Search clinical trials for: Double-Blind,

Total 5380 results

University of Vermont
World Health Organization

Active, not recruiting

Intradermal Fractional Dose IPV (fIPV) in Combination With dmLT

Poliomyelitis

United States
Mahidol University

Completed

Comparison of Anti-inflammatory Effects of Seroflo and Seretide in Patients With Asthma

Asthma

Thailand
Future University in Egypt
Ain Shams University

Completed

Post-operative Pain After Laser Root Canal Treatment of Necrotic Teeth With Apical Periodontitis

Apical Periodontitis | Pulp Disease, Dental | Pulp Necroses

Egypt
Chinese PLA General Hospital
Dalian Zhen-Ao Bio-Tech Co., Ltd.

Active, not recruiting

A Randomized, Single-blind, Controlled Clinical Study of Cardiomyopeptidin on Improving Ischemia-reperfusion Injury in Patients With Acute ST-segment Elevation Myocardial Infarction After Primary PCI

Cardiovascular Diseases

China
Yonsei University

Completed

Treatment of Fecal Incontinence Using Allogenic-Adipose-derived Mesenchymal Stem Cells: A Prospective, Dose Escalation, Randomized, Placebo-controlled, Parallel-group, Single-blind, Single-center Pilot Study

Fecal Incontinence

Korea, Republic of
Bayer

Completed

A Single-blind Pilot Study to Investigate Safety and Tolerability of the Chymase Inhibitor BAY1142524 in Clinically Stable Patients With Left-ventricular Dysfunction (CHIARA MIA 1)

Heart Failure

Germany, Denmark, Italy
XRad Therapeutics Inc

Completed

Trial of XRD-0394, a Kinase Inhibitor, in Combination With Palliative Radiotherapy in Advanced Cancer Patients

Metastasis | Recurrent Cancer | Locally Advanced Solid Tumor

United States
University of Oxford
Astellas Pharma Inc; European Organisation for Research and Treatment of Cancer... and other collaborators

Completed

Eurosarc Trial of Linsitinib in Advanced Ewing Sarcoma (LINES)

Refractory Ewing Sarcoma | Relapsed Ewing Sarcoma

United Kingdom, Germany, Netherlands, Italy, France
GlaxoSmithKline

Completed

Lapatinib In Combination With Trastuzumab Versus Lapatinib Monotherapy In Subjects With HER2-positive Metastatic Breast Cancer

Neoplasms, Breast

United States, Canada, Germany, Bulgaria, Spain, Poland, Finland, United Kingdom, Austria, Italy, Greece, Czech Republic, Croatia
Novartis Pharmaceuticals

Completed

An 8-week Study to Evaluate the Dose Response of AHU377 in Combination With Valsartan 320 mg in Patients With Mild-to-moderate Systolic Hypertension

Systolic Hypertension

United States, Spain, Hungary, Korea, Republic of, Argentina, India, Slovakia, Canada, Romania
Novartis Pharmaceuticals

Completed

A Long-term (12 Months) Safety, Tolerability and Efficacy Study of LCZ696 in Patients With Essential Hypertension

Essential Hypertension

China, Taiwan, Japan, Thailand, Korea, Republic of
US Department of Veterans Affairs

Completed

Effect of Diabetic Medications on Bone Metabolism

Type 2 Diabetes Mellitus | Osteoporosis
GlaxoSmithKline

Terminated

Lapatinib In Combination With Chemotherapy In Subjects With Relapsed Breast Cancer

Neoplasms, Breast | Relapsed Breast Cancer

United States
Ohio State University Comprehensive Cancer Center

Recruiting

Combining Immunotherapy Salvage Surgery & IORT Tx Persistent/Recurrent Head & Neck Cancer

Recurrent Laryngeal Squamous Cell Carcinoma | Recurrent Oral Cavity Squamous Cell Carcinoma | Recurrent Pharyngeal Squamous Cell Carcinoma | Locally Recurrent Head and Neck Squamous Cell Carcinoma | Head and Neck Carcinoma of Unknown Primary | Resectable Head and Neck Squamous Cell Carcinoma

United States
H. Lee Moffitt Cancer Center and Research Institute
Merck Sharp & Dohme LLC; Prometheus Laboratories

Active, not recruiting

Interleukin-2 and Pembrolizumab for Metastatic Kidney Cancer

Kidney Cancer

United States
Shanghai Cell Therapy Group Co.,Ltd
Shanghai Mengchao Cancer Hospital

Not yet recruiting

The Exploratory Study About the Effect of Using Double Filtration Plasmapheresis (DFPP) Removing Inflammatory Cytokines, Lipids and Toxic Metal Ions in Peripheral Blood in Adults

Hyperlipidemia | Sub-healthy | Toxic Metal Ions Accumulation

China
Aldeyra Therapeutics, Inc.

Completed

A Multi-Center, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Clinical Trial Evaluating the Safety of Reproxalap Ophthalmic Solution in Subjects With Dry Eye Disease

Dry Eye Disease

United States
University of Texas Southwestern Medical Center
Advanced Vision Research

Completed

A Placebo Controlled Double Masked Clinical Assessment Study of Essential Fatty Acid Supplement and Its Effect on Patients With Apparent Aqueous Deficient Dry Eye Syndrome

Dry Eye Syndrome

United States
The University of Hong Kong

Recruiting

GnRH Agonist for Dual Trigger in IVF and for Luteal Phase Support in FET

Subfertility

China
Boston University Charles River Campus
Massachusetts General Hospital; Juvenile Diabetes Research Foundation

Completed

Closed-loop Glucose Control for Automated Management of Type 1 Diabetes

Type 1 Diabetes

United States
Yuzuncu Yıl University

Completed

Efficacy of Naproxen-codeine, Naproxen+Dexamethasone, and Naproxen on Myofascial Pain

Temporomandibular Disorder

Turkey
Eli Lilly and Company

Completed

A Study to Compare the Effect of a Double Dose of Two Long-acting Insulin Therapies in Participants With Type 2 Diabetes (IMAGINE 8)

Type 2 Diabetes Mellitus

Germany, United States
Durrie Vision
Alcon Research

Completed

A Prospective, Randomized, Double-Masked, Single Center, Clinical Comparison of the Use of Systane Ultra in the Management of Dry Eyes in Bilateral Eyes

Dry Eye
Ratan K. Chaudhuri

Completed

A Randomized, Double-blinded, Placebo Controlled, Monocentric Study to Evaluate the Anti-ageing and Skin Brightening Benefit of the Test Product in Healthy Female Subjects

Skin Aging

India
Tarix Pharmaceuticals

Withdrawn

Evaluation of the Safety and Efficacy of TXA127 (Angiotensin 1-7) to Enhance Engraftment in Pediatric Patients Undergoing Single or Double Umbilical Cord Blood Transplantation

Hematologic Malignancy | Cord Blood Transplant | Inherited Metabolic Disease

United States
Ellman International

Completed

Safety and Efficacy of Single Therapy Versus Double and Triple Therapy of the Pellevé™ Wrinkle Treatment System for the Treatment of Moderate Facial Wrinkles

Appearance of Facial Wrinkles

United States
Tianjin Medical University General Hospital

Recruiting

Efficacy and Safety of Liposomal Bupivacaine Under ERAS Concept for Postoperative Analgesia of Ultrasound-Guided QLB in Gynecologic Laparoscopic Patients: A Randomized, Single-blind, Active-Controlled Clinical Study

Pharmacological Action

China
Hugel
Associacio catalana per a la recerca oncologica i les seves implicacions...

Completed

A Multi-center, Randomized, Subject Blind, Active Controlled Design Clinical Study to Evaluate the Efficacy and Safety of Volus as Compared to PowerFill® for Temporary Penile Enhancement

Penile Enhancement

Korea, Republic of
Aevi Genomic Medicine, LLC, a Cerecor company
Children's Hospital of Philadelphia; Thomas Jefferson University; Pearson/Clinical...

Completed

Phase I Single Dose, Open-Label Pharmacokinetic Study and Single-Blind, Placebo-Controlled Dose Escalation Study of NFC-1 in Adolescents With Attention-Deficit Hyperactivity Disorder (NFC1-GREAT)

Attention-deficit Hyperactivity Disorder (ADHD)

United States
Icure Pharmaceutical Inc.

Completed

A Phase I Clinical Study, Randomized, Single-blind, Placebo-controlled, Multiple Doses, Dose Escalation Study of the Safety, Tolerability and Pharmacokinetics of Donepezil Patch in Healthy Male Subjects.

Alzheimer Disease

Korea, Republic of
Hillel Yaffe Medical Center

Unknown

"Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up

Coronary Angiography

Israel
M.D. Anderson Cancer Center

Recruiting

Phase II Investigation of Pembrolizumab in Combination With Bevacizumab and Oral Cyclophosphamide in Patients With High Grade Ovarian Cancer and Surgically Documented Minimal Residual Disease After Frontline Therapy

Ovarian Cancer

United States
Raija Silvennoinen
Takeda; Celgene; Nordic Myeloma Study Group

Active, not recruiting

Ixazomib Plus Lenalidomide Plus Dexamethasone for Newly Diagnosed Myeloma Patients

Multiple Myeloma

Norway, Sweden, Finland, Lithuania
Raziel Therapeutics Ltd.

Completed

A Single Blind, Randomized, Placebo-controlled, Phase 2a, 2-cohort Study for the Evaluation of Safety and Efficacy of RZL-012 for Submental Fat Reduction in Healthy Volunteers.

Submental Fat

United States
University Hospital, Tours

Completed

Effect of Acupressure on the "Yin-Tang" and "Shen-Men" Points on Pre and Postoperative Anxiety in Elective Caesarean Section: a Prospective, Single-blind, Randomised, Controlled Trial (ACUCESAR)

Pregnancy | Cesarean Section | Preoperative Anxiety

France
General Hospital of Shenyang Military Region

Completed

Argatroban Combined With Antiplatelet Versus Antiplatelet for Acute Ischemic Stroke

Stroke, Ischemic

China
University College Cork

Completed

Effect of Vitamin D-biofortified Eggs on Wintertime Serum 25-hydroxyvitamin D in Adults: Randomized Controlled Trial (EnhanceDeggs)

Vitamin D Deficiency

Ireland
City of Hope Medical Center
National Cancer Institute (NCI)

Withdrawn

Flotetuzumab in Treating Patients With Recurrent or Refractory CD123 Positive Blood Cancer

Recurrent Hodgkin Lymphoma | Refractory Hodgkin Lymphoma | Acute Leukemia | Recurrent Acute Lymphoblastic Leukemia | Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Refractory Acute Lymphoblastic Leukemia | Systemic Mastocytosis | Recurrent Hematologic Malignancy | Hairy Cell Leukemia | Chronic... and other conditions
University of Oxford

Completed

A Single-blind Stepped Wedge Cluster Randomized Controlled Behaviour Change Trial to Determine Effectiveness of Prevention Programme of Melioidosis in Diabetics in Ubon Ratchathani, Northeast Thailand (PREMEL)

Melioidosis

Thailand
Sohag University

Recruiting

Pulmonary Hypertension in Patients Attending Sohag University Hospital: A Focus on The Etiology

Patients With Pulmonary Hypertension

Egypt
University of Washington
National Cancer Institute (NCI)

Completed

Vitamin D Deficiency, Muscle Pain, Joint Pain, and Joint Stiffness in Postmenopausal Women Receiving Letrozole For Stage I-III Breast Cancer

Pain | Arthralgia | Stage I Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IIIC Breast Cancer | Recurrent Breast Cancer | Musculoskeletal Complications

United States
University of Vermont

Completed

Evaluation of Safety, Reactogenicity and Immunogenicity of Fractional-dose Inactivated Polio Vaccine (fIPV) Given Intradermally With Double Mutant Enterotoxigenic Escherichia Coli Heat Labile Toxin (dmLT) Adjuvant

Polio

United States
Indiana University
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Building Strength Through Rehabilitation for Heart Failure Patients (BISTRO-STUDY)

Heart Failure

United States
University of Aarhus
Zimmer Biomet

Completed

Evaluation of Cemented and Cementless Fixation of Dual-mobility Hip Prosthesis in Elderly Patients With Osteoarthritis

Osteoarthritis, Hip | Arthropathy of Hip

Denmark
Johns Hopkins University
Centers for Medicare and Medicaid Services; Jewish Community Services; Johns...

Completed

Comprehensive Home-based Dementia Care Coordination for Medicare-Medicaid Dual Eligibles in Maryland

Dementia | Caregiver Burden

United States
Hadassah Medical Organization

Withdrawn

GLP Analogs for Diabetes in Wolfram Syndrome Patients

Wolfram Syndrome | Diabetes Mellitus Associated With Genetic Syndrome
Washington University School of Medicine
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Tracking Neurodegeneration in Early Wolfram Syndrome (TRACK)

Diabetes Mellitus | Type 1 Diabetes | Diabetes Insipidus | Wolfram Syndrome

United States
Cephalon, Inc.

Completed

Combination Therapy With MYOCET® (Doxorubicin HCL Liposome for Injection) in Participants With HER2-Positive Breast Cancer

Breast Cancer

Austria, Belgium, France, Germany, Italy, Spain
Yuyu Pharma, Inc.

Active, not recruiting

Phase 2, Multi-center, Randomized, Double- Masked and Placebo-Controlled Study of YP-P10 Ophthalmic Solution Compared to Placebo in Subjects With Dry Eye (ICECAP 1)

Dry Eye

United States
Gachon University Gil Oriental Medical Hospital
Kyung Hee University Hospital at Gangdong; Kyunghee University Medical Center; Sangji University Oriental Medical Hospital and other collaborators

Completed

Efficacy and Safety of Ucha-Shinki-Hwan on Korean Patients With Cold Hypersensitivity in the Hands and Feet-Double Blinded, Randomized, Multicenter, Placebo Controlled Clinical Trial

Cold Hypersensitivity

Korea, Republic of

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