GLP-1's Effect on Cardiac Parameters and Mesenteric Blood Flow

GLP-1's Influence on Intestinal Blood Flow

Sponsors

Lead Sponsor: Zealand University Hospital

Collaborator: University of Copenhagen
Glostrup University Hospital, Copenhagen

Source Zealand University Hospital
Brief Summary

to investigate the effect of the human incretin hormone GLP-1 on mesenteric blood flow and cardiac parameters

Detailed Description

to investigate the effect of the human incretin hormone GLP-1 on mesenteric blood flow and cardiac parameters, in healthy subjects, 4 arms, task force monitor

Overall Status Unknown status
Start Date November 2013
Completion Date December 2014
Primary Completion Date June 2014
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
blood flow with in 120 minutes
Enrollment 8
Condition
Intervention

Intervention Type: Other

Intervention Name: 1,5 nmol/kg,GLP-1 sc injection

Other Name: native GLP-1

Intervention Type: Other

Intervention Name: 1,5 nmol/kg GLP-1 9-36amide, sc injection

Intervention Type: Other

Intervention Name: Exendin-4 ;10 ug,sc injection

Intervention Type: Other

Intervention Name: saline

Arm Group Label: isotonic saline

Eligibility

Criteria:

Inclusion Criteria:

- healthy subjects

Exclusion Criteria:

- medical conditions

Gender: All

Minimum Age: 20 Years

Maximum Age: 80 Years

Healthy Volunteers: Accepts Healthy Volunteers

Overall Official
Last Name Role Affiliation
Lasse Bremholm, MD, ph.d. Principal Investigator Køge Hospital
Overall Contact

Last Name: Lasse Bremholm, MD, ph.d.

Phone: 0004560927874

Email: [email protected]

Location
Facility: Status: Contact: Investigator: Køge Hospital lasse bremholm, MD, ph.d. 004560927874 [email protected] Lasse Bremholm, MD, ph.d. Principal Investigator
Location Countries

Denmark

Verification Date

November 2013

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Zealand University Hospital

Investigator Full Name: MD ph.d. Lasse Bremholm

Investigator Title: MD, ass. professor, ph.d

Keywords
Has Expanded Access No
Number Of Arms 4
Arm Group

Label: GLP-1

Type: Active Comparator

Description: 1,5 nmol/kg,GLP-1 sc injection

Label: GLP-1 9-36amide

Type: Active Comparator

Description: 1,5 nmol/kg GLP-1 9-36amide, sc injection

Label: Exendin-4

Type: Active Comparator

Description: Exendin-4 ;10 ug,sc injection

Label: isotonic saline

Type: Placebo Comparator

Description: 2 ml of isotonic saline, sc injection

Study Design Info

Allocation: Randomized

Intervention Model: Single Group Assignment

Primary Purpose: Basic Science

Masking: Double (Participant, Outcomes Assessor)

Source: ClinicalTrials.gov