Latest Trials

Total 1170 results

PENTA Foundation
Medical Research Council; ANRS, Emerging Infectious Diseases

Unknown

BREATHER (PENTA 16) Short-Cycle Therapy (SCT) (5 Days on/2 Days Off) in Young People With Chronic HIV-infection (BREATHER)

HIV

United Kingdom, Uganda, Ireland, United States, France, Germany, Thailand, Ukraine
University of Washington
Bill and Melinda Gates Foundation

Completed

A Cohort for Evaluation of Open-label PrEP Use and PreP Preferences Among African Women (INSIGHT)

HIV Infections

Kenya, Malawi, South Africa, Swaziland, Uganda, Zambia, Zimbabwe
University of Lagos, Nigeria

Active, not recruiting

Low Dose Aspirin for Preventing Intrauterine Growth Restriction and Preeclampsia in Sickle Cell Pregnancy (PIPSICKLE) (PIPSICKLE)

Pregnancy Complications | Sickle Cell Disease | Preeclampsia | Intrauterine Growth Restriction

Nigeria
EndoCore Lab s.r.l.

Recruiting

Peripheral Extreme Revascularization in "No-option" Patiens With Chronic Limb Threatening Ischemia (PiPER)

Diabetic Foot | Peripheral Arterial Disease | Critical Limb-Threatening Ischemia

Italy
Cliniche Humanitas Gavazzeni

Completed

Actions Elicited by In-hospital Follow-up of Cardiac Devices (ATHENS)

Cardiac Pacemaker, Artificial | Implantable Cardioverter-Defibrillator

Italy
Parc de Salut Mar
Hospital Universitario de Canarias

Completed

Bowel Preparation for Repeat Colonoscopy After Preparation Failure (RepeatPrep Study)

Bowel Preparation for Colonoscopy

Spain
University of Birmingham
Université d'Abomey-Calavi; Kigali University Teaching Hospital

Not yet recruiting

A Stratified, Multi-ARm, muLti-site Randomised Platform Trial Aiming to Reduce the INcidence of Post-operative SSI (MARLIN)

Surgical Site Infection

South Africa, Ghana, Benin, India, Mexico, Nigeria, Rwanda
Francisco Colomina Climent

Terminated

Mortality Reduction in Septic Shock by Plasma Adsorption (ROMPA)

Septic Shock

Spain
University of Aarhus
University of Rwanda; University of Luxembourg; Rwanda Biomedical Centre; Karen... and other collaborators

Unknown

Community- and mHealth-Based Integrated Management of Diabetes in Primary Healthcare in Rwanda (D²Rwanda)

Diabetes Mellitus | Telemedicine | Community Health Workers

Rwanda
EndoCore Lab s.r.l.
Fondazione Italiana Vascolare

Recruiting

Shockwave ®S4 Catheter IVL to Treat Infrapopliteal Calcified Stenoses and/or Occlusions in CLTI Patients (LEGACY) (LEGACY)

Peripheral Arterial Disease | Critical Limb-Threatening Ischaemia

Italy
National Institute of Allergy and Infectious Diseases...
ViiV Healthcare

Active, not recruiting

More Options for Children and Adolescents (MOCHA): Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in HIV-Infected Children and Adolescents (MOCHA)

HIV Infections

Thailand, United States, Botswana, Uganda, South Africa
Centers for Disease Control and Prevention
US Department of Veterans Affairs

Completed

TBTC NAA Study: Pilot Study of Surrogate Markers for Outcome of TB Treatment

Tuberculosis

Uganda, United States, Canada, South Africa
PENTA Foundation
Institut National de la Santé Et de la Recherche Médicale, France; Program... and other collaborators

Active, not recruiting

A Randomised Trial of Dolutegravir (DTG)-Based Antiretroviral Therapy vs. Standard of Care (SOC) in Children With HIV Infection Starting First-line or Switching to Second-line ART

HIV Infection

United Kingdom, Spain, Portugal, South Africa, Thailand, Uganda, Germany, Zimbabwe
Hospital Clinic of Barcelona
Instituto de Salud Carlos III

Recruiting

Risk Stratification Using MEESSI-AHF Scale in ED and Impact on AHF Outcomes (MEESSI)

Emergencies | Acute Heart Failure

Spain
Centers for Disease Control and Prevention
Tuberculosis Trials Consortium

Recruiting

Short-course Regimens for the Treatment of Pulmonary Tuberculosis (CRUSH-TB)

Tuberculosis, Pulmonary | Tuberculosis Infection

Canada, United States, Haiti, South Africa, Uganda, Vietnam
Gilead Sciences

Recruiting

Study of Bictegravir/Emtricitabine/Tenofovir Alafenamide Fixed Dose Combination in Adolescents and Children With Human Immunodeficiency Virus-1

HIV-1 Infection

United States, Thailand, Uganda, South Africa
Global Alliance for TB Drug Development

Completed

Trial to Evaluate the Efficacy, Safety and Tolerability of BPaMZ in Drug-Sensitive (DS-TB) Adult Patients and Drug-Resistant (DR-TB) Adult Patients

Tuberculosis | Tuberculosis, Pulmonary | Tuberculosis, Multidrug-Resistant | Tuberculosis, MDR | Drug-Resistant Tuberculosis

Tanzania, Georgia, Russian Federation, Brazil, Malaysia, Philippines, South Africa, Uganda
National Institute of Allergy and Infectious Diseases...

Active, not recruiting

Evaluating the Safety and Efficacy of Long-Acting Injectable Cabotegravir Compared to Daily Oral TDF/FTC for Pre-Exposure Prophylaxis in HIV-Uninfected Women

HIV Infections

Zimbabwe, South Africa, Botswana, Kenya, Malawi, Uganda, Swaziland
University of Valencia
Hoffmann-La Roche

Unknown

Two Different Treatments 24 vs 48 Weeks Chronic Hepatitis C Genotypes 2 and/or 3 in co-Infected HIV-HCV

Chronic Hepatitis C | Co-Infection HIV-HCV

Spain
National Institute of Allergy and Infectious Diseases...
TB Alliance

Not yet recruiting

Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis (RAD-TB)

Pulmonary Tuberculosis

Botswana, Brazil, Haiti, India, Kenya, Malawi, Mexico, Peru, Philippines, South Africa, Thailand, Uganda, Zimbabwe
Hoffmann-La Roche

Completed

An Observational Study in Clinical Practice Management of Patients With Biological Drugs in Monotherapy

Rheumatoid Arthritis

Spain
Janssen Vaccines & Prevention B.V.

Completed

A Safety, Tolerability and Immunogenicity Study of 2 Different Regimens of Tetravalent Ad26.Mos4.HIV Prime Followed by Boost With Tetravalent Ad26.Mos4.HIV Along With Either Clade C gp140 Plus Adjuvant OR With a Combination of Mosaic and Clade C gp140 Plus Adjuvant in Healthy HIV Uninfected Adults (IPCAVD-012)

Healthy

United States, Rwanda, Kenya
Janssen Vaccines & Prevention B.V.

Completed

Safety, Tolerability and Immunogenicity Study of Different Vaccine Regimens of Trivalent Ad26.Mos.HIV or Tetravalent Ad26.Mos4.HIV Along With Clade C Glycoprotein (gp)140 in Healthy Human Immunodeficiency Virus (HIV)-Uninfected Adults

Healthy

United States, Rwanda
University Ghent

Completed

Monitoring Drug Efficacy and Anthelmintic Resistance in Soil-transmitted Helminth Programs (StarwormsWP2)

Soil-transmitted Helminth Infections

Bangladesh, Cambodia, Ghana, Haiti, Lao People's Democratic Republic, Rwanda, Senegal, Vietnam
WHO, Department of Maternal, Newborn, Child and...
Netherlands: Ministry of Health, Welfare and Sports; Canadian International...

Unknown

Does Provision of Point of Care CD4 Technology and Early Knowledge of CD4 Levels Affect Early Initiation and Retention on Anti-retroviral Treatment (ART) in HIV Positive Pregnant Women in the Context of Option B+ for PMTCT? (E4E)

HIV/AIDS

Zimbabwe
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID); Merck Sharp... and other collaborators

Completed

A5288/MULTI-OCTAVE: Management Using Latest Technologies to Optimize Combination Therapy After Viral Failure (MULTI-OCTAVE)

HIV-1 Infection

Kenya, Brazil, South Africa, Uganda, Zimbabwe, India, Malawi, Haiti, Thailand, Peru
PENTA Foundation
Institut National de la Santé Et de la Recherche Médicale, France; MRC CTU... and other collaborators

Completed

Strategy for Maintenance of HIV Suppression With Once Daily Integrate Inhibitor+Darunavir/Ritonavir in Children (SMILE)

HIV Infection

United Kingdom, Spain, Argentina, France, Mexico, Portugal, South Africa, Switzerland, Thailand, Uganda, Ukraine
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Efficacy and Safety of Dolutegravir-Containing Versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and Their Infants (VESTED)

HIV Infections

United States, South Africa, Thailand, Botswana, Brazil, Tanzania, Zimbabwe, India, Uganda
Global Alliance for TB Drug Development

Completed

Shortening Treatment by Advancing Novel Drugs (STAND)

Tuberculosis, Pulmonary, Drug Sensitive | Tuberculosis, Pulmonary, Multi Drug-resistant

South Africa, Zambia, Georgia, Philippines, Kenya, Malaysia, Tanzania, Uganda
National Institute of Allergy and Infectious Diseases...
National Heart, Lung, and Blood Institute (NHLBI); University of Copenhagen; US... and other collaborators

Completed

Vaccination for Recovered Inpatients With COVID-19 (VATICO)

Covid19

United States, Spain, Uganda, Nigeria, Singapore, Switzerland
Center for Primary Care and Public Health (Unisante)...
Swiss Tropical & Public Health Institute; Ecole Polytechnique Fédérale de Lausanne and other collaborators

Recruiting

Dynamic CDSA to Manage Sick Children in Rwanda (DYNAMIC-RW)

Child Health

Rwanda
Straub Medical AG

Completed

Post-Market Clinical Follow Up of Rotarex®S Catheter

Peripheral Arterial Disease

Germany, Estonia, Czechia, France, Italy
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

REMEMBER: Reducing Early Mortality & Morbidity by Empiric Tuberculosis (TB) Treatment (REMEMBER)

HIV Infection

Peru, Malawi, Uganda, South Africa, India, Haiti, Zambia, Zimbabwe, Brazil, Kenya
Dissou AFFOLABI
London School of Hygiene and Tropical Medicine; World Health Organization; Institute... and other collaborators

Completed

DIAgnostics for Multidrug Resistant Tuberculosis in Africa (DIAMA)

Tuberculosis, Multidrug-Resistant

Belgium, Benin, Cameroon, Congo, The Democratic Republic of the, Ethiopia, Guinea, Mali, Nigeria, Rwanda, Senegal
Fundación Pública Andaluza Progreso y Salud
Instituto de Salud Carlos III

Unknown

Clinical Trial to Evaluate the Efficacy of Treatment vs Discontinuation in a First Episode of Non-affective Psychosis (NONSTOP)

Psychosis Nos/Other

Spain
International Partnership for Microbicides, Inc.

Completed

An Expanded Safety Study of Dapivirine Gel 4759 in Africa

HIV Infections | Acquired Immunodeficiency Syndrome

Kenya, Malawi, Rwanda, South Africa, Tanzania
EDUARDO ALBENIZ
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain; Fundació... and other collaborators

Recruiting

The EpiGASTRIC/EDGAR Project: New Strategies for the Early Detection and Prevention of Gastric Cancer

Gastric Cancer | Gastric Neoplasms | Gastric Lesion

Spain
Merck Sharp & Dohme LLC

Active, not recruiting

Oral ISL QM as PrEP in Cisgender Women at High Risk for HIV-1 Infection (MK-8591-022) (Impower-022)

Prophylaxis | Human Immunodeficiency Virus Type 1 | HIV-I

United States, South Africa, Uganda
University of Oxford
Mahidol Oxford Tropical Medicine Research Unit

Recruiting

A Trial to Compare the Efficacy, Safety and Tolerability of Combinations of 3 Anti-malarial Drugs Against Combina-tions of 2 Anti-malarial Drugs. (DeTACT-Africa)

Plasmodium Falciparum Malaria (Uncomplicated)

Burkina Faso, Congo, The Democratic Republic of the, Gambia, Guinea, Nigeria, Niger, Rwanda, Tanzania
Rsocialform - Geriatria, Lda

Completed

Multicentre Study About the Effect of Individual Reminiscence Therapy

Neurocognitive Disorders | Cognitive Impairment | Dementia | Cognitive Decline

Portugal
COVID-19 Prevention Network
National Institute of Allergy and Infectious Diseases (NIAID); Medical Research...

Completed

Efficacy Study of COVID-19 mRNA Vaccine in Regions With SARS-CoV-2 Variants of Concern (CoVPN3008)

HIV Infections | COVID-19 | SARS-CoV-2 Infection

Uganda, Malawi, South Africa, Botswana, Zambia, Kenya, Swaziland
Centers for Disease Control and Prevention

Completed

TBTC Study 27: Moxifloxacin vs Ethambutol for TB Treatment

Tuberculosis, Pulmonary

Uganda, United States, Canada, South Africa
Hospital de Granollers

Completed

Study to Evaluate Changes in CD4 on Replacing TDF With ABC or DDI+TDF With ABC+3TC

HIV Infections

Spain
Gilead Sciences

Recruiting

Study of Cobicistat-Boosted Atazanavir (ATV/co), Cobicistat-Boosted Darunavir (DRV/co) and Emtricitabine/Tenofovir Alafenamide (F/TAF) in Children With HIV

HIV Infections | Acquired Immune Deficiency Syndrome (AIDS)

United States, South Africa, Argentina, Panama, Thailand, Zimbabwe, United Kingdom, Uganda
Catholic Relief Services
Centers for Disease Control and Prevention

Completed

Caregiver-Assisted Oral Fluid-based HIV Screening in Children: Uganda

HIV Testing

Uganda
Mayo Clinic

Completed

The Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN)

Sepsis | Shock | Critical Illness | Respiratory Failure | Bleeding | Trauma | Coma

China, Brazil, Belarus, Serbia, India, Turkey, Bosnia and Herzegovina, Croatia, Dominican Republic, Ireland, Mexico, Mongolia, Pakistan, Philippines, Poland, Saudi Arabia, Uganda
Abbott Medical Devices

Completed

Clinical Benefits in Optimized Remote HF Patient Management (COR-HF)

Congestive Heart Failure Treated

Italy
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Immediate Versus Deferred Start of Anti-HIV Therapy in HIV-Infected Adults Being Treated for Tuberculosis (STRIDE)

HIV Infection | Tuberculosis

United States, Peru, Kenya, Malawi, Uganda, Brazil, South Africa, Zimbabwe, India, Thailand, Botswana, Haiti, Zambia
Vulnerable Plaque Society

Completed

Treatment of Bifurcation Lesions by SINGLE STENT and KISSing Balloon Trial (SINGLEKISS)

Ischemic Heart Disease | Restenosis

Japan
McMaster University
National Health and Medical Research Council, Australia; Canadian Institutes... and other collaborators

Completed

INternational ORthopaedic MUlticenter Study in Fracture Care (INORMUS) (INORMUS)

Fractures or Dislocations

Philippines, Botswana, China, Colombia, Thailand, Malawi, Tanzania, Kenya, Vietnam, Mexico, India, Venezuela, South Africa, Ghana, Argentina, Ethiopia, Uganda, Brazil, Nepal, Nigeria, Pakistan, Rwanda, Cameroon, Iran, Islamic Republic of and more

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