Search clinical trials for: Open to Options (O2O)

Total 478461 results

Seoul National University Hospital
Korea Health Industry Development Institute; Seoul National University

Not yet recruiting

Randomized Controlled Trial of the Smart O2O Model Development for Chronic Diseases Management Through Digital Health

Hypertension | Diabete Mellitus
University of Michigan Rogel Cancer Center
Cancer Support Community

Terminated

Patient-centered Development of the Cancer Support Community's Open to Options ®Chatbot Program

Cancer

United States
University of Connecticut
University of Malaya

Not yet recruiting

Integrated Online-to-offline (O2O) Model of Care for HIV Prevention and Treatment Among Transgender Women (CINTAI)

HIV Prevention Program

Malaysia
University of Connecticut
University of Malaya

Not yet recruiting

Integrated Online-to-offline (O2O) Model of Care for HIV Prevention and Treatment Among Men Who Have Sex With Men (CINTAI)

HIV Prevention Program

Malaysia
Center of Endourology "Endocenter"

Not yet recruiting

Hemorrhoids: Options of Traditional Hemorrhoidectomy

Hemorrhoids | Open Hemorrhoidectomy

Russian Federation
Opsidio, LLC
Innovaderm Research Inc.

Active, not recruiting

Phase 2a Study of Efficacy and Safety of OpSCF in Moderate to Severe Atopic Dermatitis

Atopic Dermatitis

Canada, United States
Acrotech Biopharma Inc.

Active, not recruiting

A Open-label Study to Assess the Long-term Safety of Difamilast Ointment 1% in Mild to Moderate Atopic Dermatitis

Atopic Dermatitis

United States
Pfizer

Completed

B0151005 Open-Label Extension Study (ANDANTE II)

Crohn's Disease

United States, Denmark, Israel, Ireland, Australia, Czechia, Canada, United Kingdom, Hungary, Germany, New Zealand, Brazil, Switzerland, Belgium, France, Italy
University of Zurich
Johannes Gutenberg University Mainz

Withdrawn

Comparison of Surgical Treatment Options for Primary Congenital and Developmental Glaucomas (STOP-Glaucoma)

Primary Congenital Glaucoma | Developmental Glaucoma
University of Hawaii

Completed

Buffered Lidocaine in Paracervical Blocks

Pain

United States
Boehringer Ingelheim

Approved for marketing

An Open Label Safety Study of Tipranavir Co-administered With Low-dose Ritonavir in Patients With Advanced HIV-1 Infection and Limited Treatment Options.

HIV Infections

Belgium, Brazil, Canada, Denmark, El Salvador, Greece, Italy, Portugal, Spain
University Health Network, Toronto
Princess Margaret Hospital, Canada

Completed

Pantoprazole With Doxorubicin for Advanced Cancer Patients With Extension Cohort of Patients With Solid Tumours

Advanced Solid Tumours

Canada
Eisai Inc.

Approved for marketing

An Open-Label, Multi-Center, Expanded Access Program With Eribulin for the Treatment of Advanced Breast Cancer Refractory

Metastatic Breast Cancer

Canada, Belgium, France
Gilead Sciences

Approved for marketing

An Open-Label Program of Adefovir Dipivoxil in the Treatment of Patients With Lamivudine-Resistant Chronic Hepatitis B With Limited Treatment Options

Chronic Hepatitis B
Yunnan Cancer Hospital

Recruiting

The Efficacy of Watch and Wait Strategy or Surgery After Neoadjuvant Immunotherapy for Locally Advanced Colorectal Cancer With dMMR/MSI-H Guided by MRD Dynamic Monitoring: A Single-center, Open-label, Prospective, Phase II Clinical Trial. (WINDOW)

Clinical Complete Response Rate With Negative MRD

China
Minia University

Not yet recruiting

Role of Left Stellate Ganglion Block in Offering Myocardial Protection in On-pump Mitral Valve Replacement? A Histopathological and Clinical Assessment

Open Mitral Cardiac Surgery
Universidad Nacional Autonoma de Honduras

Recruiting

Sucrose as a Standard in Cesarean Section Surgical Wound Healing to Reduce Hospital Time (SAGRA)

Surgical Wound Infection | Cesarean Wound; Dehiscence

Honduras
Keep Hearing, Inc.

Not yet recruiting

ACEMg Phase IV Epidemiological Study for Hearing Preservation and Tinnitus Mitigation. (ACEMgRWD)

Sensorineural Hearing Loss | Tinnitus

United States
Guard Therapeutics AB

Not yet recruiting

A Phase 2b Dose Finding Study of RMC-035 in Participants Undergoing Open-chest Cardiac Surgery (POINTER)

Kidney Injury Following Open-Chest Cardiac Surgery

Spain, Germany, Canada, Czechia
Kayuraeffect, LLP
COD Research

Not yet recruiting

Open-label, Single-arm, Proof of Concept Study in Subjects With Mild-to-moderate Facial Hyperpigmentation (K-BRIGHT)

Facial Hyperpigmentation

United States
AstraZeneca
Fortrea

Not yet recruiting

Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma. (ARRIVAL)

Severe Asthma
Xin-Hua Xu

Recruiting

A Prospective, Open-label, Single-center, Single-arm Phase II Clinical Study of Cadonilimab (AK104) Combined With Monotherapy Chemotherapy in Patients With Advanced Non-small Cell Lung Cancer With Negative Driver Genes and Failed Immunotherapy

Non-small Cell Lung Cancer

China
Duke University

Not yet recruiting

A Phase 1 Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of JCXH-211 (SElf-Replicating RNA IL-12) Intratumoral Injection in Patients With Recurrent or Progressive High-Grade Glioma (SERIL)

Recurrent or Progressive High-grade Glioma
KalVista Pharmaceuticals, Ltd.

Not yet recruiting

Open-Label Safety, PK, and Efficacy Trial of Sebetralstat (KVD900) in Pediatric Patients (Ages 2-11) With HAE Type I or II (KONFIDENT-KID)

Hereditary Angioedema
Shanghai BDgene Co., Ltd.
Beijing Tongren Hospital

Recruiting

CRISPR/Cas9 Instantaneous Gene Editing Therapy to Intraocular Hypertensive POAG With MYOC Mutation

Primary Open Angle Glaucoma

China
Emory University
The Marcus Foundation

Not yet recruiting

A Phase 1 Open-Label Study of the Safety of Intravenous Allogeneic Neonatal Mesenchymal Cells (nMSCs) in Young Adult (1A) and Pediatric (1B) Patients With Dilated Cardiomyopathy (DCM)

Dilated Cardiomyopathy

United States
Montreal Heart Institute

Not yet recruiting

Harnessing ECG Artificial Intelligence for Rapid Treatment and Accurate Interpretation, an Open Label Randomized Controlled Trial (HEART-AI)

Structural Heart Abnormality
University of Delaware
National Institute on Drug Abuse (NIDA); Brandywine Counseling and Community...

Recruiting

Disclosure Intervention for People in Treatment for Opioid Use Disorder

Opioid Use Disorder

United States
AstraZeneca

Not yet recruiting

A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis) (JASMINE)

Polymyositis, Dermatomyositis

United States, Denmark, France, Italy, Spain, Belgium, India, Vietnam, Japan, China, Israel, Austria, Canada, Germany, Taiwan, United Kingdom, Australia, Hungary, Netherlands, Sweden, Brazil, Bulgaria, Poland, Mexico, Czechia
Guy's and St Thomas' NHS Foundation Trust

Not yet recruiting

The A D A G I O Study

Ocular Hypertension | Open Angle Glaucoma
Liverpool Heart and Chest Hospital NHS Foundation...
Biolife LLC

Not yet recruiting

Statseal® for Central Venous Catheter Insertion Sites in Critical Care (SCENIC)

Vascular Access | Critical Care | Central Venous Catheter | Central Line | Hemostatic

United Kingdom
Fundación Cardioinfantil Instituto de Cardiología

Not yet recruiting

PROgressive struCturEd Simulation-based Surgical Training Program (PROCESS) - Open Vascular Surgery (PROCESS)

Vascular Diseases | Simulation Training | Competency-Based Education
SK Life Science, Inc.

Not yet recruiting

Open-label Study of Cenobamate Monotherapy in Adult Subjects With Newly Diagnosed or Recurrent Partial-Onset Epilepsy

Focal Onset Seizure

United States
Tanta University

Recruiting

Transversus Abdominis Plane Block Versus External Oblique Intercostal Plane Block for Postoperative Analgesia in Pediatrics Undergoing Open Nephrectomy

Pediatrics | Transversus Abdominis Plane Block | Postoperative Analgesia | External Oblique Intercostal Plane Block | Open Nephrectomy

Egypt
Tanta University

Recruiting

External Oblique Intercostal Plane Block Versus Transversus Abdominis Plane Block for Postoperative Analgesia in Adult Patients Undergoing Open Nephrectomy

Nephrectomy | Transversus Abdominis Plane Block | Postoperative Analgesia | External Oblique Intercostal Plane Block

Egypt
Academisch Medisch Centrum - Universiteit van Amsterdam...

Recruiting

The (Cost-) Effectiveness of Paediatric Laparoscopic Hernia Repair Compared to Open Hernia Repair (HERNIIA-2)

Inguinal Hernia

Netherlands
SURGE Therapeutics

Not yet recruiting

Study of STM-416p Administered to Patients Undergoing Radical Prostatectomy

Prostate Cancer
Hoffmann-La Roche

Not yet recruiting

An Open-label Study to Assess the Efficacy and Safety of Satralizumab in Duchenne Muscular Dystrophy (SHIELD DMD)

Duchenne Muscular Dystrophy

United States
Medtronic - MITG

Not yet recruiting

Transorb™ Self-Gripping Resorbable Mesh in High-risk Subjects Undergoing Open Repair of Ventral Hernia (RECOVER)

Hernia | Hernia, Abdominal | Hernia, Ventral | Hernia Abdominal Wall
University of Campinas, Brazil
Fundação de Amparo à Pesquisa do Estado de São Paulo

Not yet recruiting

Resistant Hypertension An Open, Complicated ("Cum Plicare") or Complex ("Cum Plexus") Syndrome?

Hypertension | Resistant Hypertension

Brazil
Istanbul University - Cerrahpasa (IUC)

Recruiting

The Open Kinetic Chain and Closed Kinetic Chain Strengthening Exercises in Degenerative Meniscus Tears

Knee Pain Swelling | Meniscus Tear | Degenerative Disease

Turkey
University Hospital, Grenoble

Not yet recruiting

Brief Motivational Intervention (BMI) on the Deprescription of Benzodiazepines and Related Substances in Adult Chronic Drug Users (BENZ_HALTE)

Benzodiazepine Withdrawal

France
Assiut University

Recruiting

Lap Adhesiolysis in Intestinal Obstruction

Adhesions Bowel

Egypt
Milton S. Hershey Medical Center
Guardant Health, Inc.; HealthLinc, Inc; PCC Community Wellness Center

Not yet recruiting

Understanding Patient Preference on Colorectal Cancer Screening Options-PSU (U-Screen)

Colo-rectal Cancer

United States
Yale University
Usona Institute

Not yet recruiting

Open-Label Psilocybin

Safety, Feasibility, and Tolerability of Psilocybin Treatment in Individuals With Functional Impairment Due to Psychiatric Symptoms
Alcon Research

Not yet recruiting

Next Generation Rocklatan

Ocular Hypertension | Open Angle Glaucoma

United States
Clinical Hospital Centre Zagreb

Not yet recruiting

Therapeutic Options for CRAB (TheraCRAB)

Infections, Bacterial | Sepsis Bacterial
Istituto Auxologico Italiano
Catholic University of the Sacred Heart; University of Turin, Italy; Open University and other collaborators

Not yet recruiting

Exploring the Full Body Representation in Anorexia Nervosa and Bulimia Nervosa (FULLBR_ANBN)

Anorexia Nervosa/Bulimia

Italy
UCB Biopharma SRL

Not yet recruiting

An Open-label Extension Study to Evaluate Subcutaneous Zilucoplan in Pediatric Participants With Generalized Myasthenia Gravis (ziMyG+)

Generalized Myasthenia Gravis
Jazz Pharmaceuticals

Not yet recruiting

A Phase 3, Randomized, Open-label, Controlled Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

Metastatic HER2-positive Breast Cancer

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