Search clinical trials for: volunteers with renal impairment

Total 178210 results

Takeda

Completed

Effect of Febuxostat on Renal Function in Patients With Gout and Moderate to Severe Renal Impairment

Renal Impairment

United States
Avid Radiopharmaceuticals
Eli Lilly and Company

Completed

A Phase II Trial of Florbetapir (18F) Positron Emission Tomography (PET) Imaging in Japan of Healthy Volunteers, Patients With Mild Cognitive Impairment (MCI) and Patients With Alzheimer's Disease (AD)

Mild Cognitive Impairment | Alzheimer's Disease

Japan
Lexicon Pharmaceuticals

Completed

Study to Evaluate the Pharmacodynamic and Pharmacokinetic Effects of LX4211 in Subjects With Type 2 Diabetes and Renal Impairment

Type 2 Diabetes Mellitus | Renal Impairment

United States
Astellas Pharma Inc

Completed

A Pharmacokinetic Study of YM178 in Normal Subjects and Those With Mild, Moderate, and Severe Renal Impairment

Renal Impairment

United States
Janssen Research & Development, LLC

Completed

An Efficacy, Safety, and Tolerability Study of Canagliflozin in Patients With Type 2 Diabetes Mellitus Who Have Moderate Renal Impairment

Diabetes Mellitus, Type 2 | Renal Insufficiency

France, Poland, United States, Belgium, Germany, Spain, India, Romania, South Africa, Canada, Australia, Korea, Republic of, New Zealand, Russian Federation, Brazil, Malaysia, Latvia, Mexico
University of California, San Francisco

Completed

Pharmacokinetic Study in Patients With Chronic Kidney Disease and Healthy Volunteers (CKD)

Kidney Disease

United States
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study to Assess the Pharmacokinetics, Pharmacodynamics, and Safety of Canagliflozin (JNJ-28431754) in Volunteers With Varying Degrees of Kidney Function

Healthy | Renal Insufficiency

United States
University Medical Center Groningen

Terminated

Safety and Efficacy Study of Add On Aliskiren in Patients With Heart Failure and Renal Impairment (ARIANA-CHF-RD)

Heart Failure | Kidney Failure

Netherlands
Jim McAuley

Terminated

Evaluating the Transporter Protein Inhibitor Probenecid In Patients With Epilepsy

Epilepsy

United States
Novartis Pharmaceuticals

Completed

Single-dose Iloperidone Pharmacokinetics in Patients With Mild or Moderate Liver Disease, Compared to Healthy Volunteers

Hepatic Impairment

United States
Pfizer

Completed

Pharmacokinetics Of CP-690,550 In Patients With Impaired Renal Function

Renal Impairment

United States
Scios, Inc.

Completed

A Study of Short-Term Outcomes and Economic Impact For Patients With Worsening Congestive Heart Failure When Natrecor (Nesiritide) is Added to Standard-Care Therapy, Compared to Administration of Placebo With Standard-Care Therapy

Cardiomyopathies | Heart Failure, Congestive | Dyspnea, Paroxysma
Dong-A Pharmaceutical Co., Ltd.

Completed

A Pharmacokinetic Study of Udenafil in Adult Subjects With or Without Impaired Hepatic Function (udenafil)

Hepatic Impairment

Korea, Republic of
Cougar Biotechnology, Inc.

Completed

A Pharmacokinetic Study of Abiraterone Acetate in Male Participants With Impaired Renal Function Compared to Individuals With Normal Renal Function

Renal Insufficiency

United States
Pfizer

Completed

A Study to Evaluate The Pharmacokinetics Of Crizotinib (PF-02341066) In Subjects With Impaired Renal Function

Renal Impairment

United States
Chang Gung Memorial Hospital

Unknown

Phase II Study for Amyloid Binding Imaging Study of [18F]AV-45 in Patients With Mild Cognitive Impairment, Alzheimer's Disease and Healthy Volunteers ([18F]AV-45)

Alzheimer's Disease
Movetis

Completed

Prucalopride Subjects With Renal Impairment

Constipation
Basilea Pharmaceutica
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Completed

Pharmacokinetic Study,Ceftobiprole,Healthy Volunteers,Healthy Patients With End Stage Renal Disease

Streptococcal Infections | Staphylococcal Skin Infections
Kowa Research Institute, Inc.

Completed

Safety, Tolerability, and Pharmacokinetic of Single Dose of Pitavastatin 4 mg in Severe Renal Patients Versus Healthy Adult Volunteers

Severe Renal Impairment

United States
Mutual Pharmaceutical Company, Inc.

Terminated

Comparative Study of Quinine Sulfate in Healthy Patients and in Patients With Renal Impairment

Healthy | Renal Impairment

United States
Astellas Pharma Inc

Completed

A Study of the Safety and Tolerance of Regadenoson in Subjects With Renal Impairment

Coronary Artery Disease | Kidney Diseases

United States
Avid Radiopharmaceuticals

Completed

A Phase II Trial of 18F-AV-45 Positron Emission Tomography (PET) Imaging in Healthy Volunteers, Patients With Mild Cognitive Impairment (MCI) and Patients With Alzheimer's Disease (AD)

Mild Cognitive Impairment | Alzheimer's Disease

United States
Nycomed
NPS Pharma

Completed

Pharmacokinetics of 10 mg Teduglutide in Subjects With Renal Impairment Compared to Healthy Subjects With Normal Renal Function

Renal Impairment

Germany
Cephalon

Completed

A Study to Assess the Pharmacokinetics of the Hydrocodone Extended-Release Tablet (CEP-33237) in Subjects With Normal Renal Function and Subjects With Varying Degrees of Renal Impairment

Renal Impairment

United States
Sanofi

Completed

Pharmacokinetic and Tolerability Study of 14 mg Single Dose of Teriflunomide in Subjects With Severe Renal Impairment

Renal Impairment

Germany
Bracco Diagnostics, Inc

Completed

Patients With Renal Impairment Undergoing CT

Contrast Induced Nephropathy

United States
Boryung Pharmaceutical Co., Ltd
Seoul National University Hospital

Completed

A Clinical Trial to Compare and Evaluate the Pharmacokinetic Characteristics and the Safety of Fimasartan in Renal Impairment Patients and Healthy Volunteers

Renal Impairment

Korea, Republic of
Shaare Zedek Medical Center

Completed

Renal Impairment Associated With Colistin Levels

Sepsis

Israel
AstraZeneca

Completed

A Study of Fostamatinib in Subjects With Impaired Hepatic (Liver) Function

Healthy Volunteers | Pharmacokinetics | Hepatic Impairment | Amount of R406 in Blood

United States
Sahlgrenska University Hospital, Sweden

Completed

Study of Vitamin D3 Supplementation in Patients With Chronic Kidney Disease (VitaD-CKD1)

Vitamin D Deficiency | Insulin Resistance | Chronic Kidney Disease

Sweden
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study of the Pharmacokinetics of Paliperidone in Volunteers With Normal or Impaired Liver Function

Schizophrenia | Hepatic Impairment
AstraZeneca
Bristol-Myers Squibb

Completed

Treatment Effect of Saxagliptin Compared With Placebo in Patients With Type 2 Diabetes and Renal Impairment

Type 2 Diabetes

Croatia, United States, Bulgaria, Czech Republic, Poland, Russian Federation, Belarus, Estonia, Germany, Hungary, Latvia, Lithuania, Romania, Ukraine
University Hospital, Gentofte, Copenhagen
Rigshospitalet, Denmark; University of Copenhagen

Completed

The Incretin Effect in Patients With Kidney Impairment (UREMINC)

Renal Insufficiency, Chronic

Denmark
CSL Behring
Parexel

Completed

Study of a pd vWF/FVIII, Biostate®, in Subjects With Haemophilia A

Hemophilia A

Bulgaria, Poland, Russian Federation, Macedonia, The Former Yugoslav Republic of
VIVUS LLC

Completed

To Compare the Pharmacokinetics of Avanafil in Subjects With Mild and Moderate Renal Impairment to Subjects With Normal Renal Function.

Renal
ViiV Healthcare
Pfizer

Completed

Pharmacokinetics, Safety And Toleration Of Maraviroc Administered To Subjects With Various Degrees Of Renal Impaired And Normal Renal Function

Human Immunodeficiency Virus (HIV) Infection

Germany
Asan Medical Center
Dong-A Pharmaceutical Co., Ltd.

Completed

Clinical Study to Investigate the Safety and Pharmacokinetics of Udenafil Tablet in Renal Impaired Male Patients (DA8159_RI_I)

Kidney Diseases | Urologic Diseases | Renal Insufficiency

Korea, Republic of
Institute of Tropical Medicine, Belgium

Completed

IPT of Malaria With SP in Different Zones of Drug Resistance in Rwanda

Non HIV Infected Pregnant Women

Rwanda
Barts & The London NHS Trust

Unknown

Development of a Biomarker Panel for the Earlier Prediction of Acute Kidney Injury in Patients With Diabetes (BIOMARKERS)

Diabetes Mellitus | Renal Impairment

United Kingdom
Hospital de Clinicas de Porto Alegre

Unknown

Low-dose Albumin Solution in SBP: a Randomized Double-blind Pilot Study (ALTERNATE)

Renal Impairment | All Cause Mortality

Brazil
Lexicon Pharmaceuticals

Completed

Study of LX6171 in Elderly Volunteers With Age Associated Memory Impairment

Age-Related Memory Disorders

Netherlands
Phenomix
Forest Laboratories

Terminated

Study to Evaluate Safety and Efficacy of Dutogliptin in Type 2 Diabetes Mellitus Subjects With Moderate and Severe Renal Impairment

Type 2 Diabetes Mellitus | Renal Impairment

United States, Russian Federation, Ukraine
Pfizer
Medivation, Inc.

Completed

A Phase 1, Non-Randomized, Open-Label, Single-Dose Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF 01913539] In Subjects With Severely-Impaired And Normal Renal Function

Alzheimer's Disease | Huntington's Disease

United States
AstraZeneca

Completed

Evaluation of Target Organs Impairment on Patients Suffering From High Blood Pressure (PREVENTA)

Blood Pressure

France
GE Healthcare
Hvidovre University Hospital; Medpace, Inc.; i3 Statprobe

Completed

Brain Uptake and Safety With Probable Alzheimer's Disease, Amnestic Mild Cognitive Impairment and Healthy Volunteers (ALZ201)

Alzheimer's Disease | Amnestic Mild Cognitive Impairment

Norway
VIVUS LLC

Completed

A Study to Evaluate the Pharmacokinetics of VI-0521 Subjects With Renal Impairment

Renal Impairment

United States
NovaCardia, Inc.
Merck Sharp & Dohme LLC

Completed

PROTECT-2: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function

Heart Failure, Congestive
NovaCardia, Inc.
Merck Sharp & Dohme LLC

Completed

PROTECT-1: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function

Heart Failure, Congestive
Javelin Pharmaceuticals

Completed

Open-Label, Single-Dose Study to Evaluate the Safety and PK of DIC075V in Subjects With Renal Insufficiency and Hepatic Impairment Compared to Healthy Subjects and Evaluate the Safety and Pharmacokinetics of HPβCD When Administered in DIC075V Compared to Sporanox® in Healthy Subjects

Hepatic Insufficiency | Healthy | Renal Insufficiency, Chronic

United States, United Kingdom
Novartis

Completed

Pharmacokinetic Study of Vildagliptin in Patients With Renal Impairment

Type-2 Diabetes

Germany, United States

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