Search clinical trials for: intrathecal methotrexate

Total 1773 results

Erasmus Medical Center
St. Antonius Hospital; Longfonds

Active, not recruiting

Effectiveness of Methotrexate Versus Prednisolone as First-line Therapy for Pulmonary Sarcoidosis (PREDMETH)

Sarcoidosis, Pulmonary

Netherlands
Dartmouth-Hitchcock Medical Center

Completed

Myeloid-Derived Suppressor Cells and Checkpoint Immune Regulators' Expression in Allogeneic SCT Using FluBuATG (FluBuATG)

Myelodysplastic Syndromes | Leukemia, Myeloid | Multiple Myeloma | Lymphoma, Malignant | Myelofibrosis | Waldenstrom Macroglobulinemia | Leukemia, Lymphoid

United States
Istituto Ortopedico Rizzoli

Completed

Fast Track Total Hip Arthroplasty vs Standard Care (FastTrack-H)

Hip Pain Chronic | Hip Osteoarthritis

Italy
Johns Hopkins University
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Inflammation and Coronary Endothelial Function

Coronary Artery Disease

United States
Hoffmann-La Roche

Completed

A Study of MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF Therapies.

Rheumatoid Arthritis

Korea, Republic of
Pfizer

Completed

Study Evaluating the Efficacy and Safety of Etanercept and Methotrexate in Japanese Subjects With Rheumatoid Arthritis

Arthritis, Rheumatoid

Japan
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating the Combination of Etanercept and Methotrexate in Rheumatoid Arthritis Subjects

Rheumatoid Arthritis
St. Jude Children's Research Hospital
National Cancer Institute (NCI); National Institute of General Medical Sciences... and other collaborators

Completed

Total Therapy Study XVI for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia

United States
University of Nebraska

Recruiting

Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response

Rheumatoid Arthritis

United States
Institute of Hematology & Blood Diseases Hospital

Completed

Dasatinib Combined With Chemotherapy in Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia

Acute,Leukemia, Lymphoid

China
Gruppo Italiano Malattie EMatologiche dell'Adulto

Completed

Combination Chemotherapy in Treating Young Adult Patients With Acute Lymphoblastic Leukemia (LAL1308)

Leukemia

Italy
Therapeutic Advances in Childhood Leukemia Consortium
Abbott

Terminated

ABT-751 With Chemotherapy for Relapsed Pediatric ALL

Acute Lymphoblastic Leukemia | Relapsed Pediatric ALL | Recurrent Pediatric ALL | Refractory Pediatric ALL

United States
AIDS Malignancy Consortium
National Cancer Institute (NCI); The Emmes Company, LLC

Completed

Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed, HIV-Associated Burkitt's Lymphoma

Lymphoma

United States
Scottish Cancer Therapy Network

Completed

Standard Chemotherapy Compared With High-Dose Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Women With Breast Cancer

Breast Cancer

United Kingdom, Ireland
St. Jude Children's Research Hospital
National Cancer Institute (NCI)

Completed

Treatment of Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplasia

Leukemia, Myelocytic, Acute

United States
Istituto Ortopedico Rizzoli

Recruiting

Total Knee Arthroplasty: Fast Track Protocol is the Future? (FastTrack-G)

Osteoarthritis, Knee | Arthropathy of Knee

Italy
London School of Hygiene and Tropical Medicine
Oswaldo Cruz Foundation; Dr. Soetomo General Hospital; The Leprosy Mission Trust... and other collaborators

Recruiting

Methotrexate and Prednisolone Study in Erythema Nodosum Leprosum (MaPs)

Erythema Nodosum Leprosum

Bangladesh, Brazil, Ethiopia, India, Indonesia, Nepal
Medical College of Wisconsin
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute... and other collaborators

Completed

Sirolimus/Tacrolimus Versus Tacrolimus/Methotrexate for Preventing Graft-Versus-Host Disease (GVHD) (BMT CTN 0402)

Myelodysplastic Syndromes | Leukemia, Lymphocytic, Acute | Leukemia, Myelocytic, Acute | Leukemia, Myeloid, Chronic

United States, France
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Completed

Trial of Nivolumab vs Therapy of Investigator's Choice in Recurrent or Metastatic Head and Neck Carcinoma (CheckMate 141)

Squamous Cell Carcinoma of the Head and Neck

Brazil, Italy, United Kingdom, United States, Hong Kong, France, Netherlands, Germany, Argentina, Canada, Japan, Korea, Republic of, Spain, Switzerland, Taiwan
Dana-Farber Cancer Institute
Massachusetts General Hospital; Beth Israel Deaconess Medical Center

Terminated

GVAX vs. Placebo for MDS/AML After Allo HSCT

Acute Myeloid Leukemia | Chronic Myelomonocytic Leukemia | Myelodysplastic Syndrome

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Phase I Study of Methotrexate for HIV Infection

HIV Infections

United States
Loyola University

Withdrawn

Randomized Study: Standard of Care With or Without Atorvastatin for Prevention of GVHD for Matched Unrelated Donor BMT

Acute Myeloid Leukemia | Myelodysplastic Syndrome | Acute Lymphocytic Leukemia

United States
Assistance Publique - Hôpitaux de Paris

Completed

Treatment Tapering in JIA With Inactive Disease (AJIBIOREM)

Juvenile Idiopathic Arthritis

France
GlaxoSmithKline

Completed

Evaluation of Pharmacokinetics and Safety of GSK3196165 in Combination With Methotrexate in Japanese Subjects With Rheumatoid Arthritis

Arthritis, Rheumatoid

Japan
University of Alabama at Birmingham
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and other collaborators

Completed

Antifolate Effectiveness in Arthritis

Rheumatoid Arthritis | Adjuvant Arthritis

United States
Centocor, Inc.
Schering-Plough

Completed

An Efficacy and Safety Study of Golimumab in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy (GO-FORWARD)

Rheumatoid Arthritis

Australia, Poland, United States, Germany, Argentina, Canada, Korea, Republic of, Chile, New Zealand, Taiwan, Mexico, Hungary
SCRI Development Innovations, LLC
Aventis Pharmaceuticals

Completed

Weekly Docetaxel and CMF in the Adjuvant Treatment of Elderly Women With High-Risk Breast Cancer

Breast Cancer
Takeda
Takeda Development Center Americas, Inc.

Recruiting

A Study of ELAPRASE in Treatment-naïve Participants With Hunter Syndrome (Mucopolysaccharidosis [MPS] II)

Hunter Syndrome | Mucopolysaccharidosis (MPS)

United States
Peking Union Medical College Hospital

Recruiting

Drug Sensitivity Detection of Micro Tumor (PTC) to Guide Postoperative Adjuvant Treatment Strategy of Colorectal Cancer

Rectal Cancer | Colon Cancer | Chemotherapy Effect | PTC | Exon Mutation

China
Merck Sharp & Dohme LLC

Completed

Pembrolizumab (MK-3475) Versus Standard Treatment for Recurrent or Metastatic Head and Neck Cancer (MK-3475-040/KEYNOTE-040)

Head and Neck Squamous Cell Cancer
OncoImmune, Inc.

Terminated

Efprezimod Alfa (CD24Fc, MK-7110) for the Prevention of Acute Graft Versus Host Disease (GVHD) Following Myeloablative Hematopoietic Stem Cell Transplantation (HSCT) (MK-7110-005) (CATHY)

Acute Graft Versus Host Disease | Acute Myeloid Leukemia | Myelodysplastic Syndromes | Acute Lymphoblastic Leukemia | Hematopoietic Stem Cell Transplantation

United States
Cairo University

Completed

Thyroid Associated Orbitopathy Treatment by Methotrexate Against Triamcinolone Periocular Injections (TOMATO)

Thyroid Associated Orbitopathy

Egypt
Radboud University Medical Center
Erasmus Medical Center; Leiden University Medical Center; Medical Center Haaglanden and other collaborators

Active, not recruiting

A Study of the Combination of Cetuximab and Methotrexate in Recurrent or Metastatic Cancer of the Head and Neck (COMMENCE)

Squamous Cell Carcinoma of the Head and Neck

Netherlands
Massachusetts General Hospital
Dana-Farber Cancer Institute; Adienne SA

Withdrawn

Reduced Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplant (HSCT) For Lymphoma

Lymphoma

United States
National Institute of Allergy and Infectious Diseases...

Completed

Corticosteroids to Reduce Frequency of Seizures in Neurocysticercosis Patients

Neurocysticercosis

Peru
National Taiwan University Hospital

Unknown

Immune Modulation Therapy for Pompe Disease

Pompe Disease

Taiwan
M.D. Anderson Cancer Center
Astex Pharmaceuticals, Inc.

Completed

Phase I/II Study of Pentostatin Combined With Tacrolimus and Mini-Methotrexate for GVHD Prevention After MUD BMT

Lymphoma | Leukemia

United States
Nordic Society for Pediatric Hematology and Oncology
Oulu University Hospital

Suspended

Liposomal Cytarabine for Central Nervous System (CNS)-Treatment in High-risk Acute Lymphoblastic Leukemia (ALL)

Acute Lymphoblastic Leukemia

Finland, Denmark, Sweden, Iceland, Norway
University of Parma
Azienda Ospedaliero-Universitaria di Parma

Completed

Different Approaches to Maternal Hypotension During Cesarean Section

Pregnancy | Hypotension | Cesarean Section | Anesthesia,Spinal

Italy
Children's Oncology Group
National Cancer Institute (NCI)

Not yet recruiting

A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

Metastatic Osteosarcoma | Localized Osteosarcoma | Unresectable Osteosarcoma | Resectable Osteosarcoma
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S1106 Rituximab With Combination Chemotherapy or Bendamustine Hydrochloride Followed by Consolidation Chemotherapy and Stem Cell Transplantation in Older Patients With Previously Untreated Mantle Cell Lymphoma

Lymphoma

United States
University of Washington
National Cancer Institute (NCI)

Terminated

Hormone Therapy and Combination Chemotherapy Before and After Surgery in Treating Patients With Stage I-IIIA Breast Cancer

Stage I Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Estrogen Receptor-positive Breast Cancer | Progesterone Receptor-positive Breast Cancer | HER2-negative Breast Cancer

United States
Barbara Ann Karmanos Cancer Institute
National Cancer Institute (NCI)

Completed

Chemotherapy Plus Bone Marrow Transplantation in Treating Patients With Refractory Non-Hodgkin's Lymphoma, Hodgkin's Disease, or Multiple Myeloma

Lymphoma | Multiple Myeloma and Plasma Cell Neoplasm

United States
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S0213 Chemotherapy Plus Rituximab in Treating Patients With Mantle Cell Lymphoma

Lymphoma
Indiana University
Translational Breast Cancer Research Consortium

Completed

Medroxyprogesterone +/- Cyclophosphamide & Methotrexate in Hormone Receptor-Negative Recurrent/Metastatic Breast Cancer

Stage IV Breast Cancer | Recurrent Breast Cancer | Estrogen Receptor-negative Breast Cancer | Progesterone Receptor-negative Breast Cancer

United States
Sumithira Vasu

Completed

Organ-Sparing Marrow-Targeted Irradiation Before Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies

Recurrent Adult Acute Myeloid Leukemia | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Adult Acute Myeloid Leukemia With Del(5q) | Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) | Adult Acute Myeloid Leukemia With t(8... and other conditions

United States
Roswell Park Cancer Institute

Completed

Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Primary Myelofibrosis | Polycythemia Vera | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma and other conditions

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Chemotherapy and Rituximab With Peripheral Stem Cell Transplantation in Treating Patients With Mantle Cell Lymphoma

Lymphoma

United States, Puerto Rico
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia

Leukemia

United States
Medical Research Council

Unknown

Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia

Leukemia

United Kingdom

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