Search clinical trials for: Test Drug

Total 261210 results

University of Maryland, Baltimore

Completed

A Study to Evaluate of the Efficacy of Enfuvirtide During the Induction Phase of Therapy

HIV Infections

United States
University of California, San Francisco

Completed

The Effects of Rifampin on the Pharmacokinetics of Rosuvastatin

Healthy

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant

Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid... and other conditions

United States
Hamamatsu University

Completed

Comparison of Vonoprazan-based Dual and Triple Therapies for H. Pylori Eradication

Gastritis Associated With Helicobacter Pylori

Japan
Kaohsiung Veterans General Hospital.

Unknown

Comparing the Efficacy of 14-day Reverse Hybrid Therapy and 14-day Triple Therapy Plus Bismuth Therapy

Helicobacter Pylori Infection

Taiwan
ViiV Healthcare
GlaxoSmithKline; Shionogi

Completed

GSK1349572 Drug Interaction Study With Efavirenz

Infections, Human Immunodeficiency Virus and Herpesviridae

United States
Yanqing Li

Unknown

Antimicrobial Susceptibility Testing Guided Triple Therapy in Salvage Helicobacter Pylori Treatment

Antimicrobial Susceptibility Testing | Triple Therapy
International Maternal Pediatric Adolescent AIDS...
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy...

Completed

Antiviral Responses to NNRTI-Based vs. PI-Based ARV Therapy in HIV Infected Infants Who Have or Have Not Received Single Dose NVP for Prevention of Mother-to-Child Transmission of HIV (P1060)

HIV Infections

Uganda, India, Malawi, South Africa, Tanzania, Zambia, Zimbabwe
National Cancer Institute (NCI)

Completed

Phase II Study of Fluorine-18 3'-Deoxy-3'-Fluorothymidine (F-18-FLT) in Invasive Breast Cancer

Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IIB Breast Cancer | Stage IIIC Breast Cancer

United States
Centre Hospitalier Universitaire Saint Pierre
Gilead Sciences; University of Liege; Abbott; Pierre and Marie Curie University; University... and other collaborators

Completed

Nevirapine vs Ritonavir-boosted Lopinavir in ART Naive HIV-infected Adults in a Resource Limited Setting

HIV-1 Infection

Congo
University of Campania "Luigi Vanvitelli"

Completed

5 Day Concomitant Versus 10 Day Sequential Therapy for Eradication of H. Pylori Infection

Helicobacter Pylori Infection

Italy
Göteborg University

Completed

A Study on Antiretroviral Therapy (ART) Naïve Patients On Different Regimens to Treat Hiv (NORTHIV)

HIV

Sweden
Yunnan AIDS Care Center

Unknown

Safety and Efficacy of Raltegravir+TDF+3TC in HBV/HIV Co-infected Patients

HIV Infections | HBV Coinfection

China
French National Agency for Research on AIDS and...
Merck Sharp & Dohme LLC; Janssen-Cilag Tibotec

Completed

Clinical Trial to Assess the Efficacy of Darunavir/Ritonavir (DRV/r), Etravirine (ETV) and Raltegravir (MK-0518) in HIV Patients With Resistant Viruses (ANRS139 TRIO)

HIV Infections

France
National Cancer Institute (NCI)
NCIC Clinical Trials Group; Cancer and Leukemia Group B; North Central Cancer... and other collaborators

Active, not recruiting

Chemotherapy With or Without Bevacizumab in Treating Patients With Stage IB, Stage II, or Stage IIIA Non-small Cell Lung Cancer That Was Removed By Surgery

Stage IB Lung Non-Small Cell Carcinoma AJCC v7 | Stage IIA Lung Non-Small Cell Carcinoma AJCC v7 | Stage IIB Lung Non-Small Cell Carcinoma AJCC v7 | Stage IIIA Lung Non-Small Cell Cancer AJCC v7

United States, Canada, Ireland, Peru, South Africa
National Cancer Institute (NCI)

Withdrawn

A Trial Comparing Chemotherapy Versus Novel Immune Checkpoint Inhibitor (Pembrolizumab) Plus Chemotherapy in Treating Relapsed/Refractory Classical Hodgkin Lymphoma

Recurrent Classic Hodgkin Lymphoma | Refractory Classic Hodgkin Lymphoma
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Bayesian Basket Trial (PALETTE)

Sepsis
Emory University
National Cancer Institute (NCI)

Not yet recruiting

Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases

Metastatic Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Brain

United States
National Cancer Institute (NCI)

Not yet recruiting

Studying TAK-243 in Patients With Advanced Cancer

Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm
Michael Hoelscher
Radboud University Medical Center; University College, London; University of...

Recruiting

PanACEA - STEP2C -01

Pulmonary Tuberculosis | Other Specified Pulmonary Tuberculosis

Gabon, South Africa, Tanzania, Malawi, Uganda, Mozambique
1ST Biotherapeutics, Inc.
Merck Sharp & Dohme LLC

Recruiting

A Phase I/II, Open-label Study to Investigate the Safety, Tolerability, PK, and Preliminary Efficacy of FB849

Advanced Solid Tumor

United States
Washington University School of Medicine
International Headache Society

Recruiting

Puberty, Sex Hormones and Pain Sensitivity in Adolescents With Migraine (IHS)

Migraine

United States
Xijing Hospital of Digestive Diseases

Recruiting

Vonoprazan Hp Dual or Triple Eradication Regimes

Helicobacter Pylori

China
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

An Investigational Scan (68Ga-DOTATATE PET/CT) in Diagnosing Pediatric Metastatic Neuroendocrine Tumors

Neuroblastoma | Ganglioneuroblastoma | Ganglioneuroma

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Multi-modality Imaging and Collection of Biospecimen Samples in Understanding Bone Marrow Changes in Patients With Acute Myeloid Leukemia Undergoing TBI and Chemotherapy

Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia

United States
National Cancer Institute (NCI)

Active, not recruiting

Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

Glioblastoma | Malignant Glioma | Anaplastic Astrocytoma

United States, Canada, Puerto Rico, Australia, New Zealand
Merck Sharp & Dohme LLC

Active, not recruiting

Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)

Carcinoma, Non-Small-Cell Lung | Lung Neoplasms

Poland, Romania, Ukraine, Chile, Canada, United States, Argentina, China, Czechia, Estonia, France, Germany, Hungary, Italy, Japan, Korea, Republic of, Latvia, Lithuania, Mexico, Norway, Peru, Russian Federation, Spain, Thailand, Turkey, United...
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Effect of Cabozantinib S-Malate or Lenvatinib Mesylate on Weight and Body Composition in Patients With Metastatic Endocrine Cancer

Thyroid Gland Medullary Carcinoma | Differentiated Thyroid Gland Carcinoma | Malignant Adrenal Gland Pheochromocytoma | Malignant Paraganglioma

United States
National Cancer Institute (NCI)

Active, not recruiting

Randomized Trial of Topotecan With M6620, an ATR Kinase Inhibitor, in Small Cell Lung Cancers and Small Cell Cancers Outside of the Lungs

Extensive Stage Lung Small Cell Carcinoma | Limited Stage Lung Small Cell Carcinoma | Platinum-Resistant Lung Small Cell Carcinoma | Platinum-Sensitive Lung Small Cell Carcinoma | Bladder Small Cell Neuroendocrine Carcinoma | Extrapulmonary Small Cell Neuroendocrine Carcinoma | Recurrent Lung... and other conditions

United States
Phillip Brian Smith

Completed

Pharmacokinetics (PK) of Antistaphylococcal Antibiotics in Infants (NICHD-2012-02-Staph Trio) (Staph)

Systemic Infection

United States
Rush University Medical Center
Gilead Sciences; University of Chicago; University of Illinois at Chicago; Abbott; Ruth M. Rothstein CORE Center

Terminated

Immune Reconstitution of Lopinavir/Ritonavir-Based vs Efavirenz-based HAART in Advanced HIV Disease

Acquired Immune Deficiency Syndrome

United States
Andrei Iagaru
National Cancer Institute (NCI); National Institutes of Health (NIH)

Completed

Panitumumab-IRDye800 and 89Zr-Panitumumab in Identifying Metastatic Lymph Nodes in Patients With Squamous Cell Head and Neck Cancer

Squamous Cell Carcinoma of the Head and Neck | Carcinoma of the Head and Neck

United States
University of Washington
National Institute of General Medical Sciences (NIGMS)

Completed

CYP3A4 Activity and Mineral Homeostasis

Vitamin D and Calcium Homeostasis

United States
University of Nottingham
University of Oxford; Nottingham University Hospitals NHS Trust; University of... and other collaborators

Completed

Helicobacter Eradication Aspirin Trial (HEAT)

Bacterial Infection Due to Helicobacter Pylori (H. Pylori) | Gastrointestinal Ulcer Haemorrhage

United Kingdom
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Bone, Immunologic, and Virologic Effects of a Antiretroviral Regimen

HIV-1 Infection

United States, Puerto Rico
National Taiwan University Hospital

Completed

Efficacy of High-dose Dual Therapy vs Bismuth-containing Quadruple Therapy for Rescue Treatment of Hp Infection

Helicobacter Pylori Infection

Taiwan
Washington University School of Medicine

Completed

Efavirenz and Ritonavir on Human Brain P-Glycoprotein

Drug Effects

United States
Pfizer

Completed

Study to Assess Pharmacokinetics, Safety and Tolerability of PF-04965842 in Chinese Healthy Participants

HEALTHY

China
University of Liverpool
ViiV Healthcare; Makerere University

Completed

Safety and Pharmacokinetics of Dolutegravir in Pregnant HIV Mothers and Their Neonates: A Pilot Study (DolPHIN1)

Pregnancy | HIV

Uganda, South Africa
South East Asia Research Collaboration with Hawaii
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Using Telmisartan With ART During Acute HIV Infection to Reduce the CNS Reservoirs of HIV and Lymph Node Fibrosis

Acute HIV Infection | HIV CNS Involvement

Thailand
University of California, San Francisco
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Protease Inhibitors to Reduce Malaria Morbidity in HIV-Infected Pregnant Women (PROMOTE-PIs)

HIV Infections | Malaria

Uganda
Merck Sharp & Dohme LLC

Terminated

Evaluation of Renal Function, Efficacy, and Safety When Switching From Tenofovir/Emtricitabine Plus a Protease Inhibitor/Ritonavir, to a Combination of Raltegravir (MK-0518) Plus Nevirapine Plus Lamivudine in HIV-1 Participants With Suppressed Viremia and Impaired Renal Function (MK-0518-284) (RANIA)

HIV Infections
Giovanni Di Perri
University of Turin, Italy; University of Milan

Terminated

Bone Mineral Density Changes in HIV-positive Females With Osteopenia Switching to Raltegravir (RALBAT)

HIV Infection | Osteopenia

Italy
National Cancer Institute (NCI)

Completed

Veliparib and Pegylated Liposomal Doxorubicin Hydrochloride in Treating Patients With Recurrent Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer or Metastatic Breast Cancer

Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Recurrent Breast Carcinoma | Estrogen Receptor Negative | HER2/Neu Negative | Progesterone Receptor Negative | Triple-Negative Breast Carcinoma | Male Breast Carcinoma | Stage IV Breast Cancer AJCC...

United States
Columbia University
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Treatment Options for Protease Inhibitor-exposed Children (NEVEREST-III)

HIV Infections | HIV/AIDS

South Africa
Danone Research

Completed

Effects of Fermented Milk Product Enriched With Plant Sterols and Policosanols in Mild Hypercholesterolaemic Adults

Mildly Hypercholesterolemic Subjects

United Kingdom
AstraZeneca

Completed

Study to Evaluate the 2-Way Interaction Between Multiple Doses of Epanova™ and a Single Dose of Rosuvastatin (Crestor®) (ECLIPSEIII)

Hypertriglyceridemia

United States
The HIV Netherlands Australia Thailand Research...
Chulalongkorn University; Khon Kaen University

Completed

PK TDF in Thai HIV-infected Children

HIV

Thailand
National Jewish Health

Completed

Phase II Study of Amithiozone (Thiacetazone) for Patients With Mycobacterium Avium Complex Pulmonary Disease

Mycobacterium Avium-intracellulare Infection
Institute of Cardiology, Warsaw, Poland

Unknown

Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study (Pilot-CRAfT)

Heart Failure | Atrial Fibrillation

Poland

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