Search clinical trials for: Intravenous (IV) naloxone

Total 9561 results

Judith Feinberg

Unknown

Nasal Naloxone for Narcotic Overdose

Drug Overdose

United States
Norwegian University of Science and Technology
St. Olavs Hospital; Smerud Medical Research International AS; A/S Den norske...

Completed

Bioavailability of Nasal Naloxone and Injected Naloxone Compared (OPI-15-002)

Drug Overdose

Norway
INSYS Therapeutics Inc

Completed

A Study to Compare Bioavailability of Naloxone Nasal Spray, Naloxone Hydrochloride (HCl) Intravenous (IV) and Intramuscular Injection (IM) in Healthy Volunteers

Healthy Volunteer

United States
National Institute of Allergy and Infectious Diseases...

Terminated

Assessing Abuse Potential of Parenteral Buprenorphine/Naloxone in Non-Dependent Opioid Abusers

Opioid-Related Disorders

United States
Massachusetts General Hospital

Unknown

Effect of Buprenorphine/Naloxone Continuation on Pain Control and Opioid Use

Surgery | Pain, Acute | Opioid-use Disorder
Norwegian University of Science and Technology
St. Olavs Hospital; University of Iceland

Completed

A Pilot Study of the Bioavailability of Nasal Naloxone

Drug Overdose

Norway
Suvankar Majumdar

Completed

A Dose Escalation Study of Intravenous L-citrulline in Steady-state Sickle Cell Disease

Sickle Cell Disease

United States
Parc de Salut Mar
Food and Drug Administration (FDA)

Recruiting

Pharmacokinetics of Intravenous and Intranasal Formulations of Naloxone in Healthy Volunteers.

Healthy

Spain
Singapore General Hospital
Singapore Civil Defence Force

Completed

Intraosseous vs Intravenous Access for Cardiac Arrest Treatment

Cardiac Arrest

Singapore
University of Pennsylvania
National Institute of Drug Abuse; Expertise France

Completed

Medication-assisted Treatment for Injecting Drug Users in Vietnam (OIT-HCMC)

HIV Infections | Opioid Use Disorder
Dartmouth-Hitchcock Medical Center

Completed

Role of Endorphins in the Perception of Dyspnea in Patients With Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

United States
Takeda
Takeda Development Center Americas, Inc.

Active, not recruiting

Long-term Evaluation on Height and Weight in Patients With MPS II Who Started Treatment at < 6 Years of Age

Hunter Syndrome

United States, Germany, Malaysia, Philippines, Thailand, Dominican Republic, Serbia, Vietnam
Lazarski University
Poznan University of Medical Sciences; Wroclaw Medical University; Medical University...

Completed

Intravascular Access of COVID-19 Patient Under Personal Protective Equipment

Emergencies | Cardiac Arrest

Poland
Emory University

Completed

Glucose Measurement Using Microneedle Patches (GUMP)

Diabetes

United States
Norwegian University of Science and Technology
St. Olavs Hospital

Completed

Pharmacodynamics and Arteriovenous Differences of Naloxone in Healthy Participants Exposed to an Opioid (OPI-15-001)

Drug Overdose

Norway
Samjin Pharmaceutical Co., Ltd.

Completed

A Phase 4 Clinical Study to Investigate the Efficacy and Safety of Naloxone HCI IV in Patients With Stroke

Stroke, Acute

Korea, Republic of
BioNTech SE
Genentech, Inc.

Recruiting

A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer

Colorectal Cancer Stage II | Colorectal Cancer Stage III

United States, Spain, United Kingdom, Germany, Belgium, Sweden
The Hospital for Sick Children
The Physicians' Services Incorporated Foundation

Completed

Emergency Department Rapid Intravenous Rehydration (RIVR) for Pediatric Gastroenteritis

Gastroenteritis | Dehydration

Canada
Isfahan University of Medical Sciences

Completed

Randomized Trial of Intranasal Versus Intravenous Naloxone in Level of Consciousness in Suspected Opioid Overdose

Morphinan Opioid Overdose

Iran, Islamic Republic of
Polpharma Biologics S.A.

Completed

Efficacy and Safety of the Biosimilar Natalizumab PB006 in Comparison to Tysabri® (Antelope)

Relapsing-Remitting Multiple Sclerosis (RRMS)

Belarus, Ukraine, Georgia, Croatia, Moldova, Republic of, Poland, Serbia
Royal Brisbane and Women's Hospital

Unknown

Peripheral Venous Catheter Trial: 3 Day Versus No Routine Change

Phlebitis

Australia
Tranzyme, Inc.
Norgine

Completed

Ulimorelin Study of Efficacy and Safety (ULISES 008)

Gastrointestinal Dysmotility

United States, France, Czech Republic, Bulgaria, Lithuania, Romania
MD Stem Cells

Recruiting

Stem Cell Ophthalmology Treatment Study II (SCOTS2)

Glaucoma | Age-Related Macular Degeneration | Macular Degeneration | Retinitis Pigmentosa | Leber Hereditary Optic Neuropathy | Optic Atrophy | Blindness | Optic Neuropathy | Vision, Low | Retinal Disease | Stargardt Disease | Maculopathy | Retinopathy | Optic Nerve Disease | Nonarteritic Ischemic Optic Neuropathy | Vision... and other conditions

United States, United Arab Emirates
MD Stem Cells

Recruiting

Neurologic Stem Cell Treatment Study (NEST)

Stroke | Nervous System Diseases | Diabetic Neuropathies | Neurodegenerative Diseases | Cognitive Impairment | Amyotrophic Lateral Sclerosis | Dementia | Neurological Disorders | Alzheimer Disease | ALS | Traumatic Brain Injury | Cerebral Infarction | Lewy Body Disease | Cerebral Hemorrhage | Frontotemporal Dementia | Progressive... and other conditions

United States, United Arab Emirates
AbbVie

Not yet recruiting

Study of ABBV-383 Assessing Adverse Events and Clinical Activity With Subcutaneous (SC) Injection in Adult Participants With Relapsed or Refractory Multiple Myeloma

Multiple Myeloma
Alnylam Pharmaceuticals

Completed

The Study of ALN-TTR02 (Patisiran) for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Patients Who Have Already Been Treated With ALN-TTR02 (Patisiran)

TTR-mediated Amyloidosis

Portugal, Sweden, Brazil, United States, France, Spain, Germany
Polpharma Biologics S.A.

Not yet recruiting

Efficacy, Safety and Immunogenicity of the Proposed Biosimilar Vedolizumab PB016 in Comparison With Entyvio® (UCESIVE)

Ulcerative Colitis
Bayside Health
Australian and New Zealand College of Anaesthetists

Completed

Limiting IV Chloride to Reduce AKI After Cardiac Surgery (LICRA)

Patients Undergoing Cardiothoracic Surgery

Australia
University of Edinburgh
NHS Lothian

Completed

Cardiovascular Effects of Apelin In Healthy Volunteers

Healthy

United Kingdom
Menzies School of Health Research
National Health and Medical Research Council, Australia; Wellcome Trust; University... and other collaborators

Completed

Arginine Malaria Trial: Study of Adjunctive Arginine in Falciparum Malaria

Malaria, Falciparum

Indonesia
Tranzyme, Inc.
Norgine

Completed

Ulimorelin Study of Efficacy and Safety (ULISES 007) (ULISES)

Gastrointestinal Dysmotility

United States, United Kingdom, Serbia, Italy, Romania, Hungary, Poland
Lazarski University
Poznan University of Medical Sciences; Wroclaw Medical University; Medical University...

Completed

Intravascular Access in Suspected/Confirmed COVID-19 Patient

Shock | Emergency Medicine | Cardiopulmonary Arrest

Poland
Vanderbilt-Ingram Cancer Center
National Cancer Institute (NCI)

Terminated

3-Tesla MRI Response to TACE in HCC (Liver Cancer)

Advanced Adult Primary Liver Cancer | Localized Resectable Adult Primary Liver Cancer | Localized Unresectable Adult Primary Liver Cancer | Adult Primary Hepatocellular Carcinoma | Stage A Adult Primary Liver Cancer (BCLC) | Stage B Adult Primary Liver Cancer (BCLC)

United States
mads u werner
University of Kentucky

Completed

Effect of High-dose Target-controlled Naloxone Infusion on Pain and Hyperalgesia During a Burn Injury (TCI-NX-BI)

Healthy Subjects

Denmark
S.L.A. Pharma AG

Completed

Naloxone SR Capsules in Patients With Opioid Induced Constipation

Chronic Pain | Opioid Induced Constipation

Germany, United Kingdom
Mt. Sinai Medical Center, Miami
Florida Heart Research Institute

Completed

Contrast Nephropathy and Nitrates (CoNaN)

Contrast Induced Nephropathy

United States
Pocket Naloxone Corp

Completed

Pharmacokinetic Evaluation of a New Naloxone Nasal Swab, Naloxone Nasal Spray, and Intramuscular Naloxone Injection in Healthy Volunteers

Opioid Overdose

Canada
mads u werner
University of Kentucky

Completed

Effect of High-dose Naloxone Following Third Molar Extraction (TME)

Pain, Acute | Healthy Subjects | Hyperalgesia | Sensitization, Central | Inflammations, Endodontic

Denmark
GlaxoSmithKline

Completed

A Single Dose Pharmacokinetics (PK) Study of GSK2434735 in Healthy Male Volunteers

Asthma

United Kingdom
Tanta University

Completed

Effect of Intrathecal Naloxone in the Incidence of Pruritis After C.S

Pruritis

Egypt
Janssen-Cilag A.G., Switzerland

Completed

Comparison of Two Dosage Strengths of Transdermal Fentanyl Versus Transdermal Buprenorphine and Placebo in Acute Pain Models in Healthy Volunteers.

Pain
Leiden University Medical Center
U.S. Food and Drug Administration (FDA)

Recruiting

Reversal of Opioid-induced Respiratory Depression With Opioid Antagonists (ROAR)

Chronic Opioid Use | Opioid Induced Respiratory Depression

Netherlands
INSYS Therapeutics Inc

Completed

A Study to Compare Bioavailability of Naloxone Nasal Spray and Naloxone Hydrochloride (HCl) Intramuscular Injection (IM) in Healthy Volunteers

Healthy Volunteer

United States
Norwegian University of Science and Technology
St. Olavs Hospital

Completed

Pharmacokinetics and Pharmacodynamics of a New Formulation of Nasal Naloxone for Prehospital Use (OPI-14-001)

Drug Overdose

Norway
Samsung Medical Center

Completed

Pre-warmed Intravenous Fluids and Monitored Anesthesia Care

Hypothermia

Korea, Republic of
University Health Network, Toronto

Not yet recruiting

Intravenous vs Oral Acetaminophen in Postoperative Hip Fracture Adult Patients (INTACT-HIP)

Surgery | Hip-fracture
PhaseBio Pharmaceuticals Inc.

Completed

Phase 1, Randomized, Double-Blind, Placebo-Controlled Exploratory Study That Will Assess the Safety, Tolerability, Pharmacokinetics and Hemodynamic Response to a Single 30 Minute Intravenous Infusion of Vasomera™ (PB1046) in Adult Subjects With Stage 1 or 2 Essential Hypertension

Essential Hypertension

United States
University of Washington

Unknown

Subjective Analgesic Effects of Naloxone and Virtual Reality (Narcan)

Pain

United States
Duke University
National Institute on Drug Abuse (NIDA); The Emmes Company, LLC

Completed

Buprenorphine Physician-Pharmacist Collaboration in the Management of Patients With Opioid Use Disorder: CTN 0075 (Pharm-OUD-Care)

Opioid Use Disorder

United States
Kasr El Aini Hospital
Mansoura University

Completed

Influence Of Low Dose Intrathecal Naloxone On Bupivacaine - Fentanyl Spinal Anaesthesia For Lower Limb Orthopedic Surgery In Elderly Patients

Elderly | Anesthesia, Spinal

Egypt

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