Clinical Trials Sponsored by Hoffman Oncology

Total 6960 results

Hoffmann-La Roche

Completed

MabRella Study: A Study to Evaluate the Safety of Switching From Intravenous to Subcutaneous Administration of Rituximab During First-Line Treatment for Lymphoma

Lymphoma, Non Hodgkin

Spain
Hoffmann-La Roche

Completed

Study Investigating a Single Oral Dose of Fenebrutinib in Healthy Volunteers

Healthy Participants

United States
Hoffmann-La Roche

Completed

A Study of Subcutaneous Tocilizumab as Monotherapy and/or in Combination With Non-Biologic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Rheumatoid Arthritis

Rheumatoid Arthritis

Greece
Hoffmann-La Roche

Completed

A Study of Alectinib (RO5424802) in Participants With Non-Small Cell Lung Cancer Who Have Anaplastic Lymphoma Kinase (ALK) Mutation and Failed Crizotinib Treatment

Non-Small-Cell Lung Carcinoma

United States, Spain, France, Italy, Belgium, Korea, Republic of, Taiwan, United Kingdom, Luxembourg, Australia, Netherlands, Germany, Singapore, Denmark, Russian Federation, Sweden
Hoffmann-La Roche

Completed

A Dose Finding and Expansion Study of RO7051790 Administered Orally in Participants With Relapsed, Extensive-Stage Disease Small Cell Lung Cancer (ED SCLC)

Small Cell Lung Cancer

United States, Denmark, Spain, France, Canada
Hoffmann-La Roche

Completed

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam (RO7034067) Given by Mouth in Healthy Volunteers

Spinal Muscular Atrophy

Netherlands
Hoffmann-La Roche

Completed

An Observational Study of Avastin (Bevacizumab) in Combination With Chemotherapy as First-Line Treatment in Patients With Advanced Ovarian Cancer (OSCAR 1)

Ovarian Cancer

United Kingdom
Hoffmann-La Roche

Completed

A Study of Pertuzumab and Trastuzumab Subcutaneous (SC) Treatment in Combination With a Taxane in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer (SAPPHIRE)

Breast Cancer

Australia
Hoffmann-La Roche

Completed

Evaluate the Effect of Entrectinib on the Pharmacokinetics of Midazolam in Cancer Patients

Advanced Solid Tumor

United States
Hoffmann-La Roche

Completed

A Study to Assess the Effect of Maintenance Treatment With Rituximab Versus No Treatment in Participants With Progressive B-Cell Chronic Lymphocytic Leukemia (CLL)

Lymphocytic Leukemia, Chronic

Belarus, Poland
Hoffmann-La Roche

Completed

An Observational Study of First-Line Bevacizumab (Avastin) With Fluoropyrimidine-Based Chemotherapy in Participants With Metastatic Colorectal Cancer

Colorectal Cancer

Taiwan
Hoffmann-La Roche

Completed

An Observational Study of Avastin (Bevacizumab) in Patients With Metastatic Colorectal Cancer: Continued Avastin Plus Chemotherapy After First Progression in Clinical Practice

Colorectal Cancer

Croatia
Hoffmann-La Roche

Completed

A Study of Oseltamivir (Tamiflu) for Treatment of Influenza in Immunocompromised Participants.

Influenza, Human

United States, Spain, Belgium, Poland, Germany, United Kingdom, Chile, Estonia, Hungary, Italy, France, South Africa, Mexico, Israel, Brazil, Guatemala, Czechia, Lithuania, Argentina, Bulgaria, Canada, Colombia, Latvia, Romania, Switzer... and more
Hoffmann-La Roche

Completed

A Study of Subcutaneous C.E.R.A. for the Maintenance of Hemoglobin Levels in Participants With Chronic Renal Anemia Not on Dialysis.

Anemia

Netherlands
Hoffmann-La Roche

Completed

A Study to Investigate the Pharmacokinetics of RO7079901 and Meropenem in Participants With a Complicated Urinary Tract Infection

Urinary Tract Infections

United States, Serbia, Hungary, Latvia, Poland
Hoffmann-La Roche

Completed

An Observational Study of Avastin (Bevacizumab) in Elderly Patients With Non-Squamous Non-Small Cell Lung Cancer in Clinical Practice

Non-Squamous Non-Small Cell Lung Cancer

France
Hoffmann-La Roche

Completed

U-Act-After: An Observational Study on Long-Term Efficacy of Tight Control RoActemra/Actemra (Tocilizumab) and/or Methotrexate in Patients With Early Rheumatoid Arthritis Who Have Participated in the U-Act-Early Study (ML22497)

Rheumatoid Arthritis

Netherlands
Hoffmann-La Roche

Completed

A Study to Evaluate the Efficacy and Safety of Vismodegib in Combination With Ruxolitinib for the Treatment of Intermediate- or High-Risk Myelofibrosis (MF)

Myelofibrosis

Italy, United States, Canada, Germany
Hoffmann-La Roche

Completed

A Comparison of Continuous Bevacizumab (Avastin) Treatment or Placebo in Addition to Lomustine Followed by Standard of Care After Disease Progression in Participants With Glioblastoma

Glioblastoma

United Kingdom, Austria, Croatia, France, Italy, Spain, Turkey, Romania, Portugal, Canada, Greece, Sweden, Bulgaria, Estonia, Latvia
Hoffmann-La Roche

Withdrawn

A Study of Atezolizumab in Combination With an Immunotherapy Agent Investigated With or Without Anti-Cd20 Therapy in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

United States
Hoffmann-La Roche

Completed

A Dose Escalation Study of RO6874813 in Participants With Locally Advanced or Metastatic Solid Tumors

Neoplasms

France, Spain, United States
Hoffmann-La Roche

Completed

IMPACT Study: A Study of Valcyte (Valganciclovir) for Prevention of Cytomegalovirus Disease (CMV) in Kidney Allograft Recipients (IMPACT)

Cytomegalovirus Infections

United States, Belgium, United Kingdom, Canada, France, Spain, Brazil, Australia, Germany, Italy, Romania, New Zealand, Poland
Hoffmann-La Roche

Completed

A Study of Saquinavir/Ritonavir in Liver-Impaired Patients With HIV Infection.

HIV Infections

Canada, United States, Puerto Rico
Hoffmann-La Roche

Completed

A Study of Bevacizumab With Taxane Therapy in Participants With Triple Negative Breast Cancer (BATMAN)

Breast Cancer

United Kingdom
Hoffmann-La Roche

Completed

Study of Anemia in Chronic Kidney Disease (CKD) Among High-Risk Hypertensive and Diabetic Patients in Pakistan

Anemia, Diabetes, Kidney Disease, Chronic, Hypertension

Pakistan
Hoffmann-La Roche

Completed

A Study to Evaluate Safety and Effectiveness of Bevacizumab in Combination With Paclitaxel and Cisplatin/Carboplatin or Toptecan in Participants With Advanced Cervical Cancer

Cervical Cancer

Argentina
Hoffmann-La Roche

Completed

A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors

Advanced Solid Tumors

United States, France
Hoffmann-La Roche

Completed

A Study to Evaluate Safety, Pharmacokinetics, and Efficacy of RO6895882 in Participants With Advanced and/or Metastatic Solid Tumors

Neoplasms

United States, Spain, Switzerland, France, United Kingdom, Netherlands, Denmark, Finland
Hoffmann-La Roche

Completed

A Prospective, Non-Interventional Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Active Rheumatoid Arthritis

Rheumatoid Arthritis

Lebanon, Kuwait, Qatar, United Arab Emirates
Hoffmann-La Roche

Completed

An Observational Study of Pegasys in Dual- or Triple-Therapy in Patients With Chronic Hepatitis C

Hepatitis C, Chronic

Germany
Hoffmann-La Roche

Completed

An Observational Study of Avastin (Bevacizumab) in Patients With Glioblastoma Multiforme in First or Second Relapse

Glioblastoma Multiforme

Taiwan
Hoffmann-La Roche

Terminated

An Extension Study to WA19977 in Patients With Active Polyarticular-Course Juvenile Idiopathic Arthritis

Juvenile Idiopathic Arthritis

Russian Federation, Poland
Hoffmann-La Roche

Completed

A Study of Onartuzumab (MetMAb) in Combination With Bevacizumab Compared to Bevacizumab Alone or Onartuzumab Monotherapy in Participants With Recurrent Glioblastoma

Glioblastoma

United States, United Kingdom, France, Italy, Spain, Germany, Canada, Switzerland
Hoffmann-La Roche

Completed

A Study of Bevacizumab Versus Placebo in Combination With Carboplatin/Paclitaxel in Participants With Advanced or Recurrent Non-Squamous Non-Small Cell Lung Cancer Who Have Not Received Previous Chemotherapy

Non-Small Cell Lung Cancer

China
Hoffmann-La Roche

Completed

A Study of Subcutaneous RoActemra/Actemra (Tocilizumab) as Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Patients With Active Rheumatoid Arthritis

Rheumatoid Arthritis

Spain, Portugal, Ireland
Hoffmann-La Roche

Completed

Multicenter, Post-marketing, Non-interventional, Observational Study in RA Patients Treated With RoActemra/Actemra (Tocilizumab)

Rheumatoid Arthritis

China
Hoffmann-La Roche

Completed

A Study of Vemurafenib in Participants With Metastatic Melanoma

Malignant Melanoma

Canada, Spain, United Kingdom, Hungary, Australia, Austria, Belgium, Ecuador, Estonia, Finland, Ireland, Italy, Korea, Republic of, Mexico, Netherlands, Portugal, Slovenia, Sweden, Turkey, Brazil, India, Germany, Bosnia and Herzegovina and more
Hoffmann-La Roche

Completed

A Study in Participants With Asthma Initiating Treatment With Omalizumab (Xolair)

Asthma

United States
Hoffmann-La Roche

Completed

A Study of Once Monthly Intravenous Mircera for the Maintenance Treatment of Dialysis Patients With Chronic Renal Anemia.

Anemia

India
Hoffmann-La Roche

Completed

The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of RO6889450 in Healthy Volunteers

Healthy Volunteer

Netherlands
Hoffmann-La Roche

Completed

Bioavailability Study of Vemurafenib in Participants With BRAF^V600 Mutation-Positive Malignancies

Malignant Melanoma, Cancer

Hungary
Hoffmann-La Roche

Completed

An Observational Study of MabThera/Rituxan (Rituximab) Plus Chemotherapy As First-Line Treatment in Patients With Diffuse Large B-Cell Lymphoma or Follicular Lymphoma

Diffuse Large B-Cell Lymphoma

China
Hoffmann-La Roche

Terminated

A Study for Monthly Methoxy Polyethylene Glycol-Epoetin Beta Treatment in Patients With Chronic Renal Anaemia

Anemia

Indonesia
Hoffmann-La Roche

Completed

A Study of First Line Treatment With Avastin (Bevacizumab) in Combination With Carboplatin and Weekly Paclitaxel in Patients With Ovarian Cancer

Ovarian Cancer

France, Spain, Brazil, United Kingdom, Netherlands, Italy, Russian Federation, Sweden, Norway
Hoffmann-La Roche

Completed

A Study of RG1662 in Adults and Adolescents With Down Syndrome (CLEMATIS)

Down Syndrome

United States, Italy, Argentina, France, Spain, Mexico, Canada, New Zealand, Singapore, United Kingdom
Hoffmann-La Roche

Completed

Participants Preferences to Disease Modifying Agents in Relapsing Remitting Multiple Sclerosis Condition

Multiple Sclerosis, Relapsing-Remitting

Spain
Hoffmann-La Roche

Completed

A Study of Extended Therapy of PEGASYS (Peginterferon Alfa-2a) in Combination With COPEGUS (Ribavirin) in Patients With Chronic Hepatitis C and Slow Response

Hepatitis C, Chronic

Israel
Hoffmann-La Roche

Completed

A Study of Lebrikizumab in Participants With Persistent Moderate to Severe Atopic Dermatitis

Atopic Dermatitis

United States, Korea, Republic of, Canada, United Kingdom, Germany, Australia, Poland, Finland, France, Spain, Switzerland, Czechia, Netherlands, Taiwan
Hoffmann-La Roche

Completed

A Study of Two Vismodegib Regimens in Participants With Multiple Basal Cell Carcinomas

Basal Cell Carcinoma

United States, Spain, France, Germany, Netherlands, Russian Federation, Italy, Mexico, Austria, Canada
Hoffmann-La Roche

Withdrawn

Avastin (Bevacizumab) in the Treatment of Metastatic Colorectal Cancer in Normal Clinical Use in the UK Population

Metastatic Colorectal Cancer

3

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