Search clinical trials for: Sickling crisis

Total 867 results

University Hospital, Lille

Unknown

Evaluation of Cognitive Function in a Suicidal Crisis (CocaCS)

Suicide

France
Baylor College of Medicine

Terminated

Treatment of Hemoglobin SC Disease With Hydroxyurea (SCYTHE)

Hemoglobin SC Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)
National Institutes of Health (NIH)

Completed

Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG) Follow-up Observational Study II Protocol (BABY HUG)

Sickle Cell Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Long-Term Effects of Hydroxyurea in Children With Sickle Cell Anemia (The BABY HUG Follow-up Study)

Anemia, Sickle Cell

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Hydroxyurea to Prevent Organ Damage in Children With Sickle Cell Anemia

Hematologic Diseases | Anemia, Sickle Cell

United States
Emmaus Medical, Inc.

Completed

A Phase III Safety and Efficacy Study of L-Glutamine to Treat Sickle Cell Disease or Sickle βo-thalassemia

Sickle Cell Anemia | Sickle ß0-Thalassemia

United States
Vanderbilt University Medical Center
National Institute of Neurological Disorders and Stroke (NINDS); National Institutes... and other collaborators

Completed

Sickle Cell Disease - Stroke Prevention in Nigeria Trial (SPIN)

Stroke | Sickle Cell Disease | Sickle Cell Anemia

Nigeria
Vanderbilt University Medical Center
National Institute of Neurological Disorders and Stroke (NINDS); Aminu Kano... and other collaborators

Completed

Primary Prevention of Stroke in Children With SCD in Sub-Saharan Africa II (SPRING)

Stroke | Sickle Cell Disease

Nigeria
St. Jude Children's Research Hospital
Children's Hospital Medical Center, Cincinnati

Completed

Long Term Effects of Hydroxyurea Therapy in Children With Sickle Cell Disease

Sickle Cell Disease

United States
Sheffield Teaching Hospitals NHS Foundation Trust

Unknown

Impact of Isolation in Patients With IBD During the COVID-19 Crisis

Inflammatory Bowel Diseases

United Kingdom
Children's Hospital Medical Center, Cincinnati
Medical University of South Carolina; The Hospital for Sick Children; Baylor... and other collaborators

Terminated

Transcranial Doppler (TCD) With Transfusions Changing to Hydroxyurea (TWiTCH)

Sickle Cell Anemia
Centre Hospitalier Universitaire de Nice

Completed

European Pathology Laboratories and COVID-19

Clinical Practice During the COVID-19 Crisis

France
CEJKA Jean-Christophe

Completed

Impact on Performance of the Use of a Digital Cognitive Aid in Simulated Crisis and Stress Situations

War Injury

France
AstraZeneca
Iqvia Pty Ltd

Withdrawn

Study to Evaluate the Effect of Ticagrelor Versus Placebo in Reducing Vaso-Occlusive Crises Rate in Pediatric Patients With Sickle Cell Disease. (HESTIA5)

Sickle Cell Disease
Baylor College of Medicine

Terminated

Steroid Treatment for Sickle Cell Pain Crisis

Sickle Cell Disease | Vaso-occlusive Crisis

United States
Universidad Nacional Autonoma de Honduras

Unknown

Brief Cognitive Behavioral Therapy Versus Crisis Intervention Therapy Through Telepsychiatry on Psychiatric Symptoms

Anxiety | Depressive Symptoms | Perceived Stress | Post Traumatic Stress Symptoms

Honduras
University Hospital, Clermont-Ferrand

Unknown

Study of the Consequences of Infection on Compliance of Modalities of Decisions of Limitations and Stops of Treatments (COVID-19-LAT) (COVID-19-LAT)

Patient Hospitalized in Disease Infectious Unit | Patient Hospitalized in Intensive Reanimation Unit | Patient Hopsitalized in Internal Medicine Unit

France
GlycoMimetics Incorporated

Completed

Efficacy and Safety of Rivipansel (GMI-1070) in the Treatment of Vaso-Occlusive Crisis in Hospitalized Subjects With Sickle Cell Disease

Anemia, Sickle Cell

United States, Canada
University Hospital, Bordeaux

Completed

Endoplasmic Reticulum Stress and Resistance to Treatments in Ph-negative Myeloproliferative Neoplasms (PhiNESS)

Polycythemia Vera | Essential Thrombocythemia

France
Assistance Publique - Hôpitaux de Paris
Fisher and Paykel Healthcare; Orkyn'

Unknown

High-flow Oxygen for Vaso-occlusive Pain Crisis (OSONE)

Sickle Cell Disease

France
GlycoMimetics Incorporated

Completed

Study of GMI-1070 for the Treatment of Sickle Cell Pain Crisis

Sickle Cell Disease | Vaso-occlusive Crisis | Pain Crisis

United States, Canada
University of Birmingham

Unknown

Outcomes of Elective Cancer Surgery During the COVID-19 Pandemic Crisis (CovidSurg-Can)

COVID-19 | Cancer | Surgery | Coronavirus

Spain
University of Chicago
Novartis Pharmaceuticals

Terminated

Study in Locally Advanced Squamous Cell Carcinoma of Head and Neck

Head and Neck Cancer

United States
Wefight

Completed

Distress in Crisis Situations During COVID-19

Stress, Psychological

France
Abramson Cancer Center of the University of Pennsylvania

Terminated

Rapamycin in With High-Dose Etoposide and Cytarabine in Relapsed/Refractory Aggressive Lymphoid Malignancies (UPCC 25406)

Lymphoblastic Leukemia | Burkitt's Lymphoma | CML | ALL

United States
Hôpital Raymond Poincaré
Dominique FLETCHER MD-PhD; Clement DURET MD; Guillaume GERI MD-PhD

Unknown

Burnout Among Caregivers Facing COVID-19 Health Crisis at a Non-conventional Intensive Care Unit Compared to a Conventional Intensive Care Unit

COVID-19 | Stress, Psychological | Intensive Care Unit | Burnout, Caregiver
Ottawa Hospital Research Institute

Completed

Impact of Unexpected Death in Simulation: Skill Retention, Stress and Emotions

Stress | Crisis Resource Management (CRM) Skills | Advanced Cardiovascular Life Support (ACLS) Skills

Canada
Express Collaborative

Unknown

Critical Delays in Cardiopulmonary Resuscitation During Simulated Obstetric Crisis: a Prospective Observational Study.

Maternal Death During Childbirth

Canada
ADDMEDICA SASA

Completed

European Sickle Cell Disease Cohort - Hydroxyurea (ESCORT-HU)

Sickle Cell Disease

France, Germany, French Guiana, Greece, Guadeloupe, Italy, Martinique
Nirmish Shah
Bristol-Myers Squibb

Terminated

Apixaban in Patients With Sickle Cell Disease

Sickle Cell Disease | Vaso-occlusive Crisis | Reduction in Hospitalizations

United States
Indiana University
Children's Hospital Medical Center, Cincinnati; Makerere University; Doris Duke... and other collaborators

Completed

Optimizing Hydroxyurea Therapy in Children With SCA In Malaria Endemic Areas (NOHARM-MTD)

Malaria | Sickle Cell Disease | Sickle Cell Anemia

Uganda
Mallinckrodt
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Nitric Oxide Inhalation to Treat Sickle Cell Pain Crises

Anemia, Sickle Cell

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Donor Lymphocyte Infusion in Treating Patients With Persistent, Relapsed, or Progressing Cancer After Donor Hematopoietic Cell Transplant

Recurrent Hodgkin Lymphoma | Recurrent Adult Acute Myeloid Leukemia | Recurrent Adult Acute Lymphoblastic Leukemia | Recurrent Non-Hodgkin Lymphoma | Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Recurrent Plasma Cell Myeloma

United States, Germany, Italy
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Tacrolimus and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone Total-Body Irradiation With or Without Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant for Hematologic Cancer

Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell... and other conditions

United States, Italy
Baylor College of Medicine
The University of Texas Health Science Center, Houston

Terminated

Treatment of Adult Patients With Hemoglobin SC Disease (SCYTHE)

Hemoglobin SC Disease

United States
University of Manitoba
Queen's University

Completed

Action-based Cognitive Remediation for First Episode Psychosis

Cognitive Impairment | Psychosis

Canada
Astex Pharmaceuticals, Inc.
Eisai Inc.

Completed

Phase II Trial of Decitabine in Patients With Chronic Myelogenous Leukemia Blast Phase Who Are Refractory to Imatinib Mesylate (Gleevec)

Chronic Myelogenous Leukemia

United States, Canada
National Heart, Lung, and Blood Institute (NHLBI)
Mallinckrodt

Completed

Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension

Sickle Cell Anemia | Pulmonary Hypertension

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia

Chronic Kidney Disease | Sickle Cell Disease | Pulmonary Hypertension

United States
National Heart, Lung, and Blood Institute (NHLBI)
The Cleveland Clinic

Withdrawn

Hydroxyurea in Pulmonary Arterial Hypertension

Pulmonary Hypertension
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Hydroxyurea for the Treatment of Patients With Sickle Cell Anemia

Sickle Cell Anemia

United States
St. Jude Children's Research Hospital
National Heart, Lung, and Blood Institute (NHLBI); University of Memphis

Completed

Re-Aiming at Hydroxyurea Adherence for Sickle Cell With mHealth

Sickle Cell Disease

United States
Carlos Graux, MD, PhD
Celgene Corporation; Belgian Hematological Society

Completed

Azacytidine and Lymphocytes in Relapse of AML or MDS After Allogeneic Stem Cell Transplantation.

Myelodysplastic Syndrome | Acute Myelogenous Leukemia

Belgium
National Institutes of Health Clinical Center (CC)

Completed

Evaluation of Hydroxyurea Plus L-arginine or Sildenafil to Treat Sickle Cell Anemia

Sickle Cell Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Therapeutic Application of Intravascular Nitrite for Sickle Cell Disease

Sickle Cell Anemia

United States
Memorial Sloan Kettering Cancer Center
The City College of New York; North Jersey Community Research Initiative; Gay... and other collaborators

Completed

Tobacco Assessment and Intervention With Low-Income Persons Living With HIV-AIDS (PLWHA) in Community-Based AIDS Service Organizations

Tobacco Cessation | HIV | AIDS

United States
Italfarmaco

Completed

Phase II Study of GIVINOSTAT (ITF2357) in Combination With Hydroxyurea in Polycythemia Vera (PV)

Polycythemia Vera

Italy
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Tacrolimus and Mycophenolate Mofetil With or Without Sirolimus in Preventing Acute Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer

Previously Treated Myelodysplastic Syndrome | Recurrent Adult Acute Myeloid Leukemia | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma | Recurrent Adult Diffuse Small Cleaved Cell Lymphoma | Recurrent Adult Lymphoblastic... and other conditions

United States, Germany, Denmark
Incyte Corporation

Terminated

Study to Determine the Safety and Efficacy of INCB018424 in Patients With Polycythemia Vera or Essential Thrombocythemia

Myeloproliferative Neoplasm (MPN)

United States, Italy
Assistance Publique - Hôpitaux de Paris

Unknown

Music Therapy in Sickle Cell Disease Vaso-occlusive Crisis (MUSICODREP)

Vaso-occlusive Crisis

France

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