Search clinical trials for: Linaclotide 145 micrograms

Total 3508 results

Johns Hopkins University
National Institute of Mental Health (NIMH)

Completed

Study of Paroxetine and Fluconazole for the Treatment of HIV Associated Neurocognitive Disorder (ParaFlu)

HIV Associated Neurocognitive Disorder

United States
Farabi Eye Hospital

Unknown

UVX as an Adjuvant in the Treatment of Fungal Keratitis

Treatment
Aravind Eye Care System

Unknown

Clinical & Visual Outcomes of Collagen Cross Linking for Fungal Keratitis

Mycotic Corneal Ulcer

India
Vertex Pharmaceuticals Incorporated

Recruiting

A Phase 1, Open-label Study Evaluating the Pharmacokinetics and Drug-drug Interaction of VX-993 in Healthy Adults

Pain

United Kingdom
Celgene

Recruiting

A Study to Evaluate the Effect of Cytochrome P450 (CYP) 3A Inhibitor (Itraconazole) and Inducer (Rifampin) on the Drug Levels of Golcadomide (BMS-986369) in Healthy Participants

Healthy Volunteers

United States
Manchester University NHS Foundation Trust

Not yet recruiting

Interferon-gamma as Adjunctive Therapy in Chronic Pulmonary Aspergillosis: a Randomised Feasibility Study (INCAS)

Aspergillosis | Chronic Pulmonary Aspergillosis
Bayer

Completed

A Study to Learn About How Itraconazole and Carbamazepine Affect the Level of BAY2927088 in the Blood When These Drugs Are Taken Together by Healthy Participants

Healthy Volunteers | Advanced Non-small Cell Lung Cancer | EGFR Mutation | HER2 Mutation

United States
Zhejiang ACEA Pharmaceutical Co. Ltd.

Completed

A Study to Evaluate the Relative Bioavailability of STI-1558 and the Effect of Itraconazole and Rifampin on the Pharmacokinetics of STI-1558

COVID-19 Pneumonia

China
DICE Therapeutics, Inc.

Completed

A Drug-Drug Interaction Study to Assess the Pharmacokinetics of DC-806 When Orally Administered Alone, When Coadministered With Itraconazole, and When Coadministered With Carbamazepine in Healthy Adult Participants

Healthy Volunteers

United States
Eastern Cooperative Oncology Group
National Cancer Institute (NCI); Cancer and Leukemia Group B; SWOG Cancer Research...

Completed

Hormone Therapy Compared With Combination Chemotherapy in Treating Patients With Prostate Cancer

Prostate Cancer

United States
Crossject

Completed

Bioavailability Study of Midazolam Administered as a Solution by Conventional Syringe or ZENEO®

Healthy

South Africa
University of Pharmacy, Yangon

Completed

Clinical Effectiveness and Safety of Amphotericin B With Flucytosine-Fluconazole Therapy for Cryptococcal Meningitis

Cryptococcal Meningitis

Myanmar
National Institute of Allergy and Infectious Diseases...

Completed

Dexamethasone in Cryptococcal Meningitis

HIV Infections | Meningitis, Cryptococcal

United States, Puerto Rico
Donald Trump, MD

Terminated

Oral Calcitriol With Ketoconazole in CRPC

Castration-resistant Prostate Cancer

United States
Futura Medical Developments Ltd.
Parexel

Completed

Assess the Efficacy and Safety in Volunteers of DCF100, TIB200 and SPR300 vs. Placebo and Control(s) in a UV Pain Model

Pain

United Kingdom
The University of Texas Health Science Center,...
Robert Cizik Eye Clinic

Completed

Botulinum Toxin Type A Injection After Topical Anesthesia Versus Petrolatum Ointment

Forehead Wrinkles | Forehead Rhytides

United States
William N Handelman

Unknown

Systemic Uptake of Diclofenac Sodium in Combination With Miconazole as Antifungal Nail Gel When Applied Daily With Monitoring of Hepatic and Renal Enzymes, and Serum Levels of Diclofenac 12 Hours After Application, and at 3 and 6 Months Study

Tinea Unguium, Onychomycosis

United States
GlaxoSmithKline

Completed

Drug-drug Interaction Study of GSK1278863 With Pioglitazone, Rosuvastatin and Trimethoprim in Healthy Adult Volunteers

Anaemia

United States
Celgene Corporation

Completed

Study to Evaluate the Effect of Cytochrome P450 (CYP) 3A Inhibition and Induction on the Pharmacokinetics of CC-220 in Healthy Subjects

Pharmacokinetics

United States
Royal Marsden NHS Foundation Trust
Hoffmann-La Roche; Professor Cunningham's Clinical Research Fund

Completed

Combining Erlotinib Plus Bevacizumab and Gemcitabine Plus Capecitabine to Treat Advanced Pancreatic Cancer (TARGET)

Pancreatic Cancer

United Kingdom
Astellas Pharma Europe B.V.

Completed

First-in-human: Single Ascending Dose, Food Effect, Drug-drug Interaction, Multiple Ascending Dose, Proof of Pharmacology

Healthy Volunteers

United Kingdom, Germany
Vantia Ltd

Completed

Study in Healthy Male Subjects to Evaluate the Effect of Itraconazole and Rifampicin on the PK of Fedovapagon

Nocturia

Germany
InterMune

Completed

Safety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal Meningitis

HIV Infections | Meningitis, Cryptococcal

United States, Peru
M.D. Anderson Cancer Center
Spectrum Pharmaceuticals, Inc

Completed

Zevalin-Containing Nonmyeloablative Conditioning for Stem Cell Transplantation (SCT)

Lymphoma | Leukemia

United States
Shenzhen TargetRx, Inc.
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical...

Recruiting

TGRX-326 Pharmacokinetic Drug Interaction

Non Small Cell Lung Cancer

China
Nanjing Sanhome Pharmaceutical, Co., Ltd.

Not yet recruiting

The Effect of Itraconazole and Rifampicin on the Pharmacokinetics of SH-1028

Healthy Male Volunteers

China
Palleos Healthcare GmbH
Roche Pharma AG; University Hospital, Essen; University Hospital Erlangen; Phaon...

Active, not recruiting

Study to Compare a Mono Atezolizumab Window Followed by a Atezolizumab - CTX Therapy With Atezolizumab - CTX Therapy (neoMono)

Triple-negative Breast Cancer

Germany
Eli Lilly and Company
Loxo Oncology, Inc.

Terminated

Study of the Effects of Itraconazole and Carbamazepine on LY3410738 in Healthy Participants

Healthy

United States
Bristol-Myers Squibb

Withdrawn

A Study to Evaluate the Effect of Fluconazole, Bupropion, or Itraconazole on the Drug Levels and Safety of BMS-986235

Healthy Participants

United States
Children's Hospital of Philadelphia
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); University...

Completed

Pilot Study of Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease (Holiday)

Crohn Disease

United States
National Institute of Allergy and Infectious Diseases...

Completed

High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals

HIV Infections | Cryptococcal Meningitis

Kenya, Thailand, Uganda, United States, Peru, South Africa, Zimbabwe, India
Ascletis Pharmaceuticals Co., Ltd.

Completed

Study to Evaluate the Effects of Itraconazole and Rifampin on the Pharmacokinetics of ASC40 in Healthy Subjects

Healthy

China
Odonate Therapeutics, Inc.

Terminated

The Effect of Tesetaxel on the QTc Interval and the Effect of Food, Itraconazole, and Rifampin on Tesetaxel Pharmacokinetics in Patients With Advanced Solid Tumors

Advanced Solid Tumors

United States
University of Pecs

Enrolling by invitation

Plasma Concentration of Lidocaine and Bupivacaine Axillary BPB Mixture Solutions [PCLBAxMix] (PCLBAxMix)

Arm Injury

Hungary
Alexion Pharmaceuticals
Celerion; Achillion, a wholly owned subsidiary of Alexion

Completed

A Drug Interaction Study of ACH-0145228

Healthy

United States
Bayer

Completed

COPANLISIB (BAY80-6946) Drug-drug Interaction and Cardiovascular Safety Study in Advanced Solid Tumor and Non-Hodgkin's Lymphoma Patients

Medical Oncology

Canada, United States
Weill Medical College of Cornell University

Completed

Pharmacokinetics of Sublingual Versus Oral Tacrolimus in Patients Awaiting Kidney Transplantation

Kidney Failure, Chronic

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...

Terminated

A Randomized Phase II Study of SUBATM-itraconazole in Patients With Untreated Squamous NSCLC. (NA_00067809)

Non-small Cell Lung Cancer Metastatic

United States
F2G Biotech GmbH
SimbecRresearch Ltd.

Completed

Multiple Ascending Oral Dose Study of F901318 in Healthy Subjects (ORALMAD)

Invasive Aspergillosis

United Kingdom
Janssen Research & Development, LLC

Completed

A Study to Assess the Effects of Itraconazole and Rifampicin on the Single-Dose Pharmacokinetics of JNJ-53718678 in Healthy Adults

Healthy

United States
Takeda

Completed

Drug-Drug Interaction Study Between TAK-272 and Itraconazole, Digoxin or Midazolam

Japanese Healthy Adult Males

Japan
Merck Sharp & Dohme LLC

Completed

A Study to Compare the Efficacy and Safety of a Combination of Ketoconazole and Clindamycin Compared to Tetracycline/Amphotericin B Combination Cream for the Treatment of Bacterial Vaginosis and Vaginal Candidiasis (P08077)

Vaginosis, Bacterial | Candidiasis, Vulvovaginal
University of Washington
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

ITT4 Intratesticular Hormonal Milieu in Man (ITT4) (ITT4)

Healthy Males

United States
Agency for Healthcare Research and Quality (AHRQ)

Completed

Management of Vaginal Complaints: A Pilot Study Within a Practice-Based Research Network (VCAT)

Vaginitis

United States
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Completed

Combination Chemotherapy Plus Warfarin in Treating Patients With Prostate Cancer

Prostate Cancer | Thromboembolism

United States
LG Life Sciences

Completed

Pharmacokinetic Drug Interaction Study in Healthy Male Subjects

Healthy Male Volunteers

Korea, Republic of
Jonsson Comprehensive Cancer Center
Janssen Inc.

Active, not recruiting

Antiandrogen Therapy and SBRT in Treating Patients With Recurrent, Metastatic Prostate Cancer

Recurrent Prostate Carcinoma | Stage IVB Prostate Cancer AJCC v8 | Metastatic Prostate Adenocarcinoma | Prostate Adenocarcinoma With Focal Neuroendocrine Differentiation

United States
University of Texas Southwestern Medical Center

Completed

Pain Relief Effects on Length of Labor

Labor Pain

United States
Sidney Kimmel Cancer Center at Thomas Jefferson...

Completed

Ascorbic Acid and Combination Chemotherapy in Treating Patients With Locally Advanced or Recurrent Pancreatic Cancer That Cannot Be Removed by Surgery

Pancreatic Adenocarcinoma | Unresectable Pancreatic Carcinoma | Recurrent Pancreatic Carcinoma | Stage III Pancreatic Cancer | Stage IV Pancreatic Cancer

United States
National Cancer Institute (NCI)

Recruiting

Testing the Anti-Cancer Drug Darolutamide in Patients With Testosterone-driven Salivary Gland Cancers

Recurrent Salivary Gland Carcinoma | Metastatic Salivary Gland Carcinoma | Unresectable Salivary Gland Carcinoma | Locally Advanced Salivary Gland Carcinoma

United States

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