Search clinical trials for: Boosted Protease Inhibitor (bPI)

Total 5621 results

John Levine
National Cancer Institute (NCI)

Completed

A Proof of Concept Pilot Trial of Alpha-1-Antitrypsin for Pre-Emption Of Steroid-Refractory Acute GVHD

GVHD | Graft-versus-host-disease

United States
Baxalta now part of Shire
Baxalta Innovations GmbH, now part of Shire

Terminated

Stage 1 Study of ARALAST NP and GLASSIA in A1PI Deficiency

Chronic Obstructive Pulmonary Disease | Alpha1-antitrypsin Deficiency

United States, Canada, Australia
RenJi Hospital

Recruiting

Exploratory Research of PCSK9 Inhibitor on Patency of aAVF After PTA With PCB

Hemodialysis Access Failure

China
Techpool Bio-Pharma Co., Ltd.
The First Affiliated Hospital with Nanjing Medical University; Peking Union... and other collaborators

Suspended

Ulinastatin in Severe Acute Pancreatitis

Pancreatitis

China
ANRS, Emerging Infectious Diseases

Not yet recruiting

Study Evaluating the Safety, in Terms of HBV Virological Control at 96 Weeks, of 2 Antiviral Treatment Relief Strategies, in Patients Co-infected With the HIV-1 and HBV Viruses (BI-LIGHT)

HIV Infections | HBV Coinfection
Ethical Oncology Science

Completed

Phase I Study of the Proteosome Inhibitor CEP 18770 in Patients With Solid Tumours or Non-Hodgkin's Lymphomas

Lymphoma, Non-Hodgkin | Solid Tumors

Switzerland, Italy
Cytonics Corporation
Southern Star Research Pty Ltd.

Not yet recruiting

Evaluation of CYT-108, a Recombinant Protease Inhibitor, for Treatment of Mild to Moderate Primary Osteoarthritis of the Knee

Osteoarthritis | Osteoarthritis, Knee

Australia
GlaxoSmithKline

Completed

A Study to Investigate the Efficacy, Safety, and Tolerability of Repeat Doses of Inhaled GSK2269557 in Adults With Persistent, Uncontrolled Asthma

Pulmonary Disease, Chronic Obstructive

Germany
ANRS, Emerging Infectious Diseases
Janssen-Cilag Ltd.

Terminated

Management of Participants With Low-level Persistent Viremia (ANRS 161 L-VIR)

Viremia | HIV-1 Infection | Treatment Resistant Disorders

France
Grifols Therapeutics LLC

Completed

Safety and Tolerability Trial of Inhaled Alpha1-Proteinase Inhibitor (Human), Hydrophobic Chromatography Process (Alpha-1 HC) in Subjects With Cystic Fibrosis

Cystic Fibrosis

United States
Eli Lilly and Company

Completed

A Phase II Study to Determine the Efficacy and Safety of Sivelestat in Subjects With Acute Lung Injury

Acute Lung Injury | Respiratory Distress Syndrome, Adult

United States, Belgium, Spain, Canada, Australia, New Zealand
Centre Hospitalier Universitaire Saint Pierre
Gilead Sciences; University of Liege; Abbott; Pierre and Marie Curie University; University... and other collaborators

Completed

Nevirapine vs Ritonavir-boosted Lopinavir in ART Naive HIV-infected Adults in a Resource Limited Setting

HIV-1 Infection

Congo
Betta Pharmaceuticals Co., Ltd.

Completed

Safety and Efficacy Study of Icotinb in Non-small Cell Lung Cancer (NSCLC) Patients (ICOGEN)

Non-small Cell Lung Cancer

China
Second Affiliated Hospital of Guangzhou Medical...

Recruiting

Trans-Artery/Intra-Tumor Infusion of Checkpoint Inhibitors Plus Chemodrug for Immunotherapy of Advanced Solid Tumors

Melanoma | Cervical Cancer | Breast Cancer | Head and Neck Cancer | Ovarian Cancer | Lung Cancer | Pancreas Cancer | Colo-rectal Cancer | Renal Cancer | Hepatocarcinoma

China
Cephalon

Terminated

Study to Determine the Maximum Tolerated Dose and Evaluate the Efficacy and Safety of CEP-18770 (Delanzomib) in Patients With Relapsed Multiple Myeloma Refractory to the Most Recent Therapy

Multiple Myeloma

United States
Jinnah Postgraduate Medical Centre

Recruiting

Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and Mortality (MUNI-SEP)

Septic Shock | Severe Sepsis | MODS

Pakistan
Nanfang Hospital of Southern Medical University
Dongguan People's Hospital; Foshan Hospital of Traditional Chinese Medicine; Shenzhen... and other collaborators

Recruiting

Effects of Ulinastatin on Inflammatory Response During ECMO Support (Uli-ECMO)

Inflammatory Response | ECMO

China
Shanghai Zhongshan Hospital

Unknown

Protective Effect in Cardiac Surgery Patients

Cardiac Surgery
Yonsei University

Completed

Effects of Ulinastatin on Myocardial Protection and Blood Loss in Patients Undergoing Aortic Valve Replacement

Abnormal Aortic Valve

Korea, Republic of
Kirby Institute

Completed

MARCH Central Nervous System Substudy

HIV-1 Infection

Argentina, Thailand, United Kingdom
Pfizer

Completed

PF-07321332/Ritonavir and Ritonavir on Dabigatran Study in Healthy Participants

Healthy Participants

United States
Fundación FLS de Lucha Contra el Sida, las Enfermedades...

Completed

Multicentre Study To Assess Changes In Bone Mineral Density Of The Switch From Protease Inhibitors To Dolutegravir In HIV-1-Infected Subjects With Low Bone Mineral Density

HIV-1 Infection

Spain
Nanjing First Hospital, Nanjing Medical University

Recruiting

Improving Blood Lipid Management in Symptomatic Intracranial Atherosclerotic Stenosis on Clinical Outcome (sICASBLM)

Intracranial Artery Stenosis

China
Techpool Bio-Pharma Co., Ltd.
Children's Hospital of Fudan University; Shanghai Children's Medical Center; Guangzhou... and other collaborators

Unknown

Ulinastatin Injection in in Pediatric Patients Undergoing Open Heart Surgery

Congenital Heart Diseases

China
Grifols Therapeutics LLC

Completed

The Safety and Tolerability of Alpha-1 Modified Process (MP) In Subjects With Alpha-1-antitrypsin (AAT) Deficiency (STAMP)

Alpha 1-Antitrypsin Deficiency

United States, United Kingdom
BioCryst Pharmaceuticals

Active, not recruiting

Open-label Berotralstat Access to HAE Patients Previously Enrolled in Berotralstat Studies (APeX-A)

Hereditary Angioedema | HAE

France, North Macedonia, Poland, Korea, Republic of, Slovakia, South Africa, Czechia
Boehringer Ingelheim

Completed

ReAHEAD: A Study to Find Out Whether Education Improves Adherence to Dabigatran in People With Atrial Fibrillation Who Are Younger Than 75 Years

Atrial Fibrillation

Taiwan
Well- Konnect Healthcare Services and Research...
All of Us Research Program at the National Institute of Health

Active, not recruiting

Covid-19 Long Haul Preventative and Health Promotion Care Clinical Trial Acceleration Program.

COVID-19, Long Haul

United States
BioCryst Pharmaceuticals

Completed

A Long Term Safety Study of BCX7353 in Hereditary Angioedema (APeX-S)

Hereditary Angioedema | Prophylaxis | HAE

Austria, Denmark, France, Germany, Hungary, Israel, Italy, North Macedonia, Poland, Switzerland, United Kingdom, United States, Australia, Hong Kong, Korea, Republic of, New Zealand, Serbia, Slovakia, South Africa, Spain
HaEmek Medical Center, Israel

Completed

ACRIPAB- Trial: Anti Coagulation Regimen In High Risk PAtients for Bleeding (ACRIPAB)

Hematologic Diseases

Israel
Janssen Research & Development, LLC

Completed

A Study of Darunavir in Combination With Cobicistat or Ritonavir, and Dabigatran Etexilate in Healthy Participants

Healthy

Belgium
Qin Zhang

Completed

Ulinastatin Improves Post-Cardiac Surgery Cognitive Dysfunction

Cardiac Complication

China
Grifols Therapeutics LLC

Completed

Comparison of Pharmacokinetic, Safety, Tolerability of Alpha-1 MP and Prolastin In Alpha1-antitrypsin Deficient Adults (ChAMP)

Alpha 1-Antitrypsin Deficiency

United States
Boston Children's Hospital

Recruiting

Pharmacokinetics of Bivalirudin for Pediatric Anticoagulation

Drug Effect

United States
Centre Hospitalier Universitaire de la Réunion

Completed

Use of Public Health Surveillance Models in the French National Health System Database (DABI-SURV)

Atrial Fibrillation | Anticoagulants | Pharmacoepidemiology

France
KU Leuven
University Ghent; Vrije Universiteit Brussel; Universiteit Antwerpen; Université...

Terminated

The DAWN Antivirals Trial for Ambulatory COVID-19 Patients (DAWN)

Covid19 | SARS-CoV Infection

Belgium
Baxalta now part of Shire
Arriva Pharmaceuticals, Inc.

Completed

Safety Study of an Aerosolized, Recombinant Alpha 1-Antitrypsin in Subjects With Alpha 1-Antitrypsin Deficiency

Alpha1-antitrypsin Deficiency

United States
GlaxoSmithKline

Completed

Study to Evaluate Safety, Tolerability and Pharmacokinetics of GSK2269557 to Japanese Healthy Subjects

Pulmonary Disease, Chronic Obstructive

Japan
Assiut University

Not yet recruiting

Maternal alpha1 Antitrypsin as a Marker of Intrauterine Growth Restriction in Pre-eclamptic Women

Pre-Eclampsia | Intrauterine Growth Restriction | alpha1 Anti-trypsin
University of Florida

Recruiting

The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) Study (ACT)

Alpha-1 Antitrypsin Deficiency

United States
Ministry of Health, Saudi Arabia

Unknown

Trial of Alpha One Antitrypsin Inhalation in Treating Patient With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Coronavirus

Saudi Arabia
Nemours Children's Clinic

Completed

Can Aprotinin Reduce Pancreatitis After Scoliosis Surgery

Pancreatitis

United States
ANRS, Emerging Infectious Diseases
Mylan Laboratories

Active, not recruiting

ANRS 12372 MODERATO Study (MODERATO)

HIV-1-infection

Côte D'Ivoire, Burkina Faso, Cameroon
Institute of Liver and Biliary Sciences, India

Recruiting

Efficacy and Safety of Dabigatran in Patients With Cirrhosis and Portal Vein Thrombosis

Liver Cirrhosis | Portal Vein Thrombosis

India
Boehringer Ingelheim

Completed

Tolerability , PK/PD and Safety of Dabigatran Etexilate Oral Liquid Formulation in Children < 1 Year of Age

Venous Thromboembolism

Canada, France, Russian Federation
S. Andrea Hospital

Unknown

Safety Study of Dabigatran in CADASIL (SONICA)

CADASIL

Italy
Corvus Pharmaceuticals, Inc.

Completed

CPI-006 Alone and in Combination With Ciforadenant and With Pembrolizumab for Patients With Advanced Cancers

Sarcoma | Cervical Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Non-Small Cell Lung Cancer | Squamous Cell Carcinoma of the Head and Neck | Bladder Cancer | Triple Negative Breast Cancer | Endometrial Cancer | Renal Cell Cancer | Non-hodgkin Lymphoma | Metastatic Castration Resistant Prostate...

United States, Australia
Assiut University

Not yet recruiting

Serum Cystatin C for Early Detection of Acute Kidney Injury After Primary Percutaneous Coronary Intervention

Acute Kidney Injury
The Affiliated Nanjing Drum Tower Hospital of Nanjing...

Not yet recruiting

Efficacy and Safety of Sivelestat in Preventing Postoperative Acute Respiratory Distress Syndrome After Cardiac Surgery :a Single Centre Random Control Trial.

Cardiac Disease
Nanfang Hospital of Southern Medical University
Guangdong No.2 Provincial People's Hospital; Foshan Hospital of Traditional... and other collaborators

Enrolling by invitation

Effect of Early Treatment With Sivelestat Sodium in ARDS Patients (siv-ARDS)

Inflammatory Response | ARDS

China

Search clinical trials for: Boosted Protease Inhibitor (bPI)

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