Search clinical trials for: Placebo hydromorphone

Total 54098 results

M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Effect of Opioid Infusion Rate on Abuse Liability Potential of Intravenous Hydromorphone for Cancer Pain

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm

United States
Mayo Clinic

Recruiting

A Study of Intrathecal Hydromorphone for Pediatric Idiopathic Scoliosis Repair

Pain Control

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Liposomal Bupivacaine With or Without Hydromorphone for the Improvement of Pain Control After Laparotomy in Patients With Gynecological Malignancies

Malignant Female Reproductive System Neoplasm

United States
Tris Pharma, Inc.

Completed

A Trial to Evaluate the Abuse Potential of 3 Doses of GRT6005 in Adult Non-dependent Recreational Opioid Users

Abuse, Drug

Canada
Johnson & Johnson Pharmaceutical Research & Development...

Completed

Effect of Dose on the Pharmacokinetics of OROS Hydromorphone Under Fasted Conditions in Healthy Taiwanese Participants

Healthy Volunteers

Taiwan
Mundipharma Research GmbH & Co KG

Completed

Optimisation of Hydromorphone - Naloxone Ratio for the Treatment of Pain (HMX3501)

Constipation

Romania, Switzerland, Israel, Belgium, Germany, Australia, Austria, Czech Republic, Denmark, Finland, France, Netherlands, Poland, United Kingdom
Brigham and Women's Hospital

Terminated

Intrathecal Hydromorphone for Post-cesarean Delivery Pain - a Dose Finding Study

Pain | Healthy | Pregnancy

United States
Mallinckrodt

Completed

Study to Test the Effectiveness of Controlled-Release OROS® Hydromorphone HCl Compared to Placebo in Patients With Chronic Low Back Pain

Chronic Low Back Pain
Janssen-Cilag International NV

Completed

Placebo-controlled Trial With OROS Hydromorphone Hydrochloride to Treat Patients With Moderate to Severe Pain Induced by Osteoarthritis of the Hip or the Knee

Pain | Osteoarthritis, Knee | Osteoarthritis, Hip

United Kingdom, Romania, Slovakia, Czech Republic
Mallinckrodt

Completed

A Double-blind Study of Controlled Release OROS Hydromorphone Compared to Placebo in Patients With Chronic Osteoarthritis (OA) Pain

Chronic Pain
Thomas Jefferson University

Completed

Intrathecal Hydromorphone for Cesarean Section

Pain

United States
Vishal Uppal

Completed

Pre-emptive Opioid Treatment to Prevent Rebound Pain After Arthroscopic Rotator Cuff Repair and/or Acromioplasty Under General Anesthesia and Interscalene Block

Pain | Rotator Cuff Injury

Canada
Montefiore Medical Center
National Institute on Aging (NIA)

Completed

IV Acetaminophen as an Analgesic Adjunct

Acute Pain

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Levorphanol as a Second Line Opioid in Reducing Pain in Patients With Cancer

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
Grünenthal GmbH

Completed

A Clinical Study in Healthy Adults Who Sometimes Take Drugs for Pleasure Which Aims to Evaluate Whether GRT0151Y is Likely to be Abused

Pain | Acute Pain

Canada
Shirley Ryan AbilityLab
Mallinckrodt

Completed

True Functional Restoration and Analgesia in Non-Radicular Low Back Pain (Covidien)

Low Back Pain

United States
University Health Network, Toronto

Completed

Post-operative Epidural Analgesia After Minimally Invasive Lumbar Decompression and Fusion

Low Back Pain

Canada
Xinhua Hospital, Shanghai Jiao Tong University...

Completed

Intrathecal Hydromorphone for Postoperative Pain of Anorectal Surgery (IMPAS)

Analgesia | Acute Pain | Post Operative Pain | Anorectal Disorder

China
University of Alberta
University of Manitoba; The Hospital for Sick Children; Centre hospitalier de... and other collaborators

Completed

Non-Steroidal or Opioid Analgesia Use for Children With Musculoskeletal Injuries (No OUCH)

Musculoskeletal Injury

Canada
Johnson & Johnson Pharmaceutical Research & Development...

Completed

An Efficacy and Safety Study of Oral Osmotic Therapeutic System (OROS) Hydromorphone Hydrochloride (HCl) in Participants With Cancer Related Pain

Pain

China
University of British Columbia
Canadian Institutes of Health Research (CIHR); Providence Healthcare; Innerchange...

Completed

Study to Assess Longer-term Opioid Medication Effectiveness (SALOME) (SALOME)

Heroin Dependence | Opioid Dependence

Canada
Fujian Cancer Hospital

Completed

Intravenous vs Oral Analgesia in Cancer Patients With Severe Pain After Successful Titration

Cancer Pain

China
Dr. Anthony Ho

Recruiting

Epidural Versus Paravertebral Block Analgesia After Hepatectomy

Pain Control After Elective Hepatectomy

Canada
New York State Psychiatric Institute
University of Kentucky

Completed

A Study to Evaluate the Abuse Potential of Oxymorphone Compared to Other Mu Opioid Agonists.

Opioid Use Disorder

United States
Nova Scotia Health Authority
Canadian Institutes of Health Research (CIHR); Nova Scotia Health Research... and other collaborators

Completed

Palliation of Dyspnea in Advanced Chronic Obstructive Pulmonary Disease (COPD) (ROS-003)

Chronic Obstructive Pulmonary Disease (COPD)

Canada
Albert Einstein College of Medicine

Completed

IV Acetaminophen as Adjuvant Analgesic to Hydromorphone - Emergency Department Patients

Acute Pain

United States
Parc de Salut Mar

Completed

Generation of Biological Samples Positive to Hydromorphone for Anti-doping Control (HM)

Healthy Volunteers

Spain
Janssen Korea, Ltd., Korea

Completed

Study to Evaluate Effectiveness and Tolerability of OROS Hydromorphone for Cancer Pain Treatment in Korean Patients

Cancer Pain

Korea, Republic of
Qianfoshan Hospital

Not yet recruiting

Hydromorphone for Perioperative Analgesia in Lung Tumor Ablation Parallel Controlled

Pulmonary Nodule | Ablation
Second Affiliated Hospital, School of Medicine,...

Unknown

The Effect of Esketamine on Patients Undergoing Tumor Surgery

Tumor Surgery

China
Hordinsky, Maria K., MD

Terminated

Topical Hydromorphone for Wound Healing

Wound Healing

United States
Janssen Research & Development, LLC

Completed

Pharmacokinetic Profile of OROS Hydromorphone in Healthy Taiwanese Participants With Different Genotypes for the UGT2B7 Gene

Healthy Volunteers

Taiwan
Roswell Park Cancer Institute

Completed

Epidural Hydromorphone Compared With Hydromorphone Infusion in Treating Patients With Prostate Cancer Undergoing Radical Prostatectomy

Pain | Prostate Cancer

United States
Janssen Korea, Ltd., Korea

Completed

An Observational Study to Investigate Clinical Usefulness of OROS Hydromorphone in Korean Cancer Patients

Pain
Virginia Commonwealth University

Terminated

Dose and Response of Intrathecal Hydromorphone in Patients Undergoing Cesarean Section at Virginia Commonwealth University Health System

Cesarean Section | Obstetric Anesthesia

United States
Northwestern University

Withdrawn

Hydromorphone Pharmacokinetic-Pharmacodynamic Fingerprint

Pain | Ventilatory Depression

United States
Janssen Korea, Ltd., Korea

Completed

An Efficacy and Safety Study of Hydromorphone Hydrochloride (HCl) Oral Osmotic System (OROS) in the Reduction of Breakthrough Pain Medication Frequency in Participants With Cancer

Pain | Cancer
Janssen Korea, Ltd., Korea

Completed

Clinical Usefulness and Quality of Life of OROS Hydromorphone in Patients Who Have Not Been Treated With a Strong Opioid

Pain

Korea, Republic of
Alza Corporation, DE, USA

Completed

A Repeated-Dose Evaluation of a Pain Relieving Drug Use and Safety of OROS Hydromorphone HCI in Patients With Chronic Non-Malignant Pain

Pain | Analgesics | Opioid
Duke University
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health... and other collaborators

Completed

Comparing Acute Pain Management Protocols for Patients With Sickle Cell Disease

Sickle Cell Disease

United States
Alza Corporation, DE, USA

Completed

A Repeated Dose Study of the Metabolism and Action Evaluation of OROS Hydromorphone HCI (Slow Release) Tablets in Patients With Chronic Pain

Pain | Analgesics, Opioid
Janssen Pharmaceutica N.V., Belgium

Completed

A Study of the Effectiveness and Safety of Sustained-release Hydromorphone (a Strong Opioid) in Patients With Chronic Noncancer Pain.

Pain

France, Poland, Germany, Slovenia, Sweden, Czech Republic, Norway, Slovakia, Switzerland, Denmark
Alza Corporation, DE, USA

Completed

A Study to Evaluate the Effectiveness and Safety of Slow Release Hydromorphone HCL for Treatment of Patients With Osteoarthritis

Osteoarthritis, Knee | Osteoarthritis, Hip
Alza Corporation, DE, USA

Completed

Safety and Tolerability of Long-term Administration of OROS Hydromorphone HCI (Slow Release) in Cancer Pain

Pain | Analgesics, Opioid
Purdue Pharma LP

Terminated

Efficacy and Safety of Hydromorphone Hydrochloride Extended-Release Compared to Placebo in Subjects With Persistent Pain

Chronic Non-Malignant Pain

United States
Alza Corporation, DE, USA

Completed

Safety and Tolerability of Long-Term Administration of Hydromorphone HCI CR (Controlled Release)

Pain | Analgesics, Opioid
Alza Corporation, DE, USA

Completed

A Randomized, Open-Label, Single-Dose, Small Study to Evaluate the Safety and Effectiveness of Hydromorphone in Patients With Short Term, Moderate to Severe Postoperative Pain

Pain, Postoperative | Analgesia | Orthopedic Procedures
M.D. Anderson Cancer Center
Archimedes Pharma US, Inc.

Terminated

Fentanyl for Breakthrough Pain in the Emergency Department

Pain

United States
Alza Corporation, DE, USA

Completed

A Repeated-Dose Evaluation of Use of a Pain Relieving Drug and Safety of OROS Hydromorphone HCI in Patients With Chronic Cancer Pain

Pain | Analgesics, Opioid
Piramal Critical Care, Ltd.

Completed

Safety and Efficacy Study of Hydromorphone Hydrochloride by Intrathecal Administration

Management of Chronic Pain

United States

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