Search clinical trials for: third-line therapy

Total 51905 results

Chiron Corporation

Completed

A Phase I Study of the Safety of Proleukin (Aldesleukin) in Combination With Ganciclovir and Antiretroviral Therapy in HIV Seropositive Patients With Cytomegalovirus (CMV) Retinitis

HIV Infections | Cytomegalovirus Retinitis

United States
Glaxo Wellcome

Completed

The Antiviral Efficacy of Concurrent Zidovudine and 2',3'-Dideoxyinosine or 2',3'-Dideoxycytidine in Patients With Human Immunodeficiency Virus Disease

HIV Infections

United States, Puerto Rico, Australia
Mallinckrodt

Completed

The Therakos UVAR Photopheresis System in the Treatment of AIDS-Related Complex

HIV Infections

United States
Glaxo Wellcome

Completed

The Safety and Effectiveness of 1592U89 Plus 141W94 Plus DMP 266 in Patients With HIV Who Developed a Resistance to Protease Inhibitors

HIV Infections

United States
Glaxo Wellcome

Completed

A Study of a Combination of Four Drugs in Patients With Recent HIV Infection

HIV Infections

United States
Merck Sharp & Dohme LLC

Unknown

Safety and Effectiveness of an Anti-HIV Drug Combination Taken Twice Daily

HIV Infections

United States
Hoffmann-La Roche

Completed

The Safety and Effectiveness of Ganciclovir Plus Interferon Beta in Preventing the Return of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS

HIV Infections | Cytomegalovirus Retinitis

United States
Hoffmann-La Roche

Completed

A Study of Saquinavir Soft Gelatin Capsules Plus Zidovudine Plus Lamivudine in the Treatment of HIV-1 Infected Patients Who Have Never Taken Anti-HIV Drugs

HIV Infections

United States
Gilead Sciences

Completed

Safety and Effectiveness of Adding PMPA Prodrug to an Anti-HIV Drug Combination to Treat HIV-Infected Patients

HIV Infections

United States
Gilead Sciences
Glaxo Wellcome; Dupont Applied Biosciences

Completed

Safety and Effectiveness of Giving Adefovir Dipivoxil Plus Abacavir Plus Efavirenz Plus Amprenavir to HIV-Infected Patients Who Have Failed to Respond to Previous Protease Inhibitor Treatment

HIV Infections

United States
Glaxo Wellcome

Completed

The Safety and Effectiveness of Three Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Taken AZT

HIV Infections

United States, Canada, Puerto Rico
Hoffmann-La Roche

Completed

A Study to Compare the Effects of Two Anti-HIV Drug Combinations on the Immune Systems of HIV-Infected Patients

HIV Infections

United States
Merck Sharp & Dohme LLC

Unknown

The Safety and Effectiveness of Indinavir Plus Ritonavir Plus Two NRTIs in HIV-Infected Patients Who Need Early Intervention Treatment

HIV Infections

United States
Hoffmann-La Roche
Trimeris

Completed

T-20 in HIV Patients With Prior Drug Treatment and/or Resistance to Each of the Three Classes of Anti-HIV Drugs

HIV Infections

Switzerland, Spain, United Kingdom, Germany, Belgium, Australia, Sweden, Italy, Netherlands
U.S. Bioscience

Completed

A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate With Leucovorin Protection for Patients With Pneumocystis Carinii Pneumonia.

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
Hoffmann-La Roche

Completed

A Study of Zidovudine (AZT) Used Alone or in Combination With Other Anti-HIV Drugs in HIV-Infected Patients With Little or No Previous Treatment

HIV Infections

United States, Puerto Rico
Gilead Sciences
Bristol-Myers Squibb; Glaxo Wellcome; Dupont Applied Biosciences

Completed

Safety and Effectiveness of Giving an Anti-HIV Drug Combination of Adefovir Dipivoxil Plus Didanosine Plus Efavirenz Plus Lamivudine Once Daily to HIV-Infected Patients

HIV Infections

United States
Eunice Kennedy Shriver National Institute of Child...
Children's National Research Institute

Terminated

Phase I Pilot Study of Liver-Directed Gene Therapy for Partial Ornithine Transcarbamylase Deficiency

Ornithine Transcarbamylase Deficiency Disease
Merck Sharp & Dohme LLC

Unknown

Safety and Effectiveness of Giving Indinavir, Ritonavir, Stavudine, and Lamivudine to HIV-Infected Patients Who Have Never Received Anti-HIV Drugs

HIV Infections

United States
Boehringer Ingelheim

Completed

A Multi-Center, Placebo-Controlled, Double-Blind, Randomized Trial Comparing the Virologic and Immunologic Activities of 400 Mg Nevirapine in Combination With Zidovudine Versus Zidovudine Alone in Asymptomatic HIV-1 Infected Patients With 4-12 Months of Prior Zidovudine Therapy and 200-500 CD4+ Cell

HIV Infections

United States
Glaxo Wellcome

Completed

The Safety and Effectiveness of Lamivudine Plus Zidovudine, Used With and Without 1592U89, in HIV-1 Infected Patients Who Have Never Taken Anti-HIV Drugs

HIV Infections

United States, Canada, Puerto Rico
Glaxo Wellcome

Completed

A Study of Increased Lactic Acid and Abnormal Fat Distribution in HIV-Positive Patients

HIV Infections | Lipodystrophy

United States
National Institute of Allergy and Infectious Diseases...
Schering-Plough

Completed

SCH 39304 as Therapy for Acute Cryptococcal Meningitis in HIV-Infected Patients Followed by Maintenance Therapy

HIV Infections | Meningitis, Cryptococcal

United States
Dupont Merck

Completed

A Study of Efavirenz in Combination With Stavudine and Didanosine

HIV Infections

United States
Hoffmann-La Roche

Completed

The Safety and Effectiveness of Saquinavir Soft Gelatin Capsules Combined With Other Anti-HIV Drugs

HIV Infections

United States
Ortho Pharmaceuticals

Completed

A Double-Blind, Placebo-Controlled Study With Open-Label Follow-Up To Determine the Safety and Efficacy of Subcutaneous Doses of r-HuEPO in AIDS Patients With Anemia Induced by Their Disease and AZT Therapy

HIV Infections | Cytopenias

United States
AJI Pharma USA

Completed

Phase I/II Study of the Tolerance and Efficacy of Combined Use of Didanosine (2',3'-Dideoxyinosine; ddI) and Lentinan in HIV-Positive Patients

HIV Infections

United States
Hoechst Marion Roussel

Completed

A Study of the Safety and Efficacy of Chronically Administered MDL 28,574A in the Treatment of HIV-Infected Patients

HIV Infections

United States
Pharmacia

Completed

A Study of Rifabutin, Used Alone or With Ethambutol in the Prevention of Mycobacterium Avium Complex (MAC) Bacteremia in Patients With AIDS

HIV Infections | Mycobacterium Avium-Intracellulare Infection

United States
Mylan Laboratories

Completed

A Phase II/III Study of Cysteamine (Mercaptoethylamine) and Zidovudine for the Treatment of HIV Disease

HIV Infections

United States
National Center for Research Resources (NCRR)
University of Texas

Completed

Phase I Study of Tin Mesoporphyrin in Patients on Long Term Heme Therapy for Prevention of Acute Attacks of Porphyria

Porphyria
National Institute on Drug Abuse (NIDA)
Johns Hopkins University

Unknown

Randomized Study of Interventions to Enhance Adherence to Isoniazid Prevention Therapy for Tuberculosis in Injection Drug Users

Tuberculosis
National Center for Research Resources (NCRR)
Children's Hospital Colorado

Unknown

Phase I Study of Colchicine Therapy in Childhood Hepatic Cirrhosis

Liver Cirrhosis | Cirrhosis
Glaxo Wellcome

Completed

A Study of the Safety and Effectiveness of Combination Anti-HIV Therapy in HIV-Infected Adults

HIV Infections

United States
Argus Pharmaceuticals

Completed

A Study of Nystatin in HIV-Infected Patients

HIV Infections

United States
GlaxoSmithKline

Unknown

Safety and Effectiveness of TRIZIVIR (Abacavir/Lamivudine/Zidovudine) With Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs

HIV Infections

United States
Hoffmann-La Roche

Completed

A Study of Saquinavir and Zalcitabine, Used Alone and Together, in the Treatment of Advanced HIV Infection in Patients Who Stopped Taking or Who Cannot Take Zidovudine

HIV Infections

United States, Puerto Rico, Canada
Hoechst Marion Roussel

Completed

A Randomized, Double-Blind Active-Controlled, Dose-Ranging Study of the Safety and Efficacy of Chronically Administered MDL 28,574A in the Treatment of HIV-Infected Patients

HIV Infections

United States
Shaman Pharmaceuticals

Completed

Double-Blind Placebo-Controlled Study Comparing the Combination of 15% SP-303 Gel With Acyclovir Versus Acyclovir Alone for the Treatment of Recurrent Herpes Simplex Virus (HSV) Infections in Subjects With Acquired Immunodeficiency Syndrome (AIDS)

HIV Infections | Herpes Simplex

United States, Puerto Rico
National Eye Institute (NEI)

Unknown

Randomized Trials of Vitamin Supplements and Eye Disease

Macular Degeneration | Cataract
National Institute on Alcohol Abuse and Alcoholism...

Completed

Sertraline and Cognitive Therapy in Depressed Alcoholics

Depression | Alcoholism

United States
Ionis Pharmaceuticals, Inc.

Completed

A Randomized Comparison of Intravitreal ISIS 2922 Plus Ganciclovir Versus Ganciclovir as Treatment for Patients With Cytomegalovirus Retinitis ( CMVR )

HIV Infections | Cytomegalovirus Retinitis

United States
Gilead Sciences

Completed

An Open-Label Study of the Safety and Efficacy of Cidofovir for the Treatment of Relapsing Cytomegalovirus Retinitis in Patients With AIDS

HIV Infections | Cytomegalovirus Retinitis

United States
Glaxo Wellcome

Completed

A Study of Amprenavir in HIV-Infected Patients

HIV Infections

United States
Light Sciences LLC

Completed

Photodynamic Therapy System for Patients With Refractory/Unresponsive Solid Tumors

Sarcoma | Breast Cancer | Head and Neck Cancer | Colorectal Cancer | Rectal Cancer | Pelvic Cancer | Mouth Cancer | Liver Metastasis

United States
Immune Enhancement Project

Completed

Acupuncture and Herbal Treatment of Chronic HIV Sinusitis

HIV Infections | Sinusitis

United States
Glaxo Wellcome

Completed

A Treatment IND for 566C80 Therapy of Pneumocystis Carinii Pneumonia

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
Glaxo Wellcome

Completed

The Safety and Effectiveness of Zidovudine Plus Lamivudine, Used With and Without 1592U89, in HIV-1 Infected Children Who Have Taken Anti-HIV-1 Drugs

HIV Infections

United States
Hoffmann-La Roche

Completed

A Study of Saquinavir Used Alone or in Combination With Other Anti-HIV Drugs in HIV-Infected Patients

HIV Infections

United States
National Institute on Alcohol Abuse and Alcoholism...

Completed

Naltrexone Treatment of Alcohol Dependence

Alcoholism

United States

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