Search clinical trials for: E7016 TMZ

Total 1660 results

Sidney Kimmel Comprehensive Cancer Center at Johns...
Bristol-Myers Squibb; National Cancer Institute (NCI); Candel Therapeutics, Inc.

Active, not recruiting

GMCI, Nivolumab, and Radiation Therapy in Treating Patients With Newly Diagnosed High-Grade Gliomas (GMCI)

Glioma, Malignant

United States
M.D. Anderson Cancer Center

Completed

6-TG, Capecitabine and Celecoxib Plus TMZ or CCNU for Anaplastic Glioma Patients

Brain Cancer | Glioblastoma Multiforme | Anaplastic Glioma of Brain

United States
Naturex SA
Biofortis Mérieux NutriSciences

Completed

Pharmacokinetics Assessing Bioavailability of Gingerols and Shogaols of Five Ginger Extracts (KING)

Healthy Subject

France
The University of Texas Health Science Center,...
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Modernizing Perinatal Syphilis Testing

Syphilis

United States
Damanhour University

Completed

Alpha-lipoic Acid in Diabetic Patients With Ischemic Cardiomyopathy

Diabetes Mellitus | Ischemic Cardiomyopathy

Egypt
Wake Forest University Health Sciences
National Institute on Aging (NIA)

Completed

Utilizing Protein During Weight Loss to Impact Physical Function and Bone (UPLIFT-Bone)

Obesity | Fractures, Bone | Weight Loss | Diet Modification | Aging | Dietary Habits | Bone Loss | Weight Change, Body | Osteopenia, Osteoporosis

United States
South Valley University

Completed

Toclizumam Versus Dexamethasone in Severe Covid-19 Cases

Pneumonia, Viral

Egypt
Vertex Pharmaceuticals Incorporated

Completed

A Phase 3 Study of VX-659 Combination Therapy in Subjects With Cystic Fibrosis Heterozygous for the F508del Mutation and a Minimal Function Mutation (F/MF)

Cystic Fibrosis

United States, Spain, Ireland, Australia, Israel, United Kingdom, Germany, Switzerland, Canada, Denmark, Poland
Implantology Institute

Recruiting

Monolithic Zirconia Full-Mouth Implant Supported Rehabilitation Behavior

Endosseous Dental Implant Failure | Accident Caused by Broken Ceramic

Portugal
AstraZeneca

Completed

A Study to Determine the Pharmacokinetics of Cediranib in Chinese Patients With Advanced Solid Malignancies

Advanced Solid Malignancies

China
AstraZeneca

Completed

Postoperative Radiotherapy Plus Iressa or Radiotherapy Plus Cisplatin and Iressa for Advanced Head & Neck Cancer (IRESSA&H&N)

Head and Neck Cancer

Switzerland
Merck Sharp & Dohme LLC

Not yet recruiting

Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

NSCLC | Non-small Cell Lung Cancer
Vertex Pharmaceuticals Incorporated

Terminated

Evaluation of VX-659/TEZ/IVA in Cystic Fibrosis Subjects 6 Through 11 Years of Age

Cystic Fibrosis

United States
University Health Network, Toronto
Merck Sharp & Dohme LLC

Active, not recruiting

Study of the Effects of Pembrolizumab in Patients With Advanced Solid Tumors (INSPIRE)

Advanced Solid Tumors | Triple Negative Breast Cancer | Epithelial Ovarian Cancer | Malignant Melanoma | Squamous Cell Cancer of Head and Neck

Canada
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); Cancer Immunotherapy Trials Network (CITN)

Terminated

NT-I7 for Kaposi Sarcoma in Patients With or Without HIV

HIV Infection | Kaposi Sarcoma | AIDS-Related Kaposi Sarcoma

United States
GlaxoSmithKline

Completed

Risk of Re-Hospitalization in Patients With Chronic Obstructive Pulmonary Disease (COPD) Post Exacerbation

Pulmonary Disease, Chronic Obstructive
IRCCS Azienda Ospedaliero-Universitaria di Bologna

Completed

Eicosapentaenoic Free Fatty Acid and Fecal Calprotectin in Inflammatory Bowel Diseases

Crohn's Disease | Ulcerative Colitis

Italy
KU Leuven
Fund for Scientific Research, Flanders, Belgium

Completed

Study of Azithromycin for Lymphocytic Bronchiolitis/Bronchitis After Lung Transplantation (AZI002)

Lymphocytic Bronchi(Oli)Tis Post-lung Transplantation

Belgium
University of Göttingen
UZ Gent, Belgium; Policlinica de Guipuzcoa, San Sebastian, Spain

Completed

Efficacy of a Convective Prewarming System in Prevention of Perioperative Hypothermia

Perioperative Hypothermia

Belgium, Germany, Spain
Merck Sharp & Dohme LLC

Completed

Efficacy and Safety of Olaparib (MK-7339) With or Without Bevacizumab Compared to Bevacizumab With a Fluoropyrimidine in Unresectable or Metastatic Colorectal Cancer (CRC) (MK-7339-003/LYNK-003)

Metastatic Colorectal Cancer

Canada, Hungary, United States, Australia, Belgium, Chile, Colombia, France, Germany, Japan, Korea, Republic of, Latvia, Lithuania, Russian Federation, South Africa, Spain, Turkey, Ukraine
Dwight Owen
Genentech, Inc.

Recruiting

Temozolomide and Atezolizumab as Second or Third Line for the Treatment of Metastatic or Recurrent Small Cell Lung Cancer

Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Extensive Stage Lung Small Cell Carcinoma | Metastatic Lung Small Cell Carcinoma | Recurrent Lung Small Cell Carcinoma

United States
National Cancer Institute (NCI)

Active, not recruiting

Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

Adult Anaplastic Astrocytoma | Adult Anaplastic Oligodendroglioma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Recurrent Adult Brain Neoplasm

United States
Sun Yat-sen University

Recruiting

A Multicenter, Phase 3, Randomized Trial of Sequencial Chemoradiotherapy With or Without Toripalimab (PD-1 Antibody) in Newly Diagnosed Early-Stage Extranodal Natural Killer/T Cell Lymphoma, Nasal Type (ENKTL)

NK/T Cell Lymphoma Nos

China
Allecra
Medpace, Inc.

Completed

Safety and Efficacy Study of Cefepime-AAI101 in the Treatment of Complicated Urinary Tract Infections

Urinary Tract Infections

United States, Serbia, Hungary, Estonia, South Africa, Belarus, Poland, Ukraine, Argentina, Bulgaria, Croatia, Georgia, Latvia, Lithuania, Mexico, Peru, Russian Federation, Slovakia, Spain
Tibotec Pharmaceuticals, Ireland

Completed

A Study of TMC435 in Combination With Pegylated Interferon Alp\Fa-2a and Ribavirin in Patients Infected With Genotype 1 Hepatitis C Virus Who Never Received Treatment (PILLAR)

Hepatitis C

United States, Australia, France, Belgium, Germany, Spain, Denmark, Canada, New Zealand, Russian Federation, Austria, Poland, Norway
GlaxoSmithKline

Completed

Outcomes and Costs Associated With Initiating Maintenance Treatment With Fluticasone Propionate 250mcg/Salmeterol Xinafoate 50mcg Combination (FSC) Versus Anticholinergics Including Tiotropium (TIO) in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive
Abby Braitman
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Completed

Alcohol Health Education Among College Drinkers

College Student Drinking
Baylor College of Medicine

Completed

Comparative Efficacy of Phenylbutyrate (PBA) vs. Benzoate in Urea Cycle Disorders (BPA/Benzoate)

Urea Cycle Disorders, Inborn

United States
GlaxoSmithKline

Completed

Complementary Testing to Evaluate Immunogenicity of Human Papillomavirus (HPV) Vaccine (580299) in Healthy Female Subjects Aged >/= 26 Years

Infections, Papillomavirus

Netherlands
Genzyme, a Sanofi Company

Terminated

A Randomised, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Sevelamer Carbonate Tablets Dosed Three Times a Day in Hyperphosphataemic Chronic Kidney Disease Patients Not on Dialysis (ASPIRE)

Chronic Kidney Disease | Hyperphosphatemia

Germany, Greece, Portugal, Austria, France, Hungary, Italy, Spain, Sweden
Peking University Cancer Hospital & Institute

Recruiting

Induction Chemotherapy for MRF-negative, Moderate-risk, Resectable Middle and Low Rectal Cancer

Rectal Cancer

China
Vertex Pharmaceuticals Incorporated

Terminated

A Study Evaluating the Long Term Safety and Efficacy of VX-659 Combination Therapy

Cystic Fibrosis

United States, Spain, Ireland, Australia, Israel, United Kingdom, Germany, Canada, Denmark, Poland, Switzerland
Tibotec Pharmaceuticals, Ireland

Completed

PEPI-TiDP23-C103: First-in-Human Study to Examine the Safety, Tolerability, and Plasma Pharmacokinetics of Increasing Single and Repeated Oral Doses of TMC558445 and of a Combined Single Day Dosing of Oral TMC558445 and Oral TMC310911 and Also Oral Darunavir

HIV-1
University of Roma La Sapienza

Unknown

Ranolazine for Improving Symptoms of Palpitations (RYPPLE)

Ischemic Heart Disease
University of Guarulhos
ITI Foundation

Recruiting

Surgical Access Combined With Systematically Administered Antibiotics in the Treatment of Peri-implantitis

Peri-Implantitis

Brazil
National Cancer Institute (NCI)

Recruiting

Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

Multiple Myeloma | Hodgkin's Lymphoma | Non-Hodgkin's Lymphoma | Acute Leukemia | Myelodysplastic Syndrome

United States
Bausch Health Americas, Inc.

Completed

Topically Applied IDP-118 Lotion and HP Monad Lotion in Subjects With Moderate to Severe Plaque Psoriasis

Psoriasis

United States
Tan Tock Seng Hospital

Recruiting

Human vs Machine: a RCT Comparing Traditional In-person Instruction, AI Versus VR for Learning Basic CCE

Ultrasound

Singapore
Liaquat University of Medical & Health Sciences

Recruiting

Postoperative Sensitivity Following Placement With Different Restorative Materials In Vital Posterior Teeth (GCP)

Sensitivity, Tooth

Pakistan
VA Office of Research and Development

Recruiting

Telehealth Treatment of Veterans With Alcohol Misuse at Risk for Cardiovascular Disease (ACME-TM)

Hypertension | Alcohol Misuse | Elevated Cardiovascular Risk

United States
Medical University of Vienna
Medical Scientific Fund of the Mayor of Vienna

Completed

Thrombomodulin-modified Thrombin Generation Assay (TGA-TM) in Patients With Critical Infections

Critical Illness | Covid19 | Sars-CoV2 | Viral Infection | Disseminated Intravascular Coagulation | Coagulation Disorder, Blood

Austria
Istituto Ortopedico Galeazzi

Completed

Gait Analysis Following Total Ankle Replacement and Subtalar Fusion

Ankle Osteoarthritis

Italy
Erasme University Hospital
Hopital Foch

Completed

Fully Automated Anesthesia, Analgesia and Fluid Management

Hemodynamic Instability | Complication of Anesthesia | General Anesthetic Drug Overdose | Adverse Effect of Intravenous Anesthetics, Sequela | Drug Delivery System Malfunction | Underdosing of Other General Anesthetics

Belgium
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Peposertib and Radiation Therapy, Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma

Glioblastoma | Gliosarcoma

United States
Sociedad Andaluza de Enfermedades Infecciosas

Completed

Low Dose Peginterferon-α 2a for Chronic Hepatitis C, Genotypes 2 or 3, in HIV-coinfected Patients (SAEI_IFN_1)

HIV Infections | Hepatitis C, Chronic

Spain
Hyunseok Kang, MD
NeoImmuneTech

Recruiting

NT-I7 for the Treatment of Recurrent Squamous Cell Carcinoma of Head and Neck Undergoing Surgery

Recurrent Head and Neck Squamous Cell Carcinoma | Recurrent Hypopharyngeal Squamous Cell Carcinoma | Recurrent Laryngeal Squamous Cell Carcinoma | Recurrent Oral Cavity Squamous Cell Carcinoma | Recurrent Oropharyngeal Squamous Cell Carcinoma | Resectable Oropharyngeal Squamous Cell Carcinoma

United States
Johnson & Johnson Vision Care, Inc.

Completed

Comparative Clinical Evaluation of Soft Toric Lens Designs

Astigmatism | Myopia

United Kingdom
University of Roma La Sapienza

Unknown

Ranolazine Loading to Prevent PCI-induced Myocardial Injury (TWILIGHT)

Coronary Artery Disease

Italy
Cedars-Sinai Medical Center

Completed

Pneumococcal Vaccination in Patients With Inflammatory Bowel Disease

Crohn Disease | Ulcerative Colitis | Inflammatory Bowel Disease

United States
Genzyme, a Sanofi Company

Completed

Study of AMD3100 (Plerixafor) and Rituximab in Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Chronic Lymphocytic Leukemia (CLL) | Small Lymphocytic Lymphoma (SLL)

United States

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