Search clinical trials for: Orexin Receptor Antagonists

Total 37820 results

Actelion

Recruiting

A Study of Macitentan in Healthy Chinese Adult Male Participants

Healthy

China
University of Maryland, Baltimore

Withdrawn

Macitentan to Prevent PRVO (MAC-PRO)

Pulmonary Embolism

United States
Actelion

Completed

Clinical Study Assessing the Efficacy and Safety of Macitentan in Fontan-palliated Subjects (RUBATO)

Congenital Heart Disease

United States, United Kingdom, Taiwan, Germany, France, Poland, China, Australia, Czechia, Canada, Denmark, New Zealand
Janssen Research & Development, LLC

Completed

A Study of JNJ-61393215 in the Treatment of Depression

Major Depressive Disorder With Anxious Distress

United States, Moldova, Republic of, Russian Federation, Ukraine, United Kingdom
Actelion

Completed

Clinical Study to Assess the Safety, Tolerability and Efficacy of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension (MERIT-2)

Chronic Thromboembolic Pulmonary Hypertension

Poland, Ukraine, United Kingdom, China, Russian Federation, Belgium, Germany, Thailand, Hungary, France, Lithuania, Czechia, Mexico, Switzerland, Turkey
Actelion

Completed

A Study of Two Macitentan Formulations in Healthy Adult Participants

Healthy

Belgium
Actelion

Completed

Macitentan Use in an Idiopathic Pulmonary Fibrosis Clinical Study (MUSIC)

Idiopathic Pulmonary Fibrosis

United States, Israel, Spain, Australia, France, Canada, Turkey, Germany, Italy, South Africa, Slovenia, Sweden
Actelion

Completed

Study of Macitentan (ACT-064992) on Morbidity and Mortality in Patients With Symptomatic Pulmonary Arterial Hypertension (SERAPHIN)

Pulmonary Arterial Hypertension

United States, United Kingdom, Belarus, Argentina, Australia, Austria, Belgium, Bulgaria, Canada, Chile, China, Colombia, Croatia, France, Germany, Hong Kong, Hungary, India, Israel, Italy, Malaysia, Mexico, Netherlands, Norway, Peru, Poland and more
Eisai Inc.

Completed

Study of the Efficacy and Safety of Lemborexant in Subjects 55 Years and Older With Insomnia Disorder (SUNRISE 1) (SUNRISE 1)

Insomnia

United States, Spain, United Kingdom, Italy, Germany, France, Canada
KBP Biosciences

Completed

Safety, Tolerability, and Pharmacokinetics of KBP-5074 Following Oral Administration in Chronic Kidney Disease

Chronic Kidney Disease

United States
Actelion

Terminated

A Study to Evaluate Efficacy and Safety of Macitentan 75 mg in Inoperable or Persistent/Recurrent Chronic Thromboembolic Pulmonary Hypertension (MACiTEPH)

Chronic Thromboembolic Pulmonary Hypertension

United States, Germany, Japan, Korea, Republic of, Taiwan, Canada, United Kingdom, China, Austria, Italy, Bulgaria, Turkey, Spain, Thailand, Israel, Ukraine, Hungary, Mexico, Czechia, Russian Federation, France, Saudi Arabia, Singapore and more
Actelion

Completed

OPsumit USers Registry (OPUS)

Pulmonary Arterial Hypertension

United States, Puerto Rico
Actelion

Recruiting

A Study of Macitentan in Children Below 2 Years of Age

Arterial Hypertension, Pulmonary

Poland, Germany
Actelion

Recruiting

A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH) (TOMORROW)

Pulmonary Arterial Hypertension

United States, Korea, Republic of, Spain, Malaysia, China, Hungary, Mexico, Poland, Australia, Austria, Brazil, Canada, Colombia, France, Israel, Philippines, Portugal, Russian Federation, South Africa, Thailand, Ukraine, Vietnam, F...
Actelion

Completed

A Clinical Study to Investigate the Long-term Safety of the Drug Macitentan in Patients With Pulmonary Hypertension Who Were Previously Treated With Macitentan in Clinical Studies. (UMBRELLA)

Pulmonary Arterial Hypertension | Chronic Thromboembolic Pulmonary Hypertension

Belgium, France, Poland, Russian Federation, Belarus, Turkey, Ukraine
University of California, Los Angeles

Withdrawn

Macitentan in the Treatment of Organ Rejection After Lung Transplantation

Lung Transplant Rejection

United States
Actelion

Completed

Clinical Study to Evaluate the Effects of Macitentan on Exercise Capacity in Subjects With Eisenmenger Syndrome (MAESTRO)

Pulmonary Arterial Hypertension

China, Malaysia, United States, Austria, Bulgaria, Chile, France, Germany, Greece, Israel, Mexico, Philippines, Poland, Portugal, Romania, Russian Federation, Serbia, Spain, Turkey, United Kingdom, Vietnam
University Ghent
Research Foundation Flanders

Completed

Influence of Endurance Exercise and Histamine Receptors on the Gene Expression in Skeletal Muscle

Exercise | Histamine

Belgium
Nova Scotia Health Authority

Recruiting

Lemborexant for Insomnia in a Patient With Dementia: An N-of-1 Trial

Insomnia | Dementia | Frontotemporal Dementia

Canada
Beth Israel Deaconess Medical Center
Merck Sharp & Dohme LLC

Recruiting

Suvorexant and Sleep/Delirium in ICU Patients

Insomnia | Sleep Initiation and Maintenance Disorders | Postoperative Delirium | Sleep Fragmentation

United States
Brendan Lucey
Eisai Inc.

Withdrawn

Acute Effect of Lemborexant on CSF Amyloid-Beta and Tau

Alzheimer Disease

United States
Eisai Inc.

Completed

A Study to Evaluate Next-Dose Transition From Zolpidem to Lemborexant (LEM) for the Treatment of Insomnia

Insomnia

United States
Actelion

Completed

Clinical Study to Evaluate the Safety and Tolerability of Macitentan in Subjects With Combined Pre- and Post-capillary Pulmonary Hypertension (CpcPH) Due to Left Ventricular Dysfunction (MELODY-1)

Pulmonary Hypertension

United States, Austria, Belgium, Canada, Czechia, France, Germany, Israel, Italy, Spain, Switzerland
Brigham and Women's Hospital

Recruiting

Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study

Hypertension | Primary Aldosteronism

United States
Shanghai Chest Hospital

Not yet recruiting

Cardiac Adverse Reactions Related to Immune Checkpoint Inhibitor in NSCLC Patients

Cardiac Event | Immune Checkpoint Inhibitor | Adverse Reactions | Non-Small Cell Lung Cancer Patients
Milton S. Hershey Medical Center

Completed

The Efficacy of Suvorexant in Treatment of Patients With Substance Use Disorder and Insomnia: A Pilot Open Trial (Suvsubuse)

Sleep Disturbance | Craving | Cortisol; Hypersecretion

United States
The University of Texas Health Science Center,...
Peter F. McManus Charitable Trust

Completed

Role of the Orexin Receptor System in Stress, Sleep and Cocaine Use

Anxiety | Cocaine Use Disorder

United States
Impulse Dynamics

Terminated

Cardiac Contractility Modulation (CCM) Therapy in Subjects With Medically Refractory Heart Failure (IMPULSE-HF)

Heart Failure

Sweden, Austria, Germany, Poland
King Abdullah International Medical Research Center

Recruiting

The Efficacy of Leukotriene Inhibitor in Adult Patients With Moderate SARS-COV-2 Symptoms (COVID19) (PROMISE)

Moderate Covid19

Saudi Arabia
The First Affiliated Hospital with Nanjing Medical...
National Natural Science Foundation of China

Unknown

Different Platelet Activities Between Intracoronary and Peripheral Blood in Coronary Artery Disease Patients (DPABIAP)

Coronary Artery Disease

China
Actelion
EPS Corporation; Imepro Inc.; General Laboratory, BML, Inc.; Mitsubishi Logistics...

Terminated

A Clinical Study to Find Out if Macitentan is Effective and Safe in Japanese Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH).

Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Japan
University College, London
British Heart Foundation

Completed

Early Mineralocorticoid Receptor Antagonist Treatment to Reduce Myocardial Infarct Size (MINIMISE-STEMI)

ST-elevation Myocardial Infarction

United Kingdom
Actelion

Completed

Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis Patients (DUAL-1)

Systemic Sclerosis | Ulcers

Canada, United States, Belarus, Hungary, Croatia, Australia, Denmark, Ukraine, Bulgaria, Chile, Colombia, Czech Republic, Finland, Germany, India, Italy, Poland, Russian Federation
Actelion

Terminated

Clinical Study to Assess the Long-term Safety, Tolerability, and Efficacy of Macitentan in Subjects With Eisenmenger Syndrome (MAESTRO-OL)

Pulmonary Arterial Hypertension

China, Malaysia, United States, Austria, Bulgaria, Chile, France, Germany, Greece, Mexico, Philippines, Poland, Portugal, Romania, Russian Federation, Serbia, Spain, United Kingdom, Vietnam
Vanderbilt University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Brigham...

Completed

Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas

Primary Aldosteronism

United States
Washington University School of Medicine
Merck Sharp & Dohme LLC; Good Ventures Foundation

Recruiting

Sleep Trial to Prevent Alzheimer's Disease (SToP-AD)

Sleep | Alzheimer Disease

United States
Johns Hopkins University
National Institute on Drug Abuse (NIDA)

Completed

Medical Management of Sleep Disturbance During Opioid Tapering

Sleep Disturbance | Opioid Dependence | Opioid Withdrawal

United States
Actelion

Completed

Clinical Study to Assess the Efficacy and Safety of Macitentan in Patients With Pulmonary Hypertension After Left Ventricular Assist Device Implantation (SOPRANO)

Pulmonary Hypertension

United States
Actelion

Completed

Clinical Study to Investigate Effect of Macitentan on Riociguat Pharmacokinetics

Healthy Subjects

Germany
Actelion

Terminated

Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis Patients (DUAL-2)

Digital Ulcers

Spain, United States, Argentina, China, Ireland, Colombia, Israel, New Zealand, Germany, Belgium, Portugal, Netherlands, South Africa, Greece, Mexico, Poland, Puerto Rico, Russian Federation, Turkey, Ukraine, United Kingdom
Mclean Hospital

Recruiting

Targeting Orexin to Treat Nicotine Dependence

Nicotine Dependence

United States
The Scripps Research Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Completed

Medication Development in Alcoholism: Suvorexant Versus Placebo

Alcohol Use Disorder (AUD)

United States
Eisai Inc.
Purdue Pharma LP

Completed

Study of Lemborexant-Alcohol Interaction in Healthy Subjects

Healthy Subjects

Canada
Medical Practice Prof D. Ivanov

Completed

ARB, ACEi, DRi Effects on COVID-19 Course Disease (BIRCOV)

COVID-19 | Hypertension

Ukraine
HealthCore-NERI
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function (TOPCAT)

Heart Diseases | Cardiovascular Diseases | Heart Failure, Congestive

United States, Canada, Brazil, Argentina, Georgia, Russian Federation
Dr Sudarshan Rajagopal
Actelion

Not yet recruiting

Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodynamics in CTEPH (EPIPHANY)

CTEPH

United States
Abbott

Completed

A Long Term Safety Study With Atrasentan

Adenocarcinoma | Prostate Cancer

Canada, United States, France, Netherlands, United Kingdom
Johns Hopkins University
Fast Grants

Terminated

Prazosin to Prevent COVID-19 (PREVENT-COVID Trial) (PREVENT)

COVID-19

United States
MelCure SA
Universitaire Ziekenhuizen KU Leuven; University of Bern; California Institute...

Terminated

Proof of Concept Study With an Endothelin Receptor B Inhibitor (BQ-788) for Human Melanoma

Melanoma
Actelion
Chiltern International Ltd.; Medidata Solutions; Frontier Science & Technology... and other collaborators

Terminated

A Long Term Study to Find Out if Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease (SERENADE OL)

Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease

United States, United Kingdom, Israel, Austria, Russian Federation, Germany, Poland, Denmark, Argentina, Brazil, Bulgaria, France, Hungary, Romania, Sweden

Search clinical trials for: Orexin Receptor Antagonists

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