Influence of CPB and Mini CPB to the Absorption of the Metoprolol (Minimeto)

August 19, 2015 updated by: Kuopio University Hospital

Influence of CPB and Mini CPB to the Absorption of the Metoprolol After CABG

Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.

Blood samples for concentration of metoprolol are taken preoperaively, 1. and 3. day after operation, before and 10 times after intake of 50 mg metoprolol.

Sudy is randomized into 3 groups: 1. Miniperfusion n.15 2. Perfusion n.15 3. offpump n.15

Study Type

Interventional

Enrollment (Anticipated)

45

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Finland
      • Kuopio, Finland, 70100
        • Recruiting
        • Kuopio University Hospital
        • Contact:
        • Principal Investigator:
          • Martin Maaroos, MD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 75 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria: elective CABG patient -

Exclusion Criteria: contraindication to metoprolol

-

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Single Group Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: blood concentration of metoprolol
how does off-pump miniperfusion and perfusion CABG influence the absorption of metoprolol after CABG
Drug: blood concentration of metoprolol
measure blood concentration of metoprolol

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
absorbtion of the metoprolol
Time Frame: one year
absorbtion of the metoprolol, blood samples are taken centrifuged, frozed and analyzed
one year

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
atrial fibrillation
Time Frame: one year
is there correlation of incidence of the postopeative AF and absorbtion of the metoprolol
one year

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
recovery from rocedure
Time Frame: one year
How does gereral recovery correlate between randomized groups
one year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Kuopio University Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

November 1, 2012

Primary Completion (Anticipated)

December 1, 2015

Study Completion (Anticipated)

December 1, 2015

Study Registration Dates

First Submitted

November 13, 2012

First Submitted That Met QC Criteria

November 16, 2012

First Posted (Estimate)

November 19, 2012

Study Record Updates

Last Update Posted (Estimate)

August 20, 2015

Last Update Submitted That Met QC Criteria

August 19, 2015

Last Verified

August 1, 2015

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • KUH5101066

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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