Search clinical trials for: NOT program

Total 24734 results

M.D. Anderson Cancer Center

Recruiting

Pegloticase for the Reduction of Uric Acid in Patients With Tumor Lysis Syndrome

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | Tumor Lysis Syndrome

United States
Mahidol University

Recruiting

Bilateral Superficial Cervical Plexus Block in Thyroid/Parathyroid Surgery

Hyperparathyroidism | Benign Tumor of Thyroid

Thailand
Hoffmann-La Roche

Recruiting

A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study (IMbrella B)

Cancer

United States, France, Korea, Republic of, Taiwan, Japan, Spain, Belgium, Brazil, Czechia, Romania, Thailand, Australia, Bulgaria, Canada, Chile, Denmark, Germany, Greece, Guatemala, Hungary, Latvia, Mexico, Norway, Poland, Slovakia, Swit... and more
National Cancer Institute (NCI)

Active, not recruiting

Durvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung Cancer

Metastatic Lung Non-Small Cell Carcinoma | Stage IV Colorectal Cancer AJCC v7 | Stage IVA Colorectal Cancer AJCC v7 | Stage IVB Colorectal Cancer AJCC v7 | Metastatic Colorectal Carcinoma | Stage IV Lung Non-Small Cell Cancer AJCC v7

United States, Canada
Hoffmann-La Roche

Active, not recruiting

A Study of Multiple Immunotherapy-Based Treatment Combinations in Hormone Receptor (HR)-Positive Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Breast Cancer (MORPHEUS HR+BC)

Breast Neoplasms

United States, Israel, Korea, Republic of
Hoffmann-La Roche

Completed

A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420.

Acute Myeloid Leukemia

Australia, Italy, Canada, United Kingdom, United States, Denmark, Spain, Taiwan, Germany, France
Cairo University

Completed

Analgesic Efficacy of Sequential Rapid Versus Slow Intrathecal Injection Of Dexmedetomidine Followed by of Hyperbaric Bupivacaine in Inguinal Hernia Repair Surgery

Postoperative Pain

Egypt
Minia University

Completed

Ketamine Versus Dexmedetomidine in Supraclavicular Brachial Plexus Block

Supraclavicular Brachial Plexus Block

Egypt
Hoffmann-La Roche
Norwegian Radium Hospital

Completed

A Study of Bevacizumab (Avastin) in Combination With Neoadjuvant Treatment Regimens in Participants With Primary Human Epidermal Growth Factor Receptor 2 (HER2) Negative Breast Cancer

Breast Cancer

Norway
Eli Lilly and Company

Completed

A Study of LY3484356 in Healthy Female Participants

Healthy

United States
Hackensack Meridian Health

Terminated

In-vivo Regulatory T Cell Enhancement With Cyclophosphamide and Sirolimus (T-REG)

Graft Versus Host Disease

United States
Al Mashfa Medical Center

Completed

Quality of Recovery Following Opioids Free Anaesthesia in Laparoscopic Sleeve Gastrectomy

Analgesia | Bariatric Surgery | Narcotics | Recovery Quality

Saudi Arabia
M.D. Anderson Cancer Center
National Cancer Institute (NCI); Cancer Prevention Research Institute of Texas

Completed

Fucosylated T Cells for Graft Versus Host Disease (GVHD) Prevention

Lymphoma | Leukemia

United States
Chosun University Hospital

Completed

Effect of Dexmedetomidine After Thyroidectomy

Thyroid Tumor

Korea, Republic of
Joanneum Research Forschungsgesellschaft mbH

Completed

An Exploratory Study in Healthy Volunteers to Identify Factors Influencing Bioequivalence Studies on Moderately Lipophilic Drugs Using Dermal Open Flow Microperfusion (dOFM)

Healthy | Dermal Pharmacokinetic Measurements

Austria
Menoufia University

Completed

Conscious Sedation for Epilepsy Surgery

Epilepsy
Abd-Elazeem Abd-Elhameed Elbakry

Completed

Dexmedetomidine and Pregabalin for Conscious Sedation During Cataract Surgery

Conscious Sedation

Egypt
Assiut University

Completed

Dexmedetomidine Versus Midazolam Added to Ketamine in Pediatric Patients Undergoing Bone Marrow Aspiration and Biopsy

Procedural Sedation and Analgesia During Bone Marrow Aspiration and Biopsy

Egypt
Mansoura University

Unknown

Caudal Versus Intravenous Magnesium Sulfate on Emergence Agitation After Sevoflurane In Children.

Postoperative Pain | Emergence Agitation

Egypt
Leaf Vertical Inc.

Unknown

A Study of the Efficacy of Cannabidiol in Patients With Multiple Myeloma, Glioblastoma Multiforme, and GI Malignancies

Glioblastoma Multiforme | Cancer of Liver | Cancer of Pancreas | Cancer of Colon | Myeloma Multiple | Cancer of Rectum | Cancer, Gall Bladder

United States
Nationwide Children's Hospital

Completed

Measures to Lower the Stress Response in Pediatric Cardiac Surgery

Tetralogy of Fallot (TOF) | Ventricular Septal Defects (VSD) | Atrioventricular Septal Defects (AVSD)

United States
National Cancer Institute (NCI)

Completed

Wilm's Tumor 1 Protein Vaccine to Treat Cancers of the Blood

Myelodysplastic Syndrome (MDS) | Non-Hodgkin's Lymphoma (NHL) | Leukemia, Acute Myelogenous (AML) | Leukemia, Acute Lymphocytic (ALL) | Leukemia, Chronic Myelogenous (CML)

United States
Novartis

Completed

Evaluation of Efficacy and Safety of Tablets of Paracetamol, Dimethindene Maleate and Phenylephrine Hydrochloride in Reducing Symptoms of Common Cold and Flu

Nasal Congestion | Rhinorrhea | Sneezing | Upper Respiratory Tract Infection

Brazil
National Cancer Institute (NCI)

Completed

Radiation, Chemotherapy, Vaccine and Anti-MART-1 and Anti-gp100 Cells for Patients With Metastatic Melanoma

Melanoma | Skin Cancer

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Fusion Protein Cytokine Therapy After Rituximab in Treating Patients With B-Cell Non-Hodgkin Lymphoma

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Diffuse Small Cleaved Cell Lymphoma | Recurrent Grade 1 Follicular Lymphoma | Recurrent Grade 2 Follicular Lymphoma | Recurrent Marginal Zone Lymphoma | Splenic... and other conditions

United States
The Affiliated Hospital of the Chinese Academy...

Completed

HLA-mismatched MST vs HLA-matched NST for AML in Intermediate-risk

Acute Myeloid Leukemia

China
University of British Columbia

Unknown

Androgen Suppression Combined With Elective Nodal and Dose Escalated Radiation Therapy

Prostate Cancer

Canada
National Cancer Institute (NCI)

Completed

Peptide Vaccination for Patients at High Risk for Recurrent Melanoma

Melanoma

United States
National Center for Research Resources (NCRR)
University of California, Los Angeles; National Institute of Neurological Disorders...

Completed

Phase II Randomized Study of Early Surgery Vs Multiple Sequential Antiepileptic Drug Therapy for Infantile Spasms Refractory to Standard Treatment

Epilepsy | Spasms, Infantile
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Institutes of Health (NIH)

Terminated

Crohn's Allogeneic Transplant Study (CATS)

Crohn Disease

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); The Wayne D. Kuni and Joan E. Kuni Foundation

Completed

Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation, and Donor Bone Marrow Transplant Followed by Donor Natural Killer Cell Therapy, Mycophenolate Mofetil, and Tacrolimus in Treating Patients With Hematologic Cancer

Diffuse Large B-Cell Lymphoma | Acute Myeloid Leukemia | Refractory Hodgkin Lymphoma | Previously Treated Myelodysplastic Syndrome | Recurrent Mantle Cell Lymphoma | Waldenstrom Macroglobulinemia | Acute Lymphoblastic Leukemia | Refractory Plasma Cell Myeloma | Recurrent Small Lymphocytic Lymphoma | Refractory... and other conditions

United States
Kasr El Aini Hospital

Recruiting

Dexmedetomidine Infusion Dose Versus Rapid Bolus Dose Before Tracheal Intubation.

Dexmedetomidine | Intubation Complication

Egypt
Merck Sharp & Dohme LLC

Recruiting

Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) and Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009)

Non-small Cell Lung Cancer (NSCLC)

United States, Korea, Republic of
Washington University School of Medicine
United States Department of Agriculture (USDA); Project Peanut Butter; Ministry... and other collaborators

Recruiting

Improving Cognition and Gestational Duration With Targeted Nutrition (COGENT)

Postpartum Depression | Preterm Birth | Child Development | Malnutrition in Pregnancy | Antepartum Depression

Sierra Leone
Dizal Pharmaceuticals

Recruiting

Drug-drug Interactions Between AZD4205 and Itraconazole/Carbamazepine

Healthy Subjects

United States
M.D. Anderson Cancer Center

Recruiting

A Phase II Study of Vibecotamab (XmAb14045) for MRD- Positive AML and MDS After Hypomethylating Agent Failure

AML | MDS

United States
Aretaieion University Hospital

Recruiting

Opioid-free Anesthesia in Thyroidectomies

Analgesia | Pain, Acute | Pain, Post Operative | Ketamine | Dexmedetomidine | Pain, Chronic | Fentanyl | Pain, Neuropathic | Lidocaine | Analgesics | Pain, Nociceptive | Analgesics Non-narcotic

Greece
Northwestern University
National Cancer Institute (NCI)

Recruiting

Mycophenolate Mofetil in Combination With Standard of Care for the Treatment of Glioblastoma

Glioblastoma | Astrocytoma | Recurrent Glioblastoma | MGMT-Unmethylated Glioblastoma | Glioblastoma, IDH-Wildtype

United States
Gangnam Severance Hospital

Recruiting

A Study to Reduce Persistent Post-mastectomy Pain Using Opioid-free Anesthesia (RELIEF)

Breast Cancer | Pain, Post Operative | Pain, Chronic | Mastectomy

Korea, Republic of
Duke University
Food and Drug Administration (FDA)

Recruiting

Opportunistic PK/PD Trial in Critically Ill Children (OPTIC) (OPTIC)

Critically Ill | Cardiac Disease | Children, Adult

United States
Ruijin Hospital

Not yet recruiting

The Safety and Effectiveness of Cholinergic Receptor Block Therapy in the Treatment of ALS

Amyotrophic Lateral Sclerosis | Respiratory Function | Scopolamine

China
University of Edinburgh
University College, London; NHS Lothian; University of Warwick

Recruiting

Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART)

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

United Kingdom
Hoffmann-La Roche

Active, not recruiting

A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy (MAJESTY)

Primary Membranous Nephropathy

United States, China, Spain, Argentina, Brazil, France, Italy, Russian Federation, Israel, Poland, Turkey, Ukraine
ImmunityBio, Inc.

Terminated

QUILT-3.039: NANT Pancreatic Cancer Vaccine: Combination Immunotherapy in Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy

Pancreatic Cancer

United States
Hoffmann-La Roche

Active, not recruiting

A Study To Evaluate The Efficacy And Safety Of Obinutuzumab In Patients With ISN/RPS 2003 Class III Or IV Lupus Nephritis (REGENCY)

Lupus Nephritis

United States, Italy, Argentina, Germany, Colombia, South Africa, Poland, United Kingdom, Russian Federation, Brazil, France, Peru, Spain, Israel, Mexico
H. Lee Moffitt Cancer Center and Research Institute
Bristol-Myers Squibb; Iovance Biotherapeutics, Inc.

Active, not recruiting

Ipilimumab With Lymphodepletion Plus Adoptive Cell Transfer and High Dose IL-2 in Melanoma Mets Pts

Metastatic Melanoma

United States
Vanderbilt University Medical Center
National Institutes of Health (NIH); National Institute of General Medical...

Terminated

Acetaminophen in aSAH to Inhibit Lipid Peroxidation and Cerebral Vasospasm

Aneurysmal Subarachnoid Hemorrhage | Cerebral Vasospasm

United States
National Cancer Institute (NCI)

Completed

Durvalumab and Vicineum in Subjects With High-Grade Non-Muscle-Invasive Bladder Cancer Previously Treated With Bacillus Calmette-Guerin (BCG)

Urinary Bladder Neoplasms

United States
Ain Shams University

Completed

Lumbar Epidural Analgesia Versus Local Anesthesia With Dexmedetomidine Infusion in Endoscopic Lumbar Discectomy

Lumbar Disc Herniation

Egypt
Pfizer

Completed

Drug-Drug Interaction Study Assessing Effect of Carbamazepine on PF-07321332 Boosted With Ritonavir

Healthy Participant

United States

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