Search clinical trials for: ELM

Total 474 results

Vertex Pharmaceuticals Incorporated

Completed

Evaluation of ELX/TEZ/IVA in Cystic Fibrosis (CF) Subjects 2 Through 5 Years

Cystic Fibrosis

United States, United Kingdom, Canada, Australia, Germany
Vertex Pharmaceuticals Incorporated

Recruiting

Evaluation of Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) in Cystic Fibrosis (CF) Participants 12 to Less Than 24 Months of Age

Cystic Fibrosis

United Kingdom, Canada, Switzerland, Australia
Vertex Pharmaceuticals Incorporated

Completed

A Study Evaluating the Long-term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis (CF) Particpants 6 Years and Older and F/MF Genotypes

Cystic Fibrosis

Canada, France, United Kingdom, Israel, Australia, Spain, Germany, Netherlands, Denmark, Switzerland
Vertex Pharmaceuticals Incorporated

Completed

Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy

Cystic Fibrosis

United States, Spain, Ireland, Belgium, Netherlands, United Kingdom, Australia, France, Denmark, Germany, Italy, Canada
Vertex Pharmaceuticals Incorporated

Completed

A Study Evaluating the Long-term Safety of VX-445 Combination Therapy

Cystic Fibrosis

United States, Spain, Ireland, Israel, Australia, United Kingdom, Germany, Canada, Denmark, Poland, Switzerland
Vertex Pharmaceuticals Incorporated

Completed

A Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy

Cystic Fibrosis

United States, Belgium, Netherlands, United Kingdom, Canada, Australia, France, Germany, Italy, Czechia, Austria, Sweden, Greece
Vertex Pharmaceuticals Incorporated

Completed

A Study to Assess the Effect of ELX/TEZ/IVA on Glucose Tolerance in Participants With Cystic Fibrosis (CF)

Cystic Fibrosis

France, Spain, Belgium, Netherlands, Australia, Italy, Czechia
INSYS Therapeutics Inc

Completed

Study of Liposome Encapsulated Mitoxantrone (LEM) in Patients With Advanced Cancer

Tumors

United States
Vertex Pharmaceuticals Incorporated

Completed

Evaluation of VX 445/TEZ/IVA in Cystic Fibrosis Subjects 6 Through 11 Years of Age

Cystic Fibrosis

United States, Canada, Australia, Ireland, United Kingdom
Cubist Pharmaceuticals LLC

Terminated

Efficacy Study of Recombinant Protein (Ecallantide) to Reduce Blood Loss During Primary Coronary Bypass Grafting or Valve Repair/Replacement

Blood Loss, Surgical

United States
GlaxoSmithKline

Completed

Bioequivalence Study of Cephalexin Suspension 125

Infections, Respiratory Tract
University of Oslo

Completed

Essential Oil+ELA, Plaque and Gingivitis

Gingivitis | Dental Plaque

Norway
Insmed Incorporated

Recruiting

Study to Evaluate ALIS (Amikacin Liposome Inhalation Suspension) in Participants With Nontuberculous Mycobacterial Lung Infection Caused by Mycobacterium Avium Complex (ENCORE)

Mycobacterium Infections, Nontuberculous

Belgium, New Zealand, United Kingdom, United States, Argentina, Australia, Austria, Canada, Chile, Denmark, France, Germany, Greece, Hungary, Israel, Italy, Japan, Korea, Republic of, Poland, Spain, Taiwan, Turkey, Portugal
Vertex Pharmaceuticals Incorporated

Completed

Evaluation of Long-term Safety and Efficacy of VX-445 Combination Therapy in Subjects With Cystic Fibrosis Who Are 6 Years of Age and Older

Cystic Fibrosis

United States, Canada, Australia, Ireland, United Kingdom
Charite University, Berlin, Germany
German Federal Ministry of Education and Research

Completed

Augmentation of Psychotherapy With D-Cycloserine in Agoraphobia (Exposure-DCS)

Agoraphobia

Germany
Vertex Pharmaceuticals Incorporated

Approved for marketing

ELX/TEZ/IVA Expanded Access Program for Cystic Fibrosis (CF) Patients With at Least One F508del Mutation

Cystic Fibrosis
LaNova Medicines Limited

Terminated

Study of LM-108 as a Single Agent or in Combination With Pembrolizumab in Subjects With Advanced Solid Tumours

Advanced Solid Tumor

United States
Centre Antoine Lacassagne
Institut National de la Santé Et de la Recherche Médicale, France

Completed

ELR+CXCL Cytokines in Metastatic Kidney Cancers: Predictive Markers of Resistance to Sunitinib (SUNITRES)

Metastatic Kidney Cancers

France
University of Chicago
National Cancer Institute (NCI)

Completed

Sirolimus in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed By Surgery

Unspecified Childhood Solid Tumor, Protocol Specific | Unspecified Adult Solid Tumor, Protocol Specific

United States
Hoffmann-La Roche

Completed

Dose Finding Study Of CP-870,893, An Immune System Stimulating Antibody, In Combination With Paclitaxel And Carboplatin For Patients With Metastatic Solid Tumors

Neoplasms

United States
Tata Memorial Centre
All India Institute of Medical Sciences, New Delhi; Amrita Institute of Medical...

Not yet recruiting

Surgery Vs Chemoradiation for Oropharyngeal Cancer- A Phase II/III Integrated Design Randomized Control Trial (SCOPE)

Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8 | Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8

India
Institut de Recherches Internationales Servier
ADIR, a Servier Group company

Completed

Efficacy and Safety Trial With S 44819 After Recent Ischemic Cerebral Event

Post Stroke Recovery

Belgium, Italy, United Kingdom, Korea, Republic of, Czechia, Poland, Brazil, Australia, Hungary, Canada, France, Germany, Netherlands, Spain, Sweden
GlaxoSmithKline

Completed

Bioequivalence Study of Cephalexin Suspension 250

Infections, Respiratory Tract
Fundación Pública Andaluza para la gestión de la...
Andaluz Health Service

Completed

VERifynow in DIabetes Non-responsiveness: a Study on Switching From Clopidogrel to Prasugrel (VERDI)

Acute Coronary Syndrome | Diabetes Mellitus Type II

Spain
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Sirolimus as Secondary Therapy in Chronic Graft-Versus-Host Disease Not Responding To Prior Treatment

Graft Versus Host Disease

United States
CHU de Quebec-Universite Laval

Completed

Impact of C3F8 or SF6 Use and Length of Face-down Positioning (7 vs 14 Days Respectively) in Macular Hole Surgery

Cataract | Complications | Macular Holes | Visual Acuity Gain

Canada
Yale University
VA Connecticut Healthcare System

Completed

The Effect of Cycloserine on Smoking Behavior in Nicotine Dependent Smokers

Smoking

United States
Dokuz Eylul University

Completed

Comparison of Laryngeal Mask Airway Supreme and Endotracheal Tube In Patients Undergoing Gynecological Laparoscopy Surgery

Anaesthesia

Turkey
University Hospital, Bonn
Masimo Corp. (loan of medical devices); Villa Sana GmbH (loan of medical devices)

Completed

Pneumatic Compression of the Legs to Reduce Fluid Demand in Minor Surgery

ENT Surgery

Germany
Wake Forest University Health Sciences
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Healthy Living Partnership to Prevent Diabetes (HELP PD)

Obesity | Prediabetes

United States
Vertex Pharmaceuticals Incorporated

Completed

A Study Evaluating the Efficacy and Safety of VX-445/Tezacaftor/Ivacaftor in Cystic Fibrosis Subjects, Homozygous for F508del

Cystic Fibrosis

Belgium, United Kingdom, Australia, Germany
Institut de Recherches Cliniques de Montreal

Completed

Closed-loop Control of Postprandial Glucose Levels in Adults With Type 1 Diabetes

Type 1 Diabetes

Canada
Vertex Pharmaceuticals Incorporated

Completed

A Study of VX-445 in Healthy Subjects and Subjects With Cystic Fibrosis

Cystic Fibrosis

United States, Australia, Belgium, Netherlands
Vertex Pharmaceuticals Incorporated

Completed

A Phase 3 Study of VX-445 Combination Therapy in Cystic Fibrosis (CF) Subjects Heterozygous for F508del and a Gating or Residual Function Mutation (F/G and F/RF Genotypes)

Cystic Fibrosis

United States, Spain, Ireland, Belgium, Netherlands, United Kingdom, Australia, France, Canada, Denmark, Germany, Italy, Israel
Erimos Pharmaceuticals

Terminated

A Phase 1 Continuous Intravenous Infusion Study of Terameprocol (EM-1421) in Subjects With Refractory Solid Tumors

Lymphoma | Refractory Solid Tumors

United States
Erimos Pharmaceuticals

Terminated

Phase 1 Study of Terameprocol (EM-1421) in Patients With Leukemia

Chronic Lymphocytic Leukemia (CLL) | Acute Myeloid Leukemia (AML) | Chronic Myelomonocytic Leukemia (CMML) | Myelodysplastic Syndrome (MDS) | Acute Lymphocytic Leukemia (ALL) | Leukemias | Adult T Cell Leukemia (ATL) | Chronic Myeloid Leukemia (CML-BP)

United States
Shanghai Zhongshan Hospital

Recruiting

Candonilimab in Combination With LM-302 for Claudin 18.2 Positive-advanced Biliary Tract Cancer After Failure of Standard of Chemotherapy and PD1/PD-L1 Antibody

Biliary Tract Cancer | Candonilimab | Claudin 18.2

China
Yousef Zakharia
University of Iowa

Recruiting

Seleno-L Methionine (SLM)-Axitinib-Pembrolizumab

Clear Cell Renal Cell Carcinoma | Clear Cell Renal Cell Carcinoma Metastatic

United States
Mclean Hospital
University of California, Los Angeles

Completed

Prescription Opioid Addiction Treatment Study (POATS)

Substance-related Disorders | Opioid-related Disorders | Opiate Dependence

United States
LaNova Medicines Zhejiang Co., Ltd.

Recruiting

LM-302 for the Treatment of Subjects With Claudin18.2-Positive Gastric and Gastroesophageal Junction Adenocarcinoma.

Locally Advanced or Metastatic GC and GCJ Adenocarcinoma

China
Advaxis, Inc.

Completed

Study of ADXS-503 With or Without Pembro in Subjects With Metastatic Non-Small Cell Lung Cancer

Lung Cancer, Non-Small Cell | Metastatic Squamous Cell Carcinoma | Metastatic Non-Squamous Cell Carcinoma

United States
Shenyang Pharmaceutical University

Unknown

Docetaxel Lipid Microsphere (DT-LM) for Injection in Chemotherapy Patients

Advanced Cancer

China
University of Louisville

Terminated

Evaluation of a Disposable Flexible Bronchoscope, aScope IV (EVAL)

Pneumonia | Respiratory Insufficiency | Atelectasis

United States
Daiichi Sankyo, Inc.

Completed

Hydrochlorothiazide as add-on to Olmesartan/Amlodipine in Hypertension

Essential Hypertension

France, Poland, Ukraine, Belgium, Germany, Spain, Bulgaria, Romania, Denmark, Russian Federation, Netherlands, Austria, Slovakia, Czechia
Loughborough University
University of Bedfordshire

Completed

Is Mid-morning Breakfast as Healthy as Early-morning Breakfast for Blood Sugar Control in Adolescent Girls?

Postprandial Hyperglycemia

United Kingdom
Surbhi Sidana, MD

Completed

MGTA-145 + Plerixafor in the Mobilization of Hematopoietic Stem Cells for Autologous Transplantation in Multiple Myeloma

Multiple Myeloma

United States
Ulucanlar Eye Training and Research Hospital

Completed

Effect of Aflibercept on Human Corneal Endothelial Cells in Neovascular Age-Related Macular Degeneration

Age Related Macular Degeneration
EndoCeutics Inc.

Completed

Dehydroepiandrosterone (DHEA) + Acolbifene Against Vasomotor Symptoms (Hot Flushes) in Postmenopausal Women

Vasomotor Symptoms | Hot Flushes

Canada
University Health Network, Toronto

Recruiting

Effects of Teriparatide (PTH) on Bone in Men and Women With Osteoporosis

Osteoporosis

Canada
Achelios Therapeutics

Completed

Study to Determine the Efficacy and Safety of ELS-M11 in Acute Migraine

Migraine Headaches

United States

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