Search clinical trials for: Alkylating Agents

Total 187282 results

DiscGenics, Inc.
CTI Clinical Trial and Consulting Services

Completed

Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Intervertebral Disc Degeneration

Degenerative Disc Disease

United States
Pfizer

Active, not recruiting

Real-world Treatment Patterns and Effectiveness of Palbociclib and AI Therapy

Metastatic Breast Cancer

United States
Syndax Pharmaceuticals

Completed

Study to Evaluate Exemestane With and Without Entinostat (SNDX-275) in Treatment of Postmenopausal Women With Advanced Breast Cancer (ENCORE301)

Breast Cancer | ER+ Breast Cancer | Estrogen Receptor-Positive Breast Cancer | Breast Cancer, Estrogen Receptor-Positive

United States, Czechia, Canada, Hungary, Russian Federation
Becton, Dickinson and Company

Terminated

Evaluation of a 4mmx32G Pen Needle for Injection of Basal Insulin Doses Above 40 Units

Diabetes Mellitus, Type 2

United States, Canada
Organon and Co

Completed

A Comparison Study With Alendronate and Raloxifene in Postmenopausal Women With Osteoporosis (0217-189)

Osteoporosis, Postmenopausal
Cukurova University

Completed

Preoperative Melatonin or Vitamin C Administration on Postoperative Analgesia

Postoperative Pain

Turkey
Jonsson Comprehensive Cancer Center
Gilead Sciences

Terminated

Mechanisms of Idelalisib-Associated Diarrhea in Patients With Relapsed Chronic Lymphocytic Leukemia, Indolent Non-hodgkin Lymphoma, or Small Lymphocytic Lymphoma

B-Cell Non-Hodgkin Lymphoma | Recurrent Small Lymphocytic Lymphoma | Recurrent B-Cell Non-Hodgkin Lymphoma | Recurrent Chronic Lymphocytic Leukemia | Recurrent Indolent Adult Non-Hodgkin Lymphoma | Absence of Signs or Symptoms | Digestive System Signs and Symptoms | Indolent Adult Non-Hodgkin Lymphoma

United States
Chiesi Farmaceutici S.p.A.

Completed

Clinical Pharmacology Study to Evaluate the Total Systemic Exposure and Lung Bioavailability of CHF 5993 pMDI Combination in Healthy Volunteers

Asthma

Belgium
Lexicon Pharmaceuticals
Sanofi

Completed

Efficacy and Safety of Sotagliflozin Versus Placebo in Participants With Type 2 Diabetes Mellitus on Background of Sulfonylurea Alone or With Metformin

Type 2 Diabetes Mellitus

United States, Bulgaria, Estonia, Hungary, Korea, Republic of, Poland, Romania, Slovakia, Ukraine, United Kingdom
Daiichi Sankyo, Inc.

Completed

CS1008- in Combination With Sorafenib Compared to Sorafenib Alone in Subjects With Advanced Liver Cancer

Liver Neoplasms | Advanced Hepatocellular Carcinoma | Liver Cancer | Hepatic Cancer

Korea, Republic of, Taiwan, United States, Japan
Hams Hamed Abdelrahman

Completed

Melatonin and Hyaluronic Acid in Maxillary Sinus Augmentation

Edentulous; Alveolar Process, Atrophy

Egypt
Medical University of South Carolina

Completed

Respiratory Muscle Strength Training in Presbyphonia

Presbylarynx

United States
Merck Sharp & Dohme LLC
Pfizer

Completed

Effects of Once and Twice Daily Dosing Regimen of Ertugliflozin (PF-04971729, MK-8835) In Participants With Type 2 Diabetes (MK-8835-040)

Diabetes Mellitus, Type 2 | Adult
Virginia Commonwealth University
Massey Cancer Center

Completed

Sorafenib and Vorinostat in Treating Patients With Advanced Liver Cancer

Liver Cancer

United States
Centre Oscar Lambret
National Cancer Institute, France

Terminated

Evaluation of the Efficacy of Diuretics for Symptomatic Malignant Ascites Episodes in Advanced Stage of Cancer (DIASC)

Cancer

France
University of North Carolina, Chapel Hill
National Institute of Mental Health (NIMH)

Completed

Effect of Perimenstrual Ovarian Steroid Supplementation on Perimenstrual Suicidality

Suicidal Ideation

United States
Institute of Cardiology, Warsaw, Poland

Unknown

Clinical Efficacy of Potassium Canrenoate in Sinus Rhythm Restoration Among Patients With Atrial Fibrillation. (CANREN-AF)

Atrial Fibrillation, Paroxysmal
Abbott Diabetes Care

Completed

Ease of Use of New Blood Glucose Meter With In-built Insulin Calculator at Home Study (IHUT)

Diabetes Mellitus

United Kingdom
National Cancer Institute (NCI)

Completed

MS-275 and GM-CSF in Treating Patients With Myelodysplastic Syndrome and/or Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphocytic Leukemia

Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Adult Acute Megakaryoblastic Leukemia (M7) | Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Adult Acute Monoblastic Leukemia (M5a) | Adult Acute Monocytic Leukemia (M5b) | Adult Acute Myeloblastic Leukemia... and other conditions

United States
Mikkel Christensen

Completed

Glucose-Dependent Insulinotropic Polypeptide - Effects on Markers of Bone Turnover in Patients With Type 1 Diabetes

Type 1 Diabetes Mellitus
University Clinical Center Tuzla

Completed

Influence of the Different Ways of Appendix Stump Closure on Patient Outcome in Laparoscopic Appendectomy

Appendicitis

Bosnia and Herzegovina
Ifakara Health Institute
Walter Reed Army Institute of Research (WRAIR); Swiss Tropical & Public Health... and other collaborators

Unknown

Field Efficacy Of Insecticide Treated Uniforms And Skin Repellents for Malaria Prevention (URCT)

Malaria

Tanzania
Xichun Hu

Completed

Dimethyldiguanide Combined With Aromatase Inhibitor (AI) in Metastatic Breast Cancer

Metastatic Breast Cancer

China
Novo Nordisk A/S

Completed

Observational Study of Patients Using NovoMix® 30 or Levemir® for Treatment of Type 1 or Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes | Diabetes Mellitus, Type 1

Macedonia, The Former Yugoslav Republic of
Clinica Universidad de Navarra, Universidad de...
Fondo de Investigacion Sanitaria; Instituto de Salud Carlos III

Unknown

Comparison of Weight Loss Induced by Bariatric Surgery vs Conventional Treatment

Obesity

Spain
University of New Mexico
Sanofi

Completed

Comparative Trial Between 3 Types of Insulin Infusion Protocols

Hyperglycemia

United States
Yolanda de Diego Otero

Completed

Safety and Efficacy Study of Antioxidants for the Treatment of the Fragile X Syndrome (SXF-TRA152)

Fragile X Syndrome

Spain
University of Leeds

Completed

Effect of Quercetin Supplements on Healthy Males: a Four-Week Randomized Cross-Over Trial

Kidney Calculi | Cardiovascular Disease | Diabetes | Hyperuricemia | Gout

United Kingdom
Gynecologic Oncology Group
National Cancer Institute (NCI)

Withdrawn

Acetyl-L-Carnitine Hydrochloride in Preventing Peripheral Neuropathy in Patients With Recurrent Ovarian Epithelial Cancer, Primary Peritoneal Cavity Cancer, or Fallopian Tube Cancer Undergoing Chemotherapy

Pain | Fatigue | Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Ovarian Clear Cell Cystadenocarcinoma | Ovarian Endometrioid Adenocarcinoma | Ovarian Serous Cystadenocarcinoma | Neuropathy | Malignant Ovarian Mixed Epithelial Tumor | Ovarian Brenner... and other conditions
Gilead Sciences

Completed

A Phase 3 Study of Ranolazine in Subjects With Type 2 Diabetes Who Are Inadequately Controlled on Metformin Alone

Type 2 Diabetes Mellitus

United States, Russian Federation, Israel, South Africa, India, Hungary, Ukraine, Canada, Czech Republic, Mexico, Poland
Fresenius Kabi USA, LLC

Completed

Bioequivalence of Fresenius Kabi USA, LLC Glucagon for SC Injection Compared to Glucagon for Injection (Bedford Laboratories)

Hypoglycemia

United States
University of Dhaka
University of Dundee; Bangladesh Institute of Research and Rehabilitation in...

Completed

Efficacy Study of Pioglitazone and Metformin and Association Between Pioglitazone Response and Peroxisome Proliferator-activated Receptor Gamma Gene Variants in Bangladeshi Type 2 Diabetes Mellitus Subjects (T2DMCT)

Type 2 Diabetes Mellitus

Bangladesh
Sanofi

Completed

Evaluation of the Safety and Efficacy of Insulin Glargine + Glulisine or Insulin Regular + NPH Insulin (Isophane Insulin) Use in Type 2 Diabetes Mellitus Patients With Moderate Renal Failure. (DINAMO)

Diabetes Mellitus, Type 2

Brazil
Garden State Cancer Center at the Center for Molecular...

Unknown

Bispecific Antibody in Finding Tumor Cells in Patients With Colorectal Cancer

Colorectal Cancer

United States
Fudan University

Unknown

Capecitabine Metronomic Chemotherapy Plus Aromatase Inhibitor for Postmenopausal Hormone Receptor Positive Breast Cancer

Breast Cancer

China
Bristol-Myers Squibb

Completed

Safety and Efficacy of Exemestane Plus Dasatinib Versus Placebo for Advanced ER+ Breast Cancer

Breast Cancer

Czech Republic, United States, Spain, United Kingdom, Ireland, Poland, France, Sweden
CIBA VISION

Completed

Four Week Performance Comparison Between Two Commercially Available Silicone Hydrogel Lenses

Myopia
University Hospital, Essen
Bristol-Myers Squibb; GlaxoSmithKline; Merck Sharp & Dohme LLC; Boehringer Ingelheim and other collaborators

Completed

Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 5 Years Follow-up

Heart Failure | Metabolic Syndrome | HIV | Coronary Heart Disease | AIDS

Germany
AGUNCO Obstetrics and Gynecology Centre

Completed

Role of Melatonin Supplementation in Follicular Fluid of in Vitro Fertilization (IVF) Patients With Polycystic Ovarian Syndrome

Polycystic Ovary Syndrome

Italy
Novartis

Completed

Effects of Zoledronic Acid and Raloxifene on Bone Turnover Markers in Postmenopausal Women With Low Bone Mineral Density

Osteoporosis

United States
University Hospital, Ghent
University Hospital, Antwerp; Queen Fabiola Children's University Hospital,...

Recruiting

Antibiotic Dosing in Pediatric Intensive Care (ADIC)

Pharmacokinetics | Vancomycin | Amoxicillin-clavulanate | Piperacillin-tazobactam | Teicoplanin | Meropenem | Ciprofloxacin | Amikacin

Belgium
NRG Oncology
National Cancer Institute (NCI)

Active, not recruiting

Maintenance Chemotherapy With or Without Local Consolidative Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer

Recurrent Non-Small Cell Lung Carcinoma | Stage IV Non-Small Cell Lung Cancer

United States, Canada, Israel, Saudi Arabia
Academic and Community Cancer Research United
National Cancer Institute (NCI)

Active, not recruiting

Polatuzumab Vedotin, Venetoclax, and Rituximab and Hyaluronidase Human for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma

Recurrent Grade 1 Follicular Lymphoma | Recurrent Grade 2 Follicular Lymphoma | Recurrent Mantle Cell Lymphoma | Recurrent Marginal Zone Lymphoma | Refractory B-Cell Non-Hodgkin Lymphoma | Recurrent Small Lymphocytic Lymphoma | Recurrent B-Cell Non-Hodgkin Lymphoma | Recurrent Grade 3a Follicular... and other conditions

United States
University of Southern California
National Cancer Institute (NCI); Vasgene Therapeutics, Inc

Terminated

Recombinant EphB4-HSA Fusion Protein With Standard Chemotherapy Regimens in Treating Patients With Advanced or Metastatic Solid Tumors

Stage IIIA Non-Small Cell Lung Cancer | Stage IIIB Non-Small Cell Lung Cancer | Pancreatic Adenocarcinoma | Head and Neck Squamous Cell Carcinoma | Recurrent Non-Small Cell Lung Carcinoma | Stage IV Non-Small Cell Lung Cancer | Metastatic Pancreatic Adenocarcinoma | Stage III Pancreatic Cancer | Stage... and other conditions

United States
Lei Li

Unknown

Study of Universal Screening for Lynch Syndrome in Chinese Patients of Endometrial Cancer

Colorectal Neoplasms, Hereditary Nonpolyposis | Endometrial Neoplasms

China
Duke University

Not yet recruiting

RECOVER-SLEEP: Platform Protocol, Appendix_A (Hypersomnia)

Long COVID | Long COVID-19 | Hypersomnia
The First Affiliated Hospital with Nanjing Medical...

Not yet recruiting

RC48 Combined With Adebrelimab and Apatinib and S-1 of the Neoadjuvant Therapy of Locally Advanced Gastric Cancer

Gastric Cancer/Gastroesophageal Junction Adenocarcinoma
Rovi Pharmaceuticals Laboratories

Recruiting

Evaluation of the Pharmacokinetics, Safety, and Tolerability of IM Letrozole LEBE in Healthy Post-menopausal Women (LEILA-1)

Healthy

Czechia
Hôpital NOVO

Recruiting

Assessment of a Procedure for Managing Oral Anticoagulants (NACO) in the Management of Fractures (STOP-NACO)

Femur Fracture

France
Muhamed Ahmed Abdelmoaty Muhamed Alhagrasy

Recruiting

Best Treatment for Women With Both (Polycystic Ovary Syndrome) PCOS and Subclinical Hypothyroidism

Subclinical Hypothyroidism | Female Infertility | PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries

Egypt

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