Search clinical trials for: Tesofensine/Metoprolol

Total 260 results

Saniona

Completed

Co-administration of Tesofensine/Metoprolol in Subjects With Prader-Willi Syndrome (PWS) (2016-003694-18)

Confirmed Genetic Diagnosis of Prader-Willi Syndrome

Czechia, Hungary
Saniona
Profil Institut für Stoffwechselforschung GmbH

Completed

Safety and Efficacy Study of Tesofensine/Metoprolol Treatment in Subjects With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

Germany
Boehringer Ingelheim

Completed

An Evaluation of Three Doses of NS 2330 in Patients With Mild to Moderate Dementia of the Alzheimer's Type

Alzheimer Disease

United States, Canada
NeuroSearch A/S

Completed

Effect of Tesofensine on Weight Reduction in Patients With Obesity.

Obesity

Denmark
NeuroSearch A/S

Completed

Evaluation of Long Term Safety of Tesofensine in Patients With Obesity

Obesity

Denmark
NeuroSearch A/S

Completed

Effect of Tesofensine on Energy Balance in Humans.

Obesity

Denmark
Saniona

Completed

Study to Investigate the Pharmacokinetic Profile

Healthy Male Subjects

Germany
Saniona

Completed

48 Weeks, Study to Evaluate Overall Safety and Tolerability of Co-administration of Tesofensine and Metoprolol in Subjects With Hypothalamic Injury-induced Obesity (HIO)

Hypothalamic Injury-induced Obesity (HIO)

Denmark
Saniona

Withdrawn

Study of Tesomet With Open-label Extension in Subjects With Hypothalamic Obesity (HO)

Hypothalamic Obesity

United States
Saniona

Withdrawn

Study of Tesomet With Open-label Extension in Subjects With Prader-Willi Syndrome (PWS)

Prader-Willi Syndrome

United States
Boehringer Ingelheim

Completed

A Randomized, Double-blind, Placebo-controlled, Five Parallel Groups Efficacy and Safety Study of NS 2330 (Tesofensine) (0.125 mg, 0.25 mg, 0.5 mg and 1.0 mg) Administered Orally Once Daily Over 14 Weeks in Levodopa Treated Parkinson Patients With Motor Fluctuations

Parkinson Disease

Spain, Germany, France, Austria, United Kingdom, Netherlands
University Hospital Schleswig-Holstein

Completed

Intravenous Beta-blockade for Improvement of Autonomic Activity

Hypertension | Tachycardia | Heart Rate Variability

Germany
Saniona

Completed

A Study to Examine the Effect of Tesofensine and Metoprolol on the 24-hour Mean Heart Rate

Phase 1

Germany
University of Cincinnati

Terminated

Sympathetic Nervous System Modulation in Hypertension

Hypertension
AstraZeneca

Completed

Metoprolol in Acute Myocardial Infarction. A PK/PD Study

Acute Myocardial Infarction
University of Minnesota
University of Alabama at Birmingham; United States Department of Defense

Terminated

Beta-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Pulmonary Disease, Chronic Obstructive

United States
East Coast Institute for Research

Completed

Comparative Effects of Nebivolol and Metoprolol on Female Sexual Function

Hypertension | Female Sexual Dysfunction

United States
Bright Future Pharmaceuticals Factory O/B Bright...
Chinese University of Hong Kong

Unknown

Clinical Bioequivalence Study on Two Metoprolol Tablet 100mg Formulations

Healthy
AstraZeneca
St. John's Research Institute

Completed

A Study to Compare the Efficacy, Safety and Tolerability of Selomax With Its Individual Components (MARS)

Primary Hypertension

India
Janssen Research & Development, LLC

Withdrawn

A Crossover Study to Evaluate the Effect of JNJ-54452840 on Pharmacodynamics of Metoprolol Tartrate Immediate-Release in Healthy Participants

Healthy

United States
University of Florida
Food and Drug Administration (FDA)

Completed

Open-Labeled PK-PD Studies of Metoprolol ER

Blood Pressure

United States
Harbin Medical University
Beijing Chao Yang Hospital

Completed

Effect of Intravenous Metoprolol Combining RIC on Myocardial Protection in STEMI Patients

Heart Failure | Anterior Myocardial Infarction

China
Xuanwu Hospital, Beijing
Tianjin Lerentang factory

Completed

Efficacy and Safety of Metoprolol Tartrate Tablets Combined With Chinese Traditional Medicine on Premature Ventricular Complex.

Premature Ventricular Contraction
University of Calgary
Vanderbilt University

Active, not recruiting

Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects

Vasovagal Syncope

Canada
Mikkel Bring Christensen

Completed

Effects of Lipid Emulsion on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol.

Blood Pressure | Drug Overdose | Overdose of Beta-adrenergic Blocking Drug

Denmark
Neutec Ar-Ge San ve Tic A.Ş

Not yet recruiting

S-Metoprolol XR 25-50 mg Tablets vs Metoprolol Zok 50-100 mg Tablets in Hypertension Patients.

Hypertension
University of Michigan

Completed

Evaluation of Metoprolol Pharmacokinetics in Patients Receiving Hi Flux Hemodialysis

Hemodialysis | Pharmacokinetics

United States
Elpen Pharmaceutical Co. Inc.

Withdrawn

Comparison of Effectiveness of Ranolazine Plus Metoprolol Combination vs. FlecainidE pluS Metoprolol Combination in ATrial Fibrillation Recurrences FOllowing PhaRmacological or Electrical CardioverSion of AtRial Fibrillation (PRESERVE-SR)

Recurrence | Atrial Fibrillation
Trinity Hypertension & Metabolic Research Institute

Completed

Efficacy and Safety of Nebivolol Versus Metoprolol in Hypertensive Subject Taking Amlodipine

JNC 7 Stage 1 or 2 Hypertension

United States
Washington University School of Medicine

Completed

Pilot - Peri-operative Beta Blockade

Adrenergic Beta-Receptor Blockader | Troponin Levels | Cardiomyopathy, Post-surgical

United States
AstraZeneca

Completed

307B - Safety, Tolerability and Pharmacokinetics Study of TOPROL-XL® in Hypertensive Pediatric Subjects

Hypertension

United States, Dominican Republic
Mayo Clinic
AstraZeneca

Completed

A Randomized Clinical Trial of Metoprolol in Participants With Mitral Regurgitation.

Heart Valve Diseases

United States
Hackensack Meridian Health

Terminated

Post-Acute Sequelae of Coronavirus-19 (COVID-19) With Dyspnea on Exertion And Associated TaChycardia TrEatment Study (PEACE)

COVID-19 | Tachycardia | Dyspnea

United States
Vanderbilt University Medical Center

Completed

Preemptive Pharmacogenetic-guided Metoprolol Management for PostoperativeAtrial Fibrillation in Cardiac Surgery (PREEMPTIVE)

Post-operative Atrial Fibrillation

United States
Kuopio University Hospital
Oulu University Hospital; Hospital Cordia, Kuopio, Finland

Completed

Intravenous Administration of Metoprolol Versus Biatrial Pacing in the Prevention of Atrial Fibrillation After Cardiac Surgery

Atrial Fibrillation | Biatrial Pacing | Metoprolol

Finland
Kuopio University Hospital

Unknown

Influence of CPB and Mini CPB to the Absorption of the Metoprolol (Minimeto)

Drug Absorption

Finland
Bristol-Myers Squibb
PRA Health Sciences

Completed

Effect of BMS-914392 on Pharmacokinetics of Metoprolol

Atrial Fibrillation

United States
Peking University First Hospital

Completed

The Effectiveness of Metoprolol in the Prevention of Syncope Recurrence in Children and Adolescents

Syncope, Vasovagal
Shiraz University of Medical Sciences

Completed

Effect of Metoprolol on Thalassemia Cardiomyopathy

B Thalassemia

Iran, Islamic Republic of
AstraZeneca

Completed

Dose Ranging, Safety and Tolerability of TOPROL-XL® Extended-Release Tablets in Hypertensive Pediatric Subjects (307A)

Hypertension

United States, Dominican Republic
Karolinska Institutet
Uppsala University; The Swedish Research Council

Active, not recruiting

Evaluation of Decreased Usage of Betablockers After Myocardial Infarction in the SWEDEHEART Registry (REDUCE-SWEDEHEART)

ST Elevation Myocardial Infarction | Acute Myocardial Infarction | Non-ST Elevation Myocardial Infarction

Sweden
University of California, San Francisco

Withdrawn

Heart Rate Variability (HRV) to Evaluate Surgical Risk on Patients on Beta Blockers

Cardiac Event Risk

United States
Bayside Health

Withdrawn

The Influence of Heart Rate Reduction Upon Central Arterial Pressure in Younger and Older Healthy Individuals

Blood Pressure
Cytokinetics

Recruiting

Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCM (MAPLE-HCM)

Obstructive Hypertrophic Cardiomyopathy (oHCM)

United States, Denmark, Spain, Netherlands, United Kingdom, France, China, Israel, Germany, Italy, Hungary, Canada
ARCA Biopharma, Inc.
Medtronic

Completed

Genetically Targeted Therapy for the Prevention of Symptomatic Atrial Fibrillation in Patients With Heart Failure (GENETIC-AF)

Current or Recent History of Atrial Fibrillation

United States, Canada, Hungary, Netherlands, Poland, Serbia
Gilead Sciences
AstraZeneca

Terminated

Enoximone Plus Extended-Release Metoprolol Succinate in Subjects With Advanced Chronic Heart Failure

Heart Failure, Congestive

United States
Bangabandhu Sheikh Mujib Medical University, Dhaka...

Completed

Role of Ivabradine on Heart Rate and Quality of Life in Patients With Mitral Stenosis in Sinus Rhythm

Mitral Stenosis

Bangladesh
University of Alabama at Birmingham
National Heart, Lung, and Blood Institute (NHLBI); AstraZeneca

Completed

Molecular Mechanisms of Volume Overload-Aim 1(SCCOR in Cardiac Dysfunction and Disease) (P1A1)

Mitral Regurgitation

United States
Medical University of Gdansk

Recruiting

The Efficacy and Safety of Metoprolol as add-on Treatment to Standard of Care in Preventing Cardiomyopathy in Patients With DMD (MeDMD)

Muscular Dystrophy, Duchenne

Poland
Danderyd Hospital

Completed

Sympathetic and Vascular Function in Takotsubo Syndrome (SAFT)

Takotsubo Cardiomyopathy

3

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