Search clinical trials for: Plasminogen Inactivators

Total 451 results

University of Medicine and Pharmacy at Ho Chi Minh...

Unknown

Efficacy of Intravenous Tissue-type Plasminogen Activator on Acute Ischemic Stroke Patients With Large Vessel Occlusions

Stroke, Ischemic | Stroke, Acute

Vietnam
Northwestern University

Suspended

Study To antagOnize Plasminogen Activator Inhibitor-1 in Severe COVID-19

Covid19

United States
The First Hospital of Jilin University

Not yet recruiting

The Diagnostic and Prognostic Value of TAT, PIC, tPAI·C and TM in Sepsis-induced Coagulopathy

Sepsis-induced Coagulopathy
Azienda U.S.L. 1 di Massa e Carrara

Withdrawn

Efficacy and Safety of Half Dose Alteplase Added to Heparine, in Patients With Moderate Pulmonary Embolism (MONALYSE)

Pulmonary Embolism
University of California, San Diego
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Intravenous Thrombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke

Stroke

United States
Beijing Tsinghua Chang Gung Hospital

Completed

Thrombolysis Endovascular Treatment of Pulmonary Embolism (STEP)

Pulmonary Embolism | Acute Pulmonary Embolism

China
Population Health Research Institute
Heart and Stroke Foundation of Canada

Recruiting

Adjunctive, Low-dose tPA in Primary PCI for STEMI (STRIVE)

Myocardial Infarction | Percutaneous Coronary Intervention

Canada
Thomas Jefferson University
Genentech, Inc.

Unknown

Quality of Life After Stroke Using a Telemedicine-based Stroke Network (STROKE TeleQOL)

Stroke

United States
University of Washington
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Myocardial Infarction Triage and Intervention Project (MITI)

Myocardial Infarction | Myocardial Ischemia | Heart Diseases | Cardiovascular Diseases | Coronary Disease
Angde Biotech Pharmaceutical Co., Ltd.

Unknown

Injection of Recombinant Human Tissue-type Plasminogen Activator Derivative for Acute Pulmonary Embolism(rPA) (rPA)

Acute Pulmonary Embolism
Assiut University

Unknown

Regisry of the Stroke Patients in Assiut University Hospital

All Patients With Ischemic Cerebrovascular Stroke Aged ≥18 Years of Both Sex
Hospital de Clinicas de Porto Alegre

Withdrawn

Safety and Efficacy of the Penumbra™ System in Acute Middle Cerebral Artery (MCA) Stroke

Stroke

Brazil
University of Cincinnati
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Interventional Management of Stroke (IMS) II Study

Stroke

United States
University College, London

Recruiting

Nebulised Rt-PA for ARDS Due to COVID-19 (PACA)

COVID

United Kingdom
Washington University School of Medicine
Massachusetts General Hospital; National Heart, Lung, and Blood Institute (NHLBI) and other collaborators

Completed

Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis (ATTRACT)

Venous Thrombosis | Deep Vein Thrombosis | Postphlebitic Syndrome | Venous Thromboembolism | Post Thrombotic Syndrome

United States
Angde Biotech Pharmaceutical Co., Ltd.
Beijing Tiantan Hospital

Unknown

A PhaseⅡ of Injection for Recombinant Human Tissue Plasminogen Kinase Derivative in Treatment of Acute Ischemic Stroke.

Acute Ischemic Stroke

China
University of Rijeka

Completed

Neuroinflammatory Response in Patients With ICH and IVH Treated With rtPA

Brain Injuries | Intraventricular Hemorrhage | Hypertensive Intracerebral Hemorrhage
General Hospital of Shenyang Military Region

Completed

EXtending the tIme Window of Thrombolysis by ButyphThalide up to 6 Hours After Onset (EXIT-BT)

Stroke, Ischemic

China
Beijing Chao Yang Hospital

Completed

Low Dosage of rt-PA in the Treatment of Pulmonary Thromboembolism in China

Thromboembolism | Pulmonary Embolism

China
Eastern Regional Medical Center

Recruiting

Combination Tissue Plasminogen Activator (Tpa) and Dornase Alfa (Dnase) Administration Through Intrapleural Catheters for the Treatment of Loculated or Non-Draining Malignant Pleural Effusions

Loculated or Non-draining Malignant Pleural Effusions

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Thrombolysis in Myocardial Infarction (TIMI)

Myocardial Infarction | Myocardial Ischemia | Heart Diseases | Cardiovascular Diseases | Coronary Disease
Penumbra Inc.

Completed

Assess the Penumbra System in the Treatment of Acute Stroke (THERAPY)

Ischemic Stroke

United States
Assiut University
Aswan University Hospital

Completed

TPA in Acute Stroke With COVID Verus Non-COVID-19 Patients (rTPA)

Acute Ischemic Stroke

Egypt
Yale University

Withdrawn

The Safety and Efficacy of Fibrinolysis in Patients With an Indwelling Pleural Catheter for Multi-loculated Malignant Pleural Effusion.

Pleural Effusion | Cancer, Lung
M.D. Anderson Cancer Center

Recruiting

Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm

United States
Mazandaran University of Medical Sciences

Completed

Thrombolysis Outcome in Ischemic Stroke (TOSSI)

Mortality | Stroke, Acute | Thrombolytic Therapy | Alteplase

Iran, Islamic Republic of
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Thrombolysis in Myocardial Ischemia Trial (TIMI III)

Myocardial Infarction | Myocardial Ischemia | Heart Diseases | Cardiovascular Diseases | Coronary Disease | Angina Pectoris
Johns Hopkins University

Completed

Intraventricular Rt-PA in Patients With Intraventricular Hemorrhage

Cerebral Hemorrhage

United States
Sir Charles Gairdner Hospital
The University of Western Australia

Terminated

The Safety and Tolerability of Intra-abdominal t-PA and DNase on Peritonitis in Peritoneal Dialysis Patients

Peritoneal Dialysis | Peritoneal Dialysis, Continuous Ambulatory

Australia
National Institutes of Health Clinical Center (CC)

Completed

Low-Dose rtPA to Treat Blood Clots in Major Arm or Neck Veins

Thrombosis

United States
Fundació Institut de Recerca de l'Hospital de la...

Completed

Sonothrombolysis Potentiated by Microbubbles for Acute Ischemic Stroke

Cerebrovascular Stroke

Spain
Neuroscience Trials Australia
Melbourne Health; University of Melbourne; Commonwealth Scientific and Industrial... and other collaborators

Completed

Extending the Time for Thrombolysis in Emergency Neurological Deficits (EXTEND)

Stroke

Australia, Finland, New Zealand
Kartal Kosuyolu Yuksek Ihtisas Education and Research...

Completed

Comparison of Different TRansesophageal Echocardiography Guided thrOmbolytic Regimens for prosthetIc vAlve Thrombosis (TROIA)

Prosthetic Valve Thrombosis

Turkey
Grifols Therapeutics LLC

Completed

A Study of Intra-thrombus Plasmin (Human) In Acute Peripheral Arterial Occlusion

Acute Peripheral Arterial Occlusion

United States, Peru, Belgium, Bulgaria, Czech Republic, Germany, India, Poland, Romania, Serbia, Slovakia, Spain
Second Affiliated Hospital, School of Medicine,...

Recruiting

EXtending the Time Window for Thrombolysis in Posterior Circulation Stroke Without Early CT Signs

Stroke, Acute Ischemic

China
Prometic Biotherapeutics, Inc.

Completed

A Study of Prometic Plasminogen IV Infusion in Subjects With Hypoplasminogenemia

Hypoplasminogenemia | Congenital Plasminogen Deficiency

United States, Norway
Tulane University

Completed

Fibrinolysis Compared to Thoracoscopy for Pleural Infection

Pleural Diseases | Pleural Infection | Empyema | Parapneumonic Effusion

United States
Neuroscience Trials Australia

Terminated

Extending the Time for Thrombolysis in Emergency Neurological Deficits - Intra-Arterial (EXTEND-IA)

Ischemic Stroke

Australia, New Zealand
Neuroscience Trials Australia
China Medical University Hospital

Completed

EXTEND (International): Extending the Time for Thrombolysis in Emergency Neurological Deficits (International) (EXTEND)

Stroke

Taiwan
Kyorin University

Completed

Submacular Hemorrhage Associated With Retinal Arterial Macro Aneurysm

Submacular Hemorrhage | Ruptured Retinal Arterial Macro Aneurysms

Japan
Niguarda Hospital

Completed

Local Versus Systemic Thrombolysis for Acute Ischemic Stroke (SYNTHESIS)

Stroke | Cerebrovascular Accident

Italy
Prometic Biotherapeutics, Inc.
Vanderbilt University Medical Center; Cedars-Sinai Medical Center; Indiana Hemophilia...

No longer available

A Single-patient Study of Repeat-dose Administration of Prometic Plasminogen (Human) Intravenous

Hypoplasminogenemia
Seattle Children's Hospital
The Hospital for Sick Children; Medical College of Wisconsin; McMaster University and other collaborators

Terminated

Thrombolysis in Pediatric Stroke (TIPS) (TIPS)

Stroke

United States, Canada
South West Sydney Local Health District

Recruiting

Viscoelastic Testing Guided Tissue Plasminogen Activator Treatment in Acute Respiratory Failure (VETtiPAT-ARF)

Acute Respiratory Failure | Hypercoagulability | Fibrinolysis Shutdown

Australia
Melbourne Health

Completed

Tenecteplase Versus Alteplase for Stroke Thrombolysis Evaluation Trial in the Ambulance (TASTEa)

Stroke, Acute, Stroke Ischemic

Australia
Medtronic Neurovascular Clinical Affairs

Completed

Solitaire™ With the Intention For Thrombectomy as PRIMary Endovascular Treatment (SWIFT PRIME) Trial (SWIFT PRIME)

Acute Ischemic Stroke

United States
Kedrion S.p.A.

Completed

Efficacy/Safety of Human Plasminogen Eye Drop in Ligneous Conjunctivitis Patients

Ligneous Conjunctivitis

United States, Italy
Xuanwu Hospital, Beijing

Recruiting

Intra-arterial Thrombolysis After Successful Thrombectomy for Acute Ischemic Stroke in the Posterior Circulation (IAT-TOP)

Acute Ischemic Stroke | Arterial Thrombosis | Posterior Circulation Brain Infarction

China
National Institutes of Health Clinical Center (CC)

Completed

Treatment for Blood Clots in the Veins of the Legs

Embolism | Thrombophlebitis

United States
The Second Artillery General Hospital
Hunan Rui Kang Tong technology development co., LTD

Unknown

Mechanical Opening Device Implantation Following Intravenous r-tPA for Recanalization in Acute Ischemic Stroke

Ischemic Cerebrovascular Accident

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