Search clinical trials for: Pharmacokinetic based dosage change

Total 482 results

Merck KGaA, Darmstadt, Germany

Completed

Bioequivalence Trial of Concor AM® vs Bisoprolol and Amlodipine in Chinese Participants

Healthy

China
COLM Study Research Organization
Japan Heart Foundation

Completed

Combination of OLMesartan and CCB or Low Dose Diuretics in High Risk Elderly Hypertensive Patients Study (COLM-Study)

Hypertension | Cardiovascular Disease | Diabetes

Japan
GlaxoSmithKline

Completed

Pharmacokinetics and PharmacoDynamics of GW685698 in Paedeatric Asthmatic Patients

Asthma

United States
GlaxoSmithKline

Completed

Asthma Exacerbation Study

Asthma

United States, Argentina, Germany, Japan, Poland, Romania, Russian Federation, Mexico, Ukraine, Australia, Philippines
GlaxoSmithKline

Completed

RELOVAIR® Lung Deflation Study

Pulmonary Disease, Chronic Obstructive

United Kingdom
Dhaka Medical College

Enrolling by invitation

The Efficacy and Safety of Lamotrigine Versus Carbamazepine in Focal Epilepsy

Focal Epilepsy

Bangladesh
Fundación Santa Fe de Bogota

Completed

A Comparison of Epidural Analgesia: Continuous Infusion Versus Programmed Intermittent Boluses

Labor Pain

Colombia
Mylan Pharma UK Ltd.

Completed

MGR001 / Advair Diskus Local Equivalence Study in Asthma

Asthma

United States
Servier Hellas Pharmaceuticals Ltd.

Completed

Study for the Recording of Adherence to Treatment With Perindopril/Indapamide/Amlodipine Fixed Dose Combination (CONTROL-3)

Hypertensive Disease | Adherence to Medication Regime

Greece
Indonesia University

Not yet recruiting

Preemptive Analgesia Combination of Celecoxib and Pregabalin in THA

Arthroplasty Complications | Pregabalin | Analgetic | Celecoxib
Hamad Medical Corporation

Recruiting

Two Doses of the Intravenous Magnesium Sulfate Versus the Standard Single Dose ,With/ Without the Nebulized Budesonide For the Management of the Severe Asthma Exacerbation in the Emergency Room; A Randomized Controlled Trial.

Bronchial Asthma

Qatar
Yuzuncu Yıl University

Completed

General Anesthesia and General Anesthesia Combined With Thoracic Epidural Anesthesia

Thoracal Epidural Block

Turkey
Nova Scotia Health Authority
Canadian Institutes of Health Research (CIHR); Nova Scotia Health Research... and other collaborators

Completed

Palliation of Dyspnea in Advanced Chronic Obstructive Pulmonary Disease (COPD) (ROS-003)

Chronic Obstructive Pulmonary Disease (COPD)

Canada
Sidney Kimmel Cancer Center at Thomas Jefferson...
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Treatment of Sickle Cell Anemia With Stem Cell Transplant

Sickle Cell Anemia | Sickle Cell-hemoglobin C Disease | Sickle Cell-β0-thalassemia

United States
The Hearing Cooperative Research Centre
St Vincent's Hospital Melbourne; Royal Victoria Eye and Ear Hospital; Cochlear; Royal Prince Alfred Hospital, Sydney, Australia and other collaborators

Completed

Cochlear Implant With Anti-Inflammatory Agent

Hearing Loss

Australia
Arbor Pharmaceuticals, Inc.

Completed

An Efficacy and Safety Study in Children 6 to Less Than 18 Years of Age With Hypertension

Hypertension

United States, Brazil, Turkey, Poland, Mexico, Colombia, Italy, Argentina, Bulgaria, Hungary, South Africa, Ukraine
Adare Pharmaceuticals, Inc.

Completed

Efficacy, Safety, and Pharmacokinetics of APT-1011 in Subjects With Eosinophilic Esophagitis (EoE) (FLUTE)

Eosinophilic Esophagitis

Spain, United States, Belgium, Switzerland, Germany, Canada
Bogomolets National Medical University

Completed

Compartment Psoas Block Efficacy and Safety

Femur Fracture

Ukraine
GlaxoSmithKline

Completed

A Clinical Study With Fluticasone Furoate Nasal Spray And Vehicle Placebo For The Treatment Of Perennial (Year-round) Allergic Rhinitis

Rhinitis, Allergic, Perennial

United States
Novartis

Completed

Efficacy and Safety of Valsartan and Amlodipine (± HCTZ) in Adults With Moderate, Inadequately Controlled Hypertension

Hypertension

Germany
Midas Pharma GmbH

Completed

Drug-drug-interaction Study of Candesartan, Amlodipine and Atorvastatin

Healthy Volunteers

Jordan
Chongqing Medical University

Unknown

Comparison of Tandospirone, Amlodipine and Their Combination in Adults With Hypertension and Anxiety

Hypertension | Anxiety

China
Daiichi Sankyo, Inc.

Completed

18 Week Study Evaluating Safety and Efficacy of Olmesartan, Amlodipine, and Hydrochlorothiazide, in Type 2 Diabetics

Hypertension | Type 2 Diabetes

United States
Third Military Medical University

Unknown

Adrenal Artery Ablation for Primary Aldosteronism

Hypertension | Primary Aldosteronism

China
Janssen Sciences Ireland UC

Completed

A Study in Healthy Female Participants to Investigate the Effect of JNJ-56136379 at Steady-state on the Single-dose Pharmacokinetics of Ethinylestradiol and Drospirenone (Oral Contraceptive) and on the Single-dose Pharmacokinetics of Midazolam (Probe Substrate for Cytochrome P450 3A4)

Healthy

Belgium
Sankyo Pharma Gmbh

Completed

Olmesartan and an add-on Treatment in Patients With Mild to Moderate Hypertension (OLMETREAT)

Essential Hypertension

France, Austria, Switzerland, Belgium, Germany, Italy, Netherlands, United Kingdom, Portugal
Centre for Chronic Disease Control, India
All India Institute of Medical Sciences, New Delhi; Imperial College London

Recruiting

Treatment Optimisation for Blood Pressure With Single-Pill Combinations in India (TOPSPIN)

Primary Hypertension

India
Daewoong Pharmaceutical Co. LTD.

Completed

Clinical Trial to Evaluate the Efficacy and Safety of OLOMAX Tab

Hypertension | Dyslipidemias

Korea, Republic of
Stanford University

Completed

Consumer Responses to Alcohol Warnings

Alcohol Drinking

United States
National Cancer Institute (NCI)

Completed

Primary Chemotherapy With Docetaxel-Capecitabine and Doxorubicin-Cyclophosphamide in Breast Cancer

Breast Cancer | Breast Neoplasm

United States
RemeGen Co., Ltd.

Recruiting

A Study of RC48-ADC in Local Advanced or Metastatic Gastric Cancer With the HER2-Overexpression

Gastric Cancer | HER2 Overexpressing Gastric Carcinoma

China
GlaxoSmithKline

Completed

Crossover Study to Evaluate the Comparative Bioavailability of Two Fixed Dose Combination Tablet Formulations of Amlodipine and Losartan in Health Volunteers

Hypertension

Australia
Praxis Precision Medicines

Active, not recruiting

A Clinical Trial of PRAX-222 in Pediatric Participants With Early Onset SCN2A Developmental and Epileptic Encephalopathy

Epilepsy | SCN2A-DEE

United States
Assistance Publique - Hôpitaux de Paris
Novartis

Completed

Evaluation of Low Dose Corticosteroids Efficiency, Associated With Myfortic ® in the Treatment of Nephrotic Syndrome (MSN)

Nephrotic Syndrome

France
Modern Biosciences Ltd

Recruiting

Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult Subjects

Pharmacokinetics

United Kingdom
IlDong Pharmaceutical Co Ltd

Completed

Clinical Trial to Compare the Pharmacokinetics of TAH Tablet in Comparison to the Co-administration of Telmisartan, Amlodipine and Hydrochlorothiazide in Healthy Male Volunteers

Healthy

Korea, Republic of
IlDong Pharmaceutical Co Ltd

Completed

Efficacy and Safety of TAH Combination in Comparison With Telmisartan/Amlodipine Combination for Essential Hypertension Patients

Essential Hypertension

Korea, Republic of
Third Military Medical University

Completed

A Randomized, Double-Blind, Active Control Trial Comparing Effects of Telmisartan, Candesartan and Amlodipine, Alone or Plus Metformin, on Non-Diabetic, Obese Hypertensive Patients (HOT-ACME)

Hypertension | Obesity

China
Boehringer Ingelheim

Completed

BI 671800 ED in Steroid-naive Asthmatic Patients

Asthma

United States, Australia, Canada, Colombia, Korea, Republic of, Mexico, New Zealand, Peru, Philippines, Taiwan
GlaxoSmithKline

Completed

Observed Outcomes Associated With Fluticasone Propionate/Salmeterol Xinafoate or Inhaled Corticosteroids in Asthma Patients

Asthma
Nazmy Edward Seif

Completed

U/S-guided Continuous Quadratus Lumborum Block III in Percutaneous Nephrolithotomy

Analgesia | Surgery | Renal Stone

Egypt
Chiesi Farmaceutici S.p.A.

Completed

A 24-wk Dose Ranging Study to Evaluate the Efficacy and Safety of 4 Doses of a New PDE4 Inhibitor in Patients With COPD (PIONEER)

Chronic Obstructive Pulmonary Disease
University of Texas Southwestern Medical Center

Completed

Pain Relief Effects on Length of Labor

Labor Pain

United States
Weill Medical College of Cornell University
Genentech, Inc.; Biogen

Completed

Higher Dose of Rituxan Versus Standard Doses of Rituxan With Cyclophosphamide, Vincristine, and Prednisone in Subjects With Chronic ITP

Immune Thrombocytopenic Purpura

United States
Imperial College London

Completed

Pharmacokinetics of Inhaled Monodisperse Fluticasone Propionate

Healthy | Asthma

United Kingdom
Grand Hôpital de Charleroi

Recruiting

ESKETamine for FIBromyalgia Treatment (ESKEFIB)

Fibromyalgia

Belgium
Laboratorios Silanes S.A. de C.V.

Completed

Non-interaction Study Between Pregabalin and Tramadol, Administered Individually or Combination, in Healthy Subjects

Healthy

Mexico
Bristol-Myers Squibb

Completed

A Study to Evaluate the Safety, Tolerability, Drug Levels and Drug Effects of Single and Multiple Doses of BMS-986209 in Healthy Participants

Health Participants

United States
GlaxoSmithKline

Completed

Study HZA106827: Efficacy/Safety Study of Fluticasone Furoate/Vilanterol (GW642444) in Adult and Adolescent Asthmatics

Asthma

United States, Germany, Japan, Romania, Ukraine, Poland
Far Eastern Memorial Hospital
Research Ethics Review Committee

Unknown

Comparing Treatment Efficacy With High and Medium Dose of Fluticasone in Combination With Salmeterol in COPD Patients

Quality of Life | Percentage of Annual Acute Exacerbation

Taiwan

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