Search clinical trials for: Antimetabolites

Total 14877 results

Aprea Therapeutics

Completed

APR-246 & Azacitidine for the Treatment of TP53 Mutant Myelodysplastic Syndromes (MDS)

MDS

United States, France
Prelude Therapeutics

Terminated

PRT1419 as Monotherapy or in Combination With Azacitidine or Venetoclax in R/R Myeloid or B-cell Malignancies

Follicular Lymphoma | Acute Myeloid Leukemia | Myelodysplastic Syndromes | Chronic Myelomonocytic Leukemia | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Chronic Lymphocytic Leukemia | Myeloproliferative Neoplasm | Small Lymphocytic Lymphoma | B-cell Non-Hodgkin Lymphoma

United States
Uppsala University
Swedish Cancer Society

Active, not recruiting

Short Course Radiation Therapy Followed by Pre-operative Chemotherapy and Surgery in High-risk Rectal Cancer (LARCT-US)

Rectal Cancer

Sweden
UNICANCER

Completed

Neoadjuvant Treatment for Advanced Rectal Carcinoma (NACRE)

Rectal Carcinoma

France
IFOM ETS - The AIRC Institute of Molecular Oncology
Guardant Health, Inc.

Active, not recruiting

Post-surgical Liquid Biopsy-guided Treatment of Stage III and High-risk Stage II Colon Cancer Patients: the PEGASUS Trial

Colon Cancer

Spain, Italy
NCIC Clinical Trials Group

Completed

Bortezomib and Gemcitabine in Treating Patients With Relapsed Mantle Cell Lymphoma

Lymphoma

Canada
Innovent Biologics (Suzhou) Co. Ltd.

Completed

Efficacy and Safety Evaluation of Sintilimab or Placebo in Combination With XELOX as First Line Treatment in Patients With Gastric Cancer

Gastric Cancer

China
Takeda

No longer available

Expanded Access Program With Pevonedistat (Given With Azacitidine) for Adults With Higher-risk Myelodysplastic Syndromes

Myelodysplastic Syndromes
Technische Universität Dresden

Completed

Treatment of Patients With Myelodysplastic Syndrome or Acute Myelocytic Leukemia With an Impending Hematological Relapse With Azacitidine (Vidaza) (RELAZA2)

Myelodysplastic Syndrome | Acute Myelocytic Leukemia

Germany
Fujifilm Pharmaceuticals U.S.A., Inc.

Withdrawn

A Study of FF-10501-01 in Combination With Azacitidine in Patients With Myelodysplastic Syndrome

Myelodysplastic Syndrome (MDS)
Tianjin Medical University Cancer Institute and...

Unknown

A Single Arm Study of Brain Metastasis in Patients With HER2-positive Breast Cancer

TTP

China
University of Texas Southwestern Medical Center

Completed

Capecitabine and Radiation Therapy in Treating Patients With Nonmetastatic Breast Cancer After Surgery

Breast Cancer

United States
Sichuan University

Unknown

Conversion Therapy With Sintilimab Plus CAPOX in Patients With Unresectable Locally Advanced or Limited Metastatic Adenocarcinoma of the Stomach or Esophagogastric Junction (CTSCAPOXSEA)

Metastatic Gastric Cancer | Gastroesophageal Junction Adenocarcinoma | Stomach Adenocarcinoma | Locally Advanced Unresectable Gastric Adenocarcinoma

China
M.D. Anderson Cancer Center
GlaxoSmithKline

Terminated

Eltrombopag With Decitabine in Advanced Myelodysplastic Syndrome (MDS)

Leukemia

United States
Celgene

Completed

Study of Azacitidine in Adult Taiwanese Subjects With Higher-Risk Myelodysplastic Syndromes (MDS)

Myelodysplastic Syndromes

Taiwan
Hutchison Medipharma Limited

Terminated

Phase I Study of HMPL-523+Azacitidine in Elderly Patients With Acute Myeloid Leukemia

Acute Myeloid Leukemia

China
Celgene

Completed

Pharmacokinetics and Safety Study of Azacitidine in Cancer Patients With and Without Impaired Renal Function (RENAL)

Multiple Myeloma | Non-Hodgkin's Lymphoma | AML | Solid Tumors | MDS | Hodgkin's Disease

United States
Wei Jiang
Guilin Hospital of Traditional Chinese Medicine

Unknown

Demethylated Drug in the Treatment of Nasopharyngeal Carcinoma

Nasopharyngeal Carcinoma

China
The University of Hong Kong-Shenzhen Hospital

Completed

Induction Cisplatin and Capecitabine Followed by Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma

Nasopharyngeal Carcinoma
Radboud University Medical Center

Completed

Transanal Endoscopic Microsurgery (TEM) After Radiochemotherapy for Rectal Cancer (CARTS)

Rectal Tumour

Netherlands
Hoffmann-La Roche

Terminated

A Study of Whole Brain Radiation Therapy and Capecitabine in Breast Cancer Participants With Newly Diagnosed Brain Metastasis (XERAD)

Breast Cancer

France
TetraLogic Pharmaceuticals

Terminated

Study of Azacitidine With or Without Birinapant in Subjects With MDS or CMMoL

Chronic Myelomonocytic Leukemia (CMML) | Myelodysplastic Syndrome (MDS)

United States, Spain, Australia, Germany
Fudan University

Completed

The Maintenance Treatment of UFT in Advanced Gastric Cancer

Gastric Cancer
New York Medical College
Genzyme, a Sanofi Company

Completed

Allogeneic Stem Cell Transplant With Clofarabine, Ara-C and TBI for AML and ALL

Acute Lymphoblastic Leukemia | Acute Myelogenous Leukemia

United States
Japan Breast Cancer Research Network

Completed

Capecitabine vs. S-1 in Unresectable or Recurrent Breast Cancer

Breast Neoplasms

Japan
Harbin Medical University

Unknown

XELOX With Capecitabine Maintenance or XELOX in Elderly Metastatic Adenocarcinoma of Stomach

Gastric Cancer

China
ACT Biotech, Inc

Completed

A Study of Telatinib in Combination With Chemotherapy in Subjects With Advanced Gastric Cancer

Gastric Cancer

Spain, United States
Samsung Medical Center

Completed

Phase III Randomized Trial of Adjuvant XP Chemotherapy and XP/RT for Resected Gastric Adenocarcinoma

Gastric Cancer | Surgery

Korea, Republic of
Taiho Pharmaceutical Co., Ltd.

Completed

A Randomized Controlled Study of Postoperative Adjuvant Chemotherapy of Uracil- Tegafur (UFT) Compared With Surgery Alone (NSAS-CC)

Colorectal Cancer

Japan
Taiho Pharmaceutical Co., Ltd.

Completed

A Randomized Controlled Study of Postoperative Adjuvant Chemotherapy of Uracil- Tegafur (UFT) Compared With Surgery Alone (NSAS-GC)

Gastric Cancer

Japan
Sanofi

Completed

Study of Neoadjuvant Chemotherapeutic Treatment (XELOX) Followed by Chemoradiotherapy (XELOX/RT) and Surgery Versus Chemoradiotherapy Followed by Surgery and Chemotherapy in Patients With High Risk Rectal Cancer

Rectal Neoplasms

Spain
M.D. Anderson Cancer Center
Ascentage Pharma Group Inc.

Not yet recruiting

A Phase I Study of Decitabine, Lisaftoclax, and Olverembatinib in Patients With Advanced Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Myeloid Leukemia

Advanced Chronic Myeloid Leukemia | Philadelphia Chromosome-Positive Acute Myeloid Leukemia

United States
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Recruiting

Fruquintinib Plus Camrelizumab and Capecitabine as Salvage Therapy After Progression on FOLFOXIRI-based First-line Treatment in Patients With Unresectable/Metastatic Colorectal Cancer

Unresectable/Metastatic Colorectal Cancer

China
Guangdong Provincial People's Hospital
Shenzhen Chipscreen Biosciences Co.Ltd

Recruiting

A Study of Chidamide With AZA in MRD Positive AML After Transplant

Minimal Residual Disease | AML, Adult

China
Brown University
Cures Within Reach; Lifespan; Legorreta Cancer Center at Brown University

Recruiting

Targeting Androgen Signaling in Urothelial Cell Carcinoma - Neoadjuvant (TASUC-Neo)

Urothelial Carcinoma Bladder | Androgen Receptor Positive

United States
Menoufia University

Recruiting

A Study Evaluating Maintenance Therapy After First Line Chemotherapy in Metastatic Cancer Pancreas

Cancer of Pancreas

Egypt
Sun Yat-sen University
Chongqing University Cancer Hospital; Jiangxi Provincial Cancer Hospital; Shenzhen... and other collaborators

Recruiting

SBRT Combined With PD-1 Antibody and Chemotherapy in Oligometastatic Nasopharyngeal Carcinoma

Nasopharyngeal Carcinoma

China
The First Affiliated Hospital of Zhengzhou University

Not yet recruiting

Decitabine Plus Penpulimab as Second-line Therapy for Advanced ESCC Treated With PD-1 Blockade

Esophageal Squamous Cell Carcinoma
CG Pharmaceuticals, Inc

Recruiting

A Study of Ivaltinostat Plus Capecitabine or Capecitabine in Metastatic Pancreatic Adenocarcinoma

Metastatic Pancreatic Adenocarcinoma

United States
Massachusetts General Hospital
Taiho Oncology, Inc.

Recruiting

Inqovi Maintenance Therapy in Myeloid Neoplasms

Myelodysplastic Syndromes | Chronic Myelomonocytic Leukemia | Stem Cell Leukemia

United States
Chinese PLA General Hospital

Recruiting

Camrelizumab Plus Decitabine in Anti-PD-1 Treatment-naive Patients With Relapsed/Refractory Classical Hodgkin Lymphoma

Hodgkin Lymphoma

China
Chinese PLA General Hospital

Recruiting

Chidamide in Combination With Decitabine in Non-Hodgkin's Lymphoma Relapsed After Chimeric Antigen Receptor

Non Hodgkin Lymphoma

China
Esperas Pharma Inc.

Recruiting

A Study of LY2880070 in Participants With Advanced or Metastatic Cancer

Neoplasms | Soft Tissue Sarcoma | Breast Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Rectal Cancer | Triple Negative Breast Cancer | Endometrial Cancer | Colon Cancer | Solid Tumors | Pancreas Cancer

Canada, United States, Croatia, Poland
Vejle Hospital

Active, not recruiting

Neoadjuvant Chemotherapy Versus Standard Treatment in Patients With Locally Advanced Colon Cancer

Colon Cancer

Sweden, Norway, Denmark
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Completed

A Clinical Study of AL2846 Capsule Combined With Gemzar Injection in the Treatment of Advanced Pancreatic Cancer

Pancreatic Cancer

China
Pfizer

Completed

Continuation Study of B1371019(NCT03416179) and B1371012(NCT02367456) Evaluating Azacitidine With Or Without Glasdegib In Patients With Previously Untreated AML, MDS or CMML

Acute Myeloid Leukemia | Chronic Myelomonocytic Leukemia | Myelodysplastic Syndrome

Spain, Canada, Austria, Czechia, France, Hungary, Italy, Japan, Mexico, Poland, United Kingdom
OncoVerity, Inc.
Janssen Research & Development, LLC; argenx

Active, not recruiting

A Study of Cusatuzumab Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia Who Are Not Candidates for Intensive Chemotherapy (CULMINATE)

Leukemia, Myeloid, Acute

Switzerland, Israel, Spain, France, Turkey, Italy, Australia, Brazil, Russian Federation
Academisch Medisch Centrum - Universiteit van Amsterdam...

Terminated

Pre-operative Decitabine in Colon Cancer: a Proof of Principle Study (DECO)

Colon Cancer

Netherlands
Eisai Inc.

Terminated

Efficacy and Safety of Decitabine as Epigenetic Priming With Induction Chemotherapy in Pediatric Acute Myelogenous Leukemia (AML) Subjects

Pediatric Acute Myelogenous Leukemia (AML)

United States, Canada, Australia
SCRI Development Innovations, LLC
Novartis Pharmaceuticals

Completed

A Study of the Hsp90 Inhibitor AUY922 Plus Capecitabine for the Treatment of Patients With Advanced Solid Tumors

Metastatic or Unresectable Solid Tumor Malignancy

United States

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