Search clinical trials for: Alignment phase

Total 18721 results

Sun Yat-sen University

Recruiting

A Multi-center, Randomized, Double-blind, Phase II/III Clinical Trial of AK104 or Placebo in Combination With Chemotherapy as Second-line or More Lines for Recurrent or Metastatic Nasopharyngeal Carcinoma (NPC)

Recurrent or Metastatic Nasopharyngeal Carcinoma

China
Centre Hospitalier Régional Metz-Thionville

Recruiting

Quantification of Dilutional Anemia in the Initial Phase of Sepsis Management: Preliminary Retrospective Study (QUADS)

Sepsis

France
Worg Biotherapeutics Inc.

Recruiting

Phase 2 Study to Assess Efficacy & Safety of WP1302 Prevent Relapse of MMI w/Draw in Subj. w/ Graves' dz

Graves Disease

United States
MediLink Therapeutics (Suzhou) Co., Ltd.

Recruiting

A Phase II Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of YL201 in Patients With mCRPC

Metastatic Castration-resistant Prostate Cancer (mCRPC)

China
Wu Jun

Not yet recruiting

Efficacy and Safety of Sintilimab Combined With Nab-paclitaxel and Tegio (aTS) as First-line Treatment of Unresectable Locally Advanced, Recurrent or Metastatic Adenocarcinoma of Gastric and Gastroesophageal Junction，a Phase II Clinical Study

Adenocarcinoma | Gastric Cancer | GastroEsophageal Cancer

China
General Hospital of Shenyang Military Region

Not yet recruiting

Effect of Different Frequencies of Umbilical Cord-mesenchymal Stem Cells Through Peripheral Vein in Patients With ESLD

End-Stage Liver DIsease

China
Diasome Pharmaceuticlas, Inc.

Recruiting

Phase 2b Trial Comparing HDV-Insulin Lispro to Insulin Lispro in Adults With Type 1 Diabetes Receiving Insulin Degludec (OPTI-2)

Diabetes Mellitus, Type 1

United States
Ascentawits Pharmaceuticals, Ltd

Recruiting

A Phase I/II Study of AST-3424 in Subjects With Advanced Solid Tumors

Hepatocellular Carcinoma | Advanced Solid Tumors

China
Yunnan Cancer Hospital
Beijing Bethune Charitable Foundation

Recruiting

Single-arm, Single-center, Exploratory Phase II Clinical Study of Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer (ESTIMATE)

Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer

China
Innovent Biologics (Suzhou) Co. Ltd.

Not yet recruiting

A Multicenter, Phase 3 Study of IBI343 Monotherapy Versus Treatment of Investigator's Choice in Subjects With Previously Treated, Claudin (CLDN) 18.2-positive, HER2-negative, Gastric or Gastroesophageal Junction Adenocarcinoma (G-HOPE-001)

Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

China
M.D. Anderson Cancer Center
KSQ Therapeutics, Inc.

Recruiting

A Phase 1/2 Study of KSQ-001EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate the SOCS1 Gene, in Patients With Select Advanced Solid Tumors

Melanoma | Head and Neck Neoplasms | Lung Neoplasms | Advanced Solid Tumor

United States
Regina Elena Cancer Institute
Fondazione Policlinico Universitario Agostino Gemelli IRCCS; Catholic University... and other collaborators

Recruiting

Biomarkers of Efficacy and Tolerability of Sacituzumab-Govitecan in the Treatment of Patients With Triple-negative Breast Cancer in the Metastatic Phase: Prospective Multicenter Real-world Study (BIO-PROSA)

Breast Cancer

Italy
Palvella Therapeutics, Inc.

Not yet recruiting

A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study Evaluating Safety and Efficacy of QTORIN 3.9% Rapamycin Anhydrous Gel in the Treatment of Microcystic Lymphatic Malformations (SELVA)

Microcystic Lymphatic Malformation

United States
Novartis Pharmaceuticals

Recruiting

Study of Efficacy and Safety of LCZ696/Amlodipine in Grade 1 and 2 Hypertension Patients Uncontrolled by LCZ696 Monotherapy

Hypertension

Japan
Gilgamesh Pharmaceuticals

Recruiting

A Phase 2a Study to Evaluate the Safety and Tolerability of GM-2505 in Patients With MDD

Major Depressive Disorder

United Kingdom
ReCode Therapeutics

Recruiting

A Phase 1 Study Evaluating Safety and Tolerability of RCT2100 in Healthy Participants

Cystic Fibrosis

New Zealand
S-Infinity Pharmaceuticals Co., Ltd

Not yet recruiting

A Phase I Study of XH-S004 in Healthy Volunteers

Healthy Adults

China
M.D. Anderson Cancer Center
GlaxoSmithKline

Recruiting

A Phase I/II Study of Gilteritinib and Momelotinib for Patients With Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia

Myeloid Leukemia

United States
M.D. Anderson Cancer Center
Novartis Pharmaceuticals

Recruiting

Phase II Study Assessing Efficacy and Safety of Asciminib in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase.

Chronic Myeloid Leukemia

United States
Dr. Chris McGlory, PhD

Recruiting

Nutritional Intervention to Enhance Recovery After Arthroscopic Knee Surgery in Adults

Muscular Atrophy | Anterior Cruciate Ligament Reconstruction

Canada
Zhuhai Beihai Biotech Co., Ltd

Recruiting

A Study of BH009 in Head and Neck Squamous Cell Carcinoma and Ovarian Cancer

Solid Tumor, Adult

China
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Upfront Related Donor Transplantation in Patients With Myelodisplatic Syndrome : a Phase 2 Trial (FIRST ALLO MDS)

Myelodysplastic Syndromes
CSPC Baike (Shandong) Biopharmaceutical Co., Ltd.

Not yet recruiting

Phase 3 Study of TG103 Injection Combined With Metformin in Treatment of Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

China
Cancer Institute and Hospital, Chinese Academy...

Recruiting

Phase II Study of Moderate-dose Hypofractionated RT Combined With Tislelizumab for HCC With Diffuse Tumor Thrombosis

Hepatocellular Carcinoma | Radiotherapy | Tislelizumab | Tumor Thrombosis

China
Takeda

Recruiting

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease

Crohn's Disease

United States, Australia, France, Taiwan, Hungary, Korea, Republic of, Spain, Switzerland, China, Japan, Belgium, Canada, Germany, Italy, Poland, Romania, United Kingdom, Czechia, Denmark, Greece, Norway, Slovakia, Netherlands
Research Institute for Physical Chemical Problems...
Vitebsk Regional Clinical Hospital; Unitary Enterprise UNITEHPROM BSU; The 10th...

Not yet recruiting

Clinical Study in Adult Patients With Purulent-inflammatory Processes of the Skin and Soft Tissues, Phase I-II of the Wound Process (OLENKRON-01)

Chronic Venous Insufficiency | Diabetic Foot Infections

Belarus
Research Institute for Physical Chemical Problems...
The state institution N. N. Alexandrov National Cancer Centre of Belarus; Unitary...

Not yet recruiting

An Open Prospective Randomized Clinical Study of the Effectiveness, Tolerability and Safety of a Single Intraperitoneal Use of the Drug "Prospidelong, Powder for the Preparation of a Gel for Topical Use, 1000 mg in Vials, Package No. 1" in Patients With Disseminated Gastric Cancer, Phase I-II (ИНТЕЛОН-02)

Gastric Cancer With Peritoneal Dissemination

Belarus
University of California, Irvine

Recruiting

Impact of Personality on Adherence to Tyrosine Kinase Inhibitor Therapy in Pts w/Chronic Myeloid Leukemia

Chronic Myeloid Leukemia | Chronic Phase Chronic Myelogenous Leukemia

United States
M.D. Anderson Cancer Center
Syndax Pharmaceuticals

Not yet recruiting

A Phase II Study of the Menin Inhibitor Revumenib in Leukemia Associated With Upregulation of HOX Genes

Leukemia | HOX Gene

United States
Federal University of São Paulo
BRICNET - Brazilian Research in Intensive Care Network

Not yet recruiting

Vexus-guided Fluid Management in Patients With Septic Shock After the Resuscitation Phase (VEXUS)

Septic Shock | Critically Ill Patients
Swedish Orphan Biovitrum

Recruiting

A Non-interventional, Post-Marketing Study to Describe Outcome of Nitisinone Treatment in HT-1 Patients

Hereditary Tyrosinemia, Type I

China
University of Bern
Spitalzentrum Biel

Not yet recruiting

Precise Neoadjuvant Chemoresection of Low Grade NMIBC (POLO)

Bladder Cancer | Non-muscle Invasive Bladder Cancer | Low-risk

Switzerland
Shanghai Yuyao Biotech Co., Ltd.

Recruiting

An Open-Label, Multicenter, Phase I Study to Evaluate the Safety, Pharmacokinetics and Preliminary Efficacy of YY201 in Patients With Advanced Solid Tumors and Hematological Malignancies

Advanced Solid Tumor | Hematological Malignancy

China
Morphic Therapeutic, Inc

Recruiting

A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease (GARNET)

Inflammatory Bowel Diseases | Crohn's Disease

United States, Georgia
Shandong New Time Pharmaceutical Co., LTD
Sun Yat-sen University

Not yet recruiting

Phase I Study of LNF1901 in Advanced Malignant Tumors

Advanced Malignant Tumors
Second Xiangya Hospital of Central South University

Not yet recruiting

A Phase 2, Randomized, Placebo Controlled Study Investigating the Efficacy and Safety of Sorafenib in New-Onset Type 1 Diabetes Mellitus

Type 1 Diabetes
Institut de Recherches Internationales Servier

Not yet recruiting

Phase 2 Study of Irinotecan Liposome Injection, Oxaliplatin, 5-fluorouracil/Levoleucovorin in Japanese Participants Not Previously Treated for Metastatic Adenocarcinoma of the Pancreas

Metastatic Adenocarcinoma of the Pancreas

Japan
Leslie Swanson
National Institute of Mental Health (NIMH); University of Michigan; Natrol

Not yet recruiting

Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder

Bipolar Disorder | Delayed Sleep-Wake Phase Disorder

United States
British Columbia Cancer Agency

Not yet recruiting

Preliminary Assessment of [18F]BL40 in PET/CT Scans

Multiple Myeloma | Waldenström Macroglobulinemia | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Chronic Lymphocytic Leukemia | Diffuse Large B-cell Lymphoma

Canada
Chipscreen Biosciences, Ltd.

Not yet recruiting

A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetic, Pharmacodynamic Profiles and Food Effect of CS32582 Capsules

Healthy

China
Kynexis B.V.
Parexel

Recruiting

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of KYN-5356 in Healthy Subjects Aged 18 to 55 Years

Schizophrenia | Cognitive Dysfunction

United States
Carol Davila University of Medicine and Pharmacy

Recruiting

Predictive Values of Presepsin Levels in ASciteS in Patients With Chronic Liver Failure (PASS)

Liver Failure | Cirrhosis, Liver | Ascites Hepatic

Romania
National Cancer Institute (NCI)

Recruiting

Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer

Squamous Cell Carcinoma of the Head and Neck | Drug Therapy | Oropharynx | Human Papillomavirus Viruses | Cancer Vaccine

United States
Assistance Publique Hopitaux De Marseille

Not yet recruiting

Heparin-Free Chronic HemoDialysis Assessment (HepFreeHD)

End-Stage Renal Disease
Ankara City Hospital Bilkent

Recruiting

Evaluation of the Efficacy of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Unilateral Neglect in Patients With Subacute-Chronic Phase After Ischemic Stroke

Neglect, Hemispatial

Turkey
CytosinLab Therapeutics Co., Ltd.

Recruiting

CTS2190 Phase I /II Clinical Study in Patients

Pancreatic Cancer | Non-small Cell Lung Cancer | Solid Tumors | Triple-negative Breast Cancer

China
Yan Bi

Not yet recruiting

Effect of Dorzagliatin on Renal Function Outcomes in People With Type 2 Diabetes: a Multicentric, Prospective, Randomized Study.

Diabetic Nephropathy Type 2

China
Fifth Affiliated Hospital, Sun Yat-Sen University

Recruiting

Early Evaluation of Left Ventricular Systolic Function Impairment in Patients With Chronic Kidney Disease by Multimodal Ultrasonography

Chronic Kidney Diseases | Left Ventricular Systolic Dysfunction

China
Fujian Cancer Hospital

Not yet recruiting

A Phase II Clinical Study of the Efficacy and Safety of Tislelizumab Combined With Fruquintinib and Chidamide in the Treatment of Unresectable or Advanced Microsatellite Stabilized (MSS/pMMR) Colorectal Cancer With Liver Metastases

Colo-rectal Cancer
AstraZeneca

Recruiting

AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2

Gastric Cancer | Pancreatic Adenocarcinoma | Gastroesophageal Junction Cancer

United States, Spain, United Kingdom, Korea, Republic of, Canada, Japan, Malaysia, Taiwan, Singapore, Moldova, Republic of, Australia, Poland, Georgia

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