Search clinical trials for: Linaclotide 145 micrograms

Total 3471 results

Forest Laboratories
Ironwood Pharmaceuticals, Inc.

Completed

Safety and Efficacy of Linaclotide in Patients With Chronic Constipation and Prominent Abdominal Bloating

Constipation | Chronic Constipation

United States, Canada
Forest Laboratories
Ironwood Pharmaceuticals, Inc.

Completed

Phase III, Randomized, Double-Blind, Placebo-Controlled, Trial of Linaclotide Administered to Patients With Chronic Constipation

Chronic Constipation

United States, Canada
Forest Laboratories
Ironwood Pharmaceuticals, Inc.

Completed

Phase 2 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Trial of Linaclotide Administered to Patients With Opioid-Induced Constipation Receiving Chronic Opioid Treatment for Non-Cancer Pain

Opioid-Induced Constipation

United States
Forest Laboratories
Ironwood Pharmaceuticals, Inc.

Completed

Trial of Linaclotide Administered to Patients With Irritable Bowel Syndrome With Constipation

Irritable Bowel Syndrome Characterized by Constipation

United States, Canada
AbbVie
Ironwood Pharmaceuticals, Inc.

Active, not recruiting

Linaclotide Safety and Efficacy in Pediatric Participants, 6 to 17 Years of Age, With Irritable Bowel Syndrome With Constipation (IBS-C) or Functional Constipation (FC) (LINZESS)

Irritable Bowel Syndrome With Constipation | Functional Constipation

United States, Belgium, Bulgaria, Canada, Estonia, Israel, Italy, Netherlands, Poland, Puerto Rico, Spain, Ukraine, United Kingdom, Germany
SecuraBio

Completed

A Long-term, Continued Treatment and Follow-up Study in Participants With Hematologic Malignancies Treated With Duvelisib (IPI-145)

Hematologic Malignancy

United States, Italy
Nexpep Pty Ltd

Completed

Safety Study of Nexvax2 in Subjects With Coeliac Disease

Celiac Disease | Coeliac Disease

Australia
Cairo University

Unknown

Comparison of Different Doses of Dexmedetomidine Effect in the Duration of Spinal Anesthesia

Spinal Anesthesia Duration

Egypt
BioNTech SE
Pfizer

Recruiting

A Study to Learn About Variant-Adapted COVID-19 RNA Vaccine Candidate(s) in Healthy Children

COVID-19 | Severe Acute Respiratory Syndrome Coronavirus 2 | SARS-CoV-2 Virus

United States, Brazil, Puerto Rico
Sanwa Kagaku Kenkyusho Co., Ltd.

Completed

A Study to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]-SK-1405

Pruritus

United Kingdom
AstraZeneca

Completed

A Study of Cotadutide in Participants Who Have Chronic Kidney Disease With Type 2 Diabetes Mellitus

Chronic Kidney Diseases | Type 2 Diabetes Mellitus

Spain, United Kingdom, New Zealand, Australia, Canada, Poland, Germany, Japan
Forest Laboratories
Ironwood Pharmaceuticals, Inc.

Terminated

A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 7-17 Years, With Irritable Bowel Syndrome With Constipation (LIN-MD-63)

Irritable Bowel Syndrome With Constipation

United States, Canada
Medicago
Syneos Health

Completed

Immunogenicity, Safety, Tolerability of a Plant-Made H5 VLP Influenza Vaccine

RNA Virus Infections | Virus Diseases | Respiratory Tract Infections | Respiratory Tract Diseases

Canada
Dr. Anton Hommer

Completed

An Open, Non-randomized Pilot Study on the Effect of Preservative Free Tafluprost (Saflutan® Augentropfen) in Patients With Ocular Hypertension or Primary Open Angle Glaucoma With an Uncontrolled Intraocular Pressure of 30 mmHg and More

Primary Open Angle Glaucoma | Ocular Hypertension

Austria
Anergis

Completed

Efficacy Study of a Preseasonal Treatment With AllerT in Subjects With Birch Pollen Allergy

Allergic Rhinitis | Rhinoconjunctivitis

France, Sweden, Lithuania, Denmark, Latvia, Poland, Switzerland
VLP Therapeutics

Completed

To Assess the Safety, Immunogenicity and Efficacy of VLPM01 in Healthy, Malaria-Naïve Volunteers

Malaria,Falciparum

United States
Debiopharm International SA

Completed

Mass Balance Recovery and Metabolic Profile of 14C Debio 1450 Following Single Oral and Intravenous Doses in Healthy Male Subjects

Healthy

United Kingdom
Ironwood Pharmaceuticals, Inc.
Forest Laboratories

Completed

Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)

Irritable Bowel Syndrome With Constipation

United States
Astellas Pharma Inc

Completed

A Study of Oral Dosing of ASP0456 in Patients With Chronic Constipation

Chronic Constipation

Japan
Changhai Hospital
The First Affiliated Hospital of Nanchang University; The Second Hospital of... and other collaborators

Completed

Application of Linaclotide Capsule in Bowel Preparation for Colonoscopy

Bowel Preparation for Colonoscopy

China
Astellas Pharma Inc

Completed

Phase III Study to Evaluate the Efficacy and Safety of ASP0456 in Patients With Constipation Predominant Irritable Bowel Syndrome

Irritable Bowel Syndrome With Constipation (IBS-C)

Japan
Ironwood Pharmaceuticals, Inc.

Completed

Randomized, Double-blind, Dose-range-finding, Phase 2 Study of Linaclotide Administered to Patients With Irritable Bowel Syndrome With Constipation (IBS-C)

Irritable Bowel Syndrome With Constipation

United States, Canada
Radiation Therapy Oncology Group
National Cancer Institute (NCI); NRG Oncology

Completed

Interstitial Brachytherapy With or Without External-Beam Radiation Therapy in Treating Patients With Prostate Cancer

Prostate Cancer

United States, Canada
Vivozon, Inc.

Completed

Absorption, Metabolism, Excretion, and Mass Balance Study of [14C]-VVZ-149 in Healthy Adult Male Subjects

Healthy Adult Male

United States
Forest Laboratories

Completed

A Lactation Study in Women Who Are Breastfeeding or Pumping and Are Receiving Linaclotide Therapeutically (LIN-PK-01)

Irritable Bowel Syndrome | Constipation | Breast Feeding

United States
Zhiguo Liu

Completed

Application of Linaclotide Capsule in Bowel Preparation for Patients at High Risk of Inadequate Bowel Preparation

Colonoscopy

China
Astellas Pharma Inc

Completed

A Study to Evaluate Safety of Multiple Dose of ASP0456 in Healthy Subjects

Healthy | Pharmacokinetics of ASP0456

Japan
Astellas Pharma Inc

Completed

A Safety and Pharmacokinetics Study of ASP0456 in Healthy Subjects

Healthy | Pharmacokinetics of ASP0456

Japan
SecuraBio

Completed

A Phase 2a, Efficacy and Safety Study of Duvelisib in Mild Asthmatic Subjects

Asthma

Germany, United Kingdom
AbbVie
Ironwood Pharmaceuticals, Inc.

Recruiting

A Study to Assess Adverse Events and Change in Symptoms With Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional Constipation

Functional Constipation (FC) | Chronic Idiopathic Constipation (CIC)

United States, United Kingdom, Bulgaria, Netherlands
Astellas Pharma Inc

Completed

Post-marketing Surveillance of Linaclotide Tablet in Patients With Irritable Bowel Syndrome With Constipation or Chronic Constipation (Excluding Constipation Due to Organic Diseases)

Irritable Bowel Syndrome With Constipation (IBS-C) | Chronic Constipation (CC) (Excluding Constipation Due to Organic Diseases)

Japan
Astellas Pharma Inc

Completed

A Study to Evaluate the Effect of ASP0456 in Patients With Constipation Predominant Irritable Bowel Syndrome

Constipation-predominant Irritable Bowel Syndrome (IBS-C)

Japan
Erling Bjerregaard Pedersen

Completed

The Effect of Sodium Nitrite on Renal Function and Blood Pressure in Healthy Humans. A Dose-response Study

Healthy

Denmark
Texas Tech University Health Sciences Center, El...

Active, not recruiting

Efficacy of Linaclotide in Type II Diabetics With Chronic Constipation

Diabete Mellitus | Chronic Constipation

United States
Ironwood Pharmaceuticals, Inc.

Completed

Dose-range-finding, Phase 2 Trial of Oral Linaclotide Acetate Administered to Patients With Chronic Constipation

Chronic Constipation

United States
Pearl Therapeutics, Inc.

Completed

Study to Assess the Efficacy and Safety of Three Doses of PT001 in Japanese Subjects With Moderate to Severe COPD

Chronic Obstructive Pulmonary Disease

Japan
Rachel Lieberman

Terminated

Capsular Tension Rings in Intraocular Lens Rotation

Cataract | Ophthalmoplegia | Ophthalmologic Complication

United States
SecuraBio

Terminated

A Phase 1 Study of Duvelisib in Patients With Advanced Hematologic Malignancies

Hematologic Malignancies

United States
Forest Laboratories
Ironwood Pharmaceuticals, Inc.

Completed

A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 6-17 Years Who Fulfill Modified Rome III Criteria for Child/Adolescent Functional Constipation (FC)

Functional Constipation in Children Ages 6-17 Years

United States, Canada
ModernaTX, Inc.

Completed

A Safety, Reactogenicity, and Immunogenicity Study of mRNA-1045 (Influenza and Respiratory Syncytial Virus [RSV]) or mRNA-1230 (Influenza, RSV, and Severe Acute Respiratory Syndrome Coronavirus 2 [SARS-CoV-2]) Vaccine in Adults 50 to 75 Years Old

Influenza | SARS-CoV-2 | RSV

United Kingdom, Australia, United States
GlaxoSmithKline

Completed

An Investigation of the Pharmacokinetics of GSK961081 and Fluticasone Propionate in Healthy Volunteers

Pulmonary Disease, Chronic Obstructive

United Kingdom
SecuraBio

Completed

A Study of Duvelisib in Participants With Refractory Indolent Non-Hodgkin Lymphoma (DYNAMO)

Indolent Non-Hodgkin Lymphoma

Belgium, France, Italy, Spain, Canada, United States, Bulgaria, United Kingdom, Hungary, Georgia, Belarus, Czechia
BioNTech SE
Pfizer

Withdrawn

A Study to Learn About Bivalent COVID-19 RNA Vaccine Candidate(s) in Healthy Infants and Children

COVID-19
University of Tartu
Tartu University Hospital

Recruiting

The Effect of Lixisenatide on the Effect of Pituitary Hormones

Healthy | Type 1 Diabetes

Estonia
Statens Serum Institut

Completed

A Safety and Immunogenicity Trial With an Adjuvanted Tuberculosis(TB) Subunit Vaccine (THYB-01)

Tuberculosis

Netherlands
Impax Laboratories, LLC

Completed

A Study To Evaluate The Safety And Efficacy Of IPX066 In Subjects With Parkinson's Disease (APEX-PD)

Parkinson's Disease

United States, Canada, Estonia, Latvia, Lithuania, Romania, Ukraine
University of Waterloo
CSA Group

Completed

Using Pictograms to Make Privacy Agreements More Accessible

Information Fatigue Syndrome

Canada
SecuraBio

Completed

Bioequivalence of Duvelisib and Food Effect on Pharmacokinetics of IPI-145

Healthy

United States
Mayo Clinic

Completed

Omega-3 Fatty Acids to Combat Sarcopenia

Sarcopenia

United States
Hormozgan University of Medical Sciences

Completed

Comparitive Study of Two Misoprostol Regimen in Early Pregnancy Termination

Termination

Iran, Islamic Republic of

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