Search clinical trials for: Alkylating Agents

Total 188573 results

Recep Tayyip Erdogan University Training and Research...

Completed

The Effect of MTA and PRF Application in Periapical Lesions

Apical Periodontitis | Wound Heal

Turkey
Democritus University of Thrace
George Papanicolaou Hospital; Naval Hospital, Athens; Athinaiki General Clinic

Completed

Impact of 0.1% and 0.2% Sodium Hyaluronate on Postoperative Discomfort Following Phacoemulsification Surgery

Cataract

Greece
Duke University
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Determining Optimal Dose and Duration of Diuretic Treatment in People With Acute Heart Failure (The DOSE-AHF Study)

Heart Failure

United States, Canada
Adocia

Completed

A Trial to Investigate the Dose-linearity of BioChaperone® Combo 75/25 and the Safety at Three Different Doses in Subjects With Type 2 Diabetes

Type 2 Diabetes Mellitus

Germany
Novo Nordisk A/S

Completed

Comparing Patient-adjusted Versus Physician-adjusted Titration of BIAsp 30 Combined With Metformin in Type 2 Diabetes Patients

Diabetes Mellitus, Type 2 | Diabetes

Saudi Arabia, Egypt, Morocco, Indonesia, Tunisia, Vietnam
University of Pennsylvania

Terminated

Preventing Epilepsy After Traumatic Brain Injury With Topiramate (PEPTO)

Epilepsy | Traumatic Brain Injury
Novo Nordisk A/S

Terminated

Comparing Efficacy and Safety of Insulin Detemir Plus Insulin Aspart and NPH Insulin Plus Human Soluble Insulin With or Without Metformin in Chinese Patients With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

China
Novo Nordisk A/S

Completed

Comparison of Insulin Detemir, Insulin Aspart and Biphasic Insulin Aspart 30 With OAD Treatment in Type 2 Diabetes (4T)

Diabetes Mellitus, Type 2 | Diabetes

United Kingdom, Ireland
Novo Nordisk A/S

Completed

Glycemic Control of Biphasic Insulin Aspart 30 in Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

Poland
University of Bologna
Agenzia Italiana del Farmaco

Completed

Human Albumin for the Treatment of Ascites in Patients With Hepatic Cirrhosis (ANSWER)

Liver Cirrhosis | Ascites

Italy
Novo Nordisk A/S

Completed

Basal Bolus of Insulin Aspart Including Insulin NPH and Biphasic Insulin Aspart in Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

Germany, Poland, Russian Federation, Spain, Sweden, Netherlands, Singapore, Malaysia, France, Croatia, Romania, United Kingdom, Hong Kong
Assistance Publique - Hôpitaux de Paris
Institut National de la Santé Et de la Recherche Médicale, France; Centre National...

Unknown

Genetic and Environmental Risk Factors of Type 1 Autoimmune Diabetes and Its Early Complications (ISIS-DIAB)

Diabetes Mellitus | Insulin-Dependent

France
Takeda

Completed

Safety and Efficacy of TAK-442 in Subjects With Acute Coronary Syndromes

Acute Coronary Syndrome

United States, Belgium, Germany, Bulgaria, India, South Africa, Netherlands, Korea, Republic of, Canada, Chile, Peru, Russian Federation, Argentina, Hungary, Romania, Brazil, Estonia, Serbia, United Kingdom
Khon Kaen University
General Drugs House Co.,LTD.; Ubon Ratchathani Cancer Hospital, Ubon Ratchathani

Completed

Topical/Oral Melatonin for Preventing Concurrent Radiochemotherapy Induced Oral Mucositis/Xerostomia Cancer Patients

Head and Neck Cancer

Thailand
Novo Nordisk A/S

Completed

Comparison of Two Biphasic Insulin Aspart 30 Treatment Regimens in Subjects With Type 2 Diabetes Not Achieving HbA1c Treatment Targets on OADs Alone

Diabetes Mellitus, Type 2 | Diabetes

Iran, Islamic Republic of
Boehringer Ingelheim

Completed

Multiple Oral Doses of BIBR 1048 MS Solution in Healthy Volunteers

Healthy
Alcon Research

Completed

Clinical Performance of a Silicone Hydrogel Lens With Use of FID 114675A

Myopia | Contact Lens Fit
Mayo Clinic

Completed

Heart Failure and a Preserved Ejection Fraction

Heart Failure

United States
Actavis Inc.

Completed

A Relative Bioavailability Study of Finasteride 5 mg Tablets Under Fed Conditions

Healthy

Canada
Radboud University Medical Center
Institut Pasteur

Completed

Safety and Efficacy Study of Plasmodium Falciparum LSA-3 Malaria Vaccine (LSA-3-rec)

Healthy

Netherlands
Cook Research Incorporated

Active, not recruiting

Zenith® p-Branch® Endovascular Graft Pivotal Study

Aortic Aneurysm Abdominal

United States
Ipsen

Completed

Perception of Cohesion Within a Relationship (Dyadic Adjustment) on the Quality of Life of Patients With Prostate Cancer With Gonadotropin-releasing Hormone. (EQUINOXE)

Prostate Cancer

France
Aarhus University Hospital Skejby

Completed

DOCTOR Compare - A Study in the "DOCTOR" Series (Does Optical Coherence Tomography Optimize Revascularization?"

Myocardial Infarction | Coronary Disease | Atherosclerosis

Denmark
Assiut University

Not yet recruiting

Evaluation of Some Risk Factors Associated With Colorectal Cancer

Colorectal Neoplasms
National Cancer Institute (NCI)

Recruiting

Testing of Bevacizumab, Erlotinib, and Atezolizumab in Combination for Advanced-Stage Kidney Cancer

Renal Cell Carcinoma | Stage III Renal Cell Cancer AJCC v8 | Stage IV Renal Cell Cancer AJCC v8 | Papillary Renal Cell Carcinoma | Hereditary Leiomyomatosis and Renal Cell Carcinoma | Sporadic Papillary Renal Cell Carcinoma

United States
University of Mississippi Medical Center
Eli Lilly and Company

Recruiting

Empagliflozin in ESKD - A Feasibility Study

Heart Failure | Kidney Failure, Chronic

United States
Baptist Health South Florida
BeiGene

Recruiting

Zanubrutinib With Pemetrexed to Treat Relapsed/Refractory Primary and Secondary Central Nervous System (CNS) Lymphomas

Primary Central Nervous System Lymphoma | Relapsed Cancer | Refractory Cancer | Secondary Central Nervous System Lymphoma

United States
Erasmus Medical Center

Recruiting

Treatment of Vascular Stiffness in ADPKD (TRAMPOLINE)

Autosomal Dominant Polycystic Kidney

Netherlands
University of Washington
National Cancer Institute (NCI)

Recruiting

Effect of HSD3B1 (1245C) Gene Mutation on Treatment of Stage I-III Breast Cancer

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8 | Breast Adenocarcinoma | Invasive Breast Carcinoma of No Special Type

United States
Wake Forest University Health Sciences

Recruiting

SNIFF - Combo INI+EMPA Trial

Cognitive Impairment | Alzheimer Disease | Mild Cognitive Impairment

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Venetoclax and Azacitidine for the Treatment of High-Risk Recurrent or Refractory Myelodysplastic Syndrome

Chronic Myelomonocytic Leukemia | Myelodysplastic Syndrome | Recurrent Myelodysplastic Syndrome | Refractory Myelodysplastic Syndrome | Therapy-Related Myelodysplastic Syndrome

United States
Taproot Health

Recruiting

The Registry of Oncology Outcomes Associated With Testing and Treatment (ROOT)

Melanoma | Sarcoma | Kidney Cancer | Adenocarcinoma | Renal Cell Carcinoma | Cervical Cancer | Acute Myeloid Leukemia | Stomach Cancer | Breast Cancer | Head and Neck Neoplasms | Nasopharyngeal Carcinoma | Glioblastoma | Astrocytoma | Multiple Myeloma | Colorectal Cancer | Pancreatic Cancer | Esophageal Cancer | Small Bowel Cancer and other conditions

United States
Herlev and Gentofte Hospital
Danish Society of Cardiology

Recruiting

The Danish Non-vitamin K Antagonist Oral Anticoagulation Study in Patients With Venous Thromboembolism (DANNOAC-VTE) (DANNOAC-VTE)

Deep Vein Thrombosis | Pulmonary Embolism

Denmark
Wroclaw Medical University

Completed

Sodium Chloride vs. Glucose Solute as a Volume Replacement Therapy During Decongestion in Acute Heart Failure (SOLVRED-AHF)

Heart Failure | Acute Heart Failure | Congestion

Poland
Imperial College London
King's College London; Medical University of Graz; University of Bordeaux; Hospital... and other collaborators

Completed

PREvention of STroke in Intracerebral haemorrhaGE Survivors With Atrial Fibrillation (PRESTIGE-AF)

Atrial Fibrillation | Intracerebral Hemorrhage

Germany, Spain, United Kingdom
National Cancer Institute (NCI)

Active, not recruiting

Gemcitabine Hydrochloride With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Ovarian Clear Cell Cystadenocarcinoma | Ovarian Endometrioid Adenocarcinoma | Ovarian Seromucinous Carcinoma | Ovarian Serous Cystadenocarcinoma | Ovarian Undifferentiated Carcinoma | Ovarian... and other conditions

United States, Canada, Singapore
National Cancer Institute (NCI)

Active, not recruiting

Exemestane in Treating Patients With Complex Atypical Hyperplasia of the Endometrium/Endometrial Intraepithelial Neoplasia or Low Grade Endometrial Cancer

Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia | FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma | FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma | Atypical Hyperplasia

United States
National Cancer Institute (NCI)

Active, not recruiting

Imatinib Mesylate or Dasatinib in Treating Patients With Previously Untreated Chronic Phase Chronic Myelogenous Leukemia

Chronic Myeloid Leukemia, BCR-ABL1 Positive

United States, Canada
Ono Pharmaceutical Co. Ltd

Terminated

A Study of ONO-7475 in Patients With Acute Leukemias

Myelodysplastic Syndromes | Acute Leukemia

United States
Umeå University
University of California; Mead Johnson Nutrition

Active, not recruiting

Effect of Infant Formula With Bovine Lactoferrin and Low Iron Concentration on Infant Health and Immune Function (LIME)

Health of Formula-fed Children | Infant Infections in Formula-fed Children | Iron Status of Formula-fed Children

Sweden
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Venetoclax and Acalabrutinib in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma

Recurrent Mantle Cell Lymphoma | CD20 Positive | Refractory Mantle Cell Lymphoma | Blastoid Variant Mantle Cell Lymphoma | CCND1 Protein Overexpression | CD5 Positive | FCER2 Negative | Pleomorphic Variant Mantle Cell Lymphoma | t(11;14)(q13;q32)

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing the Addition of an Anti-cancer Drug, Elimusertib (BAY 1895344) ATR Inhibitor, to the Chemotherapy Treatment (Gemcitabine) for Advanced Pancreatic and Ovarian Cancer, and Advanced Solid Tumors

Advanced Malignant Solid Neoplasm | Stage II Pancreatic Cancer AJCC v8 | Stage III Pancreatic Cancer AJCC v8 | Stage IV Pancreatic Cancer AJCC v8 | Metastatic Pancreatic Adenocarcinoma | Primary Peritoneal High Grade Serous Adenocarcinoma | Advanced Pancreatic Adenocarcinoma | Platinum-Resistant... and other conditions

United States
Alliance for Clinical Trials in Oncology

Withdrawn

Testing the Safety and Effectiveness of Combining Two Drugs, PLX2853 and Trametinib in the Treatment of Advanced Uveal Melanoma

Metastatic Uveal Melanoma | Advanced Uveal Melanoma | Unresectable Uveal Melanoma
University of Nevada, Las Vegas

Completed

MOBILE Intervention in College Students With Elevated Blood Pressure (MOBILE)

Hypertension

United States
Cancer Hospital of Guangxi Medical University

Active, not recruiting

Clinical Study of the Efficacy and Safety of Transhepatic Arterial Chemoembolization Combined With Tislelizumab and Lenvatinib in Patients With Advanced Unresectable Hepatocellular Carcinoma

TACE | Lenvatinib | Tislelizumab | Advanced Unresectable Hepatocellular Carcinoma

China
AMAG Pharmaceuticals, Inc.
ResearchPoint Global

Completed

Confirmatory Study of 17P vs Vehicle for Prevention of Preterm Birth in Women w/ Previous Spontaneous Preterm Delivery (PROLONG)

Preterm Birth

United States, Spain, Russian Federation, Canada, Bulgaria, Czechia, Hungary, Italy, Ukraine
Sanofi

Completed

Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination Versus Insulin Glargine in Patients With Type 2 Diabetes (LixiLan-India)

Type 2 Diabetes Mellitus

India
Sanofi

Terminated

Efficacy and Safety of Sotagliflozin Versus Placebo in Chinese Patients With Type 2 Diabetes Mellitus Not Adequately Controlled by Metformin With or Without Sulfonylurea

Type 2 Diabetes Mellitus

China
Dow University of Health Sciences

Completed

Comparative Evaluation of Impact of Sodium Hypochlorite on the Physical Properties of Protaper Gold and Dia-X ProTaper.

Dental Pulp Diseases

Pakistan
Organon and Co

Completed

A Study of an Investigational Study Drug for Benign Prostatic Hyperplasia (0906-140)

Benign Prostatic Hyperplasia

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