Search clinical trials for: PI3K inhibitor

Total 64198 results

University of California, Irvine
Taiho Pharmaceutical Co., Ltd.

Completed

TAS-102 and Irinotecan in 2L+ Gastric and Gastroesophageal Adenocarcinoma

Gastric Adenocarcinoma | GastroEsophageal Cancer

United States
Ain Shams University

Completed

Effect of Dipeptidyl Peptidase- 4 Inhibitors on Non-Alcoholic Steatohepatitis and Type 1 Diabetes

Diabetes Mellitus, Type 1 | NASH

Egypt
National Cancer Institute (NCI)

Active, not recruiting

Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial)

Soft Tissue Sarcoma | Osteosarcoma | Ewing Sarcoma | Malignant Glioma | Ependymoma | Rhabdoid Tumor | Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Rhabdomyosarcoma | Recurrent Malignant Solid Neoplasm | Recurrent Neuroblastoma | Refractory Neuroblastoma | Refractory Non-Hodgkin Lymphoma and other conditions

United States, Puerto Rico
Leiden University Medical Center
Radboud University Medical Center; AstraZeneca; University Medical Center Groningen and other collaborators

Active, not recruiting

Durvalumab and Olaparib in Metastatic or Recurrent Endometrial Cancer (DOMEC)

Uterine Neoplasms | Endometrial Neoplasms | Endometrium Cancer

Netherlands
Baxalta now part of Shire

Completed

GLASSIA Infusion Rate Study

Healthy Volunteers | Alpha1-antitrypsin Deficiency

United States
Fundación FLS de Lucha Contra el Sida, las Enfermedades...

Completed

Multicentre Study To Assess Changes In Bone Mineral Density Of The Switch From Protease Inhibitors To Dolutegravir In HIV-1-Infected Subjects With Low Bone Mineral Density

HIV-1 Infection

Spain
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Dabrafenib and Trametinib Before and After Surgery in Treating Patients With Stage IIIB-C Melanoma With BRAF V600 Mutation

Stage IIIC Cutaneous Melanoma AJCC v7 | Stage IIIB Cutaneous Melanoma AJCC v7

United States
Uma Borate

Recruiting

SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation

Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | Acute Myeloid Leukemia With FLT3/ITD Mutation | Acute Myeloid Leukemia With KMT2A Rearrangement | Acute Myeloid Leukemia With NPM1 Mutation

United States
University of British Columbia

Terminated

Sitagliptin in Cystic Fibrosis-Related Diabetes

Cystic Fibrosis

Canada
Chinese PLA General Hospital

Completed

GSL Synthetase Inhibitor in Combination With Immune Checkpoint Inhibitor in Previously Treated Blood and Solid Tumor

Solid Tumor | Hematologic Malignancy

China
AVM Biotechnology Inc

Available

Expanded Access to Immunomodulatory AVM0703 for Solid Tumor and Blood Cancer Patients

Cancer | Breast Cancer | Glioblastoma | Gastric Cancer | Pancreatic Cancer | Hodgkin Lymphoma | Ovarian Cancer | Prostate Cancer | Acute Leukemia | Non-hodgkin Lymphoma | Squamous Cell Carcinoma | Tumor, Solid | Tumor, Brain | Spindle Cell Sarcoma
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors

Glioblastoma | Gliosarcoma | Ependymoma | Anaplastic Astrocytoma | Oligodendroglioma | Anaplastic Ependymoma | Giant Cell Glioblastoma | Astrocytoma, Grade II | Brainstem Tumors

United States
Cascadian Therapeutics Inc.

Terminated

Study of PX-866 and Vemurafenib in Patients With Advanced Melanoma

Advanced BRAF-mutant Cancers

United States
H. Lee Moffitt Cancer Center and Research Institute
Novartis Pharmaceuticals

Terminated

Oral LBH589 in Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL)

Non-Hodgkin's Lymphoma

United States
AstraZeneca

Completed

A Study to Assess the Safety and Pharmacokinetics of an Inhibitor of Poly ADP-Ribose Polymerase-1 (PARP)

Ovarian Neoplasms | BRCA1 Protein | BRCA2 Protein

Netherlands, Belgium, United Kingdom, Poland
Jiangsu HengRui Medicine Co., Ltd.

Terminated

A Study of Camrelizumab Combined With Rivoceranib Mesylate Versus Investigator's Choice of Regimen in Treatment of Patients With Advanced Hepatocellular Carcinoma (HCC)

Advanced Hepatocellular Carcinoma (HCC)

China
AstraZeneca
KuDOS Pharmaceuticals Limited

Completed

Study to Assess the Efficacy and Safety of a PARP Inhibitor for the Treatment of BRCA-positive Advanced Ovarian Cancer (ICEBERG 2)

Ovarian Neoplasm

United States, Spain, Australia, Germany, Sweden
Takeda

Completed

Study of the QOL Evaluation of Trelagliptin in Patients With Type 2 Diabetes Mellitus (TRENDS)

Type 2 Diabetes

Japan
Institute of Cancer Research, United Kingdom

Active, not recruiting

Stereotactic Body Radiotherapy for the Treatment of OPD (HALT)

NSCLC

United Kingdom, France, Switzerland, Italy, Spain
Hoffmann-La Roche

Completed

A Study of Avastin (Bevacizumab) in Combination With Thoracic Radiation and Chemotherapy in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer.

Non-Squamous Non-Small Cell Lung Cancer

Netherlands, United Kingdom
National Medical Research Center for Therapy and...

Recruiting

Efficacy and Safety of Pitavastatin and PCSK9 Inhibitors in Liver Transplant Patients (PINTL)

Dyslipidemias | Hyperlipidemias | Liver Transplant Disorder | Immunosuppression | Hydroxymethylglutaryl-CoA Reductase Inhibitors | Statins

Russian Federation
Baxalta now part of Shire
Arriva Pharmaceuticals, Inc.

Completed

Safety Study of an Aerosolized, Recombinant Alpha 1-Antitrypsin in Subjects With Alpha 1-Antitrypsin Deficiency

Alpha1-antitrypsin Deficiency

United States
Kamada, Ltd.

Completed

International Study Evaluating the Safety and Efficacy of Inhaled, Human, Alpha-1 Antitrypsin (AAT) in Alpha-1 Antitrypsin Deficient Patients With Emphysema

Emphysema

United Kingdom, Canada, Denmark, Germany, Ireland, Netherlands, Sweden
Assiut University

Not yet recruiting

Maternal alpha1 Antitrypsin as a Marker of Intrauterine Growth Restriction in Pre-eclamptic Women

Pre-Eclampsia | Intrauterine Growth Restriction | alpha1 Anti-trypsin
University of Florida

Recruiting

The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) Study (ACT)

Alpha-1 Antitrypsin Deficiency

United States
Instituto Grifols, S.A.

Completed

Study to Evaluate the Safety and Efficacy of Prolastin in Hospitalized Subjects With COVID-19

COVID-19

Spain
Ministry of Health, Saudi Arabia

Unknown

Trial of Alpha One Antitrypsin Inhalation in Treating Patient With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Coronavirus

Saudi Arabia
CSL Behring

Completed

Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency.

Emphysema | Alpha 1-proteinase Inhibitor Deficiency

Australia, Canada, Czech Republic, Denmark, Estonia, Finland, Germany, Ireland, Poland, Romania, Sweden
Samsung Medical Center

Unknown

The Proton Pump Inhibitor (PPI) Test for the Extraesophageal Manifestation of GERD

Gastroesophageal Reflux Disease

Korea, Republic of
University of Wisconsin, Madison

Completed

Campath-1H Induction to Allow Discontinuation of Calcineurin Inhibitors After Renal Transplantation

Primary Renal Transplant

United States
Pharmasset

Completed

Study Comparing Racivir and Lamivudine in Treatment-Experienced HIV Subjects

HIV Infections

United States, Argentina, Mexico, Panama
Rabin Medical Center
Kamada, Ltd.

Completed

Long Term Treatment Effect of the Safety, Tolerability and Efficacy of AAT in Type 1 Diabetes (AAT Extension)

Type 1 Diabetes | Beta Cell Preservation

Israel
Virginia Commonwealth University

Completed

Alpha-1 Anti-Trypsin (AAT) Treatment in Acute Myocardial Infarction (VCU-Alpha1RT)

Acute Myocardial Infarction

United States
AstraZeneca
KuDOS Pharmaceuticals Limited

Completed

Study to Assess the Safety and Tolerability of a PARP Inhibitor in Combination With Topotecan

Malignant Solid Tumors

United Kingdom
Ottawa Hospital Research Institute
GlaxoSmithKline; Hamilton Health Sciences Corporation; London Regional Cancer... and other collaborators

Completed

A Phase II Window of Opportunity Trial of PRMT5 Inhibitor, GSK3326595, in Early Stage Breast Cancer (OTT-19-06)

Breast Cancer

Canada
Hoffmann-La Roche

Completed

A Comparative Study to Observe the Effect of Concomitant Use of Corticosteroid Treatment in Rheumatoid Arthritis (RA) Participants Who Are Treated With a Tumor Necrosis Factor (TNF) Inhibitor or Tocilizumab (TCZ) as Their Second Biological Treatment.

Rheumatoid Arthritis

Sweden
National Heart Centre Singapore
National Taiwan University Hospital; Mackay Memorial Hospital; Peking University... and other collaborators

Recruiting

Asian Diabetes Outcomes Prevention Trial (ADOPT)

Cardiovascular Diseases | Diabetes Mellitus

Singapore
Canadian Cancer Trials Group
Melanoma and Skin Cancer Trials Limited

Recruiting

Duration of Anti-PD-1 Therapy in Metastatic Melanoma (STOP-GAP)

Unresectable/Metastatic Melanoma

Canada, Australia
University of California, Davis

Completed

A Pilot Project of Virologic, Pharmacologic and Immunologic Correlates of Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution Following Maraviroc Therapy

HIV Infections

United States
Grifols Therapeutics LLC

Terminated

Study of Human Plasma-Derived Alpha1-Proteinase Inhibitor in Subjects With New-Onset Type 1 Diabetes Mellitus

Type 1 Diabetes Mellitus

United States
Hoffmann-La Roche

Completed

A Study of DPP-IV Inhibitor in Patients With Type 2 Diabetes

Diabetes Mellitus Type 2

Mexico, United States, Estonia, Bulgaria, Latvia, Romania, Lithuania, Puerto Rico, Costa Rica
Hoffmann-La Roche

Completed

A Study of DPP-IV Inhibitor in Patients With Type 2 Diabetes

Diabetes Mellitus Type 2

Australia, Italy, United States, Germany, Canada, Puerto Rico
Jeil Pharmaceutical Co., Ltd.

Not yet recruiting

Evaluation of Efficacy and Safety When Administered JP-2266 in Type 2 Diabetes Patients

Type 2 Diabetes Mellitus

Korea, Republic of
University of Michigan Rogel Cancer Center
CSL Behring; The Leukemia and Lymphoma Society

Completed

A Pilot Study of Alpha-1-Antitrypsin (AAT) in Steroid Refractory Acute Graft vs Host Disease

Graft vs Host Disease

United States
Medical Research Council
NHS Health Technology Assessment Programme

Unknown

Protease Inhibitor Monotherapy Versus Ongoing Triple-therapy in the Long Term Management of HIV Infection (PIVOT) (PIVOT)

Acquired Immunodeficiency Syndrome | HIV Infection
Rabin Medical Center

Unknown

Safety and Efficacy of Inhaled Alpha-1 Antitrypsin in Preventing Bronchiolitis Obliterable Syndrome in Lung Transplant Recipients

Lung Transplantation | Bronchiolitis Obliterable Syndrome
Christiana Care Health Services
GlaxoSmithKline; Johnson & Johnson

Completed

Doxil Topotecan Doublet Cancer Study

Head and Neck Cancer | Small Cell Lung Cancer | Gastric Cancer | Pancreatic Cancer | Esophageal Cancer

United States
Baxalta now part of Shire
Baxalta Innovations GmbH, now part of Shire

Terminated

Stage 1 Study of ARALAST NP and GLASSIA in A1PI Deficiency

Chronic Obstructive Pulmonary Disease | Alpha1-antitrypsin Deficiency

United States, Canada, Australia
ANRS, Emerging Infectious Diseases
Janssen-Cilag Ltd.

Terminated

Management of Participants With Low-level Persistent Viremia (ANRS 161 L-VIR)

Viremia | HIV-1 Infection | Treatment Resistant Disorders

France
The University of Hong Kong
Department of Health and Human Services

Unknown

Glass Ionomer Sealant Versus Fluoride Varnish on Occlusal Caries Prevention

Child | Pit and Fissure Caries | Tooth, Deciduous | Glass Ionomer Cements

Hong Kong

Search clinical trials for: PI3K inhibitor

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