Spray in Healthy Volunteers

Pharmacokinetics

United States
University of Oxford
Multiple Sclerosis Society of Great Britain and Northern Ireland

Completed

Amiloride Clinical Trial In Optic Neuritis (ACTION)

Multiple Sclerosis | Optic Neuritis

United Kingdom
Ib Abildgaard Jacobsen

Completed

Amiloride for Resistant Hypertension

Hypertension | Type 2 Diabetes Mellitus | Microalbuminuria

Denmark
Assistance Publique - Hôpitaux de Paris

Terminated

Genetic Determinant of Blood Pressure Sensitivity to Salt Intake (JEU004)

Hypertension
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Active, not recruiting

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Amiloride vs Triamterene

Hypertension

United States
Georgetown University

Unknown

A Crossover Pilot Study of the Effect of Amiloride on Proteinuria

Proteinuria

United States
University of North Carolina
Cystic Fibrosis Foundation

Completed

Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis

Cystic Fibrosis

United States
University of Missouri-Columbia

Recruiting

ENAC Blockade and Arterial Stiffness

Insulin Resistance | Overweight and Obesity

United States
University of Cambridge
King's College London; Imperial College London; Barts & The London NHS Trust; University... and other collaborators

Unknown

Comparison of Single and Combination Diuretics in Low-Renin Hypertension (PATHWAY3)

Hypertension

United Kingdom
University Hospital Tuebingen

Terminated

Amiloride in Nephrotic Syndrome (AMILOR)

Edema | Nephrotic Syndrome | Sodium Retention

Germany
University of Southern Denmark
Odense University Hospital; Region of Southern Denmark

Completed

Increased Activity of ENaC in Proteinuric Kidney Transplant Recipients

Kidney Transplant; Complications

Denmark
University of Southern Denmark
Odense University Hospital; The Ministry of Science, Technology and Innovation... and other collaborators

Unknown

Increased Activity of a Renal Salt Transporter (ENaC) in Diabetic Kidney Disease

Hypertension | Diabetic Nephropathies

Denmark
Yale University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Mechanisms of Diuretic Resistance in Heart Failure, Aim 2 (MsDR 2)

Heart Failure

United States
Guangdong Provincial People's Hospital

Completed

A New Application of Amiloride in the Treatment of Patient With Chronic Kidney Disease In Reducing Urinary PROtein (ANTI-UPRO)

Chronic Kidney Diseases

China
Boston Children's Hospital
Cystic Fibrosis Foundation

Completed

Amiloride Solution and Tobramycin Solution for Inhalation for the Eradication of Burkholderia Dolosa in Patients With Cystic Fibrosis

Cystic Fibrosis

United States
Erasmus Medical Center

Recruiting

Treatment of Vascular Stiffness in ADPKD (TRAMPOLINE)

Autosomal Dominant Polycystic Kidney

Netherlands
State University of New York - Upstate Medical...

Terminated

Amiloride Hydrochloride as an Effective Treatment for ADHD

ADHD

United States
Erasmus Medical Center

Completed

DD-study: Diet or Diuretics for Salt-sensitivity in Chronic Kidney Disease (DD)

Chronic Kidney Disease

Netherlands
Hospices Civils de Lyon

Completed

Microcirculation & ASICs

Physiological Conditions

France
University of New Mexico
University of Pittsburgh; Dialysis Clinic, Inc.

Terminated

Epithelial Sodium Channel (ENaC) as a Novel Mechanism for Hypertension and Volume Expansion in Type 2 Diabetes

Hypertension | Proteinuria | Type II Diabetes

United States
Assistance Publique - Hôpitaux de Paris

Recruiting

AMIloride for the Treatment of Nephrogenic Diabetes Insipidus for Patients With Bipolar Disorder Treated With Lithium (AMIND)

Bipolar Disorder

France
University of Alabama at Birmingham
National Institutes of Health (NIH)

Completed

Vascular Effects of Mineralocorticoid Receptor Antagonism in Kidney Disease (VEMAKD)

Chronic Kidney Disease | Albuminuria

United States
Yonsei University

Recruiting

Comparison of Spironolactone and Amiloride on Home Blood Pressure in Resistant Hypertension

Resistant Hypertension

Korea, Republic of
Regional Hospital Holstebro

Completed

The Effects of Amiloride and Spironolactone on Renophysiological and Cardiovascular Variables (hass)

Essential Hypertension

Denmark
Erling Bjerregaard Pedersen

Completed

The Effect of Amiloride and Spironolactone in Patients With Hypertension (hass)

Hypertension

Denmark
VA Salt Lake City Health Care System

Withdrawn

Spironolactone Versus Amiloride as an Add on Agent in Resistant Hypertension

Hypertension

United States
Hospital de Clinicas de Porto Alegre
Financiadora de Estudos e Projetos

Completed

Hypertension Prevention in Pre-Hypertensive Individuals (PREVER)

Hypertension | Cardiovascular Disease | Pre-hypertension

Brazil
St George's, University of London

Terminated

Extracellular Fluid in Resistant Hypertension

Hypertension

United Kingdom
Hospital de Clinicas de Porto Alegre
Instituto de Cardiologia do Rio Grande do Sul

Unknown

Efficacy of Chlorthalidone and Hydrochlorothiazide Combined With Amiloride on Blood Pressure in Primary Hypertension.

Hypertension

Brazil
Regional Hospital Holstebro

Completed

The Effect of Amiloride and Spironolactone in Healthy Persons (SPAS)

High Blood Pressure

Denmark
Hospital de Clinicas de Porto Alegre

Completed

Antihypertensive Effectiveness of the Associations of Hydrochlorothiazide and Amiloride and Hydrochlorothiazide and Enalapril

Hypertension

Brazil
Hospital de Clinicas de Porto Alegre

Completed

Effect of Antihypertensive Agents on Diastolic Function in Patients With Sleep Apnea (DOSA-2)

Hypertension | Sleep Apnea

Brazil
Hospital de Clinicas de Porto Alegre

Completed

Effect of Antihypertensive Agents Over Sleep Apnea

Hypertension | Obstructive Sleep Apnea

Brazil
Radboud University Medical Center

Completed

The Influence of Rosiglitazone on the Diuretic Effect of Furosemide and Amiloride

Insulin Resistance

Netherlands
GlaxoSmithKline

Completed

Bioequivalence Study Between GSK3542503 Hydrochlorothiazide + Amiloride Hydrochloride 50 mg: 5 mg Tablets and Reference Product in Healthy Adult Participants Under Fasting Conditions

Hypertension

South Africa
Eurofarma Laboratorios S.A.

Unknown

Safety and Efficacy of Chlorthalidone + Amiloride to Elderly Patients Treatment With Arterial Hypertension (CARD)

Arterial Hypertension

Brazil
Hospital de Clinicas de Porto Alegre
Financiadora de Estudos e Projetos

Completed

Diuretics and Angiotensin-Receptor Blocker Agents in Patients With Stage I Hypertension (PREVER)

Hypertension | Cardiovascular Disease

Brazil
Brigham and Women's Hospital

Completed

Evaluating Alternative Medical Therapies in Primary Hyperparathyroidism

Primary Hyperparathyroidism

United States
Changi General Hospital

Completed

Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism (PA_PACES)

Primary Aldosteronism | Primary Aldosteronism Due to Aldosterone Producing Adenoma | Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)

Singapore
Medical University of Vienna

Unknown

Amiloride Hydrochlorothiazide as Treatment of Acute Inflammation of the Optic Nerve

Optic; Neuritis, With Demyelination

Austria
GlaxoSmithKline

Completed

Fracture Risk With Thiazolidinediones

Fractures, Bone | Type II Diabetes
University College, London
University of Leeds; University of Sheffield; Medical Research Council; Queen Mary... and other collaborators

Completed

MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART)

Secondary Progressive Multiple Sclerosis

United Kingdom
Cambridge University Hospitals NHS Foundation Trust
Medical Research Council

Recruiting

Comparison of Optimal Hypertension Regimens (AIMHY-INFORM)

Hypertension

United Kingdom
Chinese Academy of Medical Sciences, Fuwai Hospital

Unknown

Effects of Angiotensin II Receptor Blocker Compared With Diuretics in High-risk Hypertensive Patients (CHIEF)

Essential Hypertension

China
UCB BIOSCIENCES GmbH

Completed

Study to Evaluate the Pharmacokinetics, Safety, Tolerability of Single Dose Lacosamide in Subjects With Renal Impairment Compared to Healthy Subjects

Healthy | Renal Impairment

Germany

Search clinical trials for: Acid Sensing Ion Channel Blockers

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