Search clinical trials for: Piperacillin/Tazobactam

Total 164 results

Bayer

Completed

Comparison of Sequential IV/PO Moxifloxacin With IV Piperacillin/Tazobactam Followed by PO Amoxicillin/Clavulanic Acid in Patients With a Complicated Skin and Skin Structure Infection

Diabetic Foot | Ulcer | Abscess | Wound Infection

Italy, Spain, Greece, Ireland, Russian Federation, United Kingdom, Germany, Austria, Belgium, France, Hungary, South Africa, Romania, Bulgaria, Poland, Israel, Latvia, Ukraine, Lithuania, Netherlands
Seattle Children's Hospital
Cystic Fibrosis Foundation

Completed

Standard vs. Biofilm Susceptibility Testing in Cystic Fibrosis (CF)

Cystic Fibrosis | Chronic Bronchitis

United States
Holbaek Sygehus
Aase and Ejnar Danielsens Foundation; Region Sjælland

Unknown

Procalcitonin as a Marker of Antibiotic Therapy in Patients With Lower Respiratory Tract Infections

Pneumonia | Acute Exacerbation of Chronic Obstructive Airways Disease

Denmark
Assistance Publique - Hôpitaux de Paris

Recruiting

Antibioprophylaxis for Excision-graft Surgery in Burn Patient (A2B-TRIAL) (A2B)

Burns Surgery

France
Steven E. Coutre
National Cancer Institute (NCI)

Terminated

Ixazomib (MLN9708) in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Recurrent Adult Acute Myeloid Leukemia | Adult Acute Megakaryoblastic Leukemia (M7) | Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Adult Acute Monoblastic Leukemia (M5a) | Adult Acute Monocytic Leukemia (M5b) | Adult Acute Myeloblastic Leukemia With Maturation (M2) | Adult Acute... and other conditions

United States
Shandong University
The Second Hospital of Shandong University

Recruiting

Population Pharmacokinetics and Dosage Individualization of Antibiotics in Elderly Patients

Elderly Infection

China
University Hospital, Ghent

Completed

Assessment of the Optimal Dosing of Piperacillin-tazobactam in Intensive Care Unit Patients: Extended Versus Continuous Infusion

Infectious Disease

Belgium
Fundacion GenesisCare
Hospital La Milagrosa; Hospital Vithas Valencia Consuelo

Suspended

Ultra Low Doses of Therapy With Radiation Applicated to COVID-19 (ULTRA-COVID)

Pneumonia, Viral | Cytokine Storm

Spain
Murdoch Childrens Research Institute

Recruiting

Early Versus Late Stopping of Antibiotics in Children With Cancer and High-risk Febrile Neutropenia (ELSA-FN)

Febrile Neutropenia

Australia
Haiphong University of Medicine and Pharmacy

Completed

Combination Antibiotic Therapy Compared to Monotherapy in the Treatment of Acute COPD (COPD)

COPD Exacerbation Acute

Vietnam
Ito Hospital

Completed

Antimicrobial Prophylaxis in Thyroid and Parathyroid Surgery (Ito-RCT1)

Thyroid Disease | Parathyroid Disease

Japan
Fundación Pública Andaluza para la gestión de la...
Spanish Network for Research in Infectious Diseases

Completed

Study on Reduced Antibiotic Treatment vs Broad Spectrum Betalactam in Patients With Bacteremia by Enterobacteriaceae (SIMPLIFY)

Enterobacteriaceae Infections

Spain
Cubist Pharmaceuticals LLC

Completed

Pharmacokinetic and Safety Study of Ceftolozane/Tazobactam in Pediatric Participants Receiving Antibiotic Therapy for Proven or Suspected Gram-negative Infection or for Peri-operative Prophylaxis (MK-7625A-010)

Proven or Suspected Gram-negative Bacterial Infection | Peri-operative Prophylaxis
Novo Nordisk A/S

Completed

Dual Action of Liraglutide and Insulin Degludec in Type 2 Diabetes: A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide, Insulin Degludec and Liraglutide in Subjects With Type 2 Diabetes (DUAL™ I)

Diabetes Mellitus, Type 2 | Diabetes

United States, India, Italy, Mexico, Russian Federation, Slovakia, Spain, Canada, Taiwan, Finland, Hungary, Malaysia, South Africa, United Kingdom, Germany, Australia, Thailand, Ireland, Puerto Rico, Singapore
Merck Sharp & Dohme LLC

Completed

Imipenem/Relebactam/Cilastatin Versus Piperacillin/Tazobactam for Treatment of Participants With Bacterial Pneumonia (MK-7655A-014) (RESTORE-IMI 2)

Bacterial Pneumonia
Tianjin Medical University Cancer Institute and...
Zhejiang Hisun Pharmaceutical Co. Ltd.

Unknown

Effect Study of Tigecycline to Treat Severe Sepsis and Septic Shock (Tigecycline)

Abdominal Infection

China
Central Hospital, Nancy, France

Completed

Target Attainment of TDM-guided Infusion of Piperacillin/Tazobactam and Cefepim in Critically Ill Patients (DOSATB)

Sepsis | Critical Illness | Septic Shock | Antibiotic Toxicity

France
Loyola University

Terminated

Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for Osteomyelitis (CRO-OSTEO)

Osteomyelitis

United States
Cubist Pharmaceuticals LLC

Completed

Plasma Pharmacokinetics (PK) & Lung Penetration of Ceftolozane/Tazobactam in Participants With Pneumonia (MK-7625A-007)

Pneumonia | Critically Ill
Weill Medical College of Cornell University
Merck Sharp & Dohme LLC

Recruiting

Ceftolozane-Tazobactam for Directed Treatment of Pseudomonas Aeruginosa Bacteremia and Pneumonia in Patients With Hematological Malignancies and Hematopoietic Stem Cell Transplantation

Pneumonia | Hematologic Malignancy | Pseudomonas Aeruginosa

United States
Sunshine Coast Hospital and Health Service
The Prince Charles Hospital; Mater

Not yet recruiting

Ceftolozane/Tazobactam Continuous Infusion for Infective Exacerbations of Cystic Fibrosis and Bronchiectasis (CERTAIN)

Bronchiectasis | Cystic Fibrosis | Pseudomonas Aeruginosa | Burkholderia Cepacia Infection
Beneficência Portuguesa de São Paulo
Merck Sharp & Dohme LLC

Not yet recruiting

Ceftolozane/Tazobactam Versus Meropenem for Febrile Neutropenia on Patients Colonized With or at Risk for Infection With Extended Spectrum Beta Lactamase - Producing Pathogens (CLEMENT)

Febrile Neutropenia

Brazil
Temple University

Unknown

Clinical Outcomes With Ceftolozane-tazobactam for MDR Pseudomonas Infections

Pseudomonas Infections | Pseudomonas Aeruginosa

United States
Hamad Medical Corporation
Merck Sharp & Dohme LLC

Withdrawn

CEFtolozane-Tazobactam for the Empiric Anti-bacterial Treatment of Neutropenic Fever in Hematology Patients (CEF-10)

Hematologic Cancer | Neutropenia, Febrile

Qatar
The University of Queensland
Merck Sharp & Dohme LLC

Withdrawn

Ceftolozane-tazobactam Versus Meropenem for ESBL and AmpC-producing Enterobacterales Bloodstream Infection (MERINO III)

Bacteremia Caused by Gram-Negative Bacteria

Spain, Australia, Singapore, Italy, Saudi Arabia
Fundación Pública Andaluza para la gestión de la...

Unknown

Monitoring of Ceftolozane-Tazobactam Plasmatic Levels in Critical Patients

Serious Infection

Spain
Semmelweis University

Unknown

Ceftolozane-tazobactam for the Treatment of Respiratory Infections Due to Extensively Drug-resistant Pseudomonas Aeruginosa Among Critically Ill Patients: a Retrospective Study.

Ventilator Associated Pneumonia | Antibiotic Resistant Infection

Hungary
Merck Sharp & Dohme LLC

Recruiting

Safety and Pharmacokinetics of Ceftolozane/Tazobactam in Pediatric Participants With Nosocomial Pneumonia (MK-7625A-036)

Nosocomial Pneumonia

United States, Estonia, Greece, Spain, Ukraine, Chile, Russian Federation, Colombia
Texas Tech University Health Sciences Center
Merck Sharp & Dohme LLC

Terminated

Pharmacokinetics of Ceftolozane/Tazobactam in Patients With Burns

Burns | Pharmacokinetics

United States
Merck Sharp & Dohme LLC

Completed

MK-7625A Versus Meropenem in Pediatric Participants With Complicated Urinary Tract Infection (cUTI) (MK-7625A-034)

Pyelonephritis | Complicated Urinary Tract Infection

United States, Mexico, Russian Federation, Turkey, Greece, Hungary, Poland, Romania, South Africa, Ukraine
Royal Brisbane and Women's Hospital
The University of Queensland

Completed

Pharmacokinetics of Ceftolozane/Tazobactam in Plasma and Cerebrospinal Fluid

Pharmacokinetics

Australia
Emilio Bouza
Merck Sharp & Dohme LLC

Unknown

In Vitro Activity of Ceftolozane/Tazobactam and Imipenem/Relebactam in Clinical Isolates of Pseudomonas Aeruginosa and Enterobacterales Collected From Hematology and Oncology Patients (ACTHEON)

Ceftolozane/Tazobactam | Imipenem/Relebactam | Hematology and Oncology

Spain
Joseph L. Kuti, PharmD
Cubist Pharmaceuticals LLC; Indiana University Health; University of North Carolina and other collaborators

Completed

Population Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Adult Cystic Fibrosis Patients

Cystic Fibrosis | Cystic Fibrosis Pulmonary Exacerbation | Pseudomonas Aeruginosa Infection

United States
Cubist Pharmaceuticals LLC

Completed

Safety and Efficacy Study of Ceftolozane/Tazobactam to Treat Ventilated Nosocomial Pneumonia (MK-7625A-008) (ASPECT-NP)

Lung Diseases | Healthcare-Associated Pneumonia | Ventilator-Associated Pneumonia
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating BLI-489 and Piperacillin in Healthy Subjects

Healthy Subjects

United States
Hartford Hospital
Merck Sharp & Dohme LLC

Completed

Tissue Penetration of Ceftolozane/Tazobactam in Diabetic Patients With Lower Limb Infections

Diabetes | Healthy Volunteers | Wound Infection

United States
Wockhardt
Clinartis

Completed

A Single-dose Study to Investigate the Pharmacokinetics of Intravenous FEP-TAZ in Patients With Renal Impairment

Renal Impairment

United States
Merck Sharp & Dohme LLC

Completed

Ceftolozane/Tazobactam (MK-7625A) Plus Metronidazole Versus Meropenem for Participants With Complicated Intra-abdominal Infection (MK-7625A-015) (7625ACNPhase3)

Complicated Intra-abdominal Infections

China
University Hospital Hradec Kralove

Completed

Glycocalyx Damage and Beta-lactam Antibiotics in Surgical Critically Ill

Critical Illness

Czechia
Merck Sharp & Dohme LLC

Completed

MK-7625A Plus Metronidazole Versus Meropenem in Pediatric Participants With Complicated Intra-Abdominal Infection (cIAI) (MK-7625A-035)

Complicated Intra-Abdominal Infection

Brazil, Hungary, United States, Lithuania, Malaysia, Mexico, Romania, Russian Federation, South Africa, Spain, Turkey, Ukraine
Rhode Island Hospital

Completed

Initial Antibiotics and Delayed Appendectomy for Acute Appendicitis

Acute Appendicitis

United States
Merck Sharp & Dohme LLC

Completed

Study of Ceftolozane/Tazobactam (MK-7625A) in Japanese Participants With Uncomplicated Pyelonephritis and Complicated Urinary Tract Infection (MK-7625A-014)

Pyelonephritis | Complicated Urinary Tract Infection | Urinary Tract Infection (UTI) | Uncomplicated Pyelonephritis
Xiangbei Welman Pharmaceutical Co., Ltd

Completed

Piperacillin Sodium and Sulbactam Sodium for Injection(2:1) for Treatment of Respiratory and Urinary System Infection (PIP-SBT)

Respiratory Tract Infections | Urinary Tract Infections

China
Policlinico Hospital
Pfizer

Recruiting

Nosocomial Infections in Patients With ARDS Treated With ECMO (INF-ECMO)

Acute Respiratory Distress Syndrome | Extracorporeal Membrane Oxygenation Complication | Nosocomial Infection

Italy
Cubist Pharmaceuticals LLC

Completed

Safety and Efficacy Study to Compare IV CXA 101/Tazobactam and Metronidazole With Meropenem in Complicated Intraabdominal Infections

Complicated Intra-abdominal Infection

United States, Argentina, Serbia, Georgia, Russian Federation
Merck Sharp & Dohme LLC

Completed

Study of Ceftolozane/Tazobactam (MK-7625A) in Combination With Metronidazole in Japanese Participants With Complicated Intra-abdominal Infection (MK-7625A-013)

Intra-abdominal Infection | Complicated Intra-abdominal Infection
Haukeland University Hospital
Institut National de la Santé Et de la Recherche Médicale, France; University... and other collaborators

Completed

Long-Term Sulfonylurea Response in KCNJ11 Neonatal Diabetes (SuResponsKIR)

Permanent Neonatal Diabetes Mellitus

Norway
West Virginia University

Enrolling by invitation

Comparing Oral Versus Parenteral Antimicrobial Therapy (COPAT)

Skin and Soft Tissue Infection | Gastrointestinal Infection | Pulmonary Infection | Bone and Joint Infection | Endovascular Infection | Genitourinary Infection

United States
Merck Sharp & Dohme LLC

Completed

A De-Escalating Strategy for Antibiotic Treatment of Pneumonia in The Medical Intensive Care Unit (0787B-092)

Pneumonia | Infection
Allecra

Completed

Investigation of AAI101 Safety, Tolerability & PK in Healthy Volunteers

Healthy

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