Search clinical trials for: Placebo controlled-ileocolonic-release nicotinamide (SAD/MAD)

Total 108 results

University Hospital Schleswig-Holstein

Completed

Safety and Pharmacokinetics of Oral Controlled-ileocolonic-release Nicotinamide (CICR-NAM)

Safety Issues | Pharmacokinetic

Germany
University Hospital Schleswig-Holstein

Recruiting

Evaluation of Safety and Pharmacokinetics of Oral Controlled-ileal-release Nicotinic Acid (CIR-NA) Compared to Immediate-release Nicotinic Acid and Placebo in Healthy Subjects and Subjects With Prediabetes

Safety Issues | Pharmacokinetic

Germany
Hoffmann-La Roche

Completed

A Single Ascending And Multiple Ascending Dose Study of RO5271983 in Healthy Volunteers

Healthy Volunteer

New Zealand
Galapagos NV

Completed

A Study to Evaluate the Effects of a Single and Multiple Oral Doses of GLPG3121 in Adult, Healthy, Male Subjects

Healthy

Belgium
Dongguan HEC TaiGen Biopharmaceuticals Co., Ltd.
R&G Pharma Studies Co.,Ltd.

Completed

To Evaluate the Safety, Tolerability, and Pharmacokinetics Profile in Healthy Chinese Volunteers of TG-2349

Healthy Chinese Volunteers

China
ZYUS Life Sciences Inc.
Novotech (Australia) Pty Limited; ZYUS Life Sciences Australia Pty Ltd

Completed

Trichomylin® Safety, Tolerability & Pharmacokinetics in Healthy Adults and First in Human Osteoarthritis Pain Evaluation (HOPE)

Healthy | Osteoarthritis

Australia
Shanghai Jiatan Pharmatech Co., Ltd

Completed

Sudapyridine (WX-081) in Healthy Volunteers

Healthy

China
Innovent Biologics (Suzhou) Co. Ltd.

Recruiting

A Study to Investigate the Safety, Tolerability and Pharmacokinetics of IBI356 in Healthy Participants and in Atopic Dermatitis Patients

Healthy Participants | Atopic Dermatitis Patients

China
Inmagene LLC

Completed

Study to Evaluate IMG-004 in Healthy Participants

Healthy Participants

United States
EnnovaBio Australia Pharmaceuticals Pty Ltd

Not yet recruiting

A First-in-Human SAD/MAD Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ENC1018 in Healthy Adult Subjects

Healthy
Theravance Biopharma

Completed

SAD and MAD Study to Evaluate Safety, Tolerability, and Pharmacokinetics (PK) of TD-1473 in Healthy Subjects

Healthy

United States
Chiesi Farmaceutici S.p.A.

Completed

A Study to Investigate Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of CHF6333 in Healthy Subjects (CHF6333 FIH)

Cystic Fibrosis | Non-Cystic Fibrosis Bronchiectasis

Belgium
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Examine the Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-ascending Doses of ACT-777991 in Healthy Subjects

Healthy

Netherlands
Pharmacobio

Recruiting

A Phase I Study of DDN-A-0101 in Healthy Volunteers and Elder People

Alzheimer Disease

Korea, Republic of
Spero Therapeutics
Simbec Research

Completed

A Study of the Safety, Tolerability, and Pharmacokinetics of SPR720 in Healthy Volunteers

Healthy Volunteers

United Kingdom
Kowa Company, Ltd.

Completed

A Study to Evaluate the Safety of K-755 in Healthy Volunteers

Healthy

Australia
Ji Xing Pharmaceuticals Australia Pty Ltd
Novotech (Australia) Pty Limited

Recruiting

JX09 SAD/MAD in Healthy Participants

Resistant Hypertension

Australia
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Examine the Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-ascending Doses of ACT-1014-6470 in Healthy Subjects

Healthy

Netherlands
Aptabio Therapeutics, Inc.

Completed

Safety, Tolerability, PK and PD of SAD or MAD of APX-115 in Healthy Male Volunteers

Healthy | Safety

France
JMackem Co., Ltd
Seoul National University Hospital

Recruiting

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Oral Administration of AJH-2947 in Healthy Korean and/or Caucasian Adult Male Subjects

Diabetic Neuropathies | Neuropathic Pain | Post Herpetic Neuralgia

Korea, Republic of
7 Hills Pharma, LLC
Frontage Clinical Services, Inc.

Completed

A Phase 1 SAD and MAD Study of the Safety, Tolerability and PK of 7HP349 in Normal Healthy Male Subjects

Solid Tumor

United States
Chiesi Farmaceutici S.p.A.

Terminated

A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Repeat Doses of CHF6297 in Healthy Subjects and Patients With COPD (CHF6297 FIH)

Chronic Obstructive Pulmonary Disease

United Kingdom
Arisan Therapeutics, Inc.
United States Department of Defense; Battelle Memorial Institute; The Defense...

Recruiting

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Oral ARN-75039 in Healthy Adult Subjects

Lassa Virus Infection

United States
Hospital de Clinicas de Porto Alegre
Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil; Conselho...

Unknown

ORal ApplianCes for sLeep Apnea of the Elderly (ORACLE)

Hypertension | Cardiovascular Disease | Obstructive Sleep Apnea

Brazil
Cadent Therapeutics

Completed

Study of CAD-9303 in Subjects With Schizophrenia (Affinity-1)

Schizophrenia

United States
Cadent Therapeutics

Withdrawn

Study of CAD-1883 for Spinocerebellar Ataxia (Synchrony-1)

Spinocerebellar Ataxia Type 3 | Spinocerebellar Ataxias | Spinocerebellar Ataxia Type 1 | Spinocerebellar Ataxia Type 2 | Spinocerebellar Ataxia Type 6 | Spinocerebellar Ataxia Type 10 | Spinocerebellar Ataxia Type 7 | Spinocerebellar Ataxia Type 8 | Spinocerebellar Ataxia Type 17 | ARCA1 - Autosomal Recessive...

United States
Mayo Clinic
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Enrolling by invitation

Effect of Bile Acids on Satiety, Cell Function and Body Weight in Patients With Obesity and Abnormal Satiety Phenotype

Healthy | Obesity

United States
Waterstone Pharmaceutical (Wuhan) Co., LTD.

Completed

The Safety and Tolerability of WS016 in Healthy Chinese Volunteers

Hyperkalemia

China
Oslo University Hospital

Terminated

Diabetes Virus Detection Project, Intervention With GAD-alum (DiViD)

Enterovirus Infections | Diabetes, Type I | Autoimmunity

Norway
Diamyd Therapeutics AB

Terminated

A Phase III Study to Investigate the Impact of Diamyd in Patients Newly Diagnosed With Type 1 Diabetes (EU)

Type 1 Diabetes Mellitus

France, Germany, Finland, Italy, Netherlands, Slovenia, Spain, Sweden, United Kingdom
Pfizer

Withdrawn

A Study to Evaluate the Safety and Efficacy of Three Doses of a Controlled Release Formulation of Varenicline for Smoking Cessation

Smoking Cessation
Franklin Health Research

Active, not recruiting

IV Administration of ChromaDex's Niagen® as Compared to NAD+

Healthy Aging

United States
Maastricht University Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development

Completed

Peppermint Oil for the Treatment of Irritable Bowel Syndrome: Optimizing Therapeutic Strategies Using Targeted Delivery (PERSUADE)

Irritable Bowel Syndrome | Colonic Diseases, Functional | Abdominal Pain

Netherlands
Lund University
Region Skane

Completed

Diabetes Prevention - Immune Tolerance (DIAPREV-IT)

Type 1 Diabetes | Prediabetes

Sweden
Medical University of Graz

Active, not recruiting

Synbiotic Therapy of Gastrointestinal Symptoms During Covid-19 Infection (SynCov)

COVID

Austria
Chakshu Research, Inc.

Unknown

Safety and Efficacy Study of an Ophthalmic Solution in Patients With Age-Related Cataract

Cataract

United States
Midwest Pulmonary and Critical Care
Genentech, Inc.

Completed

Efficacy and Safety of Activase (Ateplase) vs Placebo in Complicated Pleural Effusions (CPE)/Empyemas (CPE)

Pleural Effusion Associated With Pulmonary Infection | Bacterial Pleural Effusion Other Than Tuberculosis

United States
Virginia Commonwealth University

Completed

Examining the Effect of Mental Health Disorders on Vascular Function and Exercise Tolerance

Mental Health Disorders

United States
VU University of Amsterdam

Completed

Oral Appliance Therapy in Obstructive Sleep Apnea

Obstructive Sleep Apnea

Netherlands
University of Alabama at Birmingham
Juvenile Diabetes Research Foundation; Janssen Pharmaceuticals; NOW Foods; Diamyd...

Completed

The Use of Glutamic Acid Decarboxylase (GAD) and Gamma-Amino Butyric Acid (GABA) in the Treatment of Type I Diabetes (GABA)

Type I Diabetes

United States
Kissei Pharmaceutical Co., Ltd.

Completed

Post-marketing Clinical Trial of KAD-1229 in Patients With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

Japan
Purdue Pharma LP

Completed

A Study of Oxycodone/Naloxone Controlled-release Tablets (OXN) to Assess Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain

Low Back Pain

United States
BioGaia Pharma AB
BioFortis

Recruiting

Safety and Preliminary Efficacy of BGP345A in Constipation Due to Opioid-based Medications (OIC1)

Opioid-Induced Constipation

France
Purdue Pharma LP

Completed

Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) for Uncontrolled Moderate - Severe Low Back Pain

Low Back Pain

United States, Poland, Czech Republic, Italy
Bristol-Myers Squibb

Completed

Double-Blind Comparison of the Efficacy of Continued Zidovudine Versus 2',3'-Dideoxyinosine (ddI) (BMY-40900) for the Treatment of Patients With AIDS or AIDS-Related Complex and Increasing Symptomatology Despite Treatment With Zidovudine

HIV Infections

United States, Puerto Rico
National Institute of Allergy and Infectious Diseases...

Completed

The Effectiveness of Two Anti-HIV Treatments in HIV-Infected Patients

HIV Infections

United States
Wageningen University
Roquette Frères; Sensus BV; Cosun Nutrition Center; Oceanium Ltd.; Technical University...

Not yet recruiting

Gut-brain Health Effects of PREbiotics in Older Adults With Suspected COgnitive DEcline (PRECODE)

Subjective Cognitive Decline

Netherlands
Fudan University

Unknown

Orally Fludarabine, Adriamycin and Dexamethasone (FAD) in Newly Diagnosed Peripheral T-cell Lymphomas (PTCL) (FAD)

Chemotherapy | T-Cell Lymphomas

China
University Health Network, Toronto
Canadian Society of Hospital Pharmacists

Withdrawn

Dosing Intervals of Opioid Medication for Chronic Pain

Chronic Pain

Canada
Fundación Dermabase
IPS Universitaria-Universidad de Antioquia; Grupo de Investigacion Dermatologica...

Completed

Efficacy of Methyl Aminolevulinate + Daylight in Patients With Facial Photodamage

Facial Photodamage

Colombia

Search clinical trials for: Placebo controlled-ileocolonic-release nicotinamide (SAD/MAD)

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Cambodia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations