Search clinical trials for: GLP-1 receptor antagonist

Total 11637 results

Institut de Recherches Internationales Servier

Active, not recruiting

Study of AG-120 and AG-881 in Subjects With Low Grade Glioma

Glioma

United States
LMC Diabetes & Endocrinology Ltd.
Novo Nordisk Canada Inc.

Completed

Impact of GLP-1 RAs Compared to Basal Insulin Start in Patients Living With Type 2 Diabetes and Chronic Kidney Disease

Chronic Kidney Diseases | Type 2 Diabetes

Canada
Second Xiangya Hospital of Central South University
Guangdong Provincial People's Hospital; The First Affiliated Hospital of Henan... and other collaborators

Recruiting

The Effects of Glucose Control and Weight Loss Between Beinaglutide and Dulaglutide in Type 2 Diabetes With Overweight or Obesity.

Diabetes Mellitus, Type 2 | Overweight or Obesity

China
Papworth Hospital NHS Foundation Trust

Completed

Human Vasodilatory Effect of GLP-1

Angina, Stable | Type2 Diabetes | Coronary Stenosis
University Hospital, Gentofte, Copenhagen
University of Copenhagen

Completed

Glucagon-Like Peptide-1 (GLP-1) Suppression of Alpha Cell Secretion in Type 2 Diabetes Mellitus (T2DM)

Hyperglycemia | Glucose Intolerance | Hyperglucagonemia
Aarhus University Hospital Skejby
Aarhus University Hospital; University of Aarhus

Completed

Effect of 48 Hours of Treatment With the Natural Peptide-Hormone GLP-1 in Patients With Chronic Heart Failure

Heart Failure, Congestive

Denmark
Zealand University Hospital
University of Copenhagen; Glostrup University Hospital, Copenhagen

Unknown

GLP-1's Effect on Cardiac Parameters and Mesenteric Blood Flow

Healthy

Denmark
xiaolong zhao
Shanghai Zhongshan Hospital; Second Affiliated Hospital of Soochow University; Taizhou Hospital and other collaborators

Unknown

Effect on Beta Cell Function and Glycaemic Control After Insulin and Exenatide Sequential Therapy (T2DMRS)

Type 2 Diabetes

China
University of Copenhagen
The Danish Medical Research Council

Completed

The Interaction Between Appetite Hormones

Obesity

Denmark
CellMed AG, a subsidiary of BTG plc.

Terminated

GLP-1 CellBeads® for the Treatment of Stroke Patients With Space-occupying Intracerebral Hemorrhage

Intracerebral Hemorrhage (ICH)

Germany
Yale University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

GLP-1 Analogue Effects on Food Cues, Stress, Motivation for Highly Palatable Foods, and Weight

Obesity

United States
University Hospital, Gentofte, Copenhagen
University of Copenhagen

Unknown

Intact Vagal Innervation and Glucagon-like Peptide-1 (GLP-1) Effects

Vagotomy, Truncal

Denmark
University Hospital, Basel, Switzerland
Swiss National Science Foundation

Completed

Effects of Oral GLP-1 on Glucose Homeostasis and Appetite Profile in Healthy Male Subjects

Glucose Homeostasis

Switzerland
Takeda

Completed

Efficacy and Safety of Azilsartan Medoxomil in African American Participants With Essential Hypertension

Hypertension

United States, Puerto Rico
Mikkel Christensen

Completed

Glucose-Dependent Insulinotropic Polypeptide - Effects on Markers of Bone Turnover in Patients With Type 1 Diabetes

Type 1 Diabetes Mellitus
Katarina Kos
Diabetes UK

Completed

The Microvascular Function of GLP-1 and Its Analogues

Obesity | Type 2 Diabetes

United Kingdom
Katarina Kos
University of Exeter

Terminated

Incretin and KATP Channels

Healthy Subjects

United Kingdom
Nanjing First Hospital, Nanjing Medical University

Recruiting

The Exploreration of the Management for the Positive IAA in Patients With Type 2 Diabetes After Premix Insulin Therapy

Type 2 Diabetes Mellitus

China
Bayer

Active, not recruiting

An Observational Study, Called FINEGUST, to Learn More About How People With Chronic Kidney Disease and Type 2 Diabetes Are Treated and How the Introduction of New Treatment Options, Like Finerenone, Impacts Clinical Practice (FINEGUST)

Type 2 Diabetes Mellitus | Chronic Kidney Disease

Japan, Spain, Netherlands, United Kingdom, Denmark, United States
Danish Headache Center

Unknown

Investigation of Vasodilation and Intensity of Headache Triggered by Glucagon Like Peptide-1 in Humans

Headache, Migraine

Denmark
University of Copenhagen

Completed

Effects of Intravenous Infusions of Gut Hormones on Appetite and Metabolism. (INGEAR-1)

Obesity

Denmark
University Hospital, Basel, Switzerland

Completed

Oral Administration of Peptides; Absorption From Gastrointestinal Tract

Healthy

Switzerland
Takeda

Terminated

Efficacy and Safety of Azilsartan Medoxomil Used in Combination With Metformin in Participants With Hypertension and Diabetes

Hypertension | Diabetes

United States
Shanghai 10th People's Hospital

Completed

GLP-1 RAs in Patients With Polycystic Ovary Syndrome (PCOS)

Polycystic Ovary Syndrome

China
Medical University of Graz

Completed

Efficacy of GLP-1 Infusion in Comparison to an Insulin Infusion Protocol to Reach Normoglycemia Type 2 Diabetic Patients

Hyperglycemia | Diabetes Mellitus Type 2

Austria
Sciwind Biosciences APAC CO Pty. Ltd.
Hangzhou Sciwind Biosciences Co., Ltd.

Not yet recruiting

XW004 To Evaluate the Safety, Tolerability, PK, and PD of Oral Ecnoglutide Tablet in Healthy Adults

Obesity | Type 2 Diabetes Mellitus

Australia
Sapporo Medical University
Merck Sharp & Dohme LLC

Completed

Is Glucagon-like Peptide-1 Insufficiency a Residual Risk in Coronary Artery Disease?

Coronary Artery Disease

Japan
Zydus Lifesciences Limited

Completed

A Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ZYD1, Following Subcutaneous Administration in Healthy Volunteers (ZYD1)

Type 2 Diabetes Mellitus

India
University of Pennsylvania

Completed

GLP 1 for Intraoperative Glycemic Control (GLP)

Hyperglycemia | Hypoglycemia

United States
Assaf-Harofeh Medical Center

Unknown

Glucagon Like Peptides Receptors Expression in the Stomach of Diabetes Type 2 (GLP)

Diabetes Mellitus Type 2

Israel
Steno Diabetes Center Copenhagen

Unknown

Effect of Glucagon-like Peptide 2 on Gallbladder Motility After a Meal in Young, Healthy Male Subjects

Effect of Glucagon-like Peptide 2 on Gallbladder Motility

Denmark
GlyPharma Therapeutics
VectivBio AG

Completed

Safety, Efficacy, PD of FE203799 in Short Bowel Syndrome on Parenteral Support

Short Bowel Syndrome

Denmark
Brigham and Women's Hospital

Unknown

Cardiovascular Outcomes and HbA1c Among Patients With Type 2 Diabetes Newly Initiating GLP1RAs vs Basal Insulin

Diabetes Mellitus, Type 2

United States
Jeppe Skov
Novo Nordisk A/S

Completed

GLP-1: Acute Effects on Kidney Function in Healthy Men

Kidney Functional

Denmark
Johns Hopkins University

Terminated

The Effect of Surgically Induced Weight Loss on Endocrine Function, Cardiovascular Function and Body Composition

Bariatric Surgery

United States
Brigham and Women's Hospital
Patient-Centered Outcomes Research Institute

Recruiting

PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes (PRECIDENTD)

Type2Diabetes | ASCVD

United States
University of Padova

Completed

Cardiovascular Outcomes SGLT-2 Inhibitors Versus GLP-1 Receptor Agonists

Type 2 Diabetes

Italy
Rigshospitalet, Denmark
Novo Nordisk A/S; University of Copenhagen

Completed

Mechanisms of Insulin Resistance in Critical Illness: Role of Systemic Inflammation and GLP-1

Hypoglycaemia

Denmark
University of Pisa

Completed

To Determine the Effect of GLP1 on Cognitive Function, Brain Glucose Metabolism and Neuroplasticity.

Glucose Metabolism Disorders | Obesity | Degenerative Brain Disorder

Italy
Shi Yang

Unknown

Effects of GLP-1 on Chronic Heart Failure

Heart Failure

China
Federal Research Institute of Pediatric Hematology...

Completed

IL-1 Receptor Inhibitor for Granulomatous Complications in Patients With Chronic Granulomatous Disease

Chronic Granulomatous Disease

Russian Federation
University Hospital, Basel, Switzerland

Completed

Effects of Interleukin-1 Receptor Antagonism on Hyperandrogenemia in Women With Polycystic Ovary Syndrome (FertIL)

Polycystic Ovary Syndrome

Switzerland
Radboud University Medical Center

Unknown

Effect of Anakinra on Insulin Sensitivity in Type 1 Diabetes Mellitus

Diabetes Mellitus

Netherlands
Uppsala University
Karolinska Institutet

Completed

GLP-1 Inhibits Prandial Antro-duodeno-jejunal Motility in Humans (GLPMOT)

Functional Gastrointestinal Disorders

Sweden
VA Office of Research and Development
Durham VA Medical Center

Completed

Regulation of Insulin Secretion by the GLP-1 Receptor

Insulin Secretion

United States
Diabetes Care Center of Nanjing Military Command

Unknown

Umbilical Cord Mesenchymal Stem Cells and Liraglutide in Diabetes Mellitus

Type 2 Diabetes

China
University of Nottingham

Completed

Characterizing the Incretin Effect of Amino Acids and Defining GLP-1 Role on Skeletal Muscle (Incretin)

Sarcopenia

United Kingdom
AstraZeneca

Not yet recruiting

A Pan-European Post-Authorisation Safety Study: Risk of Pancreatic Cancer Among Type 2 Diabetes Patients Who Initiated Exenatide as Compared With Those Who Initiated Other Non-Glucagon-Like Peptide 1 Receptor Agonists Based Glucose Lowering Drugs (EXCEED)

Pancreatic Cancer
Western University, Canada
Unity Health Toronto; Lawson Health Research Institute; Queen Elizabeth II Health...

Not yet recruiting

Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2

Obesity | Chronic Kidney Disease

Canada
The Affiliated Hospital of Xuzhou Medical University

Completed

Renoprotective Effects of Dulaglutide in Patients With Type 2 Diabetic Nephropathy

Type 2 Diabetic Nephropathy

China

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