An Expanded Safety Study of Dapivirine Gel 4759 in Africa

A Double-blind, Randomized, Placebo-Controlled Phase I/II Study to Evaluate the Safety and Acceptability of Dapivirine Gel 4759, 0.05%, 2.5g, a Vaginal Microbicide, Conducted Using Daily Monitored Adherence in Healthy, HIV-Negative Women.

The purpose of this study is to determine whether dapivirine gel 4759 is safe for daily use by healthy women in Kenya, Malawi, Rwanda, South Africa and Tanzania.

Study Overview

• Status: Completed
• Conditions: HIV Infections; Acquired Immunodeficiency Syndrome
• Intervention / Treatment: Drug: placebo; Drug: dapivirine

Detailed Description

To reduce the influence of adherence as a factor in the interpretation of efficacy results, IPM is considering using a DOT (Directly Observed Therapy) based method for vaginal microbicide gel delivery in a future Phase III study. IPM has denoted this DOT based method as Daily Monitored Adherence (DMA). IPM014A is a Phase I/II study designed: (1) to assess and compare the safety of a once daily application of Dapivirine Gel 4759, 0.05% 2.5g and a matching vehicle placebo gel; (2) to assess the acceptability of a once daily application of Dapivirine gel 4759, 0.05% 2.5g and a matching vehicle placebo gel; and (3) to assess the feasibility of utilizing the DMA method for a large-scale phase III efficacy study.

• Study Type: Interventional
• Enrollment (Actual): 280
• Phase: Phase 2; Phase 1

Contacts and Locations

Study Locations

• Kenya
  • Kisumu, Kenya
    • Kenya Medical Research Institute
• Malawi
  • Blantyre, Malawi
    • Johns Hopkins Project, College of Medicine
• Rwanda
  • Kigali, Rwanda
    • Projet Ubuzima
• South Africa
  • Eastern Cape
    • Paarl, Eastern Cape, South Africa
      • Be Part Clinic, Mbekweni
  • KwaZulu Natal
    • Ladysmith, KwaZulu Natal, South Africa
      • Qhakaza Mbokodo
    • Pinetown, KwaZulu Natal, South Africa
      • Prevention for HIV and AIDS Project
  • Mpumalanga
    • Agincourt, Mpumalanga, South Africa
      • Ndlela HIV Research and Clinical Tirals Unit
  • North West Province
    • Brits, North West Province, South Africa
      • Madibeng Centre for Research
  • Western Cape
    • Cape Town, Western Cape, South Africa
      • Desmond Tutu HIV Foundation, Nyanga
• Tanzania
  • Moshi, Tanzania
    • Kilimanjaro Christian Medical Centre

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 40 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

1. Women 18 to 40 years of age inclusive who can give written informed consent
2. Available for all visits and consent to follow all procedures scheduled for the study
3. Agree to daily application of gel and monitoring as per Daily Monitored Adherence (DMA) method
4. Healthy and self-reported sexually active
5. HIV-negative as determined by a HIV rapid test at time of enrollment
6. On a stable form of contraception and willing to continue on this stable method of contraception, OR, Have undergone surgical sterilisation at least 3 months prior to enrollment
7. In the absence of the use of exogenous hormone(s), have a self-reported regular menstrual cycle defined as having a minimum of 21 days and a maximum of 36 days between menses
8. Upon pelvic/speculum examination and colposcopy at the time of enrollment, the cervix and vagina appear normal as determined by the investigator
9. Asymptomatic for genital infections at the time of enrollment
10. Willing to refrain from use of vaginal products or objects within 14 days prior to enrollment and for the duration of the study
11. Willing to answer acceptability and adherence questionnaires throughout the study
12. Willing to refrain from participation in any other research study for the duration of this study
13. Willing to provide adequate locator information for study retention purposes and be reachable per local standard procedures

Exclusion Criteria:

1. Currently pregnant or last pregnancy outcome within 3 months prior to enrolment
2. Currently breast-feeding
3. Participated in any other research study within 60 days prior to screening
4. Previously participated in any HIV vaccine study
5. Untreated urogenital infections (either symptomatic or asymptomatic) within 2 weeks prior to enrollment
6. Presence of abnormal physical finding on the vulva, vaginal walls or cervix during pelvic/speculum examination and/or colposcopy
7. History of significant urogenital or uterine prolapse, undiagnosed vaginal bleeding, urethral obstruction
8. Pap smear result at screening that requires cryotherapy, biopsy, treatment (other than for infection), or further evaluation
9. Any Grade 2, 3 or 4 baseline haematology, chemistry or urinalysis laboratory abnormality according to the DAIDS Table for Grading Adverse Experiences
10. Unexplained, undiagnosed abnormal bleeding per vagina, bleeding per vagina during or following vaginal intercourse, or gynaecologic surgery within 90 days prior to enrollment
11. Any history of anaphylaxis or severe allergy resulting in angioedema; or a history of sensitivity/allergy to latex
12. Any serious acute, chronic or progressive disease
13. Any condition(s) that, in the opinion of the investigator, might interfere with adherence to study requirements or evaluation of the study objectives

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Triple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: vehicle placebo gel	Drug: placebo; dosage form: vaginal gel frequency: once daily duration: 6 weeks
Experimental: dapivirine gel	Drug: dapivirine; dosage form: vaginal gel dosage: 1.25mg dapivirine/day frequency: once daily duration: 6 weeks

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Gynaecological examinations, including pelvic/speculum examination and colposcopy, and laboratory STI testing.	Week 0, 1, 2, 4, 6 & 10
Safety laboratory tests	enrollment & last day of gel use
Adverse event/serious adverse event reports	throughout study

Secondary Outcome Measures

Outcome Measure	Time Frame
Questionnaires concerning acceptability and adherence to daily use of vaginal gel.	Week 0, 2, 6 & 10
Documentation of adherence to the DMA method including the Applicator Collection Checklist, focus groups and male interviews.	throughout study

Collaborators and Investigators

• Sponsor: International Partnership for Microbicides, Inc.
• Investigators: Study Director: Dr Annalene Nel, IPM

Study record dates

Study Major Dates

• Study Start: November 1, 2009
• Primary Completion (Actual): January 1, 2011
• Study Completion (Actual): September 1, 2011

Study Registration Dates

• First Submitted: June 8, 2009
• First Submitted That Met QC Criteria: June 8, 2009
• First Posted (Estimate): June 10, 2009

Study Record Updates

• Last Update Posted (Estimate): September 12, 2011
• Last Update Submitted That Met QC Criteria: September 9, 2011
• Last Verified: September 1, 2011

More Information

Terms related to this study

• Keywords: Healthy; Acquired Immunodeficiency Syndrome; HIV seronegativity; HIV Infections
• Additional Relevant MeSH Terms: RNA Virus Infections; Virus Diseases; Infections; Blood-Borne Infections; Communicable Diseases; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; Immune System Diseases; Slow Virus Diseases; HIV Infections; Acquired Immunodeficiency Syndrome; Immunologic Deficiency Syndromes; Anti-Infective Agents; Antiviral Agents; Anti-HIV Agents; Anti-Retroviral Agents; Dapivirine
• Other Study ID Numbers: IPM 014A

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No