Search clinical trials for: pharmacokinetics study

Total 5771 results

Pfizer

Completed

Bioavailability Study Of PF-00868554 Administered As 3x250mg Oral Tablets (Wet Granulate, 3x250mg Oral Tablets (Dry Granulate) And 750mg Solution Under Fed State

Hepatitis C Virus

Belgium
M.D. Anderson Cancer Center

Completed

Cabozantinib in Treating Patients With Locally Advanced or Metastatic Unresectable Adrenocortical Carcinoma

Metastatic Carcinoma in the Adrenal Cortex | Stage III Adrenal Cortex Carcinoma AJCC v8 | Stage IV Adrenal Cortex Carcinoma AJCC v8 | Unresectable Adrenal Cortex Carcinoma

United States
OHSU Knight Cancer Institute
Oregon Health and Science University; Janssen, LP; The Leukemia and Lymphoma...

Terminated

JNJ-40346527 in Treating Participants With Relapsed or Refractory Acute Myeloid Leukemia

Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia

United States
National Cancer Institute (NCI)

Active, not recruiting

Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)

Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Recurrent Ewing Sarcoma | Recurrent Hepatoblastoma | Recurrent Histiocytic and Dendritic Cell Neoplasm | Recurrent Langerhans Cell Histiocytosis | Recurrent Malignant Germ Cell Tumor | Recurrent Malignant Solid Neoplasm | Recurrent... and other conditions

United States, Puerto Rico
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

IACS-010759 in Advanced Cancers

Anatomic Stage III Breast Cancer AJCC v8 | Anatomic Stage IIIA Breast Cancer AJCC v8 | Anatomic Stage IIIB Breast Cancer AJCC v8 | Anatomic Stage IIIC Breast Cancer AJCC v8 | Prognostic Stage III Breast Cancer AJCC v8 | Prognostic Stage IIIA Breast Cancer AJCC v8 | Prognostic Stage IIIB Breast... and other conditions

United States
University of Southern California
National Cancer Institute (NCI)

Withdrawn

sEphB4-HSA in Treating Participants With BCG-Unresponsive or Refractory Bladder Cancer

Recurrent Bladder Carcinoma | Bladder Cancer Stage 0 | Bladder Cancer Stage I

United States
Chiang Mai University
Thailand Research Fund

Unknown

Itraconazole Pharmacokinetic With and Without Efavirenz Using the Capsule Formulation as Part of Talaromycosis Treatment in HIV-infected Adults (ITRAPK)

Pharmacokinetics | Efavirenz | Penicilliosis

Thailand
Seoul National University Hospital

Completed

Switchability Study Between Brand and Generic Topiramate

Epilepsy

Korea, Republic of
Ryazan State Medical University

Recruiting

Clinical One-stage Controlled Study of reSistant Arterial Hypertension for the desiGning of a personAlized Approach to Therapy (SAGA)

Resistant Arterial Hypertension

Russian Federation
Rabin Medical Center

Completed

Valacyclovir to Prevent Vertical Transmission of Cytomegalovirus After Maternal Primary Infection During Pregnancy

Congenital Cytomegalovirus Infection

Israel
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

Pevonedistat and Ibrutinib in Treating Participants With Relapsed or Refractory CLL or Non-Hodgkin Lymphoma

Recurrent Mantle Cell Lymphoma | Recurrent Marginal Zone Lymphoma | Recurrent Small Lymphocytic Lymphoma | Recurrent Diffuse Large B-Cell Lymphoma | Refractory Diffuse Large B-Cell Lymphoma | Refractory Chronic Lymphocytic Leukemia | Recurrent Non-Hodgkin Lymphoma | Refractory Non-Hodgkin Lymphoma | Richter Syndrome and other conditions

United States
ISA Pharmaceuticals
Regeneron Pharmaceuticals

Active, not recruiting

A Randomized Phase 2 Study of Cemiplimab ± ISA101b in HPV16-Positive OPC

Squamous Cell Carcinoma of the Oropharynx | HPV16 Positive

Netherlands, United States, United Kingdom, France, Belgium, Czechia, Spain, Italy, Germany, Brazil, Hungary, Mexico, Poland
Eben Rosenthal

Recruiting

Panitumumab-IRDye800 in Detecting Cancer in Participants With Lung Cancer During Surgery

Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Lung Carcinoma | Metastatic Malignant Neoplasm in the Lung

United States
University of Washington

Completed

Valacyclovir vs. Acyclovir as HSV-2 Suppressive Therapy: Effect on Plasma HIV-1 Levels Among HIV-1/HSV-2 Co-infected Persons (ACV-VAL)

HIV Infection | HSV Infection

Kenya
Chulalongkorn University

Completed

Citrate Pharmacokinetics in Critically Ill Liver Failure Patients Receiving CRRT (Citrate PK)

Liver Failure, Acute | Continuous Renal Replacement Therapy | Regional Citrate Anticoagulation | Pharmacokinetic | Liver Failure, Acute on Chronic | Citrate Toxicity

Thailand
Beijing Nuokangda Pharmaceutical Technology Co....

Unknown

Phase I Clinical Study for Evaluation of Pharmacokinetic, Safety, Tolerance of Norcantharidin Lipid Microsphere for Injection in Patients With Solid Tumor

Solid Tumor

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Trametinib and Pembrolizumab in Treating Patients With Recurrent Non-small Cell Lung Cancer That Is Metastatic, Unresectable, or Locally Advanced

Metastatic Lung Non-Small Cell Carcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage III Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Stage IIIA Lung Cancer AJCC v8 | Stage IIIB Lung Cancer AJCC v8 | Stage IIIC Lung Cancer AJCC v8 | Unresectable Lung Non-Small Cell... and other conditions

United States
University Hospital, Clermont-Ferrand

Unknown

Intra-monocyte Imiglucerase Kinetics in Gaucher Disease (CIMI)

Gaucher Disease

France
Heidelberg ImmunoTherapeutics GmbH

Completed

Monoclonal Antibody Therapy Against Chronic Herpes Simplex Virus 2 Infection (MATCH-2)

Herpes Genitalis

Germany
Assistance Publique - Hôpitaux de Paris

Recruiting

Baricitinib in the Treatment of New-onset Juvenile Dermatomyositis (MYOCIT) (MYOCIT)

Juvenile Dermatomyositis

France
National Cancer Institute (NCI)

Active, not recruiting

Exemestane in Treating Patients With Complex Atypical Hyperplasia of the Endometrium/Endometrial Intraepithelial Neoplasia or Low Grade Endometrial Cancer

Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia | FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma | FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma | Atypical Hyperplasia

United States
University Hospital, Clermont-Ferrand

Recruiting

Effect of Injectable Anticoagulants on Research for a Circulating Lupus-type Anticoagulant (ANTICOLA)

Antiphospholipid Syndrome | Anticoagulant Drugs

France
Assistance Publique Hopitaux De Marseille

Completed

Medico-economic Impact of Screening Atopobium Vaginae and Gardnerella Vaginalis in Molecular Biology by "Point-of-care" During Pregnancy (AuTop)

Low Risk of Preterm Delivery

France
Fondazione Melanoma Onlus

Withdrawn

"Dabrafenib and Trametinib in Circulating Free DNA BRAFV600 Mutated Metastatic Melanoma Patients: a Prospective Phase II, Open Label, Multicentre Study - (Bioliquid TAILOR Study - BIOTAILOR)"

Melanoma

Italy
Centre Hospitalier Universitaire de Saint Etienne

Not yet recruiting

Development of a Bayesian Estimator for Calculating Plasma Iohexol Clearance (CLIO)

Kidney Function Test

France
Medical University of South Carolina
National Institute on Drug Abuse (NIDA); National Institutes of Health (NIH); University of Minnesota

Recruiting

Impact of Cigarette and E-cigarette Menthol Regulation on Current Smokers of Menthol Cigarettes

Smoking Prevention and Control

United States
Bambino Gesù Hospital and Research Institute

Completed

Vancomycin and Cefoxitin During Pediatric Cardiopulmonary Bypass (VANCOCEF)

Congenital Heart Disease

Italy
Assistance Publique - Hôpitaux de Paris

Terminated

Calcineurin Activity in Renal Recipients

Renal Transplant Rejection

France
University of Southern California
National Cancer Institute (NCI)

Recruiting

FID-007 in Treating Participants With Advanced Solid Tumors

Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm

United States
Mayo Clinic
National Cancer Institute (NCI)

Active, not recruiting

Ibrutinib and Ixazomib Citrate in Treating Newly Diagnosed, Relapsed or Refractory Waldenstrom Macroglobulinemia

Waldenstrom Macroglobulinemia | Recurrent Waldenstrom Macroglobulinemia | Refractory Waldenstrom Macroglobulinemia

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Prexasertib in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors

Refractory Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Recurrent Primary Central Nervous System Neoplasm | Refractory Primary Central Nervous System Neoplasm | Childhood Solid Neoplasm

United States
Prof. Dr. med. Dirk Schadendorf

Terminated

Biopsy- and Biology-driven Optimization of Targeted Therapy in Subjects With Advanced Melanoma (BOTTOM)

Malignant Melanoma

Germany
Lawson Health Research Institute

Not yet recruiting

Personalized Pharmacotherapy Using Pharmacogenetics in Veterans (PGx)

Pharmacogenetic Testing to Determine Pharmacological Treatment in PTSD
P.O. Witteveen
Erasmus Medical Center; The Netherlands Cancer Institute

Terminated

Biomarker Development for Response Prediction by DNA Mutational Analysis (CPCT-01)

Neoplasm Metastasis

Netherlands
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Nivolumab With or Without Ipilimumab in Treating Patients With Recurrent or High Grade Gynecologic Cancer With Metastatic Peritoneal Carcinomatosis

Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Peritoneal Carcinomatosis | Malignant Peritoneal Neoplasm | Recurrent Endometrial Carcinoma | Stage IVB Uterine Corpus Cancer AJCC v8 | Recurrent Cervical Carcinoma | Metastatic Malignant Female... and other conditions

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Ribociclib and Aromatase Inhibitor in Treating Older Participants With Hormone Receptor Positive Metastatic Breast Cancer

HER2/Neu Negative | Stage IV Breast Cancer AJCC v6 and v7 | Estrogen Receptor and/or Progesterone Receptor Positive

United States
University of North Carolina, Chapel Hill
Merck Sharp & Dohme LLC

Withdrawn

The Effect of Pregnancy on the PK of Isentress®: A Longitudinal Investigation in the Second and Third Trimesters

Pregnancy | HIV
Groupe Hospitalier Paris Saint Joseph
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts

Active, not recruiting

Study of Intraocular Concentrations (Aqueous Humor, Vitreous Humor) of Antibiotics After Local and/or Systemic Administration in Endophthalmitis (CINEBIOPHTA)

Endophthalmitis

France
University of California, San Francisco

Completed

Cotinine Metabolism in Infants and Children (1058)

Secondhand Smoke Exposure

United States
Gustave Roussy, Cancer Campus, Grand Paris

Active, not recruiting

Efficacy of MEK (Trametinib) and BRAFV600E (Dabrafenib) Inhibitors With Radioactive Iodine (RAI) for the Treatment of Refractory Metastatic Differentiated Thyroid Cancer (MERAIODE)

Metastatic Radioactive Iodine Refractory Thyroid Cancer Patients With RAS or BRAF Mutation

France
VA Office of Research and Development

Completed

Nicotinic Receptors and Schizophrenia

Schizophrenia

United States
UNC Lineberger Comprehensive Cancer Center

Not yet recruiting

Pharmacokinetics of Intravaginal, Self-administered Artesunate Vaginal Pessaries Among Women in Kenya

Cervix Cancer | Cervix Intraepithelial Neoplasia Grade 3 | Cervix; Intraepithelial Neoplasia, Grade I | Cervix; Intraepithelial Neoplasia, Grade II

Kenya
Centre Henri Becquerel
Universitaire Ziekenhuizen KU Leuven; Erasmus Medical Center

Not yet recruiting

Influence of Body Composition on Chemotherapy Outcomes in Localized Breast Cancer (FATTAX)

Breast Cancer

France
Canadian Immunodeficiency Research Collaborative

Completed

Concentrations of Raltegravir in the Semen of HIV-Infected Men

HIV

Canada
Brenda Cooper, MD
National Cancer Institute (NCI)

Completed

Midostaurin and Azacitidine in Treating Elderly Patients With Acute Myelogenous Leukemia

Untreated Adult Acute Myeloid Leukemia

United States
F2G Biotech GmbH
Simbec-Orion Group

Completed

Single Ascending Oral Dose Study of F901318

Invasive Aspergillosis

United Kingdom
McMaster University
Canadian Hemophilia Society

Completed

Web-based Application for the Population Pharmacokinetic Service - Phase 1 (WAPPS)

Hemophilia A | Hemophilia B

Canada
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

TAK-659 and Paclitaxel in Treating Patients With Advanced Solid Tumors

Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Ovarian Carcinoma | Refractory Ovarian Carcinoma

United States
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating the Pharmacokinetics of the Potential Drug Interaction Between CYP2C9 Inhibitor and Substrate

Healthy Subjects
University of California, San Francisco
GlaxoSmithKline

Terminated

Dabrafenib and Trametinib With Radiosurgery in Melanoma Brain Mets

BRAFV600E Melanoma Patients

United States

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