Search clinical trials for: Everolimus and tacrolimus

Total 271905 results

Novartis Pharmaceuticals

Completed

Extension Study to Evaluate the Long-term Efficacy and Safety of Everolimus in Liver Transplant Recipients

Liver Transplant Recipient

Belgium, Spain, Germany, Italy, Australia, United States, Netherlands, Ireland, Sweden, Brazil, Colombia, France, Russian Federation, Argentina, Czechia, United Kingdom
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Concentration-controlled Everolimus to Eliminate or to Reduce Tacrolimus Compared to Tacrolimus in de Novo Liver Transplant Recipients (RAD)

Liver Transplantation

United States, Belgium, Colombia, Spain, Germany, Italy, Australia, Israel, France, Hungary, Netherlands, Argentina, Canada, Ireland, Sweden, Brazil, United Kingdom, Russian Federation, Czech Republic
Hospital Universitario Ramon y Cajal
Novartis; Astellas Pharma Inc

Unknown

Pharmacokinetic Study on the Combination of Everolimus-Tacrolimus

Kidney Diseases

Spain
Poitiers University Hospital
Chiesi Farmaceutici S.p.A.

Terminated

Prospective Cohort of Kidney Transplanted Patients Receiving an Extended Releasing Tacrolimus-Everolimus Association

Immunosuppression | Kidney Transplant

France
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Everolimus in Liver Transplant Recipients of Living Donor Liver Transplants

Liver Transplantation

United States, Japan, Saudi Arabia, Taiwan, Egypt, Italy, Korea, Republic of, Germany, India, Canada, Russian Federation, Singapore, Turkey
Joseph Kahwaji, MD, MPH
Novartis

Completed

Role of Everolimus in Highly Sensitized Patients

Highly-sensitized Kidney Transplant Recipients

United States
Medical College of Wisconsin

Withdrawn

Myfortic in High MELD Liver Transplantation

High Model for End-Stage Liver Disease (MELD) Score

United States
Northwestern University
Novartis Pharmaceuticals

Completed

Biomarkers Predicting Successful Tacrolimus Withdrawal and Everolimus (Zortress) Monotherapy Early After Liver Transplantation

Liver Transplantation

United States
Hannover Medical School

Unknown

Studying the Effect of Changing Immunosuppression in Case of Polyoma BK Virus Infection of the Renal Transplant (BKVIRUS)

Virus Diseases | Disorder Related to Renal Transplantation | Immunosuppression Related Infectious Disease

Germany
Fundação Pró Rim

Unknown

Evaluation of Early Use of Everolimus (EVE) on Cytomegalovirus (CMV) Infection in Renal Transplant Recipients

Cytomegalovirus Infections
National Taiwan University Hospital

Terminated

De Novo Everolimus-based Therapy for Renal Transplantation Using Rituximab Induction

Renal Insufficiency

Taiwan
Chang Gung Memorial Hospital

Completed

Twice-daily Tacrolimus and Everolimus Convert to Once-daily Tacrolimus and Everolimus in Liver Transplant Recipient

Liver Transplantation

Taiwan
University of Toledo Health Science Campus
Novartis Pharmaceuticals

Completed

Evaluation of Calcineurin-inhibitor Reduction With Conversion at 2 Months to Everolimus/Reduced Tacrolimus in Renal Transplant Recipients Following Campath® Induction

Renal Transplant

United States
University Medical Center Groningen
Radboud University Medical Center; Universitaire Ziekenhuizen KU Leuven; UMC... and other collaborators

Active, not recruiting

RCT Comparing Immunosuppressive Regimens in Elderly Renal Transplant Recipients (OPTIMIZE)

Elderly Patients | Immunosuppression | Renal Transplant Recipients

Netherlands, Belgium
Seung-Jung Park
Abbott Medical Devices; CardioVascular Research Foundation, Korea

Terminated

Bypass Surgery Versus Everolimus-Eluting Stent Implantation for Multivessel Coronary Artery Disease (BEST) (BEST)

Coronary Artery Disease

Thailand, Korea, Republic of, China, Malaysia
Northwestern University
Novartis

Completed

Study in Recipients of Renal Transplant Allograft to Evaluate the Impact of Two Immunosuppressive Regimens

End Stage Renal Failure With Renal Transplant

United States
Novartis Pharmaceuticals

Completed

Non-inferiority Study of Safety and Efficacy of Everolimus With Low Dose Tacrolimus to Mycophenolate Mofetil With Standard Dose Tacrolimus in Kidney Transplant Recipients

Kidney Transplant

United States, Canada
Novartis Pharmaceuticals

Completed

A Norwegian Observational Trial Evaluating the Treatment of Advanced Renal Cell Cancer Patients Under Treatment of Afinitor (OSAT)

Metastatic Renal Cell Carcinoma (mRCC)

Norway
Kasr El Aini Hospital

Completed

Efficiency of Fractional-Laser Resurfacing Followed by Topical Tacrolimus 0.03% Cream vs Tacrolimus Alone in Vitiligo

Stable Vitiligo
Rabin Medical Center
Novartis

Unknown

Reduction or Discontinuation of CNI's With Conversion to Everolimus-Based Immunosuppresion

Kidney Diseases

Israel
Novartis Pharmaceuticals

Completed

A Phase I Dose Escalation Study of RAD001 Administered in Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

Non-Hodgkin's Lymphoma

Japan
Tomoaki Kato

Unknown

Everolimus Post Orthotopic Liver Transplant

Orthotopic Liver Transplant

United States
University of Giessen
Novartis; Hoffmann-La Roche; Astellas Pharma Inc; Heidelberg University

Completed

Impact of Immunosuppressive Regimens on Polyomavirus-related Transplant Nephropathy

Polyomavirus Infections

Germany
Novartis Pharmaceuticals

Completed

Efficacy of Everolimus in Combination With Tacrolimus in Liver Transplant Recipients (HEPHAISTOS)

Liver Transplantation

Germany
University Hospital Schleswig-Holstein
University of Kiel

Completed

Polymorphism of the Cytochrome P450-system in Renal Transplants

Function of Renal Transplant

Germany
Novartis Pharmaceuticals

Completed

A National Multi-center Randomized, Open Label Study to Evaluate Efficacy and Safety of Everolimus With EC-MPS Compared to Standard Treatment Combination Tacrolimus and EC-MPS in de Novo Liver Transplant Recipients (SIMCER)

Liver Transplantation

France
King Chulalongkorn Memorial Hospital

Recruiting

The Efficacy of Everolimus With Reduced-dose Tacrolimus Versus Reduced-dose Tacrolimus in Treatment of BK Virus Infection in Kidney Transplantation Recipient (ELF)

BK Virus Infection | Kidney Transplant Infection

Thailand
University Hospital, Limoges

Completed

Pharmacokinetics of Immunosuppressive Drugs in Heart Transplant Patients (PIGREC)

Heart Transplant

France
Chulalongkorn University

Unknown

MicroRNA Expression in Everolimus-based Versus Tacrolimus-based Regimens in Kidney Transplantation

microRNA Profiles

Thailand
IRCCS Policlinico S. Matteo

Completed

Effect of Different Therapeutic Strategies on Regulatory T Cells in Kidney Transplantation (EVERTWIST)

Kidney Transplantation

Italy
Hospital de Clinicas de Porto Alegre

Unknown

A Clinical Trial to Assess the Efficacy and Safety of the Conversion to Everolimus

Kidney Transplant Recipients

Brazil
Novartis

Completed

A Twelve-month, Multicenter, Open-label, Randomized Study of the Safety, Tolerability and Efficacy of Everolimus With Basiliximab, Corticosteroids and Two Different Exposure Levels of Tacrolimus in de Novo Renal Transplant Recipients

Renal Transplantation

Switzerland
Assiut University

Unknown

The Effect of Fractional Co2 Laser Either With Tacrolimus, Calcipotriol or NB-UVB in Stable Generalized Vitiligo

Vitiligo Vulgaris
University of Kansas Medical Center
Novartis Pharmaceuticals

Recruiting

Alterations in Cognitive Function and Cerebral Blood Flow After Conversion From Calcineurin Inhibitors (CNIs) to Everolimus

End Stage Renal Disease

United States
Novartis Pharmaceuticals

Completed

Efficacy, Safety and Tolerability of Everolimus in Combination With Reduced Exposure Cyclosporine or Tacrolimus in Paediatric Liver Transplant Recipients.

Renal Function | Liver Transplant

United States, Germany, Spain, Belgium, France, Hungary, Australia, Sweden, Italy, Canada, United Kingdom, Denmark
Chiesi Farmaceutici S.p.A.
Cromsource

Completed

Envarsus® Once Daily With Everolimus in Elderly Kidney Transplant Recipients: Pharmacokinetic and Clinical Study

Kidney Transplantation

Italy
Novartis Pharmaceuticals

Completed

REnal Function in Liver Transplantation: Everolimus With Calcineurin Inhibitor (CNI)-Sparing sTrategy (REFLECT)

Liver Transplantation

Italy
Technische Universität Dresden

Terminated

Prevention of the Graft-Versus-Host-Disease in Patients After Stem Cell Transplantation With Tacrolimus and Everolimus

Graft vs Host Disease

Germany
Helio Tedesco Silva Junior
Sanofi; Novartis

Completed

Comparison Between Two Tacrolimus-based Immunosuppressant Regimens and Induction With Thymoglobulin in Kidney Transplants From Deceased Donors With Expanded Criteria

Kidney Transplantation | Cytomegalovirus

Brazil
National Institute of Allergy and Infectious Diseases...

Not yet recruiting

Expanding Liver Transplant Immunosuppression Minimization Via Everolimus (ELIMINATE)

Liver Transplant

United States
Astellas Pharma Inc

Completed

Phase III Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis

Keratoconjunctivitis | Conjunctivitis

Japan
Milton S. Hershey Medical Center
Novartis Pharmaceuticals

Completed

Conversion to Everolimus From Calcineurin Inhibitor With Mycophenolic Acid: Impact on Long Term Renal Function in Liver Transplantation.

Renal Failure | Immunosuppression

United States
Novartis Pharmaceuticals

Completed

Efficacy, Safety and Evolution of Cardiovascular Parameters in Renal Transplant Recipients (ELEVATE)

Kidney Transplantation

Germany, Belgium, Netherlands, Australia, Austria, Italy, Spain, Thailand, Estonia, Norway, Lithuania, Turkey, Mexico, Argentina, Greece, Russian Federation, Portugal, France, India, Latvia, Romania
The Netherlands Cancer Institute

Active, not recruiting

Cisplatinum and Everolimus in Patients With Metastatic or Unresectable NEC of Extrapulmonary Origin

Neuroendocrine Carcinomas

Netherlands
Novartis Pharmaceuticals

Terminated

Safety and Efficacy of RAD001 + TACE in Localized Unresectable HCC (TRACER)

Hepatocellular Carcinoma

Hong Kong, Taiwan, Thailand
German Breast Group
Novartis

Terminated

Everolimus Beyond Progress for Patients Who Had Progress Under Everolimus and Exemestane (Evelyn)

Metastatic Breast Cancer

Germany
Astellas Pharma Inc
Astellas Pharma Korea, Inc.

Completed

Pharmacokinetics of Tacrolimus in Liver Transplantation Patients Treated With Prograf and Modified Release Tacrolimus

Liver Transplantation

Korea, Republic of
Novartis Pharmaceuticals

Completed

Efficacy and Safety of RAD001 in Patients Aged 18 and Over With Angiomyolipoma Associated With Either Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM) (EXIST-2)

Lymphangioleiomyomatosis (LAM) | Tuberous Sclerosis Complex (TSC)

United States, United Kingdom, Germany, Italy, Russian Federation, Netherlands, Japan, Canada, Poland, France, Spain
University of Luebeck

Terminated

Bioresorbable Vascular Scaffolds Versus Stents in Patients With Chronic Total Occlusion (SCORE-CTO)

Coronary Artery Disease

Germany
Heleen Grootjans
Chiesi Farmaceutici S.p.A.

Recruiting

Trial Comparing Immediate Versus Extended Release Tacrolimus; Reducing Calcineurin Inhibitor Related Toxicity in Lung Transplantation Patients (REVOLUTION)

Lung Transplant; Complications

Netherlands

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