Search clinical trials for: recombinant asparaginase

Total 2801 results

medac GmbH

Completed

Comparative Efficacy and Safety of Two Asparaginase Preparations in Children With Previously Untreated Acute Lymphoblastic Leukaemia

Acute Lymphoblastic Leukemia

Netherlands
medac GmbH

Completed

Efficacy and Safety of Recombinant Asparaginase in Infants With Previously Untreated Acute Lymphoid Leukemia (ALL)

Acute Lymphoid Leukemia

Germany, Netherlands
medac GmbH
Syneos Health

Recruiting

PK, PD, Safety and Immunogenicity of Spectrila in Adults With Acute B-cell Lymphoblastic Leukaemia

Acute B-Cell Lymphoblastic Leukaemia

Brazil
Jazz Pharmaceuticals

Approved for marketing

JZP458 - Recombinant Erwinia Asparaginase for Treatment of ALL / LBL Patients With Hypersensitivity to E. Coli-derived Asparaginase

Acute Lymphoblastic Leukemia | Lymphoblastic Lymphoma
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Erwinia Asparaginase After Allergy to PEG-Asparaginase in Treating Young Patients With Acute Lymphoblastic Leukemia

Childhood Acute Lymphoblastic Leukemia | Adult Acute Lymphoblastic Leukemia

United States
Memorial Sloan Kettering Cancer Center
Jazz Pharmaceuticals

Withdrawn

Intravenous Erwinia Chrysanthemi Asparaginase in Patients With Newly Diagnosed Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia Aged 60 Years or Older

Acute Lymphoblastic Leukemia (ALL) | Newly Diagnosed Philadelphia Chromosome Negative | Aged 60 Years or Older

United States
Phoenix Children's Hospital
Jazz Pharmaceuticals; Fisher Bioservices

No longer available

Erwinase Master Treatment Protocol (EMTP)

Acute Lymphoid Leukemia | Leukemia, Acute Lymphoblastic
ERYtech Pharma
Centre Leon Berard

Completed

Administration of Allogenic Red Blood Cells Loaded L-asparaginase in Cases of Relapse of Acute Lymphoblastic Leukaemia (GRASPALL)

Acute Lymphoblastic Leukemia

France
Jazz Pharmaceuticals

Completed

A Study of Erwinaze Administered Intravenously in Patients Who Had an Allergy to Frontline Asparaginase Therapy

Acute Lymphoblastic Leukemia | Lymphoblastic Lymphoma

United States, Canada
M.D. Anderson Cancer Center

Completed

Erwinase Study in Patients With Acute Lymphoblastic Leukemia

Leukemia

United States
Nordic Society for Pediatric Hematology and Oncology
Danish Child Cancer Foundation; Medac, Hamburg, Germany

Unknown

Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses

Acute Lymphoblastic Leukemia

Denmark
ERYtech Pharma

Terminated

L-asparaginase Encapsulated in Red Blood Cells (Eryaspase) for Treatment of Adult Patients With ALL or LBL

Acute Lymphoblastic Leukemia | Lymphoblastic Lymphoma

United States
Children's Oncology Group

Recruiting

Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma

Lymphoblastic Lymphoma | B Acute Lymphoblastic Leukemia | B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 | T Acute Lymphoblastic Leukemia | Mixed Phenotype Acute Leukemia | B Acute Lymphoblastic Leukemia, BCR-ABL1-Like

United States, Canada
Fudan University

Completed

L-asparaginase Monotherapy as Salvage Treatment in Patients With NK/T Cell Lymphoma

Lymphoma

China
Jazz Pharmaceuticals

Withdrawn

An Open-Label, Single-Arm, Multicenter Pharmacokinetic Study of Intramuscular Erwinaze® (Asparaginase Erwinia Chrysanthemi)/Erwinase® (Crisantaspase)

Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL)

Spain
National Cancer Institute (NCI)

Completed

Phase II Study of Clinical Activity of Pegaspargase in Women With Relapsed or Refractory Epithelial Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal Cancer

Ovarian Neoplasms | Fallopian Tube Neoplasms | Primary Peritoneal Neoplasms

United States
Baxalta now part of Shire

Completed

Pharmacokinetic Comparison of Advate rAHF-PFM With Recombinate rAHF in Patients With Severe Hemophilia A

Hemophilia A

Germany
Rigshospitalet, Denmark
Nordic Society for Pediatric Hematology and Oncology

Completed

ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia Intermittent Versus Continuous PEG Asparaginase

Acute Lymphoblastic Leukemia

Finland, Denmark, Norway, Sweden, Iceland
Rong Tao

Completed

Social Media-based Active Self-report on Incidence and Outcomes of Adverse Events in NK/TCL Patients

Extranodal NK-T-Cell Lymphoma, Nasal Type

China
ERYtech Pharma

Completed

GRASPA Treatment for Patients With Acute Myeloblastic Leukemia (ENFORCE)

Acute Myeloid Leukemia

France
ERYtech Pharma

No longer available

Expanded Access Program: Safety of Erythrocytes Encapsulating L-asparaginase (GRASPA®) in Combination With Polychemotherapy in Patients Under 55 Years Old With Acute Lymphoblastic Leukemia (ALL) at Risk to Receive Other Formulation of Asparaginase (EAP)

Acute Lymphoblastic Leukemia

France
ERYtech Pharma

Completed

GRASPA (Erythrocytes Encapsulating L-asparaginase) in Patients With Relapse of Acute Lymphoblastic Leukemia (GRASPIVOTALL)

Acute Lymphoblastic Leukemia, in Relapse

France, Belgium
Hunan Cancer Hospital

Recruiting

Anti-PD-1 Antibody Combined With Peg-Asparaginase and Chidamide for the Early Stage of NK/T Cell Lymphoma

Chemotherapy Effect | NK/T-cell Lymphoma of Nasal Cavity | Immune Checkpoint Inhibitor | Epigenetic Disorder

China
Gruppo Italiano Malattie EMatologiche dell'Adulto

Terminated

Asparaginase Activity Monitoring (AAM) in Adult Patients With Acute Lymphoblastic Leukemia (ALL) (ALL2518)

Acute Lymphoblastic Leukemia

Italy
Aarhus University Hospital

Completed

The Association Between Asparaginase Enzyme Activity Levels and Toxicities in Childhood Acute Lymphoblastic Leukaemia in NOPHOALL 2008

Acute Lymphoblastic Leukemia

Denmark
M.D. Anderson Cancer Center
Jazz Pharmaceuticals

Withdrawn

Phase II Study of Fludarabine, Cytarabine (ARA-C) and Erwinase IV in Patients With Relapsed or Refractory Hematologic Malignancies

Hematologic Malignancy
St. Jude Children's Research Hospital
Parexel; Jazz Pharmaceuticals

Completed

Compassionate Use of Erwinase For Pediatric Patients With Acute Lymphoblastic Leukemia Or Non Hodgkins Lymphoma

Acute Lymphoblastic Leukemia | Non Hodgkins Lymphoma

United States
OHSU Knight Cancer Institute
Genentech, Inc.; Oregon Health and Science University; Servier Pharmaceuticals...

Recruiting

Calaspargase Pegol-Mnkl and Cobimetinib for the Treatment of Locally Advanced or Metastatic Pancreatic Cancer

Stage II Pancreatic Cancer AJCC v8 | Stage III Pancreatic Cancer AJCC v8 | Stage IV Pancreatic Cancer AJCC v8 | Metastatic Pancreatic Adenocarcinoma | Locally Advanced Pancreatic Adenocarcinoma | Stage IIA Pancreatic Cancer AJCC v8 | Stage IIB Pancreatic Cancer AJCC v8

United States
Children's Oncology Group
National Cancer Institute (NCI)

Recruiting

Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia

Recurrent B Acute Lymphoblastic Leukemia | Refractory B Acute Lymphoblastic Leukemia | Recurrent B Lymphoblastic Lymphoma | Refractory B Lymphoblastic Lymphoma

United States, Puerto Rico
Universidade Federal do Rio de Janeiro

Completed

Hipoenergetic Effect of Diet Associated or Not With the Consumption of Coconut Flour in Women With Overweight

Obesity | Cardiovascular Risk Factor
St. Jude Children's Research Hospital

Active, not recruiting

A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia

Acute Myeloid Leukemia | Myelodysplastic Syndromes

United States
Shandong University
Shandong Provincial Hospital; The First Affiliated Hospital of Dalian Medical...

Completed

An Investigation of rhTPO With Different Frequencies in the Management of ITP

Immune Thrombocytopenia

China
Ashkan Emadi

Completed

1336GCC: Study of Erwinaze for Treatment of Acute Myeloid Leukemia (AML)

Acute Myeloid Leukemia

United States
Peking Union Medical College
Shenyang Sunshine Pharmaceutical Co., LTD.

Unknown

Efficacy and Safety Study of Maintenance Treatment With rhTPO in Thrombocytopenic Subjects With ITP

Thrombocytopenia | Immune Thrombocytopenia | Idiopathic Thrombocytopenic Purpura

China
Aristotle University Of Thessaloniki

Unknown

Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Eukaemia During Therapy With L - Asparaginase.

Acute Lymphoblastic Leukemia

Greece
Massachusetts General Hospital

Completed

Recombinant Human Prolactin for Lactation Induction

Lactation

United States
Sun Yat-sen University
JIANGSU JIBEIER PHARMACEUTICAL CO.,LTD

Not yet recruiting

A Multi-center, Randomized, Double-blind, Phase III Clinical Trial of Leucogen Versus Placebo on Leukocyte and Platelet Whole-course Management Assisted by PFLL Chemotherapy in the Treatment of Stage IV, Recurrent or Metastatic NPC

Nasopharyngeal Carcinoma | Chemotherapy | Myelosuppression | Leucogen

China
Tianjin Medical University General Hospital

Unknown

Efficacy and Safety of Thrombopoietin In Patients With Severe and Very Severe Aplastic Anemia

Anemia, Aplastic

China
Dana-Farber Cancer Institute
Leadiant Biosciences, Inc.

Terminated

A Pilot Study of Oncaspar® + Dexamethasone in Patients With Relapsed or Refractory T-Cell Lymphoma

T-Cell Lymphoma | Relapsed T-Cell Lymphoma | Refractory T-Cell Lymphoma

United States
Steen Bonnema

Completed

rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular Goiter

Nodular Goiter

Denmark
M.D. Anderson Cancer Center
Leadiant Biosciences, Inc.

Completed

Methotrexate, Vincristine, Pegylated L-Asparaginase and Dexamethasone (MOAD) in Acute Lymphoblastic Leukemia (ALL) Salvage

Leukemia, Lymphocytic, Acute

United States
Baxalta now part of Shire
Takeda

Completed

RIXUBIS Drug Use-Result Survey (Japan)

Hemophilia B

Japan
Baxter Healthcare Corporation
PPD; Halozyme Therapeutics

Completed

Study of Subcutaneous Rehydration With Recombinant Human Hyaluronidase for Infants and Children (INFUSE-PR)

Dehydration
Baxalta now part of Shire

Completed

Phase 1 Dose Escalation, Single Dose Study to Assess Safety and Pharmacokinetics of BAX930 in Hereditary Thrombotic Thrombocytopenic Purpura (TTP)

Hereditary Thrombotic Thrombocytopenic Purpura (TTP)

United States, Germany, United Kingdom, Switzerland, Austria, Japan, Poland
Hospital de Cruces

Completed

Ultrasound Guided Artificial Insemination (UGAI)

Insemination

Spain
Corixa Corporation

Unknown

Safety and Immunogenicity of Recombinant DNA and Adenovirus Expressing L523S Protein in Early Stage Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer

United States
St. Jude Children's Research Hospital
Incyte Corporation; Amgen; Servier

Active, not recruiting

Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma

Acute Lymphoblastic Leukemia | Acute Lymphoblastic Lymphoma

United States, Australia
Massachusetts General Hospital

Withdrawn

Recombinant Human Prolactin for Lactation Induction

Lactation

United States
The First Affiliated Hospital with Nanjing Medical...

Recruiting

Efficacy and Safety of a Half-dose Bolus of r-SAK Prior to Primary PCI in ST-elevation Myocardial Infarction (OPTIMA-6)

ST Elevation Myocardial Infarction

China
Novo Nordisk A/S

Completed

Efficacy Study of IL-21 to Treat Metastatic Melanoma

Cancer | Malignant Melanoma

Australia

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