Search clinical trials for: Glycoside Hydrolase Inhibitors

Total 64647 results

AstraZeneca

Completed

24-Week, Multicenter, Randomized, Parallel-group, Open-label, Active Controlled Phase IV Study to Assess the Efficacy, Safety and Tolerability of Saxagliptin Compared With Acarbose When in Combination With Metformin in Patients With T2D Inadequately Controlled With Metformin Monotherapy (SMART)

Type 2 Diabetes Mellitus

China
Eli Lilly and Company

Completed

A Study of LY2189265 in Japanese Participants With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

Japan
Rong Hu, MD

Unknown

Neuroprotectant for Hypertensive Intracerebral Hemorrhage

Intracerebral Hemorrhage

China
Shanghai 6th People's Hospital

Unknown

the Efficacy of Acarbose and Metformin on Blood Glucose Fluctuation When Combined With Premix Insulin (CGMS)

Type 2 Diabetes

China
Boehringer Ingelheim

Terminated

Real-world Study Comparing the Adherence and Effectiveness of Linagliptin vs. Acarbose

Diabetes Mellitus, Type 2

China
Zilin Sun

Completed

Combining Saxagliptin and Acarbose to Improve Postprandial Glycaemia in Type 2 Diabetes

Type 2 Diabetes

China
Amicus Therapeutics

Recruiting

A Study to Evaluate the Safety, Efficacy, PK, PD and Immunogenicity of Cipaglucosidase Alfa/Miglustat in IOPD Subjects Aged 0 to <18 (ROSSELLA)

Glycogen Storage Disease Type II Infantile Onset

United States, Taiwan, France, Germany, Italy, United Kingdom
RenJi Hospital

Completed

Research of Intensive Lifestyle Intervention for PCOS Patients With IGT

Polycystic Ovary Syndrome

China
University of Minnesota

Completed

Evaluating Exenatide for the Treatment of Postprandial Hyperinsulinemic Hypoglycemia

Hyperinsulinemic Hypoglycemia

United States
Assistance Publique - Hôpitaux de Paris
Actelion; CRCM (Centres de Ressources et de Compétences de la Mucoviscidose)

Completed

Effect of Miglustat on the Nasal Potential Difference in Patients With Cystic Fibrosis Homozygous for the F508del Mutation (MIGLUSTAT-CF)

Cystic Fibrosis

France
Fifth Affiliated Hospital, Sun Yat-Sen University

Unknown

Safety and Efficacy of Acarbose+Saxagliptin Compared With Metformin+Saxagliptin in Patients With Type 2 Diabetes

Type 2 Diabetes Mellitus
G D Searle

Completed

Initial Phase II Efficacy and Safety Study of SC-48334 Administered in Combination With Low-Dose Zidovudine (AZT) to Symptomatic HIV-1 Infected Patients With = or > 200 to = or < 500 CD4+ Cells/mm3

HIV Infections

United States
G D Searle

Completed

Phase II Study of the Safety and Surrogate Marker Efficacy of Butyldeoxynojirimycin (SC-48334) and AZT in Symptomatic HIV-1 Infected Patients With 200 - 500 CD4+ Cells/mm3. (NOTE: Asymptomatic HIV-1 Infected Patients Also Eligible)

HIV Infections

United States
Nanjing First Hospital, Nanjing Medical University

Completed

Comparison of the FGM Profiles in Patients of Type 2 Diabetes Treated With Sitagliptin and Acarbose

Type 2 Diabetes

China
Wuhan General Hospital of Guangzhou Military Command

Completed

Sitagliptin Reduces Left Ventricular Mass in Normotensive Type 2 Diabetic Patients With Coronary Artery Disease

Coronary Artery Disease | Newly Diagnosed Type 2 Diabetes

China
Postgraduate Institute of Medical Education and...

Unknown

Effect of Linagliptin on Insulin Sensitivity and Pancreatic Beta Cell Function in Patients With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus | Insulin Sensitivity/Resistance

India
Assistance Publique - Hôpitaux de Paris

Terminated

Acarbose and Prandial Insulin for the Treatment of Gestational Diabetes Mellitus. (ACARB-GDM)

Gestational Diabetes Mellitus in Pregnancy

France
Amicus Therapeutics

Completed

A Study Comparing ATB200/AT2221 With Alglucosidase Alfa/Placebo in Adult Subjects With Late-onset Pompe Disease (PROPEL)

Pompe Disease (Late-onset)

United States, Australia, Korea, Republic of, Japan, Taiwan, Belgium, Slovenia, New Zealand, United Kingdom, France, Argentina, Canada, Spain, Bosnia and Herzegovina, Germany, Sweden, Hungary, Austria, Bulgaria, Denmark, Greece, I... and more
Population Health Research Institute
Hamilton Health Sciences Corporation

Completed

Remission Evaluation of Metabolic Interventions in Type 2 Diabetes (REMIT Pilot Trial)

Type 2 Diabetes Mellitus

Canada
Takeda

Completed

Long-term Safety Study of Alogliptin in Participants With Type 2 Diabetes in Japan

Type 2 Diabetes Mellitus
Takeda

Completed

Efficacy and Safety of Alogliptin in Participants With Type 2 Diabetes in Japan

Diabetes Mellitus, Type 2

Japan
Yale University
Tourette Association of America

Terminated

FAAH Inhibitor Trial for Adults With Tourette Syndrome

Tourette Syndrome

United States
GlaxoSmithKline

Completed

A Study to Determine the Long Term Safety and Efficacy of Albiglutide in Combination With Oral Monotherapy Antihyperglycemic Medications in Japanese Patients With Type 2 Diabetes Mellitus

Diabetes Mellitus

Japan
Novartis Pharmaceuticals

Completed

Drug Interaction of Vildagliptin (LAF237) With Voglibose in Japanese Patients With Type 2 Diabetes

Type 2 Diabetes

Japan
Merck Sharp & Dohme LLC

Completed

MK0431/ONO-5435 Phase III Clinical Trial -Add-on to Voglibose Study for Patients With Type 2 Diabetes Mellitus (MK0431-104)

Diabetes Mellitus, Non-Insulin-Dependent
Sanofi

Completed

A Study to Evaluate the Effectiveness and Safety Initiation and Titration of Insulin Glargine (U300) in Insulin-naïve Patients With Type 2 Diabetes Mellitus (T2DM) Controlled on Oral Antidiabetic Drug Treatment in Turkey (EASE)

Type 2 Diabetes Mellitus

Turkey
Third Affiliated Hospital, Sun Yat-Sen University

Recruiting

Comparison of Diabetes Retinopathy Among Type 2 Diabetic Patients Treated With Different Regimens (CORRECT)

Diabetic Retinopathy

China
Proteus Digital Health, Inc.

Withdrawn

Proteus Sustained Behavior Change Study

Type 2 Diabetes Mellitus

United States
Actelion

Terminated

Miglustat / OGT 918 in the Treatment of Cystic Fibrosis

Cystic Fibrosis

Spain
Japan Early Diabetes Intervention Study Group

Unknown

Japan Early Diabetes Intervention Study (JEDIS)

Diabetes Mellitus

Japan
Monash University

Completed

Evaluation of the Effects of Urotensin-II and Soluble Epoxide Hydrolase Inhibitors on Skin Microvessel Tone in Patients With Heart Failure, and in Healthy Volunteers

Heart Failure

Australia
RenJi Hospital

Unknown

Research of Intensive Metabolic Intervention Before Pregnancy in PCOS (PCOS)

PCOS | Impaired Glucose Tolerance

China
Amicus Therapeutics

Recruiting

A Global Prospective Observational Registry of Patients With Pompe Disease

Pompe Disease

United States, United Kingdom, Germany
The Catholic University of Korea
Bayer

Completed

Study to Evaluate the Efficacy of Acarbose,Metformin,Sitagliptin Combination Treatment in DM Patients

Type 2 Diabetes Mellitus

Korea, Republic of
Actelion

Completed

Two Period / Two Treatment Cross-over to Assess the Effect of Florastor® on Gastrointestinal Tolerability, Safety, and PK in Healthy Subjects Receiving Zavesca®

Diarrhea

Canada
Novo Nordisk A/S

Completed

Efficacy in Controlling Glycaemia With Victoza® (Liraglutide) as add-on to Metformin vs. OADs as add-on to Metformin After up to 104 Weeks of Treatment in Subjects With Type 2 Diabetes (LIRA-PRIME)

Diabetes Mellitus, Type 2 | Diabetes

United States, Canada, Serbia, Turkey, Russian Federation, India, Latvia, Puerto Rico, Lebanon, Colombia
Second Xiangya Hospital of Central South University

Unknown

Treatment of IgAN With Multi-glycoside of Tripterygium Wilfordii HOOK. f.

IgA Nephropathy

China
Vedic Lifesciences Pvt. Ltd.

Completed

To Assess the Efficacy of CitruSlim® on Body Composition as Well as Metabolic and Hormonal Factors in Overweight and Obese Individuals

Overweight and Obesity

United States
Merck Sharp & Dohme LLC

Completed

Clinical Trial to Evaluate the Safety and Efficacy of the Addition of Sitagliptin in Participants With Type 2 Diabetes Mellitus Receiving Acarbose Monotherapy (MK-0431-130)

Type 2 Diabetes Mellitus
Takeda

Completed

Efficacy and Safety of Alogliptin Used in Combination With α-glucosidase Inhibitor in Participants With Type 2 Diabetes in Japan

Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC

Completed

A Study of Sitagliptin in Patients With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Diet/Exercise Therapy (0431-054)(COMPLETED)

Diabetes Mellitus, Non-Insulin-Dependent
Boehringer Ingelheim

Completed

Japanese P III vs Voglibose and Placebo

Diabetes Mellitus, Type 2

Japan
John Mitchell

Completed

Sleep and Quality of Life in Patients With Glycogen Storage Disease on Standard Versus Modified Uncooked Cornstarch

Glycogen Storage Disease Type III | Glycogen Storage Disease Type IA | Glycogen Storage Disease Type IB | Glycogen Storage Disease Type 0

Canada
Takeda

Completed

Long-term Safety Study of Alogliptin Used in Combination With α-glucosidase Inhibitor in Participants With Type 2 Diabetes in Japan

Type 2 Diabetes Mellitus
University of Manitoba
Co-Investigator - Dr. Cheryl Rockman-Greenberg

Completed

Comparison of the Effect of a Novel Starch (Glycosade) Versus Gastrostomy Tube-Dextrose Infusion on Overnight Euglycaemia Control in Children With Glycogen Storage Disease Type I: Open Label Demonstration Trial (Glycosade GSD)

Hypoglycemia | Glycogen Storage Disorder Type 1 | Cornstarch | Glycosade

Canada
United Pharmaceuticals

Completed

Efficacy of a New Thickened Extensively Hydrolyzed Formula (ALLAR)

Protein Allergy | Cow's Milk Protein Hypersensitivity

Slovenia, Belgium, Greece, Kuwait, Lebanon
Peking University

Unknown

Cistanche Total Glycosides for Amyotrophic Lateral Sclerosis: A Randomized Control Trial (RCT) Study Assessing Clinical Response

Amyotrophic Lateral Sclerosis

China
Danone Asia Pacific Holdings Pte, Ltd.

Completed

Color Synbiotics Study

Beneficial Bacteria in Gut

Thailand
Vitaflo International, Ltd
University College London Hospitals; University Medical Center Groningen; University... and other collaborators

Completed

Glycosade v UCCS in the Dietary Management of Hepatic GSD (Glyde)

Glycogen Storage Disease

United States, United Kingdom, France, Netherlands
Empros Pharma AB
CTC Clinical Trial Consultants AB

Completed

A Proof of Concept Trial in Overweight and Obese Patients, Investigating Effect of EMP16-02 on Body Weight (Primary)

Overweight or Obesity

Sweden

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