Search clinical trials for: NK-1R antagonist

Total 33352 results

Norgine

Completed

A Multi-centre, Phase II, Double-blind, Randomised, Placebo-controlled, Parallel Group, Dose-ranging Study in Patients With Faecal Incontinence; to Evaluate the Efficacy, Safety and Tolerability of Locally Applied NRL001 Over an 8 Week Treatment Period

Faecal Incontinence

Spain, Poland, United Kingdom, Czech Republic, France, Germany, Hungary, Italy, Sweden
HealthCore-NERI
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function (TOPCAT)

Heart Diseases | Cardiovascular Diseases | Heart Failure, Congestive

United States, Canada, Brazil, Argentina, Georgia, Russian Federation
M.D. Anderson Cancer Center

Recruiting

Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells Delivered Intraperitoneally for the Management of Platinum Resistant Ovarian Cancer, Mesonephric-like Adenocarcinoma, and Pancreatic Cancer

Adenocarcinoma | Pancreatic Cancer | Ovarian Cancer

United States
China Medical University, China

Not yet recruiting

Anti-PD-1 Antibody Combined With Autologous DC and NK Cells in the Treatment of Digestive Carcinoma

PD-1 Antibody | Gastrointestinal Tumours | DC-Cell | NK-Cell
The George Institute

Not yet recruiting

The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect (CAPTIVATE)

Chronic Kidney Diseases
Fifth Affiliated Hospital, Sun Yat-Sen University

Completed

Olanzapine or Dexamethasone, With 5-HT3 RA and NK-1 RA, to Prevent CINV

Chemotherapy-induced Nausea and Vomiting

China
National Institute of Diabetes and Digestive and...
American Diabetes Association

Completed

Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH Men

Hypogonadism

United States
Monica Thakar

Completed

Phase 2 STIR Trial: Haploidentical Transplant and Donor Natural Killer Cells for Solid Tumors (STIR)

Osteosarcoma | Ewing Sarcoma | Neuroblastoma | Rhabdomyosarcoma | CNS Tumors

United States
University Ghent
Research Foundation Flanders

Completed

Influence of Endurance Exercise and Histamine Receptors on the Gene Expression in Skeletal Muscle

Exercise | Histamine

Belgium
GlaxoSmithKline

Completed

SUrvey of Guideline Adherence for Treatment of Systolic Heart Failure in Real World (SUGAR)

Heart Failure, Congestive

Korea, Republic of
Roswell Park Cancer Institute
National Comprehensive Cancer Network

Active, not recruiting

Use of Trifluridine/Tipiracil and Oxaliplatin as Induction Chemotherapy for the Treatment of Resectable Esophageal or Gastroesophageal Junction (GEJ) Adenocarcinoma

Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8 | Clinical Stage III Esophageal Adenocarcinoma AJCC v8 | Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8 | Pathologic Stage IIB Esophageal Adenocarcinoma AJCC v8 | Pathologic Stage III Esophageal Adenocarcinoma AJCC v8 and other conditions

United States
Hong Kong Children's Hospital
The University of Hong Kong

Recruiting

Quadruple Immunotherapy for Neuroblastoma

Neuroblastoma Recurrent

Hong Kong
Actelion

Withdrawn

Correlation of LONGterm Wrist ACTigraphy Recorded Physical Performance & 6-minute Walk Distance in Patients With Pulmonary Arterial Hypertension (LONGACT)

Pulmonary Arterial Hypertension
Nationwide Children's Hospital
National Pediatric Cancer Foundation

Recruiting

A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue (TINKS)

Pediatric Sarcoma, Refractory | Pediatric Sarcoma, Relapsed

United States
Royal Devon and Exeter NHS Foundation Trust
King's College London; King's College Hospital NHS Trust; Newcastle University; Newcastle-upon-Tyne Hospitals NHS Trust and other collaborators

Completed

PROMASTER - PROspective Cohort MRC ABPI STratification and Extreme Response Mechanism in Diabetes (PROMASTER)

Diabetes

United Kingdom
Wuhan Union Hospital, China
Shanghai Simnova Biotechnology Co.,Ltd.

Recruiting

Cord Blood Derived Anti-CD19 CAR-Engineered NK Cells for B Lymphoid Malignancies

Chronic Lymphocytic Leukemia | Acute Lymphocytic Leukemia | Non Hodgkin's Lymphoma

China
Memorial Sloan Kettering Cancer Center
Y-mAbs Therapeutics

Active, not recruiting

Humanized Anti-GD2 Antibody Hu3F8 and Allogeneic Natural Killer Cells for High-Risk Neuroblastoma

Neuroblastoma | High-Risk

United States
KBP Biosciences

Completed

Safety, Tolerability and Pharmacokinetics of KBP-5074 in Healthy Subjects and Subjects With Renal Impairment

Healthy | Renal Insufficiency

United States
Sociedad de Lucha Contra el Cáncer del Ecuador

Not yet recruiting

5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gliomas

Glioma | Neoplasms, Neuroepithelial | Neuroectodermal Tumors | Central Nervous System Neoplasms | Brain Tumor | High Grade Glioma | Glioma, Malignant | Neoplasm Malignant | Photosensitizing Agents | Tumour, Residual | Brain Neoplasms, Adult, Malignant

Ecuador
Xinqiao Hospital of Chongqing
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Recruiting

Anti-BCMA CAR-NK Cell Therapy for the Relapsed or Refractory Multiple Myeloma

Multiple Myeloma, Refractory

China
Wuhan Union Hospital, China
Chengdu USino Technology Biology Co., Ltd

Recruiting

Universal Chimeric Antigen Receptor-modified AT19 Cells for CD19+ Relapsed/Refractory Hematological Malignancies

B-cell Lymphoma | Acute Lymphoblastic Leukemia | Chronic Lymphoblastic Leukemia

China
University of California, San Diego
Centocor, Inc.

Completed

Infliximab (Remicade) for Patients With Acute Kawasaki Disease

Kawasaki Disease

United States
Fayoum University

Not yet recruiting

Progesterone Primed Ovarian Stimulation Protocol Versus Antagonist Protocol for PCO Patient

Polycystic Ovary Syndrome | Infertility | IVF
Xinqiao Hospital of Chongqing
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Recruiting

Anti-CD33 CAR NK Cells in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia

Leukemia, Myeloid, Acute

China
Imperial College London
Institute of Neuroscience and Medicine, Julich, Germany

Withdrawn

Investigating Salt Taste Threshold in Patients Being Investigated for Primary Hyperaldosteronism Before and After Treatment. (AldoSalt)

Hypertension | Hyperaldosteronism; Primary | Salt; Excess | Appetite Disorders

United Kingdom
M.D. Anderson Cancer Center

Recruiting

A Phase Ib Trial of Azacitidine, Venetoclax and Allogeneic NK Cells for Acute Myeloid Leukemia (ADVENT-AML)

Acute Myeloid Leukemia

United States
Joaquín Martínez López, MD, PhD
Hospital Infantil Universitario Niño Jesús, Madrid, Spain

Completed

Clinical Trial of Expanded and Activated Autologous NK Cells to Treat Multiple Myeloma (NK-VS-MM)

Multiple Myeloma

Spain
Altor BioScience
M.D. Anderson Cancer Center

Withdrawn

ALT-801-activated Natural Killer Cells After FLAG Induction for Acute Myeloid Leukemia

Acute Myeloid Leukemia

United States
CanariaBio Inc.
Korean Cancer Study Group

Recruiting

Oregovomab in Combination With Bevacizumab Plus Chemo in BRCA Wild Type Platinum Sensitive Recurrent Ovarian Cancer

Ovarian Cancer Stage IV | Ovarian Cancer Stage III | Ovarian Cancer by FIGO Stage

Korea, Republic of
Ajjai Alva, MD
Hoosier Cancer Research Network; Bayer Healthcare Pharmaceuticals, Inc./Bayer...

Terminated

Androgen Deprivation Therapy +/- Radium-223 Dichloride in Metastatic Prostate Cancer With Bone Metastases

Prostate Cancer | Bone Metastases | Prostate Neoplasms

United States
New Approaches to Neuroblastoma Therapy Consortium
Nationwide Children's Hospital; United Therapeutics

Active, not recruiting

Immunotherapy of Relapsed Refractory Neuroblastoma With Expanded NK Cells

Neuroblastoma

United States
Kowa Research Institute, Inc.

Completed

A Comparison Study to Evaluate the Pharmacokinetics and Safety of NK-104-CR in Healthy Adult Volunteers

Hyperlipidemia

United States
Bayer

Completed

A Study Using Surveys to Learn More About Treatment With Steroidal Mineralocorticoid Receptor Antagonists, How They Are Used, What Side Effects They Have, and How Satisfied People Who Receive Them Are in the US

Heart Failure | Type 2 Diabetes Mellitus | Chronic Kidney Disease

United States
Xiaojun Chen

Recruiting

GnRHa + Letrozole in Obese Progestin-insensitive Endometrial Cancer Patients

Obesity | Atypical Endometrial Hyperplasia | Endometrial Neoplasms | Progesterone Resistance

China
Institute for Human Reproduction (IHR)

Completed

GnRH Antagonist to Prepare Recipients for Embryo Transfer

Infertility

United States
Hvidovre University Hospital

Completed

Incretin Hormone Antagonism After Bariatric Surgery (INCA-BAR)

Bariatric Surgery

Denmark
ShangHai Ji Ai Genetics & IVF Institute

Completed

Effect of GH Supplementation on the Blastocyst Euploid Rate in AMA Patients--A Retrospective Cohort Study

Growth Hormone | Advanced Maternal Age | PGT-A

China
Riyadh Fertility and Reproductive Health center

Unknown

Growth Hormone Co-treatment Within a GnRH Antagonist Protocol in Patients With Poor Ovarian Response

Infertility, Female

Egypt
Xiaojun Chen

Recruiting

GnRHa + Letrozole in Obese Progestin-insensitive Endometrial Atypical Hyperplasia Patients

Obesity | Atypical Endometrial Hyperplasia | Progesterone Resistance

China
Gynecologic Oncology Trial & Investigation Consortium
Japanese Gynecologic Oncology Group

Completed

Intraperitoneal Therapy For Ovarian Cancer With Carboplatin Trial (iPocc)

Fallopian Tube Cancer | Epithelial Ovarian Cancer | Primary Peritoneal Carcinoma

Japan, United States, Hong Kong, Korea, Republic of, New Zealand, Singapore
Washington University School of Medicine
University of Pennsylvania

Withdrawn

CLCNKA (Ka Renal Chloride Channel[ClC-Ka]) Polymorphism Effects on Hypertrophy Regression

Hypertension

United States
ShangHai Ji Ai Genetics & IVF Institute

Not yet recruiting

Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Women With PCOS Undergoing PGT-A

GnRH Antagonist | Polycystic Ovarian Syndrome | Preimplantation Genetic Testing | Progestin-primed Ovarian Stimulation
ClinAmygate
Cairo University; Al-Azhar University; Beni-Suef University

Completed

Coasting Versus Antagonist Protocol in Patients at High Risk of OHSS

Ovarian Hyperstimulation Syndrome

Egypt
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Bortezomib and Vorinostat in Treating Patients With Multiple Myeloma Who Have Undergone Autologous Stem Cell Transplant

DS Stage I Plasma Cell Myeloma | DS Stage II Plasma Cell Myeloma | DS Stage III Plasma Cell Myeloma

United States
Biogen

Completed

Sorafenib With BIIB022 in Hepatocellular Carcinoma (HCC)

Hepatocellular Carcinoma

United States, Singapore, Taiwan, United Kingdom
Dana-Farber Cancer Institute
Bristol-Myers Squibb; Altor BioScience; Miltenyi Biomedicine GmbH

Recruiting

CIML NK Cell in Head & Neck Cancer

Squamous Cell Carcinoma of the Head and Neck | Recurrent Head and Neck Squamous Cell Carcinoma

United States
KBP Biosciences

Completed

Safety, Tolerability, and Pharmacokinetics of KBP-5074 Following Oral Administration in Chronic Kidney Disease

Chronic Kidney Disease

United States
ImmunityBio, Inc.

Terminated

QUILT-3.063: A Study of N-803, haNK and Avelumab in Patients With Merkel Cell Carcinoma That Has Progressed After Checkpoint Therapy

Merkel Cell Carcinoma

United States
Instituto de Investigación Hospital Universitario...
Fundación Mutua Madrileña; Hospital Infantil Universitario Niño Jesús, Madrid...

Completed

NK Cells as Consolidation Therapy of Acute Myeloid Leukemia in Children/Adolescents

Acute Myeloid Leukemia | Leukemia | Myeloid Leukemia

Spain
Biogen

Terminated

Oral Tonapofylline (BG9928) in Patients With Heart Failure and Renal Insufficiency (POSEIDON)

Heart Failure | Renal Insufficiency

United States

Search clinical trials for: NK-1R antagonist

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