Search clinical trials for: sodium bicarbonate

Total 10984 results

Masonic Cancer Center, University of Minnesota

Recruiting

Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies

Common Variable Immunodeficiency | Chronic Granulomatous Disease | Hemophagocytic Lymphohistiocytosis | Wiskott-Aldrich Syndrome | X-linked Lymphoproliferative Disease | Langerhan's Cell Histiocytosis | Chediak-Higashi Syndrome | Griscelli Syndrome | Bare Lymphocyte Syndrome | SCID | Omenn's Syndrome | Reticular... and other conditions

United States
Cerevel Therapeutics, LLC

Completed

A Trial to Evaluate the Effects of Itraconazole and Carbamazepine on the Pharmacokinetics of Emraclidine and of Emraclidine on the Pharmacokinetics of Metformin in Healthy Adult Participants

Healthy Volunteers

United States
Seoul National University Hospital

Terminated

Rhythm Control Versus Rate Control for New Onset Atrial Fibrillation

Atrial Fibrillation New Onset | Atrial Fibrillation Paroxysmal

Korea, Republic of
Rutgers, The State University of New Jersey
National Cancer Institute (NCI)

Completed

Salsalate, Venetoclax, and Decitabine or Azacitidine for the Treatment of Acute Myeloid Leukemia or Advanced Myelodysplasia/Myeloproliferative Disease

Acute Myeloid Leukemia | Chronic Myelomonocytic Leukemia | Secondary Acute Myeloid Leukemia | Myelodysplastic Syndrome | Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | Myeloproliferative Neoplasm | Myeloblasts 10 Percent or More of Bone Marrow Nucleated Cells

United States
University of Colorado, Denver

Withdrawn

Transverse Abdominus Plane Block Study (TAP)

Surgery | Colorectal Disorders

United States
Darnitsa Pharmaceutical Company
International Pharmaceutical Research Center

Completed

Bioequivalence Study of 8 mg Perindopril Tert-Butylamine / 2.5 mg Indapamide / 10 mg Amlodipine Tablets Versus 10 mg Perindopril Arginine / 2.5 mg Indapamide / 10 mg Amlodipine Film-Coated Tablets in Healthy Volunteers

Healthy Subjects | Bioequivalence

Jordan
National Institute of Allergy and Infectious Diseases...
Bristol-Myers Squibb; Rho Federal Systems Division, Inc.; Clinical Trials in...

Terminated

Optimization of NULOJIX® Usage Towards Minimizing CNI Exposure in Simultaneous Pancreas and Kidney Transplantation

Simultaneous Kidney and Pancreas Transplantation

United States
Children's Hospital Medical Center, Cincinnati
Bill and Melinda Gates Foundation; Syngene International

Completed

India Dexamethasone and Betamethasone

Preterm Birth | Antenatal Corticosteroids

India
Yangzhou University

Completed

Warfarin Prevents Portal Vein Thrombosis in Patients After Laparoscopic Splenectomy and Azygoportal Disconnection (ESWAPH)

Hypertension | Venous Thrombosis | Cirrhosis | Status;Splenectomy

China
National Cancer Institute (NCI)

Terminated

Oblimersen Plus Doxorubicin and Docetaxel in Treating Patients With Metastatic or Locally Advanced Breast Cancer

Male Breast Cancer | Stage IV Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IIIC Breast Cancer

United States
Peking University First Hospital
Peking University Cancer Hospital & Institute

Terminated

Dexamethasone, Flurbiprofen Axetil and Long-term Survival After Lung Cancer Surgery

Carcinoma, Non-Small-Cell Lung | Surgery | Dexamethasone | Long-term Effects Secondary to Cancer Therapy in Adults | Flubiprofen Axetil

China
Daiichi Sankyo, Inc.

Completed

Hydrochlorothiazide as add-on to Olmesartan/Amlodipine in Hypertension

Essential Hypertension

France, Poland, Ukraine, Belgium, Germany, Spain, Bulgaria, Romania, Denmark, Russian Federation, Netherlands, Austria, Slovakia, Czechia
Merck Sharp & Dohme LLC

Completed

Study of MK-1029 in Participants With Persistent Asthma That Cannot Be Controlled With Montelukast (MK-1029-015)

Asthma
IRCCS Policlinico S. Matteo

Terminated

Epigallocatechingallate (EGCG) in Cardiac AL Amyloidosis (EpiCardiAL)

Primary Amyloidosis of Light Chain Type

Italy
Military Institute of Medicine, Poland

Completed

Non-invasive Haemodynamic Assessment in Hypertension (FINE-PATH)

Arterial Hypertension

Poland
Vanderbilt University Medical Center

Withdrawn

Mechanism(s) Underlying Cardiovascular Effects of ARB/NEP Inhibition - Aim 2

Heart Failure NYHA Class II | Heart Failure NYHA Class III | Heart Failure NYHA Class I

United States
AstraZeneca

Completed

Bioequivalence Study of Combination Tablets of Saxagliptin / Dapagliflozin / Metformin XR (Extended-release) and Dapagliflozin / Metformin XR Relative to Individual Components in Healthy Subjects

Type 2 Diabetes Mellitus

United Kingdom
Maher elesawi kamel elesawi

Unknown

Concomitant CC and E2 Versus CC Alone in Ovulation Induction

Infertility | Anovulation

Egypt
Celgene Corporation

Completed

MTD, Safety, and Efficacy of Pomalidomide (CC-4047) Alone or With Low-dose Dexamethasone in Patients With Relapsed and Refractory Multiple Myeloma

Multiple Myeloma

United States, Canada
University of North Carolina, Chapel Hill
Wake Forest University Health Sciences; Cornell University

Completed

A Pilot Study of Plasma Renin Activity Guided vs Generic Combination Therapy for Hypertension

Hypertension | Plasma Renin Activity

United States
National Cancer Institute (NCI)

Completed

Oblimersen Plus Combination Chemotherapy and Dexrazoxane in Treating Children and Adolescents With Relapsed or Refractory Solid Tumors

Unspecified Childhood Solid Tumor, Protocol Specific | Cardiac Toxicity

United States
Sidney Kimmel Cancer Center at Thomas Jefferson...
Bristol-Myers Squibb

Completed

Nivolumab, Cisplatin, and Pemetrexed Disodium or Gemcitabine Hydrochloride in Treating Patients With Stage I-IIIA Non-small Cell Lung Cancer That Can Be Removed by Surgery

Stage IIIA Non-Small Cell Lung Cancer | Stage IIA Non-Small Cell Lung Carcinoma | Stage IIB Non-Small Cell Lung Carcinoma | Stage I Non-Small Cell Lung Cancer | Stage II Non-Small Cell Lung Cancer | Stage IA Non-Small Cell Lung Carcinoma | Stage IB Non-Small Cell Lung Carcinoma | Non-Squamous Non-Small...

United States
Assistance Publique - Hôpitaux de Paris

Recruiting

Population Pharmacokinetics of Antiepileptic in Pediatrics (EPIPOP)

Epilepsy

France
Children's Oncology Group

Recruiting

A Study of SNDX-5613 in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia

Recurrent Acute Lymphoblastic Leukemia | Refractory Acute Lymphoblastic Leukemia | Recurrent Mixed Phenotype Acute Leukemia | Refractory Mixed Phenotype Acute Leukemia | Refractory Acute Leukemia of Ambiguous Lineage | Recurrent Acute Leukemia of Ambiguous Lineage | Recurrent Acute Myeloid Leukemia... and other conditions

United States
Tris Pharma, Inc.
Forest Laboratories

Completed

Efficacy and Safety of GRT6005 in Patients With Chronic Low Back Pain.

Low Back Pain

Austria, Belgium, Denmark, Finland, Germany, Hungary, Netherlands, Poland, Spain, Sweden, United Kingdom
Virginia Commonwealth University
National Cancer Institute (NCI)

Completed

Pemetrexed Disodium and Sorafenib Tosylate in Treating Patients With Advanced Solid Tumors

Unspecified Adult Solid Tumor

United States
Hospices Civils de Lyon

Not yet recruiting

Role of BMP Pathway in MDS Progression (BMP-MDS)

Myelodysplastic Syndromes | Acute Myelogenous Leukemia

France
Mt. Sinai Medical Center, Miami

Recruiting

Trial to Assess Chelation Therapy in Critical Limb Ischemia (TACT3a)

Diabetes | Critical Limb Ischemia

United States
Centre Hospitalier Intercommunal Creteil
Merck Sharp & Dohme LLC

Completed

New Ovarian Stimulation With Random Start, Use of Progestin Protocol for Oocyte Donors (RANDOS)

Infertility

France
Anhui Provincial Hospital

Unknown

Endostar Durative Transfusion Combined With Chemotherapy in the Treatment of Advanced Lung Adenocarcinoma

Adenocarcinoma of Lung

China
Boehringer Ingelheim

Terminated

Dose Escalation Study of BIBF 1120 in Combination With Carboplatin and PLD in Relapsed Ovarian Cancer (OC)

Ovarian Neoplasms

Japan
Boehringer Ingelheim

Completed

Study to Assess the Effect of Food on the Pharmacokinetics of Meloxicam After Single Administration and to Investigate Dose-proportionality Over a Dosage Range

Healthy
National Cancer Institute (NCI)

Completed

Yttrium Y 90 Ibritumomab Tiuxetan and Rituximab in Treating Patients With Post-Transplant Lymphoproliferative Disorder

Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Waldenström Macroglobulinemia | Post-transplant Lymphoproliferative Disorder | Stage III Adult Burkitt Lymphoma | Stage III Adult Diffuse Large Cell Lymphoma | Stage IV Adult Burkitt Lymphoma | Stage IV Adult Diffuse...

United States
Eastern Maine Medical Center

Completed

Treatment of Neonatal Abstinence Syndrome (HOMENOW)

Neonatal Abstinence Syndrome

United States
Sunnybrook Health Sciences Centre
Sunnybrook Research Institute

Recruiting

MAGNAM Trial, Magnesium Versus Amiodarone in Atrial Fibrillation in Critical Care (MAGNAM)

Atrial Fibrillation New Onset

Canada
Alexion Pharmaceuticals, Inc.

Completed

A Study to Evaluate Potential Drug Interactions Between ALXN2080 and Itraconazole, Fluconazole & Carbamazepine in Healthy Adults

Healthy

United Kingdom
RenJi Hospital
Ruijin Hospital

Completed

Risk Stratification of Heart Failure in Cardiomyopathies. (EARLY-MYO-HF)

Cardiomyopathy With Unknown Etiology

China
University of Alberta

Completed

Sex Differences in Sympathetic Vascular Reactivity at High Altitude

Vasodilation | Vasoconstriction

Canada
Food and Drug Administration (FDA)
Spaulding Clinical Research LLC

Completed

CiPA Phase 1 ECG Biomarker Validation Study

Pharmacokinetics | Pharmacodynamics | Drug-induced QT Prolongation

United States
Merck Sharp & Dohme LLC
Pfizer

Completed

Ertugliflozin and Sitagliptin Co-administration Factorial Study (VERTIS FACTORAL, MK-8835-005)

Type 2 Diabetes Mellitus
MaineHealth

Completed

Prophylaxis to Reduce Postoperative Atrial Fibrillation in Cardiac Surgery

Atrial Fibrillation | Atrial Flutter

United States
AstraZeneca
Parexel

Completed

A Study to Evaluate the Food Effect on Drug Availability, Pharmacokinetic (PK) Properties, Safety and Tolerability of Two Different Dose Combination Therapy of Saxagliptin/Dapagliflozin/Metformin Extended-release (XR) Against Individual Component Co-administration.

Type 2 Diabetes Mellitus

United States
Barbara Ann Karmanos Cancer Institute
National Cancer Institute (NCI)

Completed

Aprepitant, Granisetron, & Dexamethasone in Preventing Nausea & Vomiting in Pts. Receiving Cyclophosphamide Before a Stem Cell Transplant

Lymphoma | Myelodysplastic Syndromes | Leukemia | Testicular Germ Cell Tumor | Breast Cancer | Chronic Myeloproliferative Disorders | Ovarian Cancer | Gestational Trophoblastic Tumor | Neuroblastoma | Multiple Myeloma and Plasma Cell Neoplasm | Myelodysplastic/Myeloproliferative Neoplasms | Nausea and Vomiting

United States
National Institute of Allergy and Infectious Diseases...
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Withdrawn

Safety and Effectiveness of Low Molecular Weight Sulfated Dextran in Islet Transplantation After Kidney Transplant

Diabetes Mellitus, Type I
National Institute of Allergy and Infectious Diseases...

Completed

The Effect of Efavirenz and Nelfinavir on the Blood Levels of Certain Lipid-Lowering Drugs

HIV Infections | Lipodystrophy | HIV Seronegativity

United States
Guangdong Association of Clinical Trials

Not yet recruiting

Camrelizumab Combined With SRT/WBRT and Chemotherapy in Patients With Brain Metastases of Driven Gene-negative NSCLC

Non-Small-Cell Lung Cancer
Boehringer Ingelheim

Completed

Determining Optimal Free Dose Combination of Tiotropium Bromide and BI 1744 CL in Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive

Canada, Germany, Netherlands, Sweden
Imperial College London

Withdrawn

Adjuvant Vitamin D With Corticosteroids in Active Crohn's Disease (IBDVit1)

Crohn's Disease

United Kingdom
Boehringer Ingelheim

Completed

Effects of Tipranavir/Ritonavir on the Pharmacokinetic Characteristics of Triple Drug Nucleoside and Non-nucleoside Reverse Transcriptase Inhibitor Therapy in HIV-1-infected Subjects

HIV Infections
Boehringer Ingelheim

Completed

Salmeterol Inhalation Powder Administered as the Xinafoate Salt From Hard Polyethylene Capsules Via the HandiHaler® 2, and Serevent® Diskus® in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive

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