A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease (GARNET)

May 20, 2026 updated by: Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)

A Phase 2, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of 3 Active Dose Regimens of MORF-057 in Adults With Moderately to Severely Active Crohn's Disease (GARNET)

This is a Phase 2, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of 3 active dose regimens of MORF-057 in adult study participants with moderately to severely active Crohn's disease (CD).

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

This is a Phase 2, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of induction therapy with 3 active dose regimens of MORF-057 versus matching placebo in adult study participants with moderately to severely active CD. After completion of the 14-week Induction Period, all participants will receive open-label MORF-057 during the 38-week Maintenance Period. All participants who complete the full 52-week Treatment Period will also have the opportunity to continue treatment in a 52-week Long-Term Extension.

Study Type

Interventional

Enrollment (Estimated)

385

Phase

  • Phase 2

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
  • Phone Number: 1-317-615-4559
  • Email: LillyTrials@Lilly.com

Study Contact Backup

Study Locations

  • Australia
      • Bedford Park, Australia, 5042
        • Not yet recruiting
        • Southern Adelaide Local Health Network
        • Principal Investigator:
          • Reme Mountifield
        • Contact:
          • Phone Number: +61 (8) 8204 4964
      • Herston, Australia, 4029
        • Not yet recruiting
        • Royal Brisbane and Women's Hospital
        • Principal Investigator:
          • Anthony Croft
        • Contact:
          • Phone Number: +61 (7) 3646 4273
      • Kurralta Park, Australia, 5037
        • Not yet recruiting
        • IBD SA SA Group of Specialists
        • Principal Investigator:
          • Paul Spizzo
      • Melbourne, Australia, 3004
        • Not yet recruiting
        • The Alfred Hospital
        • Principal Investigator:
          • Miles Sparrow
        • Contact:
          • Phone Number: +61 (03) 9076 8838
      • Melbourne, Australia, 3065
        • Not yet recruiting
        • St. Vincent's Hospital
        • Principal Investigator:
          • John Nik Sheng Ding
        • Contact:
          • Phone Number: +61 (3) 92313580
      • Perth, Australia, 6000
        • Not yet recruiting
        • Royal Perth Hospital
        • Principal Investigator:
          • Kenji So
      • Perth, Australia, 6009
        • Not yet recruiting
        • Sir Charles Gairdner Hospital
        • Principal Investigator:
          • Nabil Siddique
        • Contact:
          • Phone Number: +61 (0) -8645-7367
      • Woolloongabba, QLD, Australia, 4102
        • Not yet recruiting
        • Princess Alexandra Hospital, Metro South Health
        • Contact:
          • Phone Number: 61731767792
        • Principal Investigator:
          • Gerald Holtmann
  • Austria
      • Innsbruck, Austria, 6020
        • Recruiting
        • Medical University Hematology
        • Principal Investigator:
          • Robert Koch
        • Contact:
          • Phone Number: +43 (512) 504 23539
      • Salzburg, Austria, 5020
        • Recruiting
        • Salzburg Regional Hospital
        • Principal Investigator:
          • Sonja Heeren
      • Sankt Pölten, Austria, 3100
        • Recruiting
        • University Hospital St. Poelten
        • Contact:
          • Phone Number: +43 (2742) 9004 12311
        • Principal Investigator:
          • Andreas Maieron
      • Vienna, Austria, 1090
        • Recruiting
        • Medical University of Vienna
        • Principal Investigator:
          • Walter Reinisch
        • Contact:
          • Phone Number: +43 (1) 40400 62450
  • Bosnia and Herzegovina
      • Banja Luka, Bosnia and Herzegovina, 78000
        • Not yet recruiting
        • University Clinical Centre of the Republic of Srpska
        • Contact:
          • Phone Number: +387 (51) 342 100
        • Principal Investigator:
          • Renata Tamburic
      • Tuzla, Bosnia and Herzegovina, 75000
        • Not yet recruiting
        • Hospital Plava Medical Group
        • Principal Investigator:
          • Admir Kurtcehajic
      • Zenica, Bosnia and Herzegovina, 72000
        • Not yet recruiting
        • Cantonal Hospital Zenica, Department of Internal Medicine
        • Principal Investigator:
          • Lejla Saranovic Ceco
  • Brazil
      • Aracaju, Brazil, 49075-000
        • Not yet recruiting
        • NewData FBHC, NewData Clinical Research
        • Principal Investigator:
          • Alex Callado França
      • Botucatu, Brazil, 18618-687
        • Not yet recruiting
        • Faculdade de Medicina da UNESP
        • Principal Investigator:
          • Ligia Yukie Sassaki
      • Brasília, Brazil, 72145-450
        • Recruiting
        • Chronos Pesquisa Clinica
        • Principal Investigator:
          • Cintia Mendes Clemente
      • Campinas, Brazil, 13093-133
        • Not yet recruiting
        • Loema Clinical Research Institute and Consultants SS Ltda- i9 Clinical Research
        • Principal Investigator:
          • Joaquim Simoes Neto
        • Contact:
          • Phone Number: +55 (19) 98122-4244
      • Santo André, Brazil, 09080-110
        • Recruiting
        • Pesquisare
        • Principal Investigator:
          • Alexander de Sa Rolim
        • Contact:
          • Phone Number: +55 (11) 99245-2102
      • São Paulo, Brazil, 04543-011
        • Recruiting
        • Clínica Hepatogastro JK
        • Principal Investigator:
          • Rodrigo Andrey Rocco
  • Bulgaria
      • Rousse, Bulgaria, 7002
        • Not yet recruiting
        • "Medical Center Kanev" EOOD
        • Contact:
          • Phone Number: +359 (89) 980 5965
        • Principal Investigator:
          • Ruslan Kulinski
      • Sofia, Bulgaria, 1618
        • Not yet recruiting
        • Diagnostic Consultative Center XX - Sofia
        • Principal Investigator:
          • Dimitar Dimitrov
        • Contact:
          • Phone Number: +359 (878) 304 281
  • Canada
      • Alberta, Canada, T4P 1K4
        • Not yet recruiting
        • CaRe Clinic
        • Principal Investigator:
          • Josias Badenhorst
      • Chicoutimi, Canada, G7H 5H6
        • Not yet recruiting
        • Integrated University Health and Social Services Center of Saguenay-Lac-Saint-Jean
        • Principal Investigator:
          • Alban Michaud-Herbst
      • Halifax, Canada, B3H 1V7
        • Recruiting
        • Nova Scotia Health Authority
        • Principal Investigator:
          • Jennifer Jones
        • Contact:
          • Phone Number: +902 (473) 1499
      • Lethbridge, Canada, T1J 4G9
        • Not yet recruiting
        • Prairie Institute of Liver and Luminal Advanced Research
        • Principal Investigator:
          • Kaleb Marr
      • London, Canada, N6A 4L6
        • Recruiting
        • London Health Sciences Centre
        • Principal Investigator:
          • Terry Ponich
      • London, Canada, N6K 1M6
        • Not yet recruiting
        • London Digestive Disease Institute
        • Principal Investigator:
          • Vipul Jairath
        • Contact:
          • Phone Number: +519 (685) 8500
      • Montreal, Canada, H3H 1E8
        • Not yet recruiting
        • Clinique IMD
        • Principal Investigator:
          • Waqqas Afif
      • Québec, Canada, G1V 4T3
        • Recruiting
        • Diex Recherche Quebec Inc.
        • Principal Investigator:
          • Pascale Chouinard
      • Scarborough, Canada, M1B 3V4
        • Not yet recruiting
        • Scarborough Center for Inflammatory Bowel Disease
        • Principal Investigator:
          • Jason Reinglas
      • Toronto, Canada, M5G 1X5
        • Recruiting
        • Mount Sinai Hospital
        • Principal Investigator:
          • Hillary Steinhart
      • Toronto, Canada, M6R 1B5
        • Recruiting
        • St Joseph'S Health Centre Toronto
        • Principal Investigator:
          • Ian Bookman
      • Vaughan, Canada, L4L 4Y7
        • Recruiting
        • Toronto Digestive Disease Associates, Inc.
        • Principal Investigator:
          • David Ford
  • Colombia
      • Armenia, Colombia, 630004
        • Recruiting
        • Cardiomet Cequin S.A.S., Research Unit
        • Contact:
          • Phone Number: +57 (6) 731 3737
        • Principal Investigator:
          • Juan Guillermo Lopez Valencia
      • Cali, Colombia, 760032
        • Recruiting
        • Fundacion Valle del Lili
        • Principal Investigator:
          • Carlos Rojas Rodriguez
      • Floridablanca, Colombia, 681017
        • Recruiting
        • Cardiovascular Foundation of Colombia
        • Contact:
          • Phone Number: +57 (7) 639 9658
        • Principal Investigator:
          • Mario Gabriel Figueredo Meneses
      • Medellín, Colombia, 050034
        • Recruiting
        • Hospital Pablo Tobón Uribe
        • Contact:
          • Phone Number: 57 (4) 445 9963
        • Principal Investigator:
          • Gabriel Mosquera Klinger
      • Medellín, Colombia, 050012
        • Recruiting
        • Corporation for Health Studies "CES"
        • Contact:
          • Phone Number: +57 (604) 576 7272
        • Principal Investigator:
          • Veronica Posada Velez
      • Soledad, Colombia, 083001
        • Recruiting
        • Northern University Foundation Hospital
        • Contact:
          • Phone Number: +57 (575) 371 5510
        • Principal Investigator:
          • Hugo Macareno
  • Croatia
      • Osijek, Croatia, 31000
        • Recruiting
        • Poliklinika Borzan
        • Principal Investigator:
          • Vladimir Borzan
      • Rijeka, Croatia, 51000
        • Recruiting
        • Specialty hospital Medico Rijeka
        • Contact:
          • Phone Number: +385 (99) 834 3552
        • Principal Investigator:
          • Davor Stimac
      • Zadar, Croatia, 23000
        • Recruiting
        • General Hospital Zadar
        • Contact:
          • Phone Number: + (385) 98 170 1265
        • Principal Investigator:
          • Ivo Klarin
      • Zagreb, Croatia, 10000
        • Recruiting
        • Poliklinika Solmed
        • Principal Investigator:
          • Dominik Kralj
        • Contact:
          • Phone Number: + (385) 915881571
  • Czechia
      • Brno, Czechia, 602 00
        • Recruiting
        • SurGal Clinic s.r.o.
        • Principal Investigator:
          • Jan Ulbrych
        • Contact:
          • Phone Number: + (420) 724 101 038
      • Brno, Czechia, 615 00
        • Recruiting
        • Military Hospital Brno,
        • Contact:
          • Phone Number: + (420) 973 445 520
        • Principal Investigator:
          • Peter Hegyi
      • Prague, Czechia, 140 00
        • Recruiting
        • Clinoxus s.r.o., Outpatient Clinic Budejovicka
        • Contact:
          • Phone Number: +420 () 222 962 476
        • Principal Investigator:
          • Petr Hrabak
      • Prague, Czechia, 14000
        • Recruiting
        • Axon Clinical, s.r.o.
        • Principal Investigator:
          • Jan Matous
        • Contact:
          • Phone Number: + (420) 776767590
  • Estonia
      • Tallinn, Estonia, 10617
        • Not yet recruiting
        • West Tallinn Central Hospital
        • Contact:
          • Phone Number: +372 () 651 1471
        • Principal Investigator:
          • Kulliki Suurmaa
      • Tallinn, Estonia, 10138
        • Not yet recruiting
        • East Tallinn Central Hospital
        • Contact:
          • Phone Number: +372 () 5326 9290
        • Principal Investigator:
          • Peeter Koiva
      • Tartu, Estonia, 50406
        • Not yet recruiting
        • Tartu University Hospital, Department of Gastroenterology
        • Contact:
          • Phone Number: +372 () 731 8634
        • Principal Investigator:
          • Karin Kull
  • France
      • Pierre-Bénite, France, 69310
        • Recruiting
        • Hospices Civils de Lyon - Lyon Sud
        • Principal Investigator:
          • Stephane Nancey
        • Contact:
          • Phone Number: +33 () 4 78 86 12 89
      • Vandœuvre-lès-Nancy, France, 54500
        • Recruiting
        • CHRU Nancy Brabois - Hôpital d'Enfants
        • Contact:
          • Phone Number: +33 (3) 83153 631
        • Principal Investigator:
          • Marine Ferry
  • Georgia
      • Batumi, Georgia, 6010
        • Recruiting
        • High Technology Hospital Medcenter LLC
        • Contact:
          • Phone Number: +995 (593) 646 438
        • Principal Investigator:
          • Nana Bolkvadze
      • Tbilisi, Georgia, 0159
        • Recruiting
        • LTD Institute of Clinical Cardiology
        • Contact:
          • Phone Number: +995 (577) 415 937
        • Principal Investigator:
          • Irina Jashi
      • Tbilisi, Georgia, 0160
        • Recruiting
        • LTD Aversi Clinic
        • Contact:
          • Phone Number: +995 (599) 585 864
        • Principal Investigator:
          • Nino Kiknadze
      • Tbilisi, Georgia, 0159
        • Recruiting
        • Emergency Cardiology Center by Academician G. Chapidze LLC
        • Contact:
          • Phone Number: +995 (595) 527 222
        • Principal Investigator:
          • Lela Chankvetadze
      • Tbilisi, Georgia, 0180
        • Recruiting
        • LTD The First Medical Center
        • Contact:
          • Phone Number: +995 (593) 283 528
        • Principal Investigator:
          • Ekaterine Labadze
      • Tbilisi, Georgia, 0178
        • Recruiting
        • LEPL The First University Clinic of Tbilisi State Medical University
        • Contact:
          • Phone Number: +995 (593) 338 379
        • Principal Investigator:
          • Tamara Megrelishvili
  • Germany
      • Berlin, Germany, 10117
        • Recruiting
        • Charite - University Hospital Berlin
        • Contact:
          • Phone Number: +49 (30) 450 514102
        • Principal Investigator:
          • Christoph Jochum
      • Berlin, Germany, 12559
        • Recruiting
        • DRK Clinic Berlin-Koepenick
        • Contact:
          • Phone Number: 49 (152) 0157 3335
        • Principal Investigator:
          • Benjamin Moser
      • Dachau, Germany, 85221
        • Recruiting
        • Medical Care Unit Dachau
        • Contact:
          • Phone Number: +49 (08131) 61 190
        • Principal Investigator:
          • Wilfred Landry
      • Duisburg, Germany, 53119
        • Recruiting
        • Sana Hospital Duisburg
        • Contact:
          • Phone Number: +49 (203) 733 2385
        • Principal Investigator:
          • Wolfgang Nitz
      • Frankfurt am Main, Germany, 60431
        • Not yet recruiting
        • Agaplesion Markus Hospital
        • Principal Investigator:
          • Axel Dignass
        • Contact:
          • Phone Number: +49 (069) 95332201
      • Halle, Germany, 06120
        • Recruiting
        • University Hospital Halle (Saale)
        • Principal Investigator:
          • Jens Walldorf
        • Contact:
          • Phone Number: +49 (345) 557 2665
      • Heidelberg, Germany, 69120
        • Recruiting
        • Universitatsklinikum Heidelberg
        • Contact:
          • Phone Number: +49 (6221) 563 8865
        • Principal Investigator:
          • Annika Gauss
      • Kiel, Germany, 24105
        • Recruiting
        • University Hospital Schleswig-Holstein
        • Principal Investigator:
          • Stefan Schreiber
        • Contact:
          • Phone Number: +49 (431) 500 22202
      • Leipzig, Germany, 04103
        • Not yet recruiting
        • University of Leipzig Medical Cent
        • Principal Investigator:
          • Babett Holler
        • Contact:
          • Phone Number: +49 (341) 712 226
      • Magdeburg, Germany, 110 39104
        • Not yet recruiting
        • Gastropraxis Magdeburg
        • Principal Investigator:
          • Lars Zimmermann
      • Munich, Germany, 81377
        • Not yet recruiting
        • Hospital Ludwig-Maximilians-University Munich, Campus Grosshadern
        • Principal Investigator:
          • Benjamin Misselwitz
      • Wipperfürth, Germany, 51688
        • Recruiting
        • Group Practice Jakobeit
        • Principal Investigator:
          • Christian Jakobeit
        • Contact:
          • Phone Number: +49 (2267) 9201
      • Wolfsburg, Germany, 38440
        • Not yet recruiting
        • Wolfsburg Hospital Department of internal Medicine
        • Principal Investigator:
          • Nils Homann
  • Hungary
      • Budapest, Hungary, 1083
        • Recruiting
        • Semmelweis Medical University
        • Contact:
          • Phone Number: +36 (1) 459 1500
        • Principal Investigator:
          • Akos Ilias
      • Békéscsaba, Hungary, 5600
        • Recruiting
        • Bekes Megyei Kozponti Korhaz Dr. Rethy Pal Tagkorhaz IV. Belgyogyaszat
        • Principal Investigator:
          • Marta Varga
        • Contact:
          • Phone Number: +36 (66) 441 411
      • Eger, Hungary, 3300
        • Recruiting
        • Markhot Ferenc Oktatókórház
        • Contact:
          • Phone Number: +36 (36) 411 444
        • Principal Investigator:
          • Zoltan Sallo
      • Gyöngyös, Hungary, 3200
        • Recruiting
        • Bugat Pal Hospital Gyongyos
        • Contact:
          • Phone Number: +36 (37) 312 491
        • Principal Investigator:
          • Gabor Makai
      • Szekszárd, Hungary, 7100
        • Recruiting
        • CLINFAN Szolgáltató Kft
        • Principal Investigator:
          • Agnes Salamon
        • Contact:
          • Phone Number: +36 (74) 501 872
      • Székesfehérvár, Hungary, H-8000
        • Recruiting
        • Fejer County St. Gyorgy University Teaching Hospital
        • Principal Investigator:
          • Roland Fejes
        • Contact:
          • Phone Number: +36 (22) 535 732
  • India
      • Ahmedabad, India, 380009
        • Recruiting
        • Navneet Memorial Hospital SUSHRUSHA
        • Principal Investigator:
          • Kaivan Shah
        • Contact:
          • Phone Number: 91 Q83298336) 22 433
      • Bhubaneswar, India, 751003
        • Not yet recruiting
        • Institute of Medical Sciences & SUM Hospital, Siksha 'O' Anusandhan, Department of Gastroenterology & Hepatology
        • Contact:
          • Phone Number: +91 (6372) 900-010
        • Principal Investigator:
          • Ayaskanta Singh
      • Chennai, India, 600035
        • Recruiting
        • Apollo Cancer Centre
        • Principal Investigator:
          • Ganesh Subramanian
      • Coimbatore, India, 641005
        • Not yet recruiting
        • VGM Hospital
        • Contact:
          • Phone Number: +91 (4222) 327-17
        • Principal Investigator:
          • Mohanprasad Virukalapatti Gopalratnam
      • Jaipur, India, 302004
        • Recruiting
        • SMS Medical College Hospital
        • Principal Investigator:
          • Gaurav Kumar Gupta
      • Jaipur, India, 302006
        • Recruiting
        • S R Kalla Memorial Gastro and General Hospital
        • Principal Investigator:
          • Mukesh Kalla
        • Contact:
          • Phone Number: +91 (9829) 050 622
      • Kochi, India, 682041
        • Recruiting
        • Amrita Institute Of Medical Sciences and Research Centre
        • Principal Investigator:
          • Shine Sadasivan
        • Contact:
          • Phone Number: 9497556339
      • Kochi, India, 682017
        • Recruiting
        • Lisie Hospital
        • Principal Investigator:
          • Mathew Philip
      • Ludhiana, India, 141001
        • Not yet recruiting
        • Dayanand Medical College and Hospital
        • Principal Investigator:
          • Vandana Midha
        • Contact:
          • Phone Number: +91 (9891) 552 828
      • New Delhi, India, 110 017
        • Recruiting
        • Max Super Speciality Hospital
        • Principal Investigator:
          • K Madan
      • Pune, India, 411013
        • Recruiting
        • Noble Hospital Pvt Ltd
        • Contact:
          • Phone Number: +91 (9766) 968 987
        • Principal Investigator:
          • Pramod Katare
      • Rajkot, India, 360005
        • Recruiting
        • Shree Giriraj Multispeciality Hospital
        • Principal Investigator:
          • Chetan Mehta
        • Contact:
          • Phone Number: +91 (9825) 077-472
      • Rajkot, India, 360001
        • Recruiting
        • Prime Institute of Digestive Sciences
        • Contact:
          • Phone Number: +91 (98242) 12 169
        • Principal Investigator:
          • Krishnkant Rawal
      • Secunderabad, India, 500003
        • Recruiting
        • Yashoda Hospital
        • Principal Investigator:
          • B. Ravi Shankar
      • Surat, India, 395002
        • Recruiting
        • SIDS Hospital and Research Centre
        • Principal Investigator:
          • Mayank Kabrawala
      • Varanasi, India, 221005
        • Recruiting
        • Samvedna Hospital
        • Contact:
          • Phone Number: +91 (939) 107 5600
        • Principal Investigator:
          • Hemant Kumar Gupta
  • Italy
      • Bologna, Italy, 40138
        • Recruiting
        • Policlinico S. Orsola-Malpighi
        • Principal Investigator:
          • Fernando Rizzello
      • Brescia, Italy, 25124
        • Not yet recruiting
        • Poliambulanza Hospital
        • Principal Investigator:
          • Paola Cesaro
      • Catanzaro, Italy, 88100
        • Not yet recruiting
        • Universita Degli Studi-Magna Graecia-de Catanzaro
        • Principal Investigator:
          • Francesco Luzza
        • Contact:
          • Phone Number: +39 (0961) 364 7111
      • Milan, Italy, 20132
        • Recruiting
        • IRCCS San Raffaele
        • Principal Investigator:
          • Silvio Danese
        • Contact:
          • Phone Number: +39 (02) 2643 2069
      • Milan, Italy, 20162
        • Recruiting
        • Big Metropolitan Hospital Niguarda Regional Health Authority
        • Contact:
          • Phone Number: +39 (026) 444 4454
        • Principal Investigator:
          • Marcello Vangeli
      • Negrar, Italy, 37024
        • Recruiting
        • Ospedale Sacro Cuore Don G. Calabria
        • Contact:
          • Phone Number: +39 (045) 601 4838
        • Principal Investigator:
          • Angela Variola
      • Padova, Italy, 35128
        • Not yet recruiting
        • Hospital of Padova
        • Principal Investigator:
          • Fabiana Zingone
        • Contact:
          • Phone Number: +39 () 0498215656
      • Roma, Italy, 00152
        • Recruiting
        • Azienda Ospedaliera San Camillo Forlanini
        • Principal Investigator:
          • Rocco Cosintino
      • Rozzano, Italy, 20089
        • Recruiting
        • IRCCS Istituto Clinico Humanitas- Centro Malattie Infiammatorie Intestinali
        • Principal Investigator:
          • Alessandro Armuzzi
        • Contact:
          • Phone Number: +39 (338) 736 7765
      • San Donato Milanese, Italy, 20097
        • Recruiting
        • IRCCS Policlinico San Donato
        • Principal Investigator:
          • Vito Annese
      • San Giovanni Rotondo, Italy, 71013
        • Recruiting
        • IRCCS Ospedale Casa Sollievo della Sofferenza
        • Principal Investigator:
          • Fabrizio Bossa
        • Contact:
          • Phone Number: +39 (0882) 410 815
      • Turin, Italy, 10126
        • Not yet recruiting
        • University Hospital City of Health and Science of Turin - Hospital Molinette
        • Principal Investigator:
          • Davide Giuseppe Ribaldone
        • Contact:
          • Phone Number: +00393476861126
  • Japan
      • Asahikawa, Japan, 078-8510
        • Recruiting
        • Asahikawa Medical College Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Mikihiro Fujiya
      • Bunkyō, Japan, 113-8519
        • Recruiting
        • Institute of Science Tokyo Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Ryuichi Okamoto
      • Chikushino-shi, Japan, 818-8502
        • Recruiting
        • Fukuoka University Chikushi Hospital
        • Principal Investigator:
          • Takashi Hisabe
        • Contact:
          • Phone Number: 81120023812
      • Kashiwa-shi, Japan, 277-0871
        • Recruiting
        • Kokikai Tsujinaka Hospital Kashiwanoha
        • Principal Investigator:
          • Ken Takeuchi
        • Contact:
          • Phone Number: 81120023812
      • Kobe, Japan, 650-0017
        • Recruiting
        • Kobe University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Daisuke Watanabe
      • Kofu, Japan, 400-0027
        • Recruiting
        • Yamanashi Prefectural Central Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Yuichiro Kojima
      • Nagasaki, Japan, 852-8501
        • Recruiting
        • Nagasaki University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kayoko Matsushima
      • Nara, Japan, 630-8054
        • Recruiting
        • Nara Prefecture General Medical Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kei Moriya
      • Osaka, Japan, 5450051
        • Recruiting
        • Osaka Metropolitan University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Shuhei Hosomi
      • Saga, Japan, 849-8501
        • Recruiting
        • Saga University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Nanae Tsuruoka
      • Saitama, Japan, 336-0963
        • Recruiting
        • Tokitokai Tokito Clinic
        • Principal Investigator:
          • Satoki Tokito
        • Contact:
          • Phone Number: 81120023812
      • Saitama-Ken, Japan, 350 8550
        • Recruiting
        • Saitama Medical Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kato Shingo MD
      • Sakura, Japan, 285-8741
        • Recruiting
        • Toho University Sakura Medical Center
        • Principal Investigator:
          • Katsuyoshi Matsuoka
        • Contact:
          • Phone Number: 81120023812
      • Sapporo, Japan, 065-0033
        • Recruiting
        • Sapporo Higashi Tokushukai Hospital
        • Principal Investigator:
          • Atsuo Maemoto
        • Contact:
          • Phone Number: 81120023812
      • Tokyo, Japan, 169-0073
        • Recruiting
        • Tokyo Yamate Medical Center
        • Principal Investigator:
          • Masayuki Fukata
        • Contact:
          • Phone Number: 81120023812
  • Kazakhstan
      • Almaty, Kazakhstan, 050000
        • Recruiting
        • Scientific Research Institute of Cardiology and Internal Disease of the Ministry of Health of the Republic of Kazakhstan
        • Contact:
          • Phone Number: +7 (747) 105-11-95
        • Principal Investigator:
          • Jamilya Kaibullayeva
      • Astana, Kazakhstan, Z00P6K6
        • Recruiting
        • National Research Medical Center
        • Contact:
          • Phone Number: +7 (701) 884 4994
        • Principal Investigator:
          • Ainur Doszhan
      • Astana, Kazakhstan, Z00P6K6
        • Recruiting
        • Sana Clinic
        • Contact:
          • Phone Number: 7 (701) 800 8621
        • Principal Investigator:
          • Assyltay Nauryzbayeva
      • Karaganda, Kazakhstan, 100000
        • Recruiting
        • Karaganda Medical University
        • Contact:
          • Phone Number: +7 (701) 227-80-60
        • Principal Investigator:
          • Yelena Laryushina
      • Semey, Kazakhstan, 071400
        • Recruiting
        • Semey Medical University
        • Contact:
          • Phone Number: 7 (778) 177-53-81
        • Principal Investigator:
          • Aizhan Shakhanova
      • Shymkent, Kazakhstan, 160005
        • Recruiting
        • "Gastromed" Medical Center
        • Contact:
          • Phone Number: 7 (701) 732-43-67
        • Principal Investigator:
          • Assem Kurmangaliyeva
      • Shymkent, Kazakhstan, 160021
        • Recruiting
        • Diagnostic Center of Shymkent
        • Contact:
          • Phone Number: +7 (777) 502-99-55
        • Principal Investigator:
          • Ainur Chalabayeva
  • Latvia
      • Liepāja, Latvia, LV-3414
        • Recruiting
        • Liepaja Regional Hospital
        • Principal Investigator:
          • Linda Erne
      • Riga, Latvia, LV-1002
        • Recruiting
        • Pauls Stradins Clinical Univeristy Hospital
        • Principal Investigator:
          • Aldis Pukitis
        • Contact:
          • Phone Number: +371 () 2925 3394
  • Mexico
      • Durango, Mexico, 34000
        • Recruiting
        • Applied Neuroscience Research Institute A.C.
        • Contact:
          • Phone Number: +52 (618) 197 3882
        • Principal Investigator:
          • Raquel Morones Esquivel
      • Irapuato, Mexico, 36520
        • Recruiting
        • PROACTIVE CR MEXICO SA de CV
        • Principal Investigator:
          • Andrés Mendoza Sanchez
      • Jalisco, Mexico, 45640
        • Recruiting
        • Medical Clinical Surgical Center Specialized in Research
        • Principal Investigator:
          • Roberto Cruz Neri
      • Mexico City, Distrito Federal, Mexico, 06100
        • Recruiting
        • Key Stone Clinical Trials
        • Principal Investigator:
          • Karina Olvera Obregon
      • Morelia, Mexico, 58260
        • Recruiting
        • Centro de Investigacion Clinica Chapultepec S.A. de C.V.
        • Principal Investigator:
          • Victor Sevilla Lizcano
      • Mérida, Mexico, 97070
        • Recruiting
        • Medical Care and Research Sa de Cv
        • Principal Investigator:
          • AXEL MENA QUINTERO
      • Oaxaca City, Mexico, 68000
        • Recruiting
        • Oaxaca Site Management Organization
        • Principal Investigator:
          • Ana Vera Heredia
      • Querétaro, Mexico, 76000
        • Recruiting
        • Centro de Estudios Clínicos de Querétaro (CECLIQ)
        • Principal Investigator:
          • Raul Chavez Ayala
  • Moldova
      • Chisinau, Moldova, MD-2025
        • Not yet recruiting
        • PMSI "Timofei Mosneaga" Republican Clinical Hospital, Outpatient Department
        • Contact:
          • Phone Number: +373 (692) 63 789
        • Principal Investigator:
          • Victoria Babitchi
      • Chisinau, Moldova, MD-2025
        • Not yet recruiting
        • PMSI "Timofei Mosneaga" Republican Clinical Hospital, Therapy Department, Division of Gastroenterology
        • Contact:
          • Phone Number: +373 (79) 436 554
        • Principal Investigator:
          • Svetlana Turcan
      • Chisinau, Moldova, MD-2068
        • Not yet recruiting
        • "Sfanta Treime" Municipal Clinical Hospital
        • Contact:
          • Phone Number: +373 (69) 010 553
        • Principal Investigator:
          • Gheorghe Lupu
      • Chisinau, Moldova, MD2072
        • Not yet recruiting
        • Rtl Sm Srl
        • Contact:
          • Phone Number: 78855508
        • Principal Investigator:
          • Minodora Mazur
  • Poland
      • Bydgoszcz, Poland, 85-229
        • Recruiting
        • "MEDIS" Medical Center
        • Principal Investigator:
          • Maria Klopocka
        • Contact:
          • Phone Number: +48 () 601667497
      • Bydgoszcz, Poland, 85-231
        • Recruiting
        • Non-public Health Care Center KERmed Medical Centre
        • Principal Investigator:
          • Patryk Korga
        • Contact:
          • Phone Number: +48 () 533 550 245
      • Bydgoszcz, Poland, 85-794
        • Recruiting
        • CLINSANTE Clinical Research Centre Ewa Galczak-Nowak, Malgorzata Trzaska
        • Contact:
          • Phone Number: +48 () 609 183 911
        • Principal Investigator:
          • Michal Wiatr
      • Częstochowa, Poland, 42-202
        • Recruiting
        • Synexus Polska Sp. Z o.o. Branch in Czestochowa
        • Contact:
          • Phone Number: +0 (48) 538 935 600
        • Principal Investigator:
          • Jaroslaw Ziemba
      • Elblag, Poland, 82-300
        • Recruiting
        • St. John Paul 2nd Municipal Hospital in Elblag
        • Principal Investigator:
          • Krzysztof Niezgoda
        • Contact:
          • Phone Number: +48 (55) 232 3055
      • Gdansk, Poland, 80-382
        • Recruiting
        • AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Gdansku
        • Principal Investigator:
          • Marek Cesarz
        • Contact:
          • Phone Number: +48 (58) 712 9970
      • Katowice, Poland, 40-748
        • Recruiting
        • "Vita Longa" Non-Public Healthcare Facility, Limited Liability Company
        • Principal Investigator:
          • Przemyslaw Ramos
        • Contact:
          • Phone Number: +48 () 797 947 052
      • Katowice, Poland, 40-040
        • Recruiting
        • Synexus Polska - Katowicach
        • Principal Investigator:
          • Magdalena Olszanecka-Glinianowicz
        • Contact:
          • Phone Number: +48 () 604 586 316
      • Krakow, Poland, 31-156
        • Recruiting
        • "Landa" Specialist Doctor's Offices
        • Contact:
          • Phone Number: +48 () 504 042 403
        • Principal Investigator:
          • Katarzyna Landa
      • Krakow, Poland, 30-363
        • Recruiting
        • PLEJADY Medical Centre
        • Principal Investigator:
          • Monika Augustyn
        • Contact:
          • Phone Number: +48 (12) 422 3271
      • Krakow, Poland, 31-228
        • Not yet recruiting
        • Oslomed Medical Center
        • Principal Investigator:
          • Anna Drozdz
      • Kłodzko, Poland, 57-300
        • Not yet recruiting
        • GLOBE Clinical Research Sp. z o.o.
        • Contact:
          • Phone Number: +48 (661) 160 410
        • Principal Investigator:
          • Miroslaw Wojcik
      • Opole, Poland, 45-819
        • Recruiting
        • Twoja Przychodnia Medical Centre of Opole
        • Principal Investigator:
          • Marzena Kwinto
        • Contact:
          • Phone Number: +48 () 690 548 825
      • Poznan, Poland, 60-309
        • Recruiting
        • EMC Medical Institute Joint Stock Company, "Certus" Private Healthcare Facility Hospital No. 1
        • Contact:
          • Phone Number: +48 () 698120205
        • Principal Investigator:
          • Piotr Szablowski
      • Poznan, Poland, 81-537
        • Recruiting
        • Synexus Polska Sp. z o.o. Branch in Poznan
        • Principal Investigator:
          • Magdalena Andrzejewska
        • Contact:
          • Phone Number: +48 (61) 880 2994
      • Poznan, Poland, 60-324
        • Recruiting
        • Twoja Przychodnia Medical Centre of Poznan
        • Principal Investigator:
          • Ewa Furmanowska-Ladorska
      • Sopot, Poland, 81-756
        • Recruiting
        • Endoskopia Sp. z.o.o.
        • Principal Investigator:
          • Marek Horynski
        • Contact:
          • Phone Number: +48 () 501011879
      • Szczecin, Poland, 71-434
        • Recruiting
        • Twoja Przychodnia-Szczecinskie Centrum Medyczne
        • Principal Investigator:
          • Beata Gawdis-Wojnarska
        • Contact:
          • Phone Number: +48 (91) 433 2919
      • Tychy, Poland, 43-100
        • Recruiting
        • H-T. Medical Center
        • Principal Investigator:
          • Tomasz Romanczyk
        • Contact:
          • Phone Number: +48 (501) 464 891
      • Warsaw, Poland, 04-501
        • Recruiting
        • WIP Warsaw IBD Point Profesor Kierkus
        • Principal Investigator:
          • Jaroslaw Kierkus
        • Contact:
          • Phone Number: +48 (22) 815 7384
      • Warsaw, Poland, 00-189
        • Recruiting
        • MDM Healthcare Centre
        • Contact:
          • Phone Number: +0 (48) 815 7384
        • Principal Investigator:
          • Marek Woynarowski
      • Warsaw, Poland, 02-677
        • Not yet recruiting
        • ETG Warszawa
        • Contact:
          • Phone Number: + (48) 575 000 489
        • Principal Investigator:
          • Marek Bugajski
      • Warsaw, Poland, 02-786
        • Recruiting
        • WSD Medi
        • Contact:
          • Phone Number: +48 (60) 443 5392
        • Principal Investigator:
          • Michal Krogulecki
      • Warsaw, Poland, 02-672
        • Recruiting
        • Synexus Polska Sp. z o.o. Oddzial w Warszawie
        • Contact:
          • Phone Number: +48 (22) 644 4161
        • Principal Investigator:
          • Katarzyna Wierzbicka
      • Wroclaw, Poland, 52-416
        • Recruiting
        • Medical Centre Oporow
        • Principal Investigator:
          • Radoslaw Kempinski
        • Contact:
          • Phone Number: + (48) 604 911 743
      • Wroclaw, Poland, 50-381
        • Recruiting
        • Synexus Polska Sp. z o.o.
        • Principal Investigator:
          • Agnieszka Ciesiolkiewicz-Wojcik
        • Contact:
          • Phone Number: +48 (71) 772 6000
  • Romania
      • Bucharest, Romania, 020125
        • Recruiting
        • Colentina Clinical Hospital
        • Principal Investigator:
          • Radu Bogdan Mateescu
        • Contact:
          • Phone Number: +40 (2) 1315 2590
      • Bucharest, Romania, 011273
        • Recruiting
        • "Sfanta Vineri" Medical Center
        • Contact:
          • Phone Number: +40 (732) 806 599
        • Principal Investigator:
          • Marieta-Madalina Florescu
      • Bucharest, Romania, 013823
        • Recruiting
        • Monza Oncology Hospital SRL
        • Principal Investigator:
          • Ion-Eugeniu Craciun
      • Timișoara, Romania, 300239
        • Recruiting
        • Oncohelp Association
        • Contact:
          • Phone Number: +40 (767) 152 254
        • Principal Investigator:
          • Razvan Diaconescu
  • Serbia
      • Belgrade, Serbia, 11000
        • Recruiting
        • Clinical Center " Dr Dragisa Misovic Dedinje"
        • Contact:
          • Phone Number: +0 (381) 637700043
        • Principal Investigator:
          • Aleksandra Pavlovic
      • Belgrade, Serbia, 11 000
        • Recruiting
        • Zvezdara University Medical Center
        • Principal Investigator:
          • Srdjan Markovic
        • Contact:
          • Phone Number: +381 (11) 381 0390
      • Belgrade, Serbia, 11000
        • Recruiting
        • Clinical Hospital Center Bezanijska Kosa
        • Principal Investigator:
          • Marija Brankovic
        • Contact:
          • Phone Number: +381 (64) 015 0022
      • Leskovac, Serbia, 16000
        • Recruiting
        • General Hospital Leskovac
        • Contact:
          • Phone Number: +381 (64) 21023733
        • Principal Investigator:
          • Tomislav Tasic
      • Novi Sad, Serbia, 21000
        • Recruiting
        • Clinical Center of Vojvodina
        • Contact:
          • Phone Number: +0 (381) 647011964
        • Principal Investigator:
          • Olgica Latinovic Bosnjak
      • Užice, Serbia, 31000
        • Recruiting
        • General Hospital Uzice
        • Contact:
          • Phone Number: 381 (60) 513 5299
        • Principal Investigator:
          • Danijela Savic
      • Zrenjanin, Serbia, 23000
        • Recruiting
        • General Hospital "Djordje Joanovic"
        • Principal Investigator:
          • Tatjana Latinovic Radakovic
        • Contact:
          • Phone Number: +381 (060) 607 6527
  • Slovakia
      • Bratislava, Slovakia, 811 09
        • Recruiting
        • Cliniq s.r.o.
        • Principal Investigator:
          • Tibor Hlavaty
        • Contact:
          • Phone Number: +421 () 917 752 297
      • Košice, Slovakia, 04013
        • Recruiting
        • ENDOMED s.r.o.
        • Principal Investigator:
          • Miroslav Fedurco
        • Contact:
          • Phone Number: +421 () 905 271 215
      • Prešov, Slovakia, 08001
        • Recruiting
        • Gastro LM s.r.o.
        • Principal Investigator:
          • Lubomir Mihalkanin
        • Contact:
          • Phone Number: +421 () 905 794 001
      • Prešov, Slovakia, 08001
        • Recruiting
        • GASTRO I., s.r.o.
        • Contact:
          • Phone Number: +421 () 903 607 349
        • Principal Investigator:
          • Bohus Bunganic
  • Spain
      • Ferrol, Spain, 15405
        • Recruiting
        • Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval
        • Principal Investigator:
          • Ana Isabel Echarri Piudo
      • Lleida, Spain, 25198
        • Recruiting
        • Hospital Universitario Arnau de Vilanova de Lleida
        • Principal Investigator:
          • Francesc Xavier Molero Richard
      • Madrid, Spain, 28046
        • Recruiting
        • Hospital Universitario La Paz
        • Principal Investigator:
          • MARIA DOLORES MARTIN ARRANZ
        • Contact:
          • Phone Number: +34 (91) 727 7264
      • Majadahonda, Spain, 28222
        • Recruiting
        • Hospital Universitario Puerta de Hierro Majadahonda
        • Contact:
          • Phone Number: +34 () 911916453
        • Principal Investigator:
          • Irene Gonzalez Partida
      • Seville, Spain, 41009
        • Recruiting
        • Hospital Universitario Virgen Macarena
        • Principal Investigator:
          • Federico Arguelles Arias
        • Contact:
          • Phone Number: +34 (95) 500 8801
      • Valencia, Spain, 46026
        • Recruiting
        • University and Polytechnic Hospital La Fe
        • Principal Investigator:
          • Marisa Iborra Colomino
        • Contact:
          • Phone Number: +34 (961) 973 118
  • Taiwan
      • Chiayi City, Taiwan, 60002
        • Not yet recruiting
        • Ditmanson Medical Foundation Chia-Yi Christian Hospital
        • Principal Investigator:
          • Chu-Kuang Chou
        • Contact:
          • Phone Number: +886 (5) 276 5041
      • Hsinchu, Taiwan, 302
        • Not yet recruiting
        • National Taiwan University Hospital
        • Principal Investigator:
          • Meng-Tzu Weng
      • Kaohsiung City, Taiwan, 81362
        • Not yet recruiting
        • Kaohsiung Veterans General Hospital
        • Contact:
          • Phone Number: +886 (7) 342 2121
        • Principal Investigator:
          • Tzung-Jiun Tsai
      • Kaohsiung City, Taiwan, 807377
        • Not yet recruiting
        • Kaohsiung Medical University Chung-Ho Memorial Hospital
        • Contact:
          • Phone Number: 886 7 312 1101
        • Principal Investigator:
          • Wen-Hung Hsu
      • New Taipei City, Taiwan, 22060
        • Not yet recruiting
        • Far Eastern Memorial Hospital
        • Contact:
          • Phone Number: +886 (2) 77281704
        • Principal Investigator:
          • Chen-Shuan Chung
      • Taichung, Taiwan, 407219
        • Not yet recruiting
        • Taichung Veterans General Hospital
        • Principal Investigator:
          • Chung-Hsin Chang
        • Contact:
          • Phone Number: +886 (423) 592 525
      • Taichung, Taiwan, 404327
        • Not yet recruiting
        • China Medical University Hospital
        • Contact:
          • Phone Number: +886 (4) 22052121
        • Principal Investigator:
          • Tsung-Yu Tsai
      • Tainan, Taiwan, 71004
        • Not yet recruiting
        • Chi Mei Medical Center
        • Contact:
          • Phone Number: +886 (6) 243 3407
        • Principal Investigator:
          • I CHE FENG
      • Taipei, Taiwan, 11217
        • Not yet recruiting
        • Taipei Veterans General Hospital
        • Principal Investigator:
          • Jiing-Chyuan Luo
      • Taipei, Taiwan, 10449
        • Not yet recruiting
        • Mackay Memorial Hospital
        • Contact:
          • Phone Number: +886 (6) 6655-1256
        • Principal Investigator:
          • Horng-Yuan Wang
      • Taipei, Taiwan, 100225
        • Not yet recruiting
        • National Taiwan University Hospital
        • Principal Investigator:
          • Chia-Hung Tu
        • Contact:
          • Phone Number: +886 (2) 23123456 +886 (9) 726
      • Taoyuan City, Taiwan, 333
        • Not yet recruiting
        • Chang Gung Memorial Hospital - Linkou
        • Contact:
          • Phone Number: +886 (03) 328 1200
        • Principal Investigator:
          • Puo-Hsien Le
  • United States
    • California
      • Lancaster, California, United States, 93534
        • Recruiting
        • Gastro Care Institute
        • Contact:
          • Phone Number: 661-529-7550
        • Principal Investigator:
          • Kumaravel Perumalsamy
      • San Diego, California, United States, 92108
        • Not yet recruiting
        • Infinity Clinical Research
        • Principal Investigator:
          • Tommy Yen
    • Colorado
      • Colorado Springs, Colorado, United States, 80921
        • Not yet recruiting
        • Peak Gastroenterology Associates - Colorado Springs
        • Contact:
          • Phone Number: 719-362-2266
        • Principal Investigator:
          • Prashant Krishnan
    • Florida
      • Kissimmee, Florida, United States, 34741
        • Not yet recruiting
        • Clinical Research of Osceola
        • Principal Investigator:
          • Basher Atiquzzaman
        • Contact:
          • Phone Number: 407-846-6331
      • Miami, Florida, United States, 33155
        • Not yet recruiting
        • Bioresearch Partner-Kendale Lakes
        • Principal Investigator:
          • Keila Hoover
        • Contact:
          • Phone Number: 833-489-4968
      • Orlando, Florida, United States, 32803
        • Not yet recruiting
        • Endoscopic Research Inc
        • Principal Investigator:
          • Marlon Ilagan
        • Contact:
          • Phone Number: 407-241-1726
      • Palmetto Bay, Florida, United States, 33176
        • Not yet recruiting
        • Tropical Clinical Trials
        • Contact:
          • Phone Number: 754-946-4172
        • Principal Investigator:
          • MIchael Feldman
    • Georgia
      • Atlanta, Georgia, United States, 30024
        • Not yet recruiting
        • Atlanta Gastroenterology Specialists, PC
        • Principal Investigator:
          • Steven Thalvinder (Thali) Sangha
      • Atlanta, Georgia, United States, 30342
        • Not yet recruiting
        • Atlanta Gastroenterology Associates (Part of United Digestive)
        • Principal Investigator:
          • Nitin Gupta
        • Contact:
          • Phone Number: 404-257-9000
    • Louisiana
      • Houma, Louisiana, United States, 70360
        • Not yet recruiting
        • Tandem Clinical Research
        • Principal Investigator:
          • Conar Fitton
    • Missouri
      • Bridgeton, Missouri, United States, 063044
        • Not yet recruiting
        • SSM Health DePaul Hospital- St. Louis
        • Contact:
          • Phone Number: 918-880-0676
        • Principal Investigator:
          • Yezaz Ghouri
    • Nevada
      • North Las Vegas, Nevada, United States, 89030
        • Not yet recruiting
        • Las Vegas Clinical Trials
        • Principal Investigator:
          • Christian Stone
    • North Carolina
      • Fayetteville, North Carolina, United States, 28304
        • Not yet recruiting
        • Cross Creek Medical Clinic
        • Contact:
          • Phone Number: 920-437-5130
        • Principal Investigator:
          • Nitinchandra Desai
      • High Point, North Carolina, United States, 27260
        • Not yet recruiting
        • Peters Medical Research
        • Contact:
          • Phone Number: 336-883-9773
        • Principal Investigator:
          • Roy Peters
      • Raleigh, North Carolina, United States, 27612
        • Recruiting
        • Wake Research Associates
        • Principal Investigator:
          • Lisa Cohen
        • Contact:
          • Phone Number: 336-613-6908
    • South Carolina
      • Summerville, South Carolina, United States, 29486
        • Recruiting
        • Palmetto Gastroenterology Clinical Research
        • Principal Investigator:
          • Brett Van Leer-Greenberg
        • Contact:
          • Phone Number: 843-376-0670
    • Tennessee
      • Johnson City, Tennessee, United States, 44060
        • Recruiting
        • Gastrointestinal Associates of Northeast Tennessee
        • Principal Investigator:
          • Chakradhar Reddy
        • Contact:
          • Phone Number: 423-208-9073
    • Texas
      • Cedar Park, Texas, United States, 78613
        • Recruiting
        • GI Alliance - Cedar Park
        • Principal Investigator:
          • Junaid Siddiqui
      • Denton, Texas, United States, 76210
        • Not yet recruiting
        • North Texas Gastroenterology
        • Principal Investigator:
          • Vijaya Dasari
      • Houston, Texas, United States, 77030
        • Recruiting
        • The University of Texas Health Science Center at Houston
        • Principal Investigator:
          • Tugrul Purnak
      • Lewisville, Texas, United States, 75067
        • Not yet recruiting
        • Prime Clinical Research - Lewisville
        • Contact:
          • Phone Number: 817-907-7330
        • Principal Investigator:
          • Ayodele Osowo
      • Mansfield, Texas, United States, 76063
        • Not yet recruiting
        • Prime Clinical Research
        • Principal Investigator:
          • Olufemi Abiodun
      • San Marcos, Texas, United States, 76092
        • Recruiting
        • Texas Digestive Disease Consultants
        • Contact:
          • Phone Number: 512-878-1100
        • Principal Investigator:
          • Shannon Marek
      • Tyler, Texas, United States, 75701
        • Recruiting
        • Tyler Research Institute, LLC
        • Principal Investigator:
          • George Duvall
        • Contact:
          • Phone Number: 903-630-6211
    • Utah
      • Ogden, Utah, United States, 84403
        • Recruiting
        • Care Access Research - Ogden
        • Principal Investigator:
          • Chad Gonzales
    • Virginia
      • Lynchburg, Virginia, United States, 24502
        • Recruiting
        • Gastroenterology Associates of Central Virginia
        • Principal Investigator:
          • Larry Clark, Jr.

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Key Inclusion Criteria:

  • Has signs/symptoms of CD for at least 90 days prior to screening
  • Has a CDAI score of 220 to 450, with an average daily stool subscore ≥4 points and/or an average daily abdominal pain subscore of ≥2 points
  • Has an SES-CD score of ≥6 (or an SES-CD score of ≥4 if CD is isolated to the ileum)
  • Demonstrated an inadequate response, loss of response, or intolerance to at least one of the following treatments: Corticosteroids, Immunosuppressants (eg, azathioprine, 6-mercaptopurine, methotrexate) and/or advanced therapies for CD (eg, biologic agents, Janus kinase [JAK] inhibitors, applicable investigational products)

Key Exclusion Criteria:

  • Diagnosed with indeterminate colitis, microscopic colitis, ischemic colitis, radiation colitis, or UC, or has clinical findings suggestive of UC
  • Has CD that is isolated to the oral cavity, stomach, duodenum, jejunum, or perianal region, without colonic or ileal involvement
  • Has had extensive bowel resection (>100 cm), and/or more than 3 resections, and/or has a known diagnosis of short bowel syndrome
  • Is currently receiving total parenteral nutrition, tube feeding, or a formula diet
  • Has positive findings on a subjective neurological screening questionnaire
  • Has a concurrent, clinically significant, serious, unstable comorbidity
  • Previous treatment with vedolizumab or other licensed or investigational integrin inhibitors
  • Is currently participating in any other interventional study or has received any investigational therapy within 30 days
  • Previous exposure to MORF-057 and/or a known hypersensitivity to drugs with a similar mechanism to MORF-057
  • Unable to attend study visits or comply with study procedures
  • Has a history of any major neurological disorders, including: stroke, multiple sclerosis, brain tumor, demyelinating, or neurodegenerative disease

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Group 1 (Part A)
Blinded MORF-057 Dosing Regimen 1 for Induction Period and open-label MORF-057 for Maintenance Period
Drug: MORF-057
MORF-057 is a small molecule that is designed to selectively inhibit integrin α4β7 and is administered orally.
Other Names:
  • zotemtegrast
Experimental: Group 2 (Part A)
Blinded MORF-057 Dosing Regimen 2 for Induction Period and open-label MORF-057 for Maintenance Period
Drug: MORF-057
MORF-057 is a small molecule that is designed to selectively inhibit integrin α4β7 and is administered orally.
Other Names:
  • zotemtegrast
Placebo Comparator: Group 3 (Part A)
Blinded matching placebo for Induction Period and open-label MORF-057 for Maintenance Period
Drug: MORF-057
MORF-057 is a small molecule that is designed to selectively inhibit integrin α4β7 and is administered orally.
Other Names:
  • zotemtegrast
Drug: Placebo
Matching placebo (identical appearance to MORF-057) administered orally.
Experimental: Group 4 (Part B)
Blinded MORF-057 Dosing Regimen 1 for Induction Period and open-label MORF-057 for Maintenance Period
Drug: MORF-057
MORF-057 is a small molecule that is designed to selectively inhibit integrin α4β7 and is administered orally.
Other Names:
  • zotemtegrast
Experimental: Group 5 (Part B)
Blinded MORF-057 Dosing Regimen 2 for Induction Period and open-label MORF-057 for Maintenance Period
Drug: MORF-057
MORF-057 is a small molecule that is designed to selectively inhibit integrin α4β7 and is administered orally.
Other Names:
  • zotemtegrast
Placebo Comparator: Group 6 (Part B)
Blinded matching placebo for Induction Period and open-label MORF-057 for Maintenance Period
Drug: MORF-057
MORF-057 is a small molecule that is designed to selectively inhibit integrin α4β7 and is administered orally.
Other Names:
  • zotemtegrast
Drug: Placebo
Matching placebo (identical appearance to MORF-057) administered orally.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Proportion of participants with endoscopic response at Week 14 as determined using the Simple Endoscopic Score-CD (SES-CD)
Time Frame: Baseline to Week 14
The SES-CD is an endoscopic scoring system for evaluating CD activity. Endoscopic response is defined as an SES-CD decrease from baseline of ≥50%
Baseline to Week 14

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Proportion of participants with clinical response at Week 14 as determined using the Crohn's Disease Activity Index (CDAI)
Time Frame: Baseline to Week 14
The CDAI is a composite of subscores for clinical and laboratory findings, and patient-reported CD symptoms. Clinical response is defined as a reduction from baseline CDAI score by ≥100 points or a CDAI score of <150 points.
Baseline to Week 14
Proportion of participants with clinical remission at Week 14 as determined using the CDAI.
Time Frame: Baseline to Week 14
The CDAI is a composite of subscores for clinical and laboratory findings, and patient-reported CD symptoms. Clinical remission is defined as a CDAI score of <150 points.
Baseline to Week 14

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)

Investigators

  • Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

July 18, 2024

Primary Completion (Estimated)

September 1, 2028

Study Completion (Estimated)

June 1, 2030

Study Registration Dates

First Submitted

January 16, 2024

First Submitted That Met QC Criteria

January 17, 2024

First Posted (Actual)

January 26, 2024

Study Record Updates

Last Update Posted (Actual)

May 22, 2026

Last Update Submitted That Met QC Criteria

May 20, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 27383
  • MORF-057-203 (Other Identifier: Morphic Therapeutic, Inc)
  • J6E-MC-KWAB (Other Identifier: Eli Lilly and Company)
  • U1111-1297-7265 (Other Identifier: UTN)
  • 2023-508158-24 (Other Identifier: EU Trial (CTIS))

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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