Search clinical trials for: metformin placebo

Total 55378 results

AstraZeneca

Completed

A Study Assessing Saxagliptin Treatment in Subjects With Type 2 Diabetes Who Are Not Controlled With Diet and Exercise

Type 2 Diabetes

United States
Response Pharmaceuticals

Completed

Study of KD026 in Combination With Metformin in Subjects With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

United States
McMaster University

Withdrawn

Continuation of Metformin to Improve And Keep Peri-operative Glycemic Control (CANTAKE)

Diabetes Mellitus Type 2
Guy's and St Thomas' NHS Foundation Trust
King's College London

Unknown

Metformin And Longevity (METAL)

Prostate Cancer

United Kingdom
Juan Pablo Castanedo-Cazares
Hospital Central "Dr. Ignacio Morones Prieto"

Unknown

Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity

Acanthosis Nigricans

Mexico
Peking University Third Hospital

Completed

Effect of Metformin on Patients With Polycystic Ovary Syndrome

PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries

China
AstraZeneca

Completed

Study Assessing Saxagliptin Treatment In Type 2 Diabetic Subjects Who Are Not Controlled With Metformin Alone

Diabetes Mellitus, Type 2

United States, Chile, Argentina, Brazil, Canada, Mexico, Puerto Rico, Taiwan, Australia
AstraZeneca

Completed

The Purpose of the Study is to Compare Two Fixed Dose Combination Tablets of Dapagliflozin/Metformin XR in Healthy Subjects Under Fasting and Fed Conditions

Healthy Subjects in Fasted and Fed State

Brazil
Bristol-Myers Squibb

Completed

A Research Study to Assess the Mechanism By Which Glucovance, Metformin, and Glyburide Work To Control Glucose Levels In Patients With Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

United States
Yooyoung Pharmaceutical Co., Ltd.

Active, not recruiting

Clinical Trial to Assess the Efficacy and Safety of YYC405 in Type 2 Diabetes Patients

Type 2 Diabetes

Korea, Republic of
AstraZeneca

Completed

Efficacy and Safety Study of Saxagliptin + Metformin Immediate Release (IR) Versus Metformin IR Alone in Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

United States, Puerto Rico, Germany, Hungary
Seoul National University Bundang Hospital

Completed

Initial Combination of Gemigliptin and Metformin on Microbiota Change (INTESTINE)

Diabetes

Korea, Republic of
Mannkind Corporation

Completed

Efficacy and Safety of Prandial Inhalation of Technosphere/Insulin in Combination With Metformin or Technosphere/Insulin Alone Versus 2 Oral Anti-Diabetic Agents in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2

United States, Brazil, Spain, Argentina, Canada, Chile, Mexico, Poland, Russian Federation, Ukraine, Czech Republic
University Medical Centre Ljubljana

Completed

PDE-4 Inhibitor Roflumilast and Polycystic Ovary Syndrome

Obesity | PCOS

Slovenia
Maria Sandberg Westerstahl

Terminated

Effect of Exercise or Metformin on Nocturnal Blood Pressure and Other Risk Factors for CVD Among Obese Adolescents

Cardiovascular Diseases

Sweden
National Cancer Institute (NCI)

Completed

Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMI

Obesity | Colorectal Cancer | Adenomatous Polyp

Canada, United States
Massachusetts General Hospital
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Unknown

Metformin Treatment in Polycystic Ovary Syndrome (PCOS)

Polycystic Ovary Syndrome
University of Hawaii
National Institute of General Medical Sciences (NIGMS)

Unknown

Metformin for HIV Inflammation

Coronary Artery Disease | HIV

United States
Torrent Pharmaceuticals Limited

Completed

Study to Evaluate the Bioequivalence of a Test Tablet Formulation of Metformin HCl (1000 mg), Compared to an Equivalent Dose of a Commercially Available Reference Drug Product (Glucophage®, Bristol-Myers Squibb Company) in Fasted, Healthy, Adult Subjects

Healthy

United States
Torrent Pharmaceuticals Limited

Completed

Study to Evaluate the Bioequivalence of a Test Tablet Formulation of Metformin HCl (1000 mg), Compared to an Equivalent Dose of a Commercially Available Reference Drug Product (Glucophage®, Bristol-Myers Squibb Company) in Fed, Healthy, Adult Subjects

Healthy

United States
Shenzhen People's Hospital

Unknown

Effect of Metformin as add-on Therapy on Glycemic Control and Other Outcomes in Type 1 Diabetes

Type 1 Diabetes Mellitus | Metformin

China
Boehringer Ingelheim

Completed

Relative Bioavailability of Multiple Oral Doses of BI 187004 and Metformin After Co-administration Compared to Multiple Oral Doses of BI 187004 Alone and Metformin Alone in Healthy Male Subjects

Healthy

Germany
Children's Hospital Los Angeles

Terminated

Metformin and Transient Hyperglycemia

Hyperglycemia | Diabetes Mellitus | Insulin Resistance | Acute Lymphoblastic Leukemia

United States
GlaxoSmithKline

Completed

AVANDAMET Versus Metformin And Sulphonylurea In People With Poorly Controlled Type 2 Diabetes

Non-Insulin-Dependent Diabetes Mellitus

Spain, Germany, Belgium, United Kingdom, Ireland, Netherlands, Italy, France, Mexico, Switzerland, Lithuania
Daping Hospital and the Research Institute of Surgery...

Completed

Combination of Metformin With Gefitinib to Treat NSCLC (CGMT)

NSCLC | Advanced Cancer | EGFR Gene Amplification | Stage IV NSCLC | Stage IIIB NSCLC

China
Centro Universitario de Ciencias de la Salud, Mexico

Completed

Conjugated Linoleic Acid / Leucine Versus Metformin on Visceral Fat in Metabolic Syndrome

Metabolic Syndrome
Tampere University Hospital
Turku University Hospital; Helsinki University Central Hospital; Oulu University... and other collaborators

Completed

Metformin Use to Improve Pregnancy Outcome in Women With Type 1 Diabetes.

Type1diabetes | Insulin Resistance | Diabetic Pregnancy

Finland
Mayo Clinic

Completed

Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.

Insulin Resistance | Prediabetic State

United States
Novo Nordisk A/S

Completed

Effect of Repaglinide and Metformin Combination Tablet or Rosiglitazone and Metformin in Fixed Dose Combination on Blood Glucose Control in Patients With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

United States, Puerto Rico
Laboratorios Silanes S.A. de C.V.

Completed

Effect of Oral Combination Therapy in a Single Dosage Form in Patients With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

Mexico
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study to Assess the Bioequivalence of 2 Fixed Dose Combination (FDC) Tablets of Canagliflozin and Metformin Immediate Release (IR) (50 mg/1,000 mg) With Respect to the Individual Components of Canagliflozin (1 x 100 mg) and Metformin IR Tablets (2 x 1,000 mg) in Healthy Volunteers

Healthy

United States
University of Minnesota

Not yet recruiting

Pioglitazone-Metformin Combination Treatment for High Risk Oral Preneoplasia

Oral Leukoplakia

United States
Fudan University

Recruiting

Metformin and Insulin to Pancreatic Cancer Related Diabetes (Type 3c)

Diabete Mellitus | Pancretic Cancer

China
Lille Catholic University
Centre Hospitalier Arras

Recruiting

Impact of Metformin on Leptin Transport in Cerebrospinal Fluid of Obese Patients (LEPTOB)

Obesity Without Type 2 Diabetes, With BMI>30

France
Bethesda Diabetes Research Center
University Medical Center Groningen; Maastricht University Medical Center; Medical... and other collaborators

Recruiting

Pregnancy Outcomes: Effects of Metformin Study (POEM Study) (POEM)

Insulin Resistance | Gestational Diabetes

Netherlands
Chang Gung Memorial Hospital

Unknown

Gut Microbiota and Bile Acids in Type 2 Diabetes Mellitus

Diabetes Mellitus, Type 2 | Metformin | YH1

Taiwan
GlaxoSmithKline

Completed

AVANDAMET Versus Metformin For Type 2 Diabetes Mellitus

Diabetes Mellitus, Type 2

Canada
Hospices Civils de Lyon

Unknown

Metformin Use in Chronic Kidney Disease: The CKD-Met Study (CKD-Met)

Type 2 Diabetes | Chronic Kidney Disease

France
AstraZeneca
Bristol-Myers Squibb

Completed

A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Saxagliptin (BMS-477118) in Combination With Metformin IR or Metformin XR in Pediatric Patients With Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin Alone

Diabetes Mellitus, Type 2

United States, Mexico, Canada, United Kingdom, India, Belgium, Taiwan
Hoffmann-La Roche

Completed

A Study of Taspoglutide Versus Placebo for the Treatment of Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin Plus Pioglitazone.

Diabetes Mellitus Type 2

United States, France, Canada, Mexico, Guatemala, Germany, Brazil, Puerto Rico, Costa Rica
Boehringer Ingelheim
Eli Lilly and Company

Completed

Bioequivalence of a Fixed Dose Combination Tablet of Empagliflozin/Metformin Extended Release Compared With Mono Compound Tablets in Healthy Subjects

Healthy

Germany
Fundación Pública Andaluza para la gestión de la...

Unknown

Metformin Experience on Minimal Hepatic Encephalopathy (EME)

Liver Cirrhosis | Hepatic Encephalopathy

Spain
LG Life Sciences

Completed

Trial to Evaluate the Efficacy and Safety of Gemigliptin Compared With Placebo Added on Insulin Alone or on Insulin in Combination With Metformin in Type 2 DM (ZEUS II Study)

Type 2 Diabetes Mellitus
The Catholic University of Korea
Bayer

Completed

Study to Evaluate the Efficacy of Acarbose,Metformin,Sitagliptin Combination Treatment in DM Patients

Type 2 Diabetes Mellitus

Korea, Republic of
Novo Nordisk A/S

Completed

Effect of Liraglutide as add-on to Metformin Compared to Either Liraglutide or Metformin Alone, or to a Combination of Metformin and a SU (Sulphonylurea) Agent in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

Germany, Poland, United Kingdom, Denmark, France, Austria, Czech Republic, Australia
GlaxoSmithKline

Completed

A Type 2 Diabetes Study of the Longer-Term Glycemic Effect of AVANDAMET vs. Metformin

Diabetes Mellitus, Type 2

United States, Taiwan, Argentina, Canada, Philippines, Korea, Republic of, Mexico, Brazil, Pakistan
PT. Pyridam Farma Tbk
PT Pharma Metric Labs

Completed

Bioequivalence Study of Metformin Hydrochloride 500 mg Film-Coated Tablets in Indonesia Healthy Subject

Drug Use

Indonesia
Hager salah el din

Completed

Evaluation of the Effect of Metformin on Metastatic Breast Cancer as Adjuvant Treatment

Metastatic Breast Cancer

Egypt
Jiangsu HengRui Medicine Co., Ltd.

Unknown

Dual Add-on Therapy in Type 2 Diabetes Poorly Controlled With Metformin Monotherapy

Diabetes Mellitus, Type II
National Cheng-Kung University Hospital

Terminated

Metformin in Stage IV Lung Adenocarcinoma

Non-small Cell Lung Cancer

Taiwan

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